scholarly journals Development of the “National Asbestos Profile” to Eliminate Asbestos-Related Diseases in 195 Countries

2021 ◽  
Vol 18 (4) ◽  
pp. 1804
Author(s):  
Diana Arachi ◽  
Sugio Furuya ◽  
Annette David ◽  
Alexander Mangwiro ◽  
Odgerel Chimed-Ochir ◽  
...  
Keyword(s):  
National Income ◽  
Relevant Information ◽  
Data Availability ◽  
World Health ◽  
Country Level ◽  
Public Data ◽  
The Status ◽  
Global Status ◽  
Bona Fide ◽  
Health Organization

Worldwide, 230,000+ people die annually from asbestos-related diseases (ARDs). The World Health Organization (WHO) recommends that countries develop a National Asbestos Profile (NAP) to eliminate ARDs. For 195 countries, we assessed the global status of NAPs (A: bona fide NAP, B: proxy NAP, C: relevant published information, D: no relevant information) by national income (HI: high, UMI: upper-middle, LMI: lower-middle, LI: low), asbestos bans (banned, no-ban) and public data availability. Fourteen (7% of 195) countries were category A (having a bona fide NAP), while 98, 51 and 32 countries were categories B, C and D, respectively. Of the 14 category-A countries, 8, 3 and 3 were LMI, UMI and HI, respectively. Development of a bona fide NAP showed no gradient by national income. The proportions of countries having a bona fide NAP were similar between asbestos-banned and no-ban countries. Public databases useful for developing NAPs contained data for most countries. Irrespective of the status of national income or asbestos ban, most countries have not developed a NAP despite having the potential. The global status of NAP is suboptimal. Country-level data on asbestos and ARDs in public databases can be better utilized to develop NAPs for globally eliminating ARDs.

Suicide in Developing Countries (1)

Crisis ◽  
2005 ◽  
Vol 26 (3) ◽  
pp. 104-111 ◽  
Author(s):  
Lakshmi Vijayakumar ◽  
K. Nagaraj ◽  
Jane Pirkis ◽  
Harvey Whiteford
Keyword(s):  
Developing Countries ◽  
Public Health Problem ◽  
Data Availability ◽  
World Health ◽  
Global Public Health ◽  
Socioeconomic Indicators ◽  
Suicide Rates ◽  
Country Level ◽  
Education Levels ◽  
Health Organization

Abstract. Objective. Suicide is a global public health problem, but relatively little epidemiological investigation of the phenomenon has occurred in developing countries. This paper aims to (1) examine the availability of rate data in developing countries, (2) provide a description of the frequency and distribution of suicide in those countries for which data are available, and (3) explore the relationship between country-level socioeconomic factors and suicide rates. It is accompanied by two companion papers that consider risk factors and preventive efforts associated with suicide in developing countries, respectively. Method. Using World Health Organization data, we calculated the average annual male, female, and total suicide rates during the 1990s for individual countries and regions (classified according to the Human Development Index [HDI]), and examined the association between a range of socioeconomic indicators and suicide rates. Results. For reasons of data availability, we concentrated on medium HDI countries. Suicide rates in these countries were variable. They were generally comparable with those in high HDI countries from the same region, with some exceptions. High education levels, high telephone density, and high per capita levels of cigarette consumption were associated with high suicide rates; high levels of inequality were associated with low suicide rates. Conclusion. Epidemiological investigations of this kind have the potential to inform suicide prevention efforts in developing countries, and should be encouraged.

ARIMA model for forecasting COVID-19 Death cases in India (Preprint)

2020 ◽  
Author(s):  
Jeya Sutha M
Keyword(s):  
Arima Model ◽  
Public Health Emergency ◽  
World Health ◽  
The People ◽  
The World ◽  
The Status ◽  
The Government ◽  
Health Organization ◽  
Spread Of Infection ◽  
Death Cases

UNSTRUCTURED COVID-19, the disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly contagious disease. On January 30, 2020 the World Health Organization declared the outbreak as a Public Health Emergency of International Concern. As of July 25, 2020; 15,947,292 laboratory-confirmed and 642,814 deaths have been reported globally. India has reported 1,338,928 confirmed cases and 31,412 deaths till date. This paper presents different aspects of COVID-19, visualization of the spread of infection and presents the ARIMA model for forecasting the status of COVID-19 death cases in the next 50 days in order to take necessary precaution by the Government to save the people.

The study of Iranian children and adolescents’ physical activity: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Adel Alizadeh ◽  
Reza Negarandeh ◽  
Fahimehe Bagheri Amiri ◽  
Zahra Yazdani
Keyword(s):  
Physical Activity ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
World Health ◽  
Chi Square ◽  
The Status ◽  
Newcastle Ottawa Scale ◽  
Health Organization ◽  
Iranian Children

Abstract Objectives This systematic and meta-analysis review was conducted to determine the status of Iranian children and adolescents’ physical activity. Content All the related articles which were published in the major databases, including Pubmed, Scopus, Web of Science, Embase, Magiran, SID from the beginning of 2010 to the end of 2019, were reviewed by researchers. The Newcastle-Ottawa scale was also used to evaluate the quality of articles. Moreover, I 2 index and chi-square were used to assess the heterogeneity between the results. Summary 490 articles were found as a result of the search in the selected international and local databases, where finally, 10 articles were included into the meta-analysis after the elimination of the duplicated articles and applying inclusion and exclusion criteria. The results indicated that 29.5% of the girls were considered active according to WHO criteria (16.1–42.8: 95% CI) and also 20.5% of the boys (7.3–33.7: 95% CI). Outlook Overall, this study’s findings showed that a large percentage of Iranian children and adolescents do not achieve the level of physical activity recommended by the World Health Organization. This can lead to undesirable consequences for this group of population that is considered as the human capital of any country; consequently, it seems necessary to take basic measures at the micro and macro levels in order to reduce such problems in the society.

scholarly journals Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases

2019 ◽  
Vol 9 (12) ◽  
Author(s):  
Lucia Mundo ◽  
Maria Raffaella Ambrosio ◽  
Francesco Raimondi ◽  
Leonardo Del Porro ◽  
Raffaella Guazzo ◽  
...  
Keyword(s):  
Protein Expression ◽  
Burkitt Lymphoma ◽  
Human Cancer ◽  
Large Family ◽  
World Health ◽  
Loss Of Function ◽  
Interaction Interface ◽  
Mrna And Protein Expression ◽  
Bona Fide ◽  
Health Organization

AbstractMYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases lacking MYC protein expression despite the translocation involving the MYC gene. Therefore, in the present study we aimed to better characterize such cases. Our results identified two sub-groups of MYC protein negative BL: one lacking detectable MYC protein expression but presenting MYCN mRNA and protein expression; the second characterized by the lack of both MYC and MYCN proteins but showing MYC mRNA. Interestingly, the two sub-groups presented a different pattern of SNVs affecting MYC gene family members that may induce the switch from MYC to MYCN. Particulary, MYCN-expressing cases show MYCN SNVs at interaction interface that stabilize the protein associated with loss-of-function of MYC. This finding highlights MYCN as a reliable diagnostic marker in such cases. Nevertheless, due to the overlapping clinic, morphology and immunohistochemistry (apart for MYC versus MYCN protein expression) of both sub-groups, the described cases represent bona fide BL according to the current criteria of the World Health Organization.

scholarly journals PELATIHAN KADER POSYANDU PTM (PENYAKIT TIDAK MENULAR) DIWILAYAH TELUK BOGAM

2018 ◽  
Vol 2 (1) ◽  
pp. 111-113
Author(s):  
Yogie Irawan ◽  
Riky Riky ◽  
Rastia Ningsih
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Status Report ◽  
Global Status ◽  
Health Organization

Penyakit tidak menular (PTM) sudah menjadi masalah kesehatan masyarakat secara global, regional,nasional dan lokal. Global status report on NCD World Health Organization (WHO) tahun 2010 melaporkan bahwa 60% penyebab kematian semua umur di dunia adalah karena PTM. Kegiatan ini berupa pelatihan kader posyandu mengenai penyakit tidak menular diwilayah kerja Puskesmas Teluk Bogam. Penyuluhan dilaksanakan di Puskesmas Teluk Bogam. Tujuan kegiatan ini adalah untuk untuk meningkatkan pengetahuan dan keterampilannya dalam mendeteksi dini dan mengontrol hipertensi dengan cara memberikan penyuluhan tentang hipertensi, pentingnya mengontrol hipertensi dan bagaimana cara mengukur tekanan darah.  Kata kunci : Lansia

scholarly journals Establishment of the South Korean national antimicrobial resistance surveillance system, Kor-GLASS, in 2016

2018 ◽  
Vol 23 (42) ◽  
Author(s):  
Hyukmin Lee ◽  
Eun-Jeong Yoon ◽  
Dokyun Kim ◽  
Seok Hoon Jeong ◽  
Jong Hee Shin ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Surveillance System ◽  
Action Plan ◽  
World Health ◽  
Surveillance Systems ◽  
The South ◽  
South Korean ◽  
Antimicrobial Resistance Surveillance ◽  
The Status ◽  
Health Organization

Surveillance plays a pivotal role in overcoming antimicrobial resistance (AMR) in bacterial pathogens, and a variety of surveillance systems have been set up and employed in many countries. In 2015, the World Health Organization launched the Global Antimicrobial Resistance Surveillance System (GLASS) as a part of the global action plan to enhance national and global surveillance and research. The aims of GLASS are to foster development of national surveillance systems and to enable collection, analysis and sharing of standardised, comparable and validated data on AMR between different countries. The South Korean AMR surveillance system, Kor-GLASS, is compatible with the GLASS platform and was established in 2016 and based on the principles of representativeness, specialisation, harmonisation and localisation. In this report, we summarise principles and processes in order to share our experiences with other countries planning to establish a national AMR surveillance system. The pilot operation of Kor-GLASS allowed us to understand the national burden of specific infectious diseases and the status of bacterial AMR. Issues pertaining to high costs and labour-intensive operation were raised during the pilot, and improvements are being made.

Gene-Specific DNA Methylation Profiles in Pediatric Medulloblastomas

2021 ◽  
pp. 109352662110366
Author(s):  
Naz Kanit ◽  
Ozge Uysal Yoca ◽  
Dilek Ince ◽  
Nur Olgun ◽  
Erdener Ozer
Keyword(s):  
Dna Methylation ◽  
Precision Medicine ◽  
World Health ◽  
Clinicopathological Parameters ◽  
Molecular Subgroups ◽  
Histological Subtypes ◽  
Pediatric Medulloblastoma ◽  
The Status ◽  
Health Organization ◽  
Methylation Profiling

Introduction Medulloblastoma is the most common pediatric central nervous tumor of high malignancy that has been classified into both histological subtypes and molecular subgroups by the 2016 World Health Organization classification. However, there is a still need to understand the genomic characteristics and predict the clinical course. The aim of the study is to investigate the significance of the methylation profiles in molecular subclassification and precision medicine of the disease. Methods The study enrolled 47 pediatric medulloblastoma patients. DNA methylation levels of KLF4, SPINT2, RASSF1A, EZH2, ZIC2, and PTCH1 genes were analyzed using methylation-specific pyrosequencing. The significance of the statistical relationship between methylation profiles and clinicopathological parameters including molecular subgroups and histological subtypes, the status of metastasis, and event-free survival were analyzed. Results DNA methylation analysis demonstrated that KLF4, PTCH1, and ZIC2 hypermethylation were associated with the SHH-activated subgroup, whereas both SPINT2 and RASSF1A hypermethylation were associated with metastatic disease. EZH2 gene was not methylated in any of the samples. Conclusion We think that customized DNA methylation profiling may be a useful tool in the molecular subclassification of pediatric medulloblastoma and a potential technical approach in precision medicine.

scholarly journals The Costs of Implementing Vaccination With the RTS,S Malaria Vaccine in Five Sub-Saharan African Countries

2019 ◽  
Vol 4 (2) ◽  
pp. 238146831989628 ◽  
Author(s):  
Elisa Sicuri ◽  
Fadima Yaya Bocoum ◽  
Justice Nonvignon ◽  
Sergi Alonso ◽  
Bakar Fakih ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Relevant Information ◽  
Candidate Vaccine ◽  
World Health ◽  
Future Price ◽  
African Countries ◽  
Fourth Dose ◽  
Sub Saharan ◽  
Expanded Program On Immunization ◽  
Health Organization

Background. The World Health Organization has recommended pilot implementation of a candidate vaccine against malaria (RTS,S/AS01) in selected sub-Saharan African countries. This exploratory study aimed to estimate the costs of implementing RTS,S in Burkina Faso, Ghana, Kenya, Mozambique, and Tanzania. Methods. Key informants of the expanded program on immunization at all levels in each country were interviewed on the resources required for implementing RTS,S for routine vaccination. Unit prices were derived from the same sources or from international price lists. Incremental costs in 2015 US dollars were aggregated per fully vaccinated child (FVC). It was assumed the four vaccine doses were either all delivered at health facilities or the fourth dose was delivered in an outreach setting. Results. The costs per FVC ranged from US$25 (Burkina Faso) to US$37 (Kenya) assuming a vaccine price of US$5 per dose. Across countries, recurrent costs represented the largest share dominated by vaccines (including wastage) and supply costs. Non-recurrent costs varied substantially across countries, mainly because of differences in needs for hiring personnel, in wages, in cold-room space, and equipment. Recent vaccine introductions in the countries may have had an impact on resource availability for a new vaccine implementation. Delivering the fourth dose in outreach settings raised the costs, mostly fuel, per FVC by less than US$1 regardless of the country. Conclusions. This study provides relevant information for donors and decision makers about the cost of implementing RTS,S. Variations within and across countries are important and the unknown future price per dose and wastage rate for this candidate vaccine adds substantially to the uncertainty about the actual costs of implementation.

scholarly journals Trauma from abuse, suggestibility and EMDR

2019 ◽  
Author(s):  
Francesca Romana Ficorilli
Keyword(s):  
Sexual Abuse ◽  
Traumatic Event ◽  
World Health ◽  
The Face ◽  
Bona Fide ◽  
The Subject ◽  
The Moment ◽  
Health Organization ◽  
The Individual ◽  
The Way

One of the most complete definitions of Trauma describes it as an "extreme, unsustainable and inevitable threatening experience, in the face of which the individual experiences a sense of helplessness", an event outside the range of usual human experiences, which overwhelm the normal human capacity for adaptation. A modern and current understanding of the concept of Trauma occurs with Bowlby, which places it for the first time in a "relational" context. He argues that the way people react in adverse life situations, particularly to a traumatic event, depends on the type of attachment that has been established between the child and his attachment figures (AFs). The concept of "child abuse and neglect" includes different forms of violence against children, ranging from verbal abuse to rape. Law 66 of 15 February 1996 introduced specific rules on child sexual abuse, in particular the way of listening to children in order to collect good testimony. The theory that today represents the point of reference for most research on the accuracy of memory in testimony, considers memory a "reconstructive" process, and is the result of the interaction between interpretation that is given by the subject in the coding phase, recovery of clues based on the general knowledge possessed by the subject and the context in which it is in the moment in which it must remember. Loftus' studies on false memories affirm that eye witnessing, however bona fide it may be, can be completely unreliable because there are many distortions of memory. The problem of suggestibility in memory is not so much that the momentary account can be modified, but that a distortion of the original episode of what is represented in memory of the event in question takes place, which, from that moment on, will be irreversibly modified. The therapeutic crisis support is the first phase of the therapeutic work following the abuse and has as its privileged recipients the victim and the adult who takes care of them. Currently, a trauma-focused therapy such as EMDR (Eye Movement Desensitization and Reprocessing), an evidence-based psychotherapy approach, is used, recognized by the World Health Organization (WHO) as the elective therapy for the treatment of PTSD and several psychopathologies related to traumatic events, including sexual abuse. Not only because the victims of abuse could in turn perpetrate the cycle of abuse, but also so that victimisation is not considered an unchangeable characteristic of the person.

scholarly journals Neglected tropical diseases in Brazil

2009 ◽  
Vol 51 (5) ◽  
pp. 247-253 ◽  
Author(s):  
José Angelo L. Lindoso ◽  
Ana Angélica B.P. Lindoso
Keyword(s):  
Neglected Tropical Diseases ◽  
Clinical Manifestations ◽  
Northern Region ◽  
New Drugs ◽  
World Health ◽  
Tropical Diseases ◽  
The North ◽  
The World ◽  
The Status ◽  
Health Organization

Poverty is intrinsically related to the incidence of Neglected Tropical Diseases (NTDs). The main countries that have the lowest human development indices (HDI) and the highest burdens of NTDs are located in tropical and subtropical regions of the world. Among these countries is Brazil, which is ranked 70th in HDI. Nine out of the ten NTDs established by the World Health Organization (WHO) are present in Brazil. Leishmaniasis, tuberculosis, dengue fever and leprosy are present over almost the entire Brazilian territory. More than 90% of malaria cases occur in the Northern region of the country, and lymphatic filariasis and onchocerciasis occur in outbreaks in a particular region. The North and Northeast regions of Brazil have the lowest HDIs and the highest rates of NTDs. These diseases are considered neglected because there is not important investment in projects for the development of new drugs and vaccines and existing programs to control these diseases are not sufficient. Another problem related to NTDs is co-infection with HIV, which favors the occurrence of severe clinical manifestations and therapeutic failure. In this article, we describe the status of the main NTDs currently occurring in Brazil and relate them to the HDI and poverty.

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