scholarly journals Whey Protein Derived Mouthdrying Found to Relate Directly to Retention Post Consumption but Not to Induced Differences in Salivary Flow Rate

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 587
Author(s):  
Victoria Norton ◽  
Stella Lignou ◽  
Lisa Methven
Keyword(s):  
Whey Protein ◽  
Flow Rate ◽  
Protein Concentration ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Sensory Profile ◽  
Sensory Panel ◽  
Saliva Flow ◽  
Whey Beverages ◽  
Future Work

Whey protein is fortified into beverages to provide functional benefits, however, these beverages are considered mouthdrying. To date whey protein derived mouthdrying has not been quantified using a ‘physical measure’ in parallel with rated perception. Saliva flow could also relate to whey protein derived mouthdrying, however this has not been previously tested as an intervention. Accordingly, volunteers (n = 40) tested mouthdrying in different whey beverages and the sensory profile was evaluated by a trained sensory panel (n = 10). Volunteers also rated mouthdrying combined with collection of saliva samples post beverage consumption to measure retention to the oral cavity. To modulate saliva flow rate, volunteers both chewed on parafilm (to increase saliva flow) and used cotton wool (to remove saliva) before tasting beverages and rating mouthdrying. Both the volunteers and sensory panel rated whey protein beverages (WPB) as significantly more mouthdrying than the control beverage (whey permeate). The significantly higher rating of mouthdrying from the volunteers coincided with significantly higher protein concentration in saliva samples post WPB consumption, supporting mucoadhesion as the mechanism. Modulating saliva flow did not lead to any difference in rated mouthdrying and future work would be beneficial to evaluate further the influence of natural variation in salivary flow rate.

Association Between Salivary Flow Rate and the Use of Systemic Medication Among 76-, 81-, and 86-year-old Inhabitants in Helsinki, Finland

1992 ◽  
Vol 71 (12) ◽  
pp. 1875-1880 ◽  
Author(s):  
T.O. Narhi ◽  
J.H. Meurman ◽  
A. Ainamo ◽  
J.M. Nevalainen ◽  
K.G. Schmidt-Kaunisaho ◽  
...  
Keyword(s):  
Flow Rate ◽  
Age Groups ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Flow Rates ◽  
Systemic Medication ◽  
Younger Age ◽  
Significant Difference ◽  
The Difference ◽  
Saliva Flow

The aim of this study was to examine salivary flow rate and its association with the use of medication in a representative sample of 76-, 81-, and 86-year-old subjects, totaling 368. In this study, 23% (n = 80) of the subjects were unmedicated. From one to three daily medications were used by 47% (n = 168) and more than four medications by 30% (n = 104). The most commonly used medications were nitrates, digitalis or anti-arrhythmic drugs (47.7%), analgesics and antipyretics (32.6%), and diuretics (29.5%). The mean number used daily was significantly higher in 86-year-olds than in the two younger age groups (p < 0.01). No significant differences in this respect were found between genders. Among the unmedicated subjects, 76-year-olds had significantly higher stimulated salivary flow rates than did the 81-year-olds (p < 0.05). Unmedicated women showed significantly lower unstimulated (p < 0.01) and stimulated flow rates than did men (p < 0.05). Stimulated salivary flow rate was also significantly higher in the 76-year-old medicated subjects than in the medicated 86-year-old subjects (p < 0.05). No statistically significant differences were found in unstimulated salivary flow rates among the three age groups. Medicated women showed significantly lower unstimulated salivary flow rates than men (p < 0.001), although the difference in stimulated saliva flow was not significant. A statistically significant difference in unstimulated and stimulated salivary flow rates was found between unmedicated persons and those who took from four to six, or more than seven, prescribed medications daily.

Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults

1992 ◽  
Vol 71 (6) ◽  
pp. 1275-1278 ◽  
Author(s):  
M. Navazesh ◽  
R.A. Mulligan ◽  
V. Kipnis ◽  
P.A. Denny ◽  
P.C. Denny
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Young Group ◽  
Salivary Flow Rate ◽  
Flow Rates ◽  
Aged Group ◽  
Whole Saliva ◽  
Saliva Flow

Unstimulated and chewing-stimulated whole saliva samples were obtained from 42 healthy Caucasians; 21 were between 18 and 35 years of age, and 21 between 65 and 83 years of age. The unstimulated salivary flow rate was significantly lower in the aged group, but the stimulated flow rate was significantly higher in the aged than in the young group. Both groups showed significantly increased flow during salivary stimulation. MG1 and MG2 concentrations in unstimulated and stimulated saliva samples were significantly lower in the aged group. There were no significant correlations between salivary flow rates and MG1 and MG2 concentrations.

scholarly journals THE IMPROVEMENT OF SALIVA FLOW RATE BY GARGLING GREEN TEA STEPPING IN MENOPAUSE WOMEN WITH XEROSTOMIA

2020 ◽  
Vol 8 (10) ◽  
pp. 460-465
Author(s):  
Kiki Erika Tampubolon ◽  
◽  
Wilda Hafny Lubis ◽  
Awaluddin Saragih ◽  
◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Green Tea ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Control Group ◽  
Analytical Test ◽  
Menopausal Women ◽  
Before And After ◽  
Saliva Flow

Endocrine and biological changes occur in postmenopausal women, the production of steroid sex hormones that affect the health of the oral cavity, with the reduction of all or part of estrogen resulting in xerostomia (dry mouth). The treatment of Xerostomia was carried out using local, mechanical and chemical stimulation. The purpose of this study was to determine the effect of gargling of green tea steeping on salivary flow rates in postmenopausal women with xerostomia at Darussalam Public Health Center in Medan.This is an experimental study using the design of control group, pretest-posttest and the non-probability of purposive sampling. Fourty menopausal women with xerostomia were used as sample. The treatment group gargled with green tea steeping while the control group gargled with distilled water. Saliva was collected into the pots for three minutes before and after treatment by spitting method. The analytical test used was the paired T-test and the unpaired.The results showed that there was an increase in salivary flow rate with green tea brushing rinse by 0.281750 ml/min and with aquades rinsing by 0.03335 ml/min. Furthermore, there was an effect of gargling with green tea steeping, namely an increase in the flow rate of saliva and this research can be an alternative treatment to relieve xerostomia in menopausal women.The green tea gargling was better in stimulating salivary flow rate.

scholarly journals Differences in the salivary inorganic ions levels and salivary flow rate of the periodontitis and non-periodontitis patients

2020 ◽  
Vol 32 (2) ◽  
Author(s):  
Rizki Amalina ◽  
Mahdalena Mahdalena ◽  
Grahita Aditya
Keyword(s):  
Calcium Phosphate ◽  
Flow Rate ◽  
Inorganic Ions ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Plaque Deposition ◽  
Periodontal Inflammation ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Saliva Flow

Introduction: Saliva contains numerous proteins and electrolytes that may serve as biomarkers of pathological conditions, including periodontitis. Saliva flow also influenced by pathological conditions, such as periodontitis. Therefore, saliva analysis, as one of the biomarker source needs to be examined. This study was aimed to analyse the differences salivary inorganic ions levels (calcium, phosphate, and bicarbonate) and salivary flow rate in periodontitis and non-periodontitis patients. Methods: This research was analytic-observational using two groups, the healthy periodontal group consisting of 21 people (PI scores between 0-0.2) and the periodontitis group consisting of 21 people (PI scores between 0.7-8.0). Unstimulated saliva was collected using a passive drolling method. The calcium, phosphate and bicarbonate levels in the saliva were analysed using UV/Vis spectrophotometers. Results: Calcium, phosphate and bicarbonate levels in saliva were different between groups. Salivary flow rate also different between groups. There was a significant difference (p = 0.00) in the calcium, phosphate and bicarbonate levels between groups (t-test), and also significantly different (p = 0.000) salivary flow rate between groups. The higher the salivary flow rate, the higher the levels of calcium, phosphate and bicarbonate would be. Conclusion: Periodontitis condition increases the level of salivary inorganic ions and salivary flow rate because of periodontal inflammation. This inflammation mainly because of plaque deposition and calculus. Increased level of inorganic ions in the saliva such as calcium, phosphate, and bicarbonate, and also the salivary flow rate indicates the existence of a periodontal disease.

On the Relationship between the Rate of Salivary Flow and Salivary Fluoride Clearance

2015 ◽  
Vol 49 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Ralph M. Duckworth ◽  
S. Jones
Keyword(s):  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Time Of Application ◽  
Saliva Flow Rate ◽  
Whole Saliva ◽  
Observed Behaviour ◽  
Saliva Flow ◽  
Unstimulated Whole Saliva ◽  
The Relationship

The amount of fluoride retained in the mouth following the application of dentifrices, mouthwashes, etc. may be important in determining their anticaries efficacy. In this study we investigated the relationship between the salivary flow rate and salivary fluoride clearance. Ten adults tested six mouthrinses, consisting of aqueous sodium fluoride solutions (0.013, 0.026 mol/l) with and without added sodium chloride (1.28 mol/l) or sucrose (0.44 mol/l), in a randomised order. Prior to each test, subjects swallowed, rinsed for 2 min with 2 ml water and then expectorated into a preweighed container to obtain a measure of initial saliva flow rate. Next, the procedure was repeated using one of the test rinses. Finally, samples of unstimulated whole saliva were collected for up to 3 h after each mouthrinse application and analysed for fluoride. Salivary fluoride concentrations were significantly lower after application of mouthrinses that contained either sucrose or NaCl, both of which compounds markedly enhanced salivary flow, than after the use of corresponding mouthrinses without any additive. Area under the salivary fluoride clearance curve (AUC) values were inversely correlated with salivary flow rate on an individual basis (p < 0.01). The observed behaviour could not be completely attributed to treatment dilution by saliva at the time of application.

scholarly journals An Investigation of the Influence of Age and Saliva Flow on the Oral Retention of Whey Protein and Its Potential Effect on the Perception and Acceptance of Whey Protein Beverages

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2506 ◽  
Author(s):  
Victoria Norton ◽  
Stella Lignou ◽  
Stephanie P. Bull ◽  
Margot A. Gosney ◽  
Lisa Methven
Keyword(s):  
Older Adults ◽  
Whey Protein ◽  
Protein Concentration ◽  
Age Groups ◽  
Salivary Flow ◽  
Potential Effect ◽  
Main Study ◽  
Time Intervals ◽  
Unstimulated Saliva ◽  
Saliva Flow

Protein fortified products are regularly recommended to older adults to improve nutritional status and limit sarcopenia. However protein fortification can elicit negative sensory attributes such as mouthdrying. Sensitivity to mouthdrying can increase with age, yet the influence of saliva flow and mucoadhesion remain uncertain. Here, two studies tested different whey protein beverages (WPB); 22 healthy younger volunteers completed a pilot and 84 healthy volunteers from two age groups (18–30; 65+) completed the main study. In both studies salivary flow rates (mL/min) were measured and saliva samples were collected at time intervals post beverage consumption to measure mucoadhesion to the oral cavity, where protein concentration was analysed by Bradford Assay. Volunteers rated perception and acceptability of WPBs in the main study. WPB consumption resulted in significantly increased protein concentration (p < 0.0001) in saliva samples compared with a control whey permeate beverage. Older adults had significantly lower unstimulated saliva flow (p = 0.003) and significantly increased protein concentration (p = 0.02) in saliva samples, compared with younger adults. Heating of WPB significantly (p < 0.05) increased mouthdrying and thickness perception and reduced sweetness compared with unheated WPB. Mucoadhesion is concluded to be a true phenomenon in WPBs and increases with age.

Psychological Stress and Its Influence on Salivary Flow Rate, Total Protein Concentration and IgA, IgG and IgM Titers

2010 ◽  
Vol 17 (6) ◽  
pp. 396-404 ◽  
Author(s):  
Nathália Matos-Gomes ◽  
Marilise Katsurayama ◽  
Fabiano Hiromichi Makimoto ◽  
Linda Luciana Oliveira Santana ◽  
Edijane Paredes-Garcia ◽  
...  
Keyword(s):  
Psychological Stress ◽  
Flow Rate ◽  
Total Protein ◽  
Protein Concentration ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Total Protein Concentration

Effects of Consuming Catha Edulis Forsk (khat)on the Gene Manifestation of CHRM1 and CHRM3 in relation to Salivary Glands, Saliva Flow Rates, pH and Dental Caries in Yemeni Consumers

2020 ◽  
Vol 14 (1) ◽  
pp. 482-488
Author(s):  
Sawsan Abdullah Alshahrani ◽  
Nawaf Abdulrahman Almufareh ◽  
Bandary Almarshady ◽  
Rasil Khaled Alotaibi ◽  
Wedad Saeed Al-Qahtani
Keyword(s):  
Oral Cavity ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Catha Edulis ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Saliva Flow ◽  
The Impact

Background: The current study has been conducted to estimate the impact of Catha Edulis Forsk (simply known as khat) on pH and saliva flow rate in teeth unaffected by caries among patients from Arab, Yemen, consuming the plant. The goal was to evaluate the relation of these indicators with gene manifestation of CHRM1 and CHRM3, which contributes to the regulation of saliva secretions. Methods: Overall, 60 respondents aged between 27 and 54 years were selected for the research. They were distributed among two groups, group I and group II, including 30 respondents equally. Group I incorporated respondents consuming no khat, having teeth caries, adequate saliva flow, and generally, healthy oral cavity. In turn, group II incorporated respondents consuming khat having caries-free teeth, inadequate saliva flow and relatively unhealthy oral cavity. Saliva samples were taken from all respondents. They were analyzed for indicators of flow rate as well as pH of saliva. Salivary gland biopsy specimens have also been taken. The whole RNA was allocated, cDNA synthesized and reinforced to estimate the gene manifestation of CHRM1 and CHRM3. Results: A considerable rise in the mean salivary flow rate along with a drastic decline in the mean salivary pH within caries-free teeth among the respondents consuming khat was observed during the study. The mRNA expressions CHRM1 and CHRM3 were significantly increased among participants consuming khat. Results were contrasted to the control group of patients not consuming khat. Conclusion: The characteristics of salivary flow rate, pH, and caries-free teeth have been related to the gene manifestations of CHRM1 and CHRM3 in respondents consuming khat.

scholarly journals Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

Geriatrics ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 70
Author(s):  
Fumi Mizuhashi ◽  
Takao Morita ◽  
Shuji Toya ◽  
Ritsuko Sato ◽  
Yuko Watarai ◽  
...  
Keyword(s):  
Flow Rate ◽  
Proteomic Analysis ◽  
Protein Concentration ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Type I ◽  
Protein Ingredient ◽  
Healthy Elderly ◽  
Calcium Blocker ◽  
Oral Dryness

Oral dryness as a side effect of certain drugs is increasing. The aim of this study was to examine the change of the protein ingredient in saliva of oral dryness patients caused by calcium blocker. Six patients taking calcium blocker and six healthy elderly were enrolled. Unstimulated salivary flow rate, protein concentration, and flow rate of protein were measured and compared between the patients taking calcium blocker and healthy elderly. iTRAQ (Isobaric Tag for Relative and Absolute Quantitation) proteomic analysis was performed to extract the salivary protein changed in patient taking calcium blocker, and the intensities of Western blotting products were quantified (unpaired t-test). Unstimulated salivary flow rate was significantly lower on patients taking calcium blocker (p < 0.01). Protein concentration tended to be higher and the flow rate of protein tended to be lower on patients. As the result of iTRAQ proteomic analysis, calmodulin-like protein 3, glutathione S-transferase P, and keratin type I cytoskeletal 13 increased characteristically in patient taking calcium blocker, and the expression in calmodulin-like protein 3 was significantly larger (p < 0.01). The results of this study indicated that calmodulin-like protein 3 increased in patients taking calcium blocker and could be a salivary biomarker for oral dryness caused by calcium blocker.

scholarly journals The Effect Of Gargling Green Tea On Salivary Flow Rate On Female With Xerostomia At Puskesmas Darussalam Medan

2017 ◽  
Vol 16 (2) ◽  
Author(s):  
Wilda Hafny Lubis ◽  
Kiky Erika Tampubolon ◽  
Awaluddin Saragih
Keyword(s):  
Green Tea ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Secretion ◽  
Mean Difference ◽  
Hot Water ◽  
Salivary Flow Rate ◽  
Control Group ◽  
The Mean ◽  
Saliva Flow

Introduction: Saliva is important in maintaining the health of the oral environment. A reduction of the saliva flow by 40% to 50% will cause xerostomia. Xerostomia as the main complaint, experience by about 14%-46% of patients. The objective of this research is to find out the influence of green tea gargle to saliva flow rate in xerostomia patient. Materials and Methods: Green tea with the Latin name Camellia sinensis (L). Polyphenol compounds, catechins in this tea cause a bitter taste that can stimulate the central nervous system resulting in increased salivary secretion. Green tea weighing 3 grams, brewed with 20 ml of hot water an let to stand for 5 minutes then strained and used it for gargeling. The subjects of the study were female of Puskesmas Darussalam visitors. The sample was selected using purposive sampling method and they consisted of 20 people for gargling group of green tea and 20 for gargeling aquades. Saliva was obtained by spitting method. Results: The mean difference in salivary flow rate gargling the aquades was about 0.033350 ml / min, while the mean difference of salivary flow rate gargling the green tea was about 0.281750 ml/min. The statistical T test was unpaired, p = 0,000 difference in mean difference of salivary flow rate was significant, between treatment group and control group. Conclusion(s): The group with green tea gargeling was better in stimulating salivary flow rate.

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