scholarly journals Obesity and Multiple Sclerosis—A Multifaceted Association

2021 ◽  
Vol 10 (12) ◽  
pp. 2689
Author(s):  
Thomas-Gabriel Schreiner ◽  
Tudor-Marcel Genes
Keyword(s):  
Multiple Sclerosis ◽  
Epidemiological Data ◽  
Future Research ◽  
Common Mechanism ◽  
Exclusion Criteria ◽  
Childhood And Adolescent Obesity ◽  
The Common ◽  
The One ◽  
Inflammatory Component

Background: Given the common elements in the pathophysiological theories that try to explain the appearance and evolution of obesity and multiple sclerosis, the association between the two pathologies has become an increasingly researched topic in recent years. On the one hand, there is the chronic demyelinating inflammation caused by the autoimmune cascade of multiple sclerosis, while on the other hand, according to the latest research, it has been shown that obesity shares an inflammatory component with most chronic diseases. Methods: The authors performed independent research of the available literature in the most important electronic databases (PubMed, Google Scholar, Embase, and Science Direct) in February 2021. After applying the exclusion criteria, the reviewers focused on the most relevant articles published during the last 10 years with respect to epidemiology and pathophysiology. Results: The data presented are a step forward in trying to elucidate the intricate relationship between obesity and MS, especially the causal relationship between childhood and adolescent obesity and MS, focusing on the epidemiological associations observed in the most relevant observational studies conducted in recent years. In the second part, the authors comment on the latest findings related to the pathophysiological mechanisms that may explain the correlations between obesity and multiple sclerosis, focusing also on the role of adipokines. Conclusions: Based on available epidemiological data, obesity in early life appears to be strongly associated with a higher risk of MS development, independent of other risk factors. Although much research has been done on the pathophysiology of obesity, MS, their possible common mechanism, and the role of adipokines, further studies are needed in order to explain what remains unknown. No relevant data were found regarding the association between obesity, disability (high EDSS score), and mortality risk in MS patients. Thus, we consider that this topic should be elucidated in future research.

scholarly journals Evidence for biological shaping of hair ice

2015 ◽  
Vol 12 (14) ◽  
pp. 4261-4273 ◽  
Author(s):  
D. Hofmann ◽  
G. Preuss ◽  
C. Mätzler
Keyword(s):  
Organic Matter ◽  
Dead Wood ◽  
Complex Mixture ◽  
Fulvic Acids ◽  
Common Mechanism ◽  
Ice Growth ◽  
Physical Chemical ◽  
Broad Leaf ◽  
The Common

Abstract. An unusual ice type, called hair ice, grows on the surface of dead wood of broad-leaf trees at temperatures slightly below 0 °C. We describe this phenomenon and present physical, chemical, and biological investigations to gain insight in the properties and processes related to hair ice. Tests revealed that the biological activity of a winter-active fungus is required in the wood for enabling the growth of hair ice. We confirmed the fungus hypothesis originally suggested by Wegener (1918) by reproducing hair ice on wood samples. Treatment by heat and fungicide suppresses the formation of hair ice. Fruiting bodies of Asco- and Basidiomycota are identified on hair-ice-carrying wood. One species, Exidiopsis effusa (Ee), was present on all investigated samples. Both hair-ice-producing wood samples and those with killed fungus show essentially the same temperature variation, indicating that the heat produced by fungal metabolism is very small, that the freezing rate is not influenced by the fungus activity, and that ice segregation is the common mechanism of ice growth on the wood surface. The fungus plays the role of shaping the ice hairs and preventing them from recrystallisation. Melted hair ice indicates the presence of organic matter. Chemical analyses show a complex mixture of several thousand CHO(N,S) compounds similar to fulvic acids in dissolved organic matter (DOM). The evaluation reveals decomposed lignin as being the main constituent. Further work is needed to clarify its role in hair-ice growth and to identify the recrystallisation inhibitor.

scholarly journals AI-Enabled Sensing and Decision-Making for IoT Systems

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Hao Qinxia ◽  
Shah Nazir ◽  
Ma Li ◽  
Habib Ullah ◽  
Wang Lianlian ◽  
...  
Keyword(s):  
Decision Making ◽  
Real Life ◽  
Research Community ◽  
Smart Sensors ◽  
Future Research ◽  
New Paradigm ◽  
Exclusion Criteria ◽  
Intelligent Devices ◽  
Research Questions

The influential stage of Internet of Things (IoT) has reformed all fields of life in general but specifically with the emergence of artificial intelligence (AI) has drawn the attention of researchers into a new paradigm of life standard. This revolution has been accepted around the globe for making life easier with the use of intelligent devices such as smart sensors, actuators, and many other devices. AI-enabled devices are more intelligent and capable of doing a specific task which saves a lot of resources and time. Different approaches are available in the existing literature to tackle diverse issues of real life based on AI and IoT systems. The role of decision-making has its own importance in the AI-enabled and IoT systems. In-depth knowledge of the existing literature is dire need of the research community to summarize the literature in effective way by which practitioners and researchers can benefit from the prevailing proofs and suggest new solutions for solving a particular problem of AI-enabled sensing and decision-making for the IoT system. To facilitate research community, the proposed study presents a systematic literature review of the existing literature, organizes the evidences in a systematic way, and then analyzes it for future research. The study reported the literature of the last 5 years based on the research questions, inclusion and exclusion criteria, and quality assessment of the selected study. Finally, derivations are drawn from the included paper for future research.

scholarly journals Paramyxoviruses and Multiple Sclerosis

2012 ◽  
Vol 9 (3) ◽  
pp. 500-503
Author(s):  
Baghdad Science Journal
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Neurological Disease ◽  
Epidemiological Data ◽  
Igg Antibodies ◽  
Significant Difference ◽  
Elisa Technique

Multiple Sclerosis (MS) is a progressive neurological disease characterized by periods of quiescence and exacerbation, epidemiological data suggest the notion that MS is an acquired autoimmune disease caused by environmental factors, probably infectious, in genetically susceptible individuals.The submitted research was attempted to study the possible viral (Paramyxoviruses) role in MS, the sera of 57 MS patients were assayed for anti-measles and anti-mumps IgG antibodies using ELISA technique, the results were compared in order to establish the presence or absence of a significant difference regarding both number of positive cases and antibodies titer between the two groups, the results revealed that there is no in number of measles positive cases in both MS patients and controls while a significant difference in number of positive cases of mumps and measles anti-measles IgG titer and a highly significant difference regarding mumps IgG Abs titer between the two studied groups, this may be considered as a preliminary indicator to the role of those two paramyxoviruses in MS.

appealed to the Queen on being besieged by the wild sense, especially in the concluding cantos, of leaving Irish (see Vi4.1n). In reading this ‘darke conceit’, an iron world to enter a golden one. But do these no one could have failed to recognize these allusions. ways lead to an end that triumphantly concludes the The second point is that Spenser’s fiction, when 1596 poem, or to an impasse of the poet’s imaginat-compared to historical fact, is far too economical ive powers? For some readers, Book VI relates to the with the truth: for example, England’s intervention earlier books as Shakespeare’s final romances relate in the Netherlands under Leicester is, as A.B. Gough to his earlier plays, a crowning and fulfilment, ‘a 1921:289 concludes, ‘entirely misrepresented’. It summing up and conclusion for the entire poem and would seem that historical events are treated from for Spenser’s poetic career’ (N. Frye 1963:70; cf. a perspective that is ‘far from univocally celebratory Tonkin 1972:11). For others, Spenser’s exclamation or optimistic’, as Gregory 2000:366 argues, or in of wonder on cataloguing the names of the waters what Sidney calls their ‘universal consideration’, i.e. that attend the marriage of the Thames and the what is imminent in them, namely, their apocalyptic Medway, ‘O what an endlesse worke haue I in hand, import, as Borris 1991:11–61 argues. The third | To count the seas abundant progeny’ (IV xii point, which is properly disturbing to many readers 1.1–2), indicates that the poem, like such sixteenth-in our most slaughterous age, especially since the century romances as Amadis of Gaul, could now go matter is still part of our imaginative experience as on for ever, at least until it used up all possible virtues Healy 1992:104–09 testifies, is that Talus’s slaughter and the poet’s life. As Nohrnberg 1976:656 aptly of Irena’s subjects is rendered too brutally real in notes, ‘we find ourselves experiencing not the allegorizing, and apparently justifying, Grey’s atrocit-romance of faith or chastity, but the romance of ies in subduing Irish rebels (see V xii 26–27n). Here romance itself ’. For still others, there is a decline: Spenser is a product of his age, as was the Speaker ‘the darkening of Spenser’s spirit’ is a motif in many of the House of Commons in 1580 in reporting studies of the book, agreeing with Lewis 1936:353 the massacre of Spanish soldiers at Smerwick: ‘The that ‘the poem begins with its loftiest and most Italians pulled out by the ears at Smirwick in solemn book and thence, after a gradual descent, Ireland, and cut to pieces by the notable Service of a sinks away into its loosest and most idyllic’; and with noble Captain and Valiant Souldiers’ (D’Ewes Neuse 1968:331 that ‘the dominant sense of Book 1682:286). As this historical matter relates to Book V, VI is one of disillusionment, of the disparity between it displays the slaughter that necessarily attends the the poet’s ideals and the reality he envisions’; or that triumph of justice, illustrating the truth of the common the return to pastoral signals the failure of chivalry in adage, summum ius, summa iniuria, even as Guyon’s Book V to achieve reform (see DeNeef 1982b). destruction of the Bower shows the triumph of tem-Certainly canto x provides the strong sense of an perance. This is justice; or, at best, what justice has ending. As I have suggested, ‘it is as difficult not to become, and what its executive power displayed in see the poet intruding himself into the poem, as it is that rottweiler, Talus, has become, in our worse than not to see Shakespeare in the role of Prospero with ‘stonie’ age as the world moves towards its ‘last the breaking of the pipe, the dissolving of the vision, ruinous decay’ (proem 2.2, 6.9). In doing so, Book and our awareness (but surely the poet’s too) that his V confirms the claim by Thrasymachus in Plato’s work is being rounded out’ (1961a:202). Republic: justice is the name given by those in power Defined as ‘doing gentle deedes with franke to keep their power. It is the one virtue in the poem delight’ (vii 1.2), courtesy is an encompassing virtue that cannot be exercised by itself but within the book in a poem that sets out to ‘sing of Knights and Ladies must be over-ruled by equity, circumvented by mercy, gentle deeds’ (I proem 1.5). As such, its flowering and, in the succeeding book, countered by courtesy. would fully ‘fashion a gentleman or noble person in vertuous and gentle discipline’ (Letter to Raleigh 8). Courtesy: Book VI

2014 ◽  
pp. 36-36
Keyword(s):  
Strong Sense ◽  
Executive Power ◽  
House Of Commons ◽  
Historical Events ◽  
The Third ◽  
The World ◽  
Historical Fact ◽  
The Common ◽  
The One

Self-Directed Approaches to the Treatment of Depression

2016 ◽  
pp. 468-477
Author(s):  
Pim Cuijpers ◽  
Annet Kleiboer
Keyword(s):  
Depressive Disorders ◽  
Future Research ◽  
Evidence Based ◽  
Advantages And Disadvantages ◽  
Self Help ◽  
Treatment Of Depression ◽  
High Prevalence ◽  
Evidence Based Treatments ◽  
The Common

This article examines self-directed approaches to the treatment of depression. It first considers some of the reasons why the uptake of mental health services by depressed people is low, despite the high prevalence of depressive disorders and the availability of evidence-based treatments. It then looks at the role of self-management in increasing access to evidence-based treatments for depression. It also defines what self-directed treatments are and goes on to discuss the different types of self-directed therapy, the common components of self-directed interventions for depression, Internet-based interventions for depression, and the advantages and disadvantages of self-directed interventions. Finally, it summarizes the findings from research on self-directed interventions for depression and suggests directions for future research and development in this area. Some titles of self-help books that can be used in self-directed interventions are presented.

scholarly journals Role of Klotho in Chronic Calcineurin Inhibitor Nephropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Kang Luo ◽  
Sun Woo Lim ◽  
Yi Quan ◽  
Sheng Cui ◽  
Yoo Jin Shin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aging Process ◽  
Calcineurin Inhibitor ◽  
Calcineurin Inhibitors ◽  
Common Mechanism ◽  
Protective Mechanism ◽  
Klotho Protein ◽  
The Common ◽  
And Oxidative Stress

Calcineurin inhibitors (CNIs) are the most popular immunosuppressants in organ transplantation, but nephrotoxicity is a major concern. The common mechanism underlying chronic CNI nephropathy is oxidative stress, and the process of chronic CNI nephropathy is similar to that of aging. Current studies provide evidence that antiaging Klotho protein plays an important role in protecting against oxidative stress, and its signaling is a target for preventing oxidative stress-induced aging process. In this review, we focus on the association between Klotho and oxidative stress and the protective mechanism of action of Klotho against oxidative stress in chronic CNI nephropathy. In addition, we discuss the delivery strategy for Klotho in CNI-induced nephropathy.

scholarly journals The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 628 ◽  
Author(s):  
Eder ◽  
Adler ◽  
Dobrowolska ◽  
Kamhieh-Milz ◽  
Witowski
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adipose Tissue ◽  
Bowel Disease ◽  
Future Research ◽  
Therapeutic Outcomes ◽  
Mesenteric Fat ◽  
Energy Store ◽  
Inflammatory Bowel ◽  
The One

Abstract: Though historically regarded as an inert energy store, adipose tissue is a complex endocrine organ, which is increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). Accumulating evidence points to visceral adipose tissue and specifically to its mesenteric component, or “creeping fat” as impacting on the disease course through its immunomodulatory properties. On the one hand, mesenteric fat acts as a physical barrier to inflammation and is involved in controlling host immune response to translocation of gut bacteria. On the other hand, however, there exists a strong link between visceral fat and complicated course of the disease with unfavorable therapeutic outcomes. Furthermore, “creeping fat” appears to play different roles in different IBD phenotypes, with the greatest pathogenetic contribution probably to an ileal form of Crohn’s disease. In this review, we summarize and discuss the existing literature on the subject and identify high-priority areas for future research. It may be that a better understanding of the role of mesenteric fat in IBD will determine new therapeutic targets and translate into improved clinical outcomes.

scholarly journals Francophonie et études francophones: considérations historiques et métacritiques sur quelques concepts majeurs (Francophonie and Francophone studies: historical considerations and metacritiques on a few major concepts)

2006 ◽  
Vol 3 (2) ◽  
Author(s):  
François Provenzano
Keyword(s):  
Theoretical Work ◽  
Point Of View ◽  
Future Research ◽  
Anglo Saxon ◽  
Francophone Studies ◽  
Academic Context ◽  
French Speaking ◽  
First Occurrence ◽  
The Common ◽  
The One

The so called French-speaking world is much more than a community of speakers using the same language. Since the era of decolonization, language has become a major economical stake for France, as well as an important symbolic struggle against Anglo-Saxon linguistic and political hegemony. In the academic context also, the developments of Francophone studies demonstrate a current preoccupation with integrating francophone reality into the common encyclopaedia. This paper steps back from such contemporary debates. Analysing the historical and epistemological backgrounds from which francophone projects have been emerging since the end of the nineteenth century, the paper discusses a number of useful concepts for approaching francophone realities. I argue that the main difficulty of the theoretical work in this field is the diversity of definitions of the object, as well as the inability to separate it from ideological content. Starting with the so called first occurrence of the word ‘francophonie’, I examine the institutional, sociolinguistic, poetical and socioliterary definitions that have attempted to explain the constitutive dimensions of an abstract francophone unity. Taking a metacritical point of view, and inspired by Pierre Bourdieu’s sociological works on the one hand and discursive approaches on the other, this article hopes to present pointers for future research into the study of French-speaking zones, peoples and cultures.

On the use of uno in Colombian Spanish: the role of transitivity

2019 ◽  
Vol 12 (1) ◽  
pp. 35-64
Author(s):  
Luz Marcela Hurtado ◽  
Ivan Ortega-Santos
Keyword(s):  
Focus Of Attention ◽  
Future Research ◽  
Null Pronouns ◽  
Overt Pronouns ◽  
Colombian Spanish ◽  
The One ◽  
First Time ◽  
Two Bodies ◽  
Impersonal Pronoun

Abstract Our goal is to explore the intersection of two bodies of literature, namely, the one on impersonal constructions with an emphasis on uno ‘one’, and the one on the effect of transitivity and the focus of attention on the distribution of overt vs. null pronouns, where it has been shown that overt pronominal subjects are disfavored in transitive contexts as opposed to intransitive contexts. Through a variationist analysis of the expression of uno in Barranquilla, Colombia, in the PRESSEA-BARRANQUILLA corpus, we extend this line of inquiry to this impersonal pronoun and study in detail for the first time the effect of the various components of transitivity on the distribution of overt pronouns. Specifically, various transitivity parameters put forward by Hopper and Thompson are shown to correctly predict the distribution of uno, namely, number of participants and kinesis whereas sentence polarity, aspect and individuation of the object yield mixed results meriting future research.

Multiple Sclerosis and Exercise

2005 ◽  
Vol 7 (2) ◽  
pp. 36-41 ◽  
Author(s):  
Herbert I. Karpatkin
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Relevant Literature ◽  
Future Research ◽  
Review Of The Literature ◽  
Therapeutic Benefits ◽  
Neurologic Disorders ◽  
Respiratory Training ◽  
Exercise Guidelines

Compared with other neurologic disorders, relatively little literature exists to define or support the role of exercise in MS. This review describes issues relating to exercise in patients with MS, discusses relevant literature, offers exercise guidelines for persons with MS, and suggests topics for future research. Unique aspects of MS that affect physical therapy are addressed, including disease progression, fatigue, and thermosensitivity. Review of the literature includes discussion of strength training, aerobic exercise, and respiratory training. While physical activity was once contraindicated in persons with MS, current literature supports its therapeutic benefits in these patients. More research could be focused on the specific types of exercise appropriate for this patient population.

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