scholarly journals Bioprinting Scaffolds for Vascular Tissues and Tissue Vascularization

2021 ◽  
Vol 8 (11) ◽  
pp. 178
Author(s):  
Peter Viktor Hauser ◽  
Hsiao-Min Chang ◽  
Masaki Nishikawa ◽  
Hiroshi Kimura ◽  
Norimoto Yanagawa ◽  
...  
Keyword(s):  
3D Printing ◽  
Large Scale ◽  
Three Dimensional ◽  
Biological Properties ◽  
Biological Molecules ◽  
Future Directions ◽  
Artificial Tissue ◽  
Hydrogel Synthesis ◽  
Cell Sources ◽  
Hybrid Scaffolds

In recent years, tissue engineering has achieved significant advancements towards the repair of damaged tissues. Until this day, the vascularization of engineered tissues remains a challenge to the development of large-scale artificial tissue. Recent breakthroughs in biomaterials and three-dimensional (3D) printing have made it possible to manipulate two or more biomaterials with complementary mechanical and/or biological properties to create hybrid scaffolds that imitate natural tissues. Hydrogels have become essential biomaterials due to their tissue-like physical properties and their ability to include living cells and/or biological molecules. Furthermore, 3D printing, such as dispensing-based bioprinting, has progressed to the point where it can now be utilized to construct hybrid scaffolds with intricate structures. Current bioprinting approaches are still challenged by the need for the necessary biomimetic nano-resolution in combination with bioactive spatiotemporal signals. Moreover, the intricacies of multi-material bioprinting and hydrogel synthesis also pose a challenge to the construction of hybrid scaffolds. This manuscript presents a brief review of scaffold bioprinting to create vascularized tissues, covering the key features of vascular systems, scaffold-based bioprinting methods, and the materials and cell sources used. We will also present examples and discuss current limitations and potential future directions of the technology.

scholarly journals Dispensing-Based Bioprinting of Hybrid Scaffolds with Vessel-like Channels for Tissue Engineering Applications – A Brief Review

2017 ◽  
Author(s):  
Saman Naghieh ◽  
Md Sarker ◽  
Mohammad Izadifar ◽  
Xiongbiao Chen
Keyword(s):  
Tissue Engineering ◽  
Imaging Techniques ◽  
Critical Role ◽  
Three Dimensional ◽  
Biological Properties ◽  
Biological Molecules ◽  
Future Research ◽  
Key Issues ◽  
Future Research Directions ◽  
Hybrid Scaffolds

Over the past two decades, significant progress has been achieved in the field of tissue engineering (TE) to restore/repair damaged tissues or organs and, in this regard, scaffolds made from biomaterials have played a critical role. Notably, recent advances in biomaterials and three-dimensional (3D) printing have enabled the manipulation of two or more biomaterials of distinct, yet complementary, mechanical and/or biological properties to form so-called hybrid scaffolds mimicking native tissues. Among various biomaterials, hydrogels synthesized to incorporate living cells and/or biological molecules have dominated due to their hydrated tissue-like environment. Moreover, dispensing-based bioprinting has evolved to the point that it can now be used to create hybrid scaffolds with complex structures. However, the complexities associated with multi-material bioprinting and synthesis of hydrogels used for hybrid scaffolds pose many challenges for their fabrication. This paper presents a brief review of dispensing-based bioprinting of hybrid scaffolds for TE applications. The focus is on the design and fabrication of hybrid scaffolds, including imaging techniques, potential biomaterials, physical architecture, mechanical properties, cell viability, and the importance of vessel-like channels. The key issues and challenges for dispensing-based bioprinting of hybrid scaffolds are also identified and discussed along with recommendations for future research directions. Addressing these issues will significantly enhance the design and fabrication of hybrid scaffolds to and pave the way for translating them into clinical applications.

scholarly journals 3D Printing of Thermo-Sensitive Drugs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1524
Author(s):  
Sadikalmahdi Abdella ◽  
Souha H. Youssef ◽  
Franklin Afinjuomo ◽  
Yunmei Song ◽  
Paris Fouladian ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Future Directions ◽  
Digital Light Processing ◽  
Fused Deposition ◽  
Printing Technique ◽  
3D Printed ◽  
Semi Solid ◽  
Selection Of

Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

scholarly journals Current research in development of polycaprolactone filament for 3D bioprinting: a review

2021 ◽  
Vol 926 (1) ◽  
pp. 012080
Author(s):  
C Amni ◽  
Marwan ◽  
S Aprilia ◽  
E Indarti
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Development Stage ◽  
Biological Properties ◽  
Fabrication Process ◽  
3D Bioprinting ◽  
Three Dimensional Printing ◽  
Further Development ◽  
Dimensional Printing ◽  
The Ideal

Abstract Three-dimensional printing (3DP) provides a fast and easy fabrication process without demanding post-processing. 3D-bioprinting is a special class in 3DP. Bio-printing is the process of accurately 3DP structural design using filament. 3D bio-printing technology is still in the development stage, its application in various engineering continues to increase, such as in tissue engineering. As a forming material in 3D printing, many types of commercial filaments have been developed. Filaments can be produced from either natural or synthetic biomaterials alone, or a combination of the two as a hybrid material. The ideal filament must have precise mechanical, rheological and biological properties. Polycaprolactone (PCL) is specifically developed and optimized for bio-printing of 3D structures. PCL is a strategy in 3D printing to better control interconnectivity and porosity spatially. Structural stability and less sensitive properties environmental conditions, such as temperature, humidity, etc make PCL as an ideal material for the FDM fabrication process. In this review, we provide an in-depth discussion of current research on PCL as a filament currently used for 3D bio-printing and outline some future perspectives in their further development.

3D printing towards implementing Industry 4.0: sustainability aspects, barriers and challenges

2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Abrar Malik ◽  
Mir Irfan Ul Haq ◽  
Ankush Raina ◽  
Kapil Gupta
Keyword(s):  
3D Printing ◽  
Industry 4.0 ◽  
Large Scale ◽  
Industrial Revolution ◽  
Energy Savings ◽  
Three Dimensional ◽  
Global Market ◽  
Printing Industry ◽  
Enabling Factors ◽  
Content Type

Purpose Environmental degradation has emerged as one of the major limitations of industrial revolution and has led to an increased focus towards developing sustainable strategies and techniques. This paper aims to highlight the sustainability aspects of three-dimensional (3D) printing technology that helps towards a better implementation of Industry 4.0. It also aims to provide a brief picture of relationships between 3D printing, Industry 4.0 and sustainability. The major goal is to facilitate the researchers, scholars, engineers and recommend further research, development and innovations in the field. Design/methodology/approach The various enabling factors for implementation of Industry 4.0 are discussed in detail. Some barriers to incorporation of 3D Printing, its applications areas and global market scenario are also discussed. A through literature review has been done to study the detailed relationships between 3D printing, Industry 4.0 and sustainability. Findings The technological benefits of 3D printing are many such as weight savings, waste minimization and energy savings. Further, the production of new 3D printable materials with improved features helps in reducing the wastage of material during the process. 3D printing if used at a large scale would help industries to implement the concept of Industry 4.0. Originality/value This paper focuses on discussing technological revolution under Industry 4.0 and incorporates 3D printing-type technologies that largely change the product manufacturing scenario. The interrelationships between 3D printing, Industry 4.0 and sustainability have been discussed.

scholarly journals Three-Dimensional Printing Using Recycled High-Density Polyethylene: Technological Challenges and Future Directions for Construction

Buildings ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 165 ◽  
Author(s):  
Faham Tahmasebinia ◽  
Marjo Niemelä ◽  
Sanee Ebrahimzadeh Sepasgozar ◽  
Tin Lai ◽  
Winson Su ◽  
...  
Keyword(s):  
Numerical Model ◽  
3D Printing ◽  
Construction Industry ◽  
High Density Polyethylene ◽  
Waste Product ◽  
Three Dimensional ◽  
High Density ◽  
Future Directions ◽  
Waste Products ◽  
Recycled Waste

Three-dimensional (3D) printing technologies are transforming the design and manufacture of components and products across many disciplines, but their application in the construction industry is still limited. Material deposition processes can achieve infinite geometries. They have advanced from rapid prototyping and model-scale markets to applications in the fabrication of functional products, large objects, and the construction of full-scale buildings. Many international projects have been realised in recent years, and the construction industry is beginning to make use of such dynamic technologies. Advantages of integrating 3D printing with house construction are significant. They include the capacity for mass customisation of designs and parameters to meet functional and aesthetic purposes, the reduction in construction waste from highly precise placement of materials, and the use of recycled waste products in layer deposition materials. With the ultimate goal of improving construction efficiency and decreasing building costs, the researchers applied Strand 7 Finite Element Analysis software to a numerical model designed for 3D printing a cement mix that incorporates the recycled waste product high-density polyethylene (HDPE). The result: construction of an arched, truss-like roof was found to be structurally feasible in the absence of steel reinforcements, and lab-sized prototypes were manufactured according to the numerical model with 3D printing technology. 3D printing technologies can now be customised to building construction. This paper discusses the applications, advantages, limitations, and future directions of this innovative and viable solution to affordable housing construction.

scholarly journals A combined 3D printing/CNC micro-milling method to fabricate a large-scale microfluidic device with the small size 3D architectures: an application for tumor spheroid production

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ebrahim Behroodi ◽  
Hamid Latifi ◽  
Zeinab Bagheri ◽  
Esra Ermis ◽  
Shabnam Roshani ◽  
...  
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Large Scale ◽  
Three Dimensional ◽  
Micro Milling ◽  
Tumor Spheroid ◽  
Microfluidic Chips ◽  
Difficult Time ◽  
Micro Channels ◽  
Milling Method

AbstractThe fabrication of a large-scale microfluidic mold with 3D microstructures for manufacturing of the conical microwell chip using a combined projection micro-stereolithography (PµSL) 3D printing/CNC micro-milling method for tumor spheroid formation is presented. The PµSL technique is known as the most promising method of manufacturing microfluidic chips due to the possibility of creating complex three-dimensional microstructures with high resolution in the range of several micrometers. The purpose of applying the proposed method is to investigate the influence of microwell depths on the formation of tumor spheroids. In the conventional methods, the construction of three-dimensional microstructures and multi-height chips is difficult, time-consuming, and is performed using a multi-step lithography process. Microwell depth is an essential parameter for microwell design since it directly affects the shear stress of the fluid flow and the diffusion of nutrients, respiratory gases, and growth factors. In this study, a chip was made with microwells of different depth varying from 100 to 500 µm. The mold of the microwell section is printed by the lab-made PµSL printer with 6 and 1 µm lateral and vertical resolutions. Other parts of the mold, such as the main chamber and micro-channels, were manufactured using the CNC micro-milling method. Finally, different parts of the master mold were assembled and used for PDMS casting. The proposed technique drastically simplifies the fabrication and rapid prototyping of large-scale microfluidic devices with high-resolution microstructures by combining 3D printing with the CNC micro-milling method.

scholarly journals Hydrogels: A Novel Drug Delivery System

2020 ◽  
Vol 1 (8) ◽  
pp. 439-451
Author(s):  
Tayyaba Rana ◽  
Madeeha Fatima ◽  
Abdul Qayyum Khan ◽  
Zainab Naeem ◽  
Sumiyya Javaid ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Three Dimensional ◽  
Biological Molecules ◽  
Extensive Literature ◽  
Swelling Capacity ◽  
Hydrogel Synthesis ◽  
Sanitary Products ◽  
Ionic Bonds ◽  
Cross Links ◽  
Novel Drug

Hydrogels are water-swollen networks, which are cross-linked structures consisting of hydrophilic polymers. They are made three-dimensional by the creation of the cross-links by joining them through covalent or ionic bonds. Hydrogels have been used in various areas including industry and medicine due to their excellent characteristics such as high swelling capacity, high content of water, compatibility with other biological molecules, controlled chemical and physical properties, high mechanical integrity and biodegradability. They have been the center of attention of researchers from the past 50 years because of their promising applications in industries and other areas. They are used in different fields, in medicine, in the diagnosis of the diseases, in culturing of cells, in injuries as wound healers, in cosmetics, in skin diseases like pruritis, in environmental pollution reduction and other miscellaneous applications such as in diapers for babies and sanitary products. Extensive literature can be found on the subject of hydrogels. The present review discusses the history, description of hydrogels, basic properties, classification, different techniques or methods of hydrogel synthesis and the areas in which hydrogels find applications.

scholarly journals Three-Dimensional-Printing of Bio-Inspired Composites

2016 ◽  
Vol 138 (2) ◽  
Author(s):  
Grace X. Gu ◽  
Isabelle Su ◽  
Shruti Sharma ◽  
Jamie L. Voros ◽  
Zhao Qin ◽  
...  
Keyword(s):  
3D Printing ◽  
Material Properties ◽  
Large Scale ◽  
Spider Silk ◽  
Three Dimensional ◽  
Hierarchical Structures ◽  
Building Blocks ◽  
Alternative Methods ◽  
Natural Materials ◽  
Multiple Materials

Optimized for millions of years, natural materials often outperform synthetic materials due to their hierarchical structures and multifunctional abilities. They usually feature a complex architecture that consists of simple building blocks. Indeed, many natural materials such as bone, nacre, hair, and spider silk, have outstanding material properties, making them applicable to engineering applications that may require both mechanical resilience and environmental compatibility. However, such natural materials are very difficult to harvest in bulk, and may be toxic in the way they occur naturally, and therefore, it is critical to use alternative methods to fabricate materials that have material functions similar to material function as their natural counterparts for large-scale applications. Recent progress in additive manufacturing, especially the ability to print multiple materials at upper micrometer resolution, has given researchers an excellent instrument to design and reconstruct natural-inspired materials. The most advanced 3D-printer can now be used to manufacture samples to emulate their geometry and material composition with high fidelity. Its capabilities, in combination with computational modeling, have provided us even more opportunities for designing, optimizing, and testing the function of composite materials, in order to achieve composites of high mechanical resilience and reliability. In this review article, we focus on the advanced material properties of several multifunctional biological materials and discuss how the advanced 3D-printing techniques can be used to mimic their architectures and functions. Lastly, we discuss the limitations of 3D-printing, suggest possible future developments, and discuss applications using bio-inspired materials as a tool in bioengineering and other fields.

scholarly journals Advances on Bone Substitutes through 3D Bioprinting

2020 ◽  
Vol 21 (19) ◽  
pp. 7012 ◽  
Author(s):  
Tullio Genova ◽  
Ilaria Roato ◽  
Massimo Carossa ◽  
Chiara Motta ◽  
Davide Cavagnetto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
New Technologies ◽  
Treatment Options ◽  
Three Dimensional ◽  
Bone Substitutes ◽  
Biological Properties ◽  
3D Bioprinting ◽  
Cell Sources ◽  
Biological Cost ◽  
Living Tissues

Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

scholarly journals Three-Dimensional Printing Using Recycled High-Density Polyethylene: Technological Challenges and Future Directions for Construction

2018 ◽  
Author(s):  
Faham Tahmasebinia ◽  
Marjo Niemelä ◽  
Sanee M. Ebrahimzadeh Sepasgozar ◽  
Tin Yiu Lai ◽  
Winson Su ◽  
...  
Keyword(s):  
Numerical Model ◽  
3D Printing ◽  
Construction Industry ◽  
High Density Polyethylene ◽  
Three Dimensional ◽  
High Density ◽  
Future Directions ◽  
Waste Products ◽  
House Construction ◽  
Recycled Waste

Three-dimensional (3D) printing technologies are transforming the design and manufacture of components and products across a variety of disciplines, however their application in the construction industry is still limited. Material deposition processes can achieve infinite geometries and have advanced from rapid prototyping and model-scale markets to their application in fabricating functional products, large objects and the construction of full-scale buildings. Many international projects have recently been realized and the construction industry is beginning to utilise these dynamic technologies. The potential advantages for integrating 3D printing into house construction are significant, these include the capacity for mass customization of designs and parameters for functional and aesthetic purposes, reduction in construction waste from highly precise material placement, and the use of recycled waste products in layer deposition materials. With the ultimate goal of improving construction efficiency and decreasing building costs, applying Strand7 Finite Element Analysis software, a numerical model was designed specifically for 3D printing in a cement mix incorporated with recycled waste product High Density Polyethylene (HDPE) and found that construction of an arched truss-like roof was structurally feasible without the need for steel reinforcements. The lab sizes prototypes were manufactured based on the destined numerical model by using a 3D printing technology. Currently available 3D printing technologies can be adopted for building construction and this paper discusses the applications, advantages, limitations and future directions of 3D printing as an innovative and viable solution for affordable house construction.

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