scholarly journals Role and Merits of Green Based Nanocarriers in Cancer Treatment

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5686
Author(s):  
Abdulrahman M. Elbagory ◽  
Rahaba Makgotso Marima ◽  
Zodwa Dlamini
Keyword(s):  
Cancer Treatment ◽  
Critical Analysis ◽  
Biomedical Applications ◽  
Review Article ◽  
Current Evidence ◽  
Potential Toxicity ◽  
Smart Vehicles ◽  
Synthesis Of Nanoparticles ◽  
Green Materials ◽  
Different Types

The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking the potential toxicity into consideration, the incorporation of natural “green” materials, derived from plants or microbial sources, in the nanocarriers fabrication, improve their safety and biocompatibility. These green components can be used as a mechanical platform or as targeting ligand for the payload or can play a role in the synthesis of nanoparticles. Several studies reported the use of green based nanocarriers for the treatment of diseases such as cancer. This review article provides a critical analysis of the different types of green nanocarriers and their synthesis mechanisms, characterization, and their role in improving drug delivery of anticancer drugs to achieve precision cancer treatment. Current evidence suggests that green-based nanocarriers can constitute an effective treatment against cancer.

scholarly journals An Overview on Biomaterials: Pharmaceutical and Biomedical Applications

2021 ◽  
Vol 11 (1-s) ◽  
pp. 154-161
Author(s):  
Nikita A Naidu ◽  
Kamlesh Wadher ◽  
Milind Umekar
Keyword(s):  
Biomedical Applications ◽  
Structure And Function ◽  
Review Article ◽  
The Body ◽  
Organ Regeneration ◽  
Different Types ◽  
Metal Ceramic ◽  
Regenerative Medicines ◽  
And Function ◽  
Living Creature

The development of biomaterials have existed from around half a century and manifest its use in different fields. Biomaterials are used in living creature body, looking on its biocompatibility nature. In recent years, advances of biomaterials are showing a marked presence in the fast growing fields of pharmaceuticals and medicines. According to their availability, different types of biomaterials like metal, ceramic, polymer and their composites are used for several purpose in the body. In this review article, types of biomaterials have been discussed with their advantages, disadvantages and recent applications in the pharmaceutical field such as implants used to mimic the structure and function of tissues, dental implants, wound healing, cell regeneration, regenerative medicines, delivery of drugs and different organ regeneration. Organ regeneration leading to replacement of organs such as heart, trachea and lungs etc. by use of specific biomaterials have been reported with the diagnosis of diseases and its treatment.

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

Innovatory role of nanomaterials as bio-tools for treatment of cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Khuram Shahzad Ahmad ◽  
Muntaha Talat ◽  
Shaan Bibi Jaffri ◽  
Neelofer Shaheen
Keyword(s):  
Cancer Treatment ◽  
Cancer Therapeutics ◽  
Physicochemical Characteristics ◽  
Global Scale ◽  
Current Review ◽  
Anti Cancer ◽  
Different Types ◽  
Cancerous Cells

AbstractConventional treatment modes like chemotherapy, thermal and radiations aimed at cancerous cells eradication are marked by destruction pointing the employment of nanomaterials as sustainable and auspicious materials for saving human lives. Cancer has been deemed as the second leading cause of death on a global scale. Nanomaterials employment in cancer treatment is based on the utilization of their inherent physicochemical characteristics in addition to their modification for using as nano-carriers and nano-vehicles eluted with anti-cancer drugs. Current work has reviewed the significant role of different types of nanomaterials in cancer therapeutics and diagnostics in a systematic way. Compilation of review has been done by analyzing voluminous investigations employing ERIC, MEDLINE, NHS Evidence and Web of Science databases. Search engines used were Google scholar, Jstore and PubMed. Current review is suggestive of the remarkable performance of nanomaterials making them candidates for cancer treatment for substitution of destructive treatment modes through investigation of their physicochemical characteristics, utilization outputs and long term impacts in patients.

scholarly journals Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 893
Author(s):  
Luc Rochette ◽  
Marianne Zeller ◽  
Yves Cottin ◽  
Catherine Vergely
Keyword(s):  
Cancer Treatment ◽  
Molecular Hydrogen ◽  
Nuclear Dna ◽  
Sharp Decrease ◽  
Particle Therapy ◽  
Great Promise ◽  
Small Molecular Weight ◽  
Proton Beam Radiotherapy ◽  
Different Types ◽  
Underlying Mechanisms

Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons (H+) and molecular hydrogen (H2) in the cell are critical in a wide variety of processes. A new cancer treatment uses H2, a biologically inactive gas. Due to its small molecular weight, H2 can rapidly penetrate cell membranes and reach subcellular components to protect nuclear DNA and mitochondria. H2 reduces oxidative stress, exerts anti-inflammatory effects, and acts as a modulator of apoptosis. Exogenous H2, administered by inhalation, drinking H2-rich water, or injecting H2-rich saline solution, is a protective therapy that can be used in multiple diseases, including cancer. In particle therapy, cyclotrons and synchrotrons are the accelerators currently used to produce protons. Proton beam radiotherapy (PBT) offers great promise for the treatment of a wide variety of cancers due to the sharp decrease in the dose of radiation at a defined point. In these conditions, H2 and different types of H2 donors may represent a novel therapeutic strategy in cancer treatment.

Biomedical applications of methionine-based systems

2021 ◽  
Author(s):  
Jie Liu ◽  
Jun Huang ◽  
Peikun Xin ◽  
Guiting Liu ◽  
Jun Wu
Keyword(s):  
Liver Disease ◽  
Cancer Treatment ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Functional Modification ◽  
Disease Therapy ◽  
Derivatives Of

Spurred by the structure, metabolism, and derivatives of methionine, this review systematically summarizes its recent progress in functional modification, cancer treatment, liver disease therapy.

scholarly journals Embodied Energy and Embodied GWP of Windows: A Critical Review

Energies ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3788
Author(s):  
Francesco Asdrubali ◽  
Marta Roncone ◽  
Gianluca Grazieschi
Keyword(s):  
Critical Analysis ◽  
Strong Dependence ◽  
Primary Energy ◽  
Point Of View ◽  
Embodied Energy ◽  
Construction Sector ◽  
Industrialized Countries ◽  
Different Types ◽  
Operational Phase ◽  
Operational Impact

The construction sector is one of the most energy-intensive in the industrialized countries. In order to limit climate change emissions throughout the entire life cycle of a building, in addition to reducing energy consumption in the operational phase, attention should also be paid to the embodied energy and CO2 emissions of the building itself. The purpose of this work is to review data on embodied energy and GWP derived from EPDs of different types of windows, to identify the LCA phases, the most impacting materials and processes from an environmental point of view and to perform a critical analysis of the outcomes. The results show a strong dependence on the typology of the frame, with wooden windows having competitive performances: lower average primary energy non-renewable (1123 MJ/FU), higher average primary energy renewable (respectively 817 MJ/FU) and lower global warming potential (54 kgCO2eq/FU). More transparency and standardization in the information conveyed by the program operators is, however, desirable for a better comparability of windows performances. In particular, the inclusion of the operational impact in the EPD is sporadic, but strongly important, since it can be the most impactful phase.

A high-density nanowire electrode on paper for biomedical applications

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 8680-8687 ◽  
Author(s):  
P. Mostafalu ◽  
S. Sonkusale
Keyword(s):  
Biomedical Applications ◽  
High Density ◽  
Different Types ◽  
Paper Substrates

Different types of nanowires made from platinum, nickel and copper are fabricated and patterned with microscale resolution on paper substrates and employed for biomedical applications.

Manganese-based advanced nanoparticles for biomedical applications: future opportunity and challenges

Nanoscale ◽  
2021 ◽  
Author(s):  
Shagufta Haque ◽  
Sanchita Tripathy ◽  
Chitta Ranjan Patra
Keyword(s):  
Biomedical Applications ◽  
Review Article ◽  
Present Review ◽  
Future Opportunity

The present review article provides the insight of an overall survey on the recent advancements of manganese nanomaterials for biomedical nanotechnology and other fields.

Surface Modification of Gold Nanostars Through the Changes on Gold Seed Concentrations

MRS Advances ◽  
2018 ◽  
Vol 3 (41) ◽  
pp. 2449-2454
Author(s):  
Juan Carlos Martinez Espinosa ◽  
Miguel Jose Yacaman ◽  
German Plascencia Villa ◽  
Victor Hugo Romero Arellano ◽  
Ana Karen Zavala Raya
Keyword(s):  
Biomedical Applications ◽  
Surface Enhanced Raman Spectroscopy ◽  
Diameter Distribution ◽  
Biological Assays ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman ◽  
Gold Seed ◽  
Gold Nanomaterials ◽  
Specific Membrane

AbstractDue to its excellent optical properties, gold nanomaterials with anisotropic morphology are playing an important role in biomedical applications, specifically in the use of Surface Enhanced Raman Spectroscopy (SERS) technique for biological assays. In this work, we verified the behavior of the star shape nanoparticle peaks obtained by chemical synthesis (precursor reactant: HAuCl4, cationic surfactant: CTAB) and whose peaks were formed from the different concentrations of gold seeds (55, 65, 75 and 85 ul) which were added to the total solution (5.275 ml). The shape and size of the nanoparticles was verified with a Hitachi S-5500 microscope with a BF & DF SEM / STEM detector, and for the diameter distribution (hydrodynamic) was carried out by the dynamic light distribution technique with a Malvern DLS system Zetasizer Nano ZS. Particle sizes (peak-to-peak considering) were obtained with variations from 107 to 166 nm. The results suggest adding 75 ul of gold seeds to obtain uniform nanostars with well defined peaks. These gold nano-stars could be applied for identification of specific membrane markers for the study of different types of cancer by the SERS technique.

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