scholarly journals Four Decades of COPD Mortality Trends: Analysis of Trends and Multiple Causes of Death

2021 ◽  
Vol 10 (5) ◽  
pp. 1117
Author(s):  
Alberto Fernández-García ◽  
Mónica Pérez-Ríos ◽  
Alberto Fernández-Villar ◽  
Gael Naveira ◽  
Cristina Candal-Pedreira ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Chronic Obstructive ◽  
Joinpoint Regression ◽  
Mortality Trend ◽  
Mortality Trends ◽  
Obstructive Pulmonary Disease ◽  
Underlying Cause Of Death ◽  
Copd Mortality ◽  
Age Of Death

There is little information on chronic obstructive pulmonary disease (COPD) mortality trends, age of death, or male:female ratio. This study therefore sought to analyze time trends in mortality with COPD recorded as the underlying cause of death from 1980 through 2017, and with COPD recorded other than as the underlying cause of death. We conducted an analysis of COPD deaths in Galicia (Spain) from 1980 through 2017, including those in which COPD was recorded other than as the underlying cause of death from 2015 through 2017. We calculated the crude and standardized rates, and analyzed mortality trends using joinpoint regression models. There were 43,234 COPD deaths, with a male:female ratio of 2.4. Median age of death was 82 years. A change point in the mortality trend was detected in 1996 with a significant decrease across the sexes, reflected by an annual percentage change of −3.8%. Taking deaths into account in which COPD participated or contributed without being the underlying cause led to an overall 42% increase in the mortality burden. The most frequent causes of death when COPD was not considered to be the underlying cause were bronchopulmonary neoplasms and cardiovascular diseases. COPD mortality has decreased steadily across the sexes in Galicia since 1996, and age of death has also gradually increased. Multiple-cause death analysis may help prevent the underestimation of COPD mortality.

scholarly journals Discordance in investigator-reported and adjudicated sudden death in TIOSPIR

2017 ◽  
Vol 3 (1) ◽  
pp. 00073-2016 ◽  
Author(s):  
Robert A. Wise ◽  
Peter R. Kowey ◽  
George Austen ◽  
Achim Mueller ◽  
Norbert Metzdorf ◽  
...  
Keyword(s):  
Sudden Death ◽  
Cause Of Death ◽  
Causes Of Death ◽  
System Organ Class ◽  
Chronic Obstructive ◽  
Supporting Evidence ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Class Level ◽  
Underlying Cause Of Death

Accurate and consistent determination of cause of death is challenging in chronic obstructive pulmonary disease (COPD) patients. TIOSPIR (N=17 135) compared the safety and efficacy of tiotropium Respimat 5/2.5 µg with HandiHaler 18 µg in COPD patients. All-cause mortality was a primary end-point. A mortality adjudication committee (MAC) assessed all deaths. We aimed to investigate causes of discordance in investigator-reported and MAC-adjudicated causes of death and their impact on results, especially cardiac and sudden death.The MAC provided independent, blinded assessment of investigator-reported deaths (n=1302) and assigned underlying cause of death. Discordance between causes of death was assessed descriptively (shift tables).There was agreement between investigator-reported and MAC-adjudicated deaths in 69.4% of cases at the system organ class level. Differences were mainly observed for cardiac deaths (16.4% investigator, 5.1% MAC) and deaths assigned to general disorders including sudden death (17.4% investigator, 24.6% MAC). Reasons for discrepancies included investigator attribution to the immediate (e.g. myocardial infarction (MI)) over the underlying cause of death (e.g. COPD) and insufficient information for a definitive cause.Cause-specific mortality varies in COPD, depending on the method of assignment. Sudden death, witnessed and unwitnessed, is common in COPD and often attributed to MI without supporting evidence.

scholarly journals A divergence between underlying and final causes of death in selected conditions: an analysis of death registries in Peru

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5948 ◽  
Author(s):  
Rodrigo M. Carrillo-Larco ◽  
Antonio Bernabe-Ortiz
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Communicable Diseases ◽  
Chronic Obstructive ◽  
Mortality Trends ◽  
Obstructive Pulmonary Disease ◽  
Final Cause ◽  
Study Country ◽  
Underlying Causes ◽  
Final Causes

BackgroundThe underlying cause of death is used to study country and global mortality trends and profiles. The final cause of death could also inform the ultimately cause of death in individuals with underlying conditions. Whether there is a pattern between the underlying and final cause of death has not been explored using national death registries. We studied what final causes of death were most common among selected underlying causes using national death registries in Peru, 2015.MethodsUnderlying and final causes of death were classified according to their ICD-10 codes. Underlying causes included chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), hypertension (HTN), diabetes, and selected cancers (cervix, breast, stomach, prostate, and lung). Final causes were categorized as: communicable, cardiovascular, and cancers. Descriptive statistics were used.ResultsA total of 77,065 death registries were analyzed; cases had a mean age of 69.4 (SD: 19.3) years at death and were mostly men (53.9%). When the underlying cause was HTN, the most frequent final cause was cardiovascular diseases (82.3%). For all the other underlying causes, the most frequent final cause was communicable diseases: COPD (86.4%), CKD (79.3%), cancer (76.5%), and diabetes (68.3%).ConclusionsIn four selected underlying causes of death there was a divergence with respect to the final cause, suggesting there was a shift from non-communicable to communicable causes. Although efforts should be deployed to prevent underlying non-communicable diseases, potential communicable complications should not be neglected.

scholarly journals Mortality in Emergency Services in a University Teaching Hospital: A Retrospective Study

2019 ◽  
Vol 41 (2) ◽  
pp. 17-20
Author(s):  
Tirtha Man Shrestha ◽  
Ramesh P Aacharya ◽  
Ram P Neupane ◽  
Bigyan Prajapati
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Septic Shock ◽  
Mortality Rate ◽  
Cause Of Death ◽  
Causes Of Death ◽  
Emergency Services ◽  
University Teaching ◽  
Chronic Obstructive ◽  
Age Group ◽  
Obstructive Pulmonary Disease

Introduction: Emergency services are the gateway between the community and hospital that provides 24-hour access for most needy patients in critical and emergency conditions. Mortality rate varies in emergency department across the world and even in different emergency units of the same hospital. This retrospective study was done in adult emergency services of a tertiary hospital to determine mortality rate and analyze causes of death. Methods: A retrospective observational study of mortality cases to analyze mortality rate and causes of death of patients for a period of 6 months between October 2017 to March 2018 was carried out in the adult emergency services of Tribhuvan University Teaching Hospital, Kathmandu. Data required were collected from copies of death certificates. Results: During the study period, a total of 128 patients died in emergency, accounting 0.5% of total patient. Male deaths (52.3%) were slightly higher compared to female deaths (47.7%). Age group 66-75 years had the highest (24.2%) of total mortalities in the emergency. The most common immediate cause of death was sepsis/septic shock (21.9%) followed by cardiopulmonary arrest, aspiration, respiratory failure, other causes of shock and poisoning. The commonest antecedent cause of death was attributed to respiratory causes. Similarly, the most common contributory cause of death was chronic obstructive pulmonary disease. Conclusion: Older age group is prone to the mortality risk. Sepsis/septic shock was the most common immediate cause of death. Pneumonia was the most common antecedent causes of death. Chronic obstructive pulmonary disease was the commonest contributory cause.

scholarly journals US Obesity Mortality Trends and Associated Noncommunicable Diseases Contributing Conditions Among White, Black, and Hispanic Individuals by Age from 1999 to 2017

2021 ◽  
Author(s):  
Federico Gerardo de Cosio ◽  
Beatriz Diaz-Apodaca ◽  
Amanda Baker ◽  
Miriam Patricia Cifuentes ◽  
Hector Ojeda-Casares ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Cox Regression ◽  
Noncommunicable Diseases ◽  
Mortality Trends ◽  
Time To Death ◽  
Hazard Ratios ◽  
The Usa ◽  
Causes Of Mortality ◽  
Underlying Cause Of Death ◽  
Age Of Death

AbstractThis study aims to assess the effect of obesity as an underlying cause of death in association with four main noncommunicable diseases (NCDs) as contributing causes of mortality on the age of death in White, Black, and Hispanic individuals in the USA. To estimate mortality hazard ratios, we ran a Cox regression on the US National Center for Health Statistics mortality integrated datasets from 1999 to 2017, which included almost 48 million cases. The variable in the model was the age of death in years as a proxy for time to death. The cause-of-death variable allowed for the derivation of predictor variables of obesity and the four main NCDs. The overall highest obesity mortality HR when associated with NCD contributing conditions for the year 1999–2017 was diabetes (2.15; 95% CI: 2.11–2.18), while Whites had the highest HR (2.46; 95% CI: 2.41–2.51) when compared with Black (1.32; 95% CI: 1.27–1.38) and Hispanics (1.25; 95% CI: 1.18–1.33). Hispanics had lower mortality HR for CVD (1.21; 95% CI: 1.15–1.27) and diabetes (1.25; 95% CI: 1.18–1.33) of the three studied groups. The obesity death mean was 57.3 years for all groups. People who die from obesity are, on average, 15.4 years younger than those without obesity. Although Hispanics in the USA have a higher prevalence of diabetes and cardiovascular disease (CVD), they also have the lowest mortality HR for obesity as an underlying cause of death when associated with CVD and cancer. While there is no obvious solution for obesity and its complications, continued efforts to address obesity are needed.

scholarly journals Mortality trends due to chronic obstructive pulmonary disease in Brazil

2014 ◽  
Vol 60 (3) ◽  
pp. 255-261 ◽  
Author(s):  
Gustavo Silveira Graudenz ◽  
Gabriel Pereira Gazotto
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Polynomial Regression ◽  
Functional Relation ◽  
Mortality Rates ◽  
Chronic Obstructive ◽  
Mortality Trends ◽  
Obstructive Pulmonary Disease ◽  
Increasing Trend ◽  
Copd Mortality

Objective: the purpose of this study was to update and analyze data on mortality trend due to chronic obstructive pulmonary disease (COPD) in Brazil. Methods: initially, the specific COPD mortality rates were calculated from 1989 to 2009 using data collected from DATASUS (Departamento de Informática do SUS - Brazilian Health System Database). Then, the polynomial regression models from the observed functional relation were estimated based on mortality coefficients and study years. Results: we verified that the general mortality rates due to COPD in Brazil showed an increasing trend from 1989 to 2004, and then decreased. Both genders showed the same increasing tendencies until 2004 and decreased thereafter. The age group under 35 years old showed a linear decreasing trend. All other age groups showed quadratic tendencies, with increases until the years of 1998-1999 and then decreasing. The South and Southeast regions showed the highest COPD mortality rates with increasing trends until the years 2001-2002 and then decreased. The North, Northeast and Central-West regions showed lower mortality rates but increasing trend. Conclusion: this is the first report of COPD mortality stabilization in Brazil since 1980.

scholarly journals Time series of diabetes attributable mortality from 2008 to 2017

2021 ◽  
Author(s):  
U. Fedeli ◽  
E. Schievano ◽  
S. Masotto ◽  
E. Bonora ◽  
G. Zoppini
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Death Certificate ◽  
Attributable Mortality ◽  
Joinpoint Regression ◽  
Annual Percent Change ◽  
Percent Change ◽  
Underlying Causes ◽  
Underlying Cause Of Death ◽  
Circulatory Diseases

Abstract Purpose Diabetes is a growing health problem. The aim of this study was to capture time trends in mortality associated with diabetes. Methods The mortality database of the Veneto region (Italy) includes both the underlying causes of death, and all the diseases mentioned in the death certificate. The annual percent change (APC) in age-standardized rates from 2008 to 2017 was computed by the Joinpoint Regression Program. Results Overall 453,972 deaths (56,074 with mention of diabetes) were observed among subjects aged ≥ 40 years. Mortality rates declined for diabetes as the underlying cause of death and from diabetes-related circulatory diseases. The latter declined especially in females − 4.4 (CI 95% − 5.3/− 3.4), while in males the APC was − 2.8 (CI 95% − 4.0/− 1.6). Conclusion We observed a significant reduction in mortality during the period 2008–2017 in diabetes either as underlying cause of death or when all mentions of diabetes in the death certificate were considered.

scholarly journals Heart failure quantified by underlying cause and multiple cause of death in Brazil between 2006 and 2016

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Paolo Blanco Villela ◽  
Sonia Carvalho Santos ◽  
Glaucia Maria Moraes de Oliveira
Keyword(s):  
Heart Failure ◽  
Cause Of Death ◽  
Health Management ◽  
Age Groups ◽  
International Classification Of Diseases ◽  
Geographic Region ◽  
Chronic Obstructive ◽  
Mortality Trends ◽  
Historical Series ◽  
Underlying Cause Of Death

Abstract Background The Global Burden of Disease (GBD) does not produce estimates of heart failure (HF) since this condition is considered the common end to several diseases (i.e., garbage code). This study aims to analyze the interactions between underlying and multiple causes of death related to HF in Brazil and its geographic regions, by sex, from 2006 to 2016. Methods Descriptive study of a historical series of death certificates (DCs) related to deaths that occurred in Brazil between 2006 and 2016, including both sexes and all age groups. To identify HF as the underlying cause of death or as a multiple cause of death, we considered the International Classification of Diseases (ICD) code I50 followed by any digit. We evaluated the deaths and constructed graphs by geographic region to compare with national data. Results We included 1,074,038 DCs issued between 2006 and 2016 that included code I50 in Parts I or II of the certificate. The frequency of HF as the multiple cause of death in both sexes was nearly three times higher than the frequency of HF as an underlying cause of death; this observation remained consistent over the years. The Southeast region had the highest number of deaths in all years (about 40,000 records) and approximately double the number in the Northeast region and more than four times the number in the North region. Codes of diseases clinically unrelated to HF, such as diabetes mellitus, chronic obstructive pulmonary disease, and stroke, were mentioned in 3.11, 2.62, and 1.49% of the DCs, respectively. Conclusions When we consider HF as the underlying cause of death, we observed an important underestimation of its impact on mortality, since when analyzed as a multiple cause of death, HF is present in almost three times more deaths recorded in Brazil from 2006 to 2016. The mentioning of conditions with little association with HF at the time of the death highlights the importance of HF as a complex syndrome with multiple components that must be considered in the analysis of mortality trends for implementation of public health management programs.

scholarly journals Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study

2021 ◽  
Vol 10 (19) ◽  
pp. 4544
Author(s):  
Caroline Borciuch ◽  
Mathieu Fauvernier ◽  
Mathieu Gerfaud-Valentin ◽  
Pascal Sève ◽  
Yvan Jamilloux
Keyword(s):  
General Population ◽  
Cause Of Death ◽  
Causes Of Death ◽  
Mortality Rates ◽  
Still’S Disease ◽  
Blood Disorders ◽  
Mortality Trends ◽  
Still's Disease ◽  
Disease Mortality ◽  
Underlying Cause Of Death

Still’s disease (SD) is often considered a benign disease, with low mortality rates. However, few studies have investigated SD mortality and its causes and most of these have been single-center cohort studies. We sought to examine mortality rates and causes of death among French decedents with SD. We performed a multiple-cause-of-death analysis on data collected between 1979 and 2016 by the French Epidemiological Center for the Medical Causes of Death. SD-related mortality rates were calculated and compared with the general population (observed/expected ratios, O/E). A total of 289 death certificates mentioned SD as the underlying cause of death (UCD) (n = 154) or as a non-underlying causes of death (NUCD) (n = 135). Over the study period, the mean age at death was 55.3 years (vs. 75.5 years in the general population), with differences depending on the period analyzed. The age-standardized mortality rate was 0.13/million person-years and was not different between men and women. When SD was the UCD, the most frequent associated causes were cardiovascular diseases (n = 29, 18.8%), infections (n = 25, 16.2%), and blood disorders (n = 11, 7.1%), including six cases (54%) with macrophage activation syndrome. As compared to the general population, SD decedents aged <45 years were more likely to die from a cardiovascular event (O/E = 3.41, p < 0.01); decedents at all ages were more likely to die from infection (O/E = 7.96–13.02, p < 0.001).

scholarly journals Association between ambient fine particulate matters and chronic obstructive pulmonary disease (COPD) mortality: an analysis in Southeastern China

2020 ◽  
Author(s):  
Zhijian Chen ◽  
Qiuli Fu ◽  
Guangming Mao ◽  
Lizhi Wu ◽  
Peiwei Xu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Mixed Model ◽  
Fine Particles ◽  
Chronic Obstructive ◽  
Particulate Matters ◽  
Southeastern China ◽  
Obstructive Pulmonary Disease ◽  
Adverse Health Effects ◽  
Copd Mortality

Abstract Background: The objective of this study was to investigate the association between ambient particulate matters(PMs)and chronic obstructive pulmonary disease (COPD) mortality.Methods: Generalized Additive Mixed Model was employed to investigate the effects of ambient fine and coarse PMs on COPD mortality using 13,066 deaths from 2014 to 2016 among six cities in Zhejiang Province in Southeastern China.Results: The daily average death count due to COPD was 3, varying from 1 to 7among six cities. The daily 24-hour mean concentrations were diverse among cities, from 29.7 to 56.8 µg/m3 for PM2.5, 16.7 to 30.3 µg/m3 for PM2.5−10, and 50.3 to 87.1 µg/m3 for PM10, respectively. The analysis showed that daily exposure to PM2.5 and PM10 was associated with increased mortality due to COPD and that weak effects were observed between PM2.5−10 and COPD mortality.Conclusions: Our results provided evidence that the fine particles in air pollution have stronger functions on adverse health effects other than coarser particles in Southeastern China, which may be considered as a potential clinic target in PM-associated COPD.

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