scholarly journals Cellular and Molecular Adaptation of Bovine Granulosa Cells and Oocytes under Heat Stress

Animals ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 110 ◽  
Author(s):  
Adnan Khan ◽  
Muhammad Zahoor Khan ◽  
Saqib Umer ◽  
Ibrar Muhammad Khan ◽  
Huitao Xu ◽  
...  
Keyword(s):  
Heat Stress ◽  
Dairy Cattle ◽  
Granulosa Cells ◽  
Elevated Temperatures ◽  
Mitigation Strategies ◽  
Future Research ◽  
Stressed Animal ◽  
Regulate Body Temperature ◽  
And Function ◽  
The Impact

Heat stress has long been recognized as a challenging issue that severely influences the reproductive functions of dairy cattle, disrupting oocyte development during fetal growth. These detrimental effects of heat stress are the result of either the hyperthermia associated with heat stress or the physiological adjustments made by the heat-stressed animal to regulate body temperature. In addition, elevated temperatures have been implicated in increasing the production of reactive oxygen species. Thus, understanding the impact of heat stress on reproductive functions, from a cellular to molecular level, might help in selecting heat-resilient dairy cattle and developing heat stress mitigation strategies. In the present paper, we have attempted to describe the changes in the reproductive system and function of dairy cattle in response to heat stress by reviewing the latest literature in this area. The review provides useful knowledge on the cellular and genetic basis of oocyte and granulosa cells in heat-stressed dairy cattle, which could be helpful for future research in this area.

scholarly journals Exercise under heat stress: thermoregulation, hydration, performance implications and mitigation strategies

2021 ◽  
Author(s):  
Julien D. Periard ◽  
Thijs M.H. Eijsvogels ◽  
Hein A.M. Daanen
Keyword(s):  
Heat Stress ◽  
Exercise Performance ◽  
Thermal Strain ◽  
Mitigation Strategies ◽  
Body Core Temperature ◽  
Aerobic Performance ◽  
Future Research ◽  
Hydration Status ◽  
Fatigue Development ◽  
The Impact

A rise in body core temperature and loss of body water via sweating are natural consequences of prolonged exercise in the heat. This review provides a comprehensive and integrative overview of how the human body responds to exercise under heat stress and the countermeasures that can be adopted to enhance aerobic performance under such environmental conditions. The fundamental concepts and physiological processes associated with thermoregulation and fluid balance are initially described, followed by a summary of methods to determine thermal strain and hydration status. An outline is provided on how exercise-heat stress disrupts these homeostatic processes, leading to hyperthermia, hypohydration, sodium disturbances and in some cases exertional heat illness. The impact of heat stress on human performance is also examined, including the underlying physiological mechanisms that mediate the impairment of exercise performance. Similarly, the influence of hydration status on performance in the heat and how systemic and peripheral hemodynamic adjustments contribute to fatigue development is elucidated. This review also discusses strategies to mitigate the effects of hyperthermia and hypohydration on exercise performance in the heat, by examining the benefits of heat acclimation, cooling strategies and hyperhydration. Finally, contemporary controversies are summarized and future research directions provided.

scholarly journals Normative range parenting and the developing brain: a scoping review of the literature

2019 ◽  
Author(s):  
Madeline Farber ◽  
Dylan Gee ◽  
Ahmad R. Hariri
Keyword(s):  
Mental Health ◽  
Brain Development ◽  
Scoping Review ◽  
Developmental Trajectories ◽  
Future Research ◽  
Risk And Resilience ◽  
Abuse And Neglect ◽  
Brain Structure And Function ◽  
And Function ◽  
The Impact

Studies of early adversity such as trauma, abuse, and neglect highlight the critical importance of quality caregiving in brain development and mental health. However, the impact of normative range variability in caregiving on such biobehavioral processes remains poorly understood. Thus, we lack an essential foundation for understanding broader, population-representative developmental mechanisms of risk and resilience. Here, we conduct a scoping review of the extant literature centered on the question, “Is variability in normative range parenting associated with variability in brain structure and function?” After removing duplicates and screening by title, abstract, and full-text, 23 records were included in a qualitative review. The most striking outcome of this review was not only how few studies have explored associations between brain development and normative range parenting, but also how little methodological consistency exists across published studies. In light of these limitations, we propose recommendations for future research on normative range parenting and brain development. In doing so, we hope to facilitate evidence-based research that will help inform policies and practices that yield optimal developmental trajectories and mental health.

scholarly journals Analysis of heat-induced protein aggregation in human mitochondria

2018 ◽  
Author(s):  
Anne Wilkening ◽  
Cornelia Rüb ◽  
Marc Sylvester ◽  
Wolfgang Voos
Keyword(s):  
Heat Stress ◽  
Mammalian Cells ◽  
Elevated Temperatures ◽  
Protein Biosynthesis ◽  
High Sensitivity ◽  
Small Subset ◽  
Loss Of Function ◽  
Mitochondrial Translation ◽  
The Impact ◽  
Induced Aggregation

AbstractAs proteins in mammalian cells exhibit optimal stability at natural temperatures, small temperature variations may cause unfolding and subsequent non-specific aggregation. As this process leads to a loss of function of the affected polypeptides as well as to further cytotoxic stress, aggregate formation has been recognized as a major pathogenic factor in human diseases. In this study we determined the impact of physiological heat stress on mammalian mitochondria on a proteomic level. The overall solubility of endogenous mitochondrial proteins was only marginally affected by a treatment at elevated temperatures. However, we identified a small subset of polypeptides that exhibited an exceptionally high sensitivity to heat stress. The mitochondrial translation elongation factor Tu (Tufm), a protein essential for organellar protein biosynthesis, was highly aggregation-prone and lost its solubility already under mild heat stress conditions. In parallel, mitochondrial translation as well as the import of cytosolic proteins was defective in heat stressed mitochondria. Both types of nascent polypeptides, derived from translation as well as from import exhibited a strong heat-induced aggregation tendency. We propose a model that a quick and specific inactivation of elongation factors may prevent an accumulation of misfolded nascent polypeptides and thereby attenuate proteotoxicity under stress.

scholarly journals Milk production, mortality, and economic parameters in the context of heat-stressed dairy cattle.

2021 ◽  
Vol 16 (062) ◽  
Author(s):  
Rachael Vriezen
Keyword(s):  
Heat Stress ◽  
Dairy Cattle ◽  
Milk Yield ◽  
Data Extraction ◽  
Animal Health ◽  
Mitigation Measures ◽  
Research Gaps ◽  
Economic Decision Making ◽  
Economic Parameters ◽  
The Impact

Abstract As climate change progresses, higher temperatures and longer periods of extreme weather are likely to increasingly impact the production and health of dairy cattle, in turn affecting farm-level profits and economic decision-making. This review identifies and summarizes the currently available research on the effect of climate-related heat stress or heat stress mitigation measures on milk yield, mortality, and economic parameters on dairy farms. A scoping review approach was adopted to map the volume, range, and characteristics of the existing body of evidence and to identify research gaps. Through a comprehensive search, 286 studies published between 2010 and 2020 were identified and underwent data extraction and analysis. These studies were conducted in 46 countries, and encompassed both research and non-research herds as well as simulation models. The Temperature-Humidity Index (THI) was the most common indicator of heat stress, although a range of atmospheric, physiological, and descriptive indicators were used. Three-quarters of these studies examined at least one heat stress mitigation strategy, such as genetic manipulations, mechanical interventions, and diet manipulation. Approximately 97% of studies evaluated the impact of heat stress on milk yield, and 10% of studies examined at least one economic parameter. Research gaps exist in the analysis of economic parameters related to heat stress in dairy cattle. Given the urgent and increasing nature of climate challenges, additional economic analyses of the effects of heat stress in dairy cattle are needed to inform production and animal health decisions in a rapidly changing environment.

scholarly journals Effects of hydration status on cognitive performance and mood

2014 ◽  
Vol 111 (10) ◽  
pp. 1841-1852 ◽  
Author(s):  
Natalie A. Masento ◽  
Mark Golightly ◽  
David T. Field ◽  
Laurie T. Butler ◽  
Carien M. van Reekum
Keyword(s):  
Water Consumption ◽  
Cognitive Abilities ◽  
The Elderly ◽  
Future Research ◽  
Hydration Status ◽  
Fluid Regulation ◽  
Optimal Maintenance ◽  
And Function ◽  
The Impact

Although it is well known that water is essential for human homeostasis and survival, only recently have we begun to understand its role in the maintenance of brain function. Herein, we integrate emerging evidence regarding the effects of both dehydration and additional acute water consumption on cognition and mood. Current findings in the field suggest that particular cognitive abilities and mood states are positively influenced by water consumption. The impact of dehydration on cognition and mood is particularly relevant for those with poor fluid regulation, such as the elderly and children. We critically review the most recent advances in both behavioural and neuroimaging studies of dehydration and link the findings to the known effects of water on hormonal, neurochemical and vascular functions in an attempt to suggest plausible mechanisms of action. We identify some methodological weaknesses, including inconsistent measurements in cognitive assessment and the lack of objective hydration state measurements as well as gaps in knowledge concerning mediating factors that may influence water intervention effects. Finally, we discuss how future research can best elucidate the role of water in the optimal maintenance of brain health and function.

What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review

2015 ◽  
Vol 45 (12) ◽  
pp. 2461-2480 ◽  
Author(s):  
R. Gurung ◽  
D. P. Prata
Keyword(s):  
Bipolar Disorder ◽  
Brain Structure ◽  
Association Studies ◽  
Structure And Function ◽  
Future Research ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Brain Structure And Function ◽  
And Function ◽  
The Impact

The powerful genome-wide association studies (GWAS) revealed common mutations that increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority were not known to be functional or associated with these illnesses. To help fill this gap, their impact on human brain structure and function has been examined. We systematically discuss this output to facilitate its timely integration in the psychosis research field; and encourage reflection for future research. Irrespective of imaging modality, studies addressing the effect of SZ/BD GWAS risk genes (ANK3, CACNA1C, MHC, TCF4, NRGN, DGKH, PBRM1, NCANandZNF804A) were included. Most GWAS risk variations were reported to affect neuroimaging phenotypes implicated in SZ/BD: white-matter integrity (ANK3andZNF804A), volume (CACNA1CandZNF804A) and density (ZNF804A); grey-matter (CACNA1C, NRGN, TCF4andZNF804A) and ventricular (TCF4) volume; cortical folding (NCAN) and thickness (ZNF804A); regional activation during executive tasks (ANK3, CACNA1C, DGKH, NRGNandZNF804A) and functional connectivity during executive tasks (CACNA1CandZNF804A), facial affect recognition (CACNA1CandZNF804A) and theory-of-mind (ZNF804A); but inconsistencies and non-replications also exist. Further efforts such as standardizing reporting and exploring complementary designs, are warranted to test the reproducibility of these early findings.

scholarly journals Cadmium Addition Effects on Anaerobic Digestion with Elevated Temperatures

Energies ◽  
2019 ◽  
Vol 12 (12) ◽  
pp. 2367
Author(s):  
Yonglan Tian ◽  
Shusen Li ◽  
Ying Li ◽  
Huayong Zhang ◽  
Xueyue Mi ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Anaerobic Digestion ◽  
Volatile Fatty Acids ◽  
Elevated Temperatures ◽  
Anaerobic Fermentation ◽  
Oxygen Demand ◽  
Future Research ◽  
Coenzyme F420 ◽  
Peak Period ◽  
The Impact

Anaerobic fermentation with biogas as an energy source is influenced by the presence of heavy metals. However, the availability of the heavy metals is dependent on the digestion temperature. In this study, the impacts of Cd on the characteristics of biogas, substrate biodegradation, and enzyme activity during anaerobic co-digestion were investigated under varying digestion temperatures. The results showed that 1 mg/L initial Cd concentration improved cumulative biogas yields by 404.96%, 16.93%, and 5.56% at 55 °C, 45 °C, and 35 °C, respectively. In contrast, at low temperatures (25 °C), the yield decreased by 0.77%. In the 55 °C group, Cd addition improved the activity of cellulase (p < 0.05) and coenzyme F420 (p < 0.01). The total chemical oxygen demand (COD) during the peak period and the transformation of hydrolytic organic components into volatile fatty acids (VFAs) influenced the CH4 and biogas yields. There were no significant differences in cellulase, dehydrogenase, and coenzyme F420 activities with or without Cd addition when the digestion temperature was 45 °C, 35 °C, and 25 °C. Therefore, thermophilic digestion is recommended for the efficient degradation of Cd-contaminated biowaste. Moreover, the impact of metals on the performance of anaerobic digestion should be considered together with temperature conditions in future research and practice.

scholarly journals The genetic and molecular basis for improving heat stress tolerance in wheat

aBIOTECH ◽  
2021 ◽  
Author(s):  
Lv Sun ◽  
Jingjing Wen ◽  
Huiru Peng ◽  
Yingyin Yao ◽  
Zhaorong Hu ◽  
...  
Keyword(s):  
Heat Stress ◽  
Stress Tolerance ◽  
Heat Tolerance ◽  
Genetic Basis ◽  
Molecular Mechanisms ◽  
Elevated Temperatures ◽  
New Technologies ◽  
Wheat Breeding ◽  
Heat Stress Tolerance ◽  
The Impact

AbstractWheat production requires at least ~ 2.4% increase per year rate by 2050 globally to meet food demands. However, heat stress results in serious yield loss of wheat worldwide. Correspondingly, wheat has evolved genetic basis and molecular mechanisms to protect themselves from heat-induced damage. Thus, it is very urgent to understand the underlying genetic basis and molecular mechanisms responsive to elevated temperatures to provide important strategies for heat-tolerant varieties breeding. In this review, we focused on the impact of heat stress on morphology variation at adult stage in wheat breeding programs. We also summarize the recent studies of genetic and molecular factors regulating heat tolerance, including identification of heat stress tolerance related QTLs/genes, and the regulation pathway in response to heat stress. In addition, we discuss the potential ways to improve heat tolerance by developing new technologies such as genome editing. This review of wheat responses to heat stress may shed light on the understanding heat-responsive mechanisms, although the regulatory network of heat tolerance is still ambiguous in wheat.

scholarly journals The Impact of Anthropogenic Climate Change on Egyptian Livestock Production

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3127
Author(s):  
Amira A. Goma ◽  
Clive J. C. Phillips
Keyword(s):  
Climate Change ◽  
Heat Stress ◽  
Milk Production ◽  
Human Population ◽  
Production Systems ◽  
Livestock Production ◽  
Mitigation Strategies ◽  
Animal Products ◽  
Alternative Scenarios ◽  
The Impact

Egypt is one of the hottest countries in the world, and extreme climate events are becoming more frequent, which is consistent with the warming of the planet. The impact of this warming on ecosystems is severe, including on livestock production systems. Under Egyptian conditions, livestock already suffer heat stress periods in summer. The predicted increases in temperature as result of climate change will affect livestock production by reducing growth and milk production because of appetite suppression and conception rate reductions and will increase animal welfare concerns. In severe cases, these effects can result in death. We review the heat stress effects on livestock behaviour, reproduction, and production in the context of predicted climate change for Egypt over the course of this century and offer alternative scenarios to achieve food security for a growing human population. As an example, we combine predictions for reduced milk production during heat stress and human population trajectories to predict that milk availability per person will decline from 61 kg/year in 2011 to 26 kg/year in 2064. Mitigation strategies are discussed and include the substitution of animal-based foods for plant-based foods and laboratory-grown animal products.

scholarly journals PERBANDINGAN SUHU LINGKUNGAN DAN PRODUKTIVITAS TERNAK SAPI PERAH MELALUI PENDEKATAAN STOCHASTIC FRONTIER (Study Kasus di Peternakan Rakyat KUTT Suka Makmur)

2016 ◽  
Vol 6 (1) ◽  
pp. 16-24
Author(s):  
Dela Harini ◽  
Bagus Priyo Purwanto ◽  
Suryahadi
Keyword(s):  
Heat Stress ◽  
Dairy Cattle ◽  
Environmental Temperature ◽  
Stochastic Frontier ◽  
Herd Size ◽  
Descriptive Statistics ◽  
Environment Temperature ◽  
The Impact ◽  
Small Holder

This study observed environmental temperature and rearing management of dairy cattlein KUTT Suka Makmur. This research was aimed to evaluate comparison of environment temperature, productivity, and the technic inefficiency dairy cattle in lowland and highland. Datacollected from 40 respondents in lowland and 40 respondents in highland regions. Data analyzed using descriptive statistics and stochastic frontier production. The results showed that temperatures in the lolands were higher than that of highland, at the range of 24-27 oC, socattle experiencing heat stress, the impact was cattle consumedless feed. In contrast, the highlands temperature relatively low, at range of22-24 oC and produce more milk than that of lowland. The significant variabel of stochastic frontier was herd size about -0.2655 (p<0.10) and -0.2180 (p<0.02) in lowland and highland respectively. Increasing the number of cattle in small holder farms was not efficiencs, due to the increasing in a number of forages and consentrat for the cattle.

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