scholarly journals Non-Overt Coagulopathy in Non-ICU Patients with Mild to Moderate COVID-19 Pneumonia

2020 ◽  
Vol 9 (6) ◽  
pp. 1781 ◽  
Author(s):  
Daniela Mazzaccaro ◽  
Francesca Giacomazzi ◽  
Matteo Giannetta ◽  
Alberto Varriale ◽  
Rosa Scaramuzzo ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Early Stage ◽  
Characteristic Curve ◽  
Thrombotic Complication ◽  
Chi Square ◽  
Icu Patients ◽  
Non Invasive Ventilation ◽  
Chi Square Test ◽  
Thrombotic Complications ◽  
Better Than

Introduction: Aim of the study is to assess the occurrence of early stage coagulopathy and disseminated intravascular coagulation (DIC) in patients with mild to moderate respiratory distress secondary to SARS-CoV-2 infection. Materials and methods: Data of patients hospitalized from 18 March 2020 to 20 April 2020 were retrospectively reviewed. Two scores for the screening of coagulopathy (SIC and non-overt DIC scores) were calculated. The occurrence of thrombotic complication, death, and worsening respiratory function requiring non-invasive ventilation (NIV) or admission to ICU were recorded, and these outcomes were correlated with the results of each score. Chi-square test, receiver-operating characteristic curve, and logistic regression analysis were used as appropriate. p Values < 0.05 were considered statistically significant. Results: Data of 32 patients were analyzed. Overt-DIC was diagnosed in two patients (6.2%), while 26 (81.2%) met the criteria for non-overt DIC. Non-overt DIC score values ≥4 significantly correlated with the need of NIV/ICU (p = 0.02) and with the occurrence of thrombotic complications (p = 0.04). A score ≥4 was the optimal cut-off value, performing better than SIC score (p = 0.0018). Values ≥4 in patients with thrombotic complications were predictive of death (p = 0.03). Conclusions: Overt DIC occurred in 6.2% of non-ICU patients hospitalized for a mild to moderate COVID-19 respiratory distress, while 81.2% fulfilled the criteria for non-overt DIC. The non-overt DIC score performed better than the SIC score in predicting the need of NIV/ICU and the occurrence of thrombotic complications, as well as in predicting mortality in patients with thrombotic complications, with a score ≥4 being detected as the optimal cut-off.

scholarly journals Clinical and Demographic Predictors of Mortality due to COVID-19 Pandemic: A Retrospective Study

2021 ◽  
Vol 11 (5) ◽  
pp. 74-81
Author(s):  
Ayushi Rajkumar Jain ◽  
Doss Prakash ◽  
Sheetal Swamy
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Early Stage ◽  
Major Complication ◽  
Respiratory Arrest ◽  
Chi Square ◽  
High Risk Factors ◽  
Demographic Predictors ◽  
Chi Square Test ◽  
The Common

The alarming statistics of COVID-19 surges up in 2021 throwing an enormous burden on the healthcare system across the world. According to WHO reports on 14th April 2021, globally 136,996,364 confirmed COVID-19 cases are reported across the continents, including 2,951,832 deaths. The state of Maharashtra reported the maximum number of cases of India including high mortality rate. This study was conducted to identify and describe the relation of different predictors (Age, gender, duration of hospital stay, presence of co morbidities) of mortality among the COVID-19 deceased patients by retrospectively analyzing the medical case records of 121 patients from a dedicated COVID hospital at Aurangabad from July 2020 to December 2020. Chi-square test was performed to assess the association between causes of death with different cluster of variables and their significance. This study helps us to identify risk factors that show association between various predictors and mortality rate in COVID-19 patients. Out of 121 deaths, 96 (79%) were male, 61 (49.6%) were in age group between 60-79 years, ARDS was one of the major complication in the deceased patients accounting 29.8% and cardio respiratory arrest was the common cause of death among the deceased patients with 85%. It was also observed that mortality rate was very higher in the initial five days of hospitalization with critical care support. Our result findings provide clinical inferences for physicians to identify high-risk factors with COVID-19 at a very early stage. Key words: COVID-19, Mortality rate, Demographic predictors, Co-morbidities, Cardio respiratory arrest.

scholarly journals Level of Satisfaction in the Use of the Wraparound Hawley and Thermoplastic Maxillary Retainers

2019 ◽  
Vol 90 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Adenilson Silva Chagas ◽  
Karina Maria Salvatore Freitas ◽  
Rodrigo Hermont Cançado ◽  
Fabricio Pinelli Valarelli ◽  
Luiz Filiphe Gonçalves Canuto ◽  
...  
Keyword(s):  
The Other ◽  
Chi Square ◽  
Level Of Satisfaction ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Chi Square Test ◽  
Orthodontic Patients ◽  
Better Than

ABSTRACT Objective To compare the level of satisfaction in the use of wraparound Hawley and thermoplastic maxillary retainers. Materials and Methods The study sample included 70 orthodontic patients (24 males and 46 females), who were in the retention stage (mean age = 20.80 years). All patients wore the two types of maxillary retainer for 1 month each, along with a 3×3 fixed mandibular retainer. After the use of each retainer, the patients responded to a questionnaire evaluating the level of satisfaction with their use of the maxillary retainer. Intergroup comparison was performed by independent t tests. Chi-square test was used to evaluate preference for the type of retainer by gender. Results The thermoplastic retainer was better for swallowing and the wraparound Hawley appliance was better for hygiene and durability. The other factors evaluated (adaptation, speech, comfort, esthetics, satisfaction, and fitting) did not show significant differences between the retainers. There was also no significant difference in preference for the appliances. Conclusions Regarding the overall satisfaction and the preference, there was no difference between the wraparound Hawley and thermoplastic retainers. The wraparound Hawley appliance was better in hygiene and resistance than the thermoplastic retainer; and the thermoplastic appliance was better than the wraparound Hawley for swallowing fluids and saliva.

Correlation between Oncotype DX recurrence score and classical risk factors in early breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12011-e12011
Author(s):  
Fernando Namuche ◽  
Rossana Esther Ruiz Mendoza ◽  
Claudio J. Flores ◽  
Alfredo Aguilar ◽  
Henry Leonidas Gomez
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Recurrence Score ◽  
Risk Category ◽  
Tumor Diameter ◽  
Case Scenario ◽  
Chi Square ◽  
Er Positive ◽  
Chi Square Test ◽  
Clinicopathological Variables

e12011 Background: OncotypeDx(ODX) predicts the likelihood of estrogen receptor (ER) positive breast cancer (BC) recurrence and assesses the likely benefit from both hormonal therapy and chemotherapy. Many clinical scores that estimate the risk category of ODX are being tested. Ki67 is frequently incorporated into these assessments, although there is no standard cut-off for its use. Methods: We retrospectively reviewed the electronic medical files of 190 patients with early stage ER+ BC for whom ODX recurrence score (RS) was available from 2014 to 2016. Our objective was to find out the degree to which classical clinicopathological variables -as defined by St. Gallen(SG) 2015- could predict ODX risk category, also to determine an optimal Ki67 cut-off in order to establish an accurate classification. Chi square test was used. Results: Mean age at diagnosis was 59 years (28-89). Mean tumor diameter was 15mm, 84.2% were intermediate grade. Mean expression of ER, PR and Ki67 were 87%, 53% and 22%, respectively. According to ODX 62.1% patients were low risk, 30.5% intermediate risk and 7.4% high risk. An overall concordance of 46.8% (73/190) was found between SG 2015 and the risk category of ODX (75.7% for low, 33.3% for intermediate and 23.9% for high RS). When changing SG Ki67 cutoffs to ≤20% (for low Ki67) and ≥30% (for high Ki67), an overall concordance of 56.3% (107/190) was found (69.6% for low, 47.3% for intermediate and 23.9% for high RS, with p=0.00) (Table 1). Conclusions: In best-case scenario, SG classical clinicopathological variables correctly classified 56.3% of patients of our series. Despite being a specialized center, the utility of classical clinicopathological variables for predicting ODX risk category is limited. [Table: see text]

scholarly journals Improved Label Propagation Model to Predict Drug - drug Interactions

2018 ◽  
Vol 173 ◽  
pp. 02007
Author(s):  
Zhice Yan ◽  
Lasheng Zhao ◽  
Xiaopeng Wei ◽  
Qiang Zhang
Keyword(s):  
Drug Interactions ◽  
Characteristic Curve ◽  
Clinical Stage ◽  
Real Life ◽  
Propagation Model ◽  
Label Propagation ◽  
Chi Square ◽  
Propagation Algorithm ◽  
Proposed Model ◽  
Chi Square Test

Drug-drug interactions (DDIs) is one of the most concerned issues in drug design. Accurate prediction of potential DDIs in clinical trials can reduce the occurrence of side effects in real life of drugs. Therefore, we propose a model to predict DDIs. The model integrates several methods that can improve label propagation algorithm. Firstly, the chi-square test (CHI) method is adopted to filter or select the features that contain a large amount of information. Secondly, the sample similarity calculation method is reconstructed by label similarity and feature similarity. Then the label initialization information of unlabeled samples is constructed. Finally, we use label propagation algorithm to estimate the labels of the unlabeled drugs. The results show that the proposed model can obtain higher the area under the receiver operating characteristic curve (AUROC) and the area under the precision-recall curve (AUPR), which provides a favorable guarantee for the discovery of DDIs in the clinical stage.

scholarly journals Acanthamoeba keratitis related to contact lens in a tertiary hospital in China

2019 ◽  
Author(s):  
Weiwei Li ◽  
Zhiqun Wang ◽  
Jinghao Qu ◽  
Yang Zhang ◽  
Xuguang Sun
Keyword(s):  
Confocal Microscopy ◽  
Contact Lens ◽  
Contact Lenses ◽  
Early Stage ◽  
Tap Water ◽  
Acanthamoeba Keratitis ◽  
Tertiary Hospital ◽  
Chi Square ◽  
Soft Contact Lenses ◽  
Chi Square Test

Abstract Backgroud To report the clinical and microbiological features of Acanthamoeba keratitis (AK) related to contact lens in a tertiary hospital in China. Methods In this retrospective study, medical results of 61 cases of AK related to contact lens were reviewed from January 2000 to December 2017. The data included patients’ demographics, lens type, history, risk factors, the disease stages, reports of corneal scrapings and culture, treatment. Moreover, the genotype identification of part of these isolates was carried out with a PCR assay and sequence analysis of the 18S ribosomal DNA gene. Results There were 64 eyes included in the study. And 32.8% of cases wore soft contact lenses, 67.2% of patients used overnight orthokeratology. In the cases (20eyes) of early stage, 65% (13 eyes) had positive results in Giemsa stained smears, trophozoites were seen in 7 eyes (35%) in 0.9% sodium chloride (NaCl) wet mounts. Six eyes (30%) were diagnosed by confocal microscopy together with clinical sign. In the orthokeratology patients, 87.8% (36/41) of cases rinsed the lenses and/or cases with tap water, while 55% of soft lens wearers wore their lens during showering. The genotype of 9 isolates was determined, all the strains belonged to genotype T4. In the orthokeratology related cases, patients required therapeutic penetrating keratoplasty after 2005 were less than before 2005 (Chi-square test, χ2= 4.209，P = 0.04). Conclusions More than two thirds of cases were associated with orthokeratology. The examinations of Giemsa stained smears, 0.9% NaCl wet mounts and confocal microscopy should be done for the highly suspected cases of early stage to help the early diagnosis. The rate of therapeutic keratoplasty was decrease after 2005 compare with before 2005 in the cases of orthokeratology.

scholarly journals Perbandingan Hasil Belajar Matematika Antara Yang Menggunakan Pendekatan Konstruktivisme Dengan Pendekatan Open Ended

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Avini Nurazhimah Arfa
Keyword(s):  
Learning Outcomes ◽  
Research Method ◽  
Mathematics Learning ◽  
Research Data ◽  
T Test ◽  
Chi Square ◽  
Learning Mathematics ◽  
Significant Difference ◽  
Chi Square Test ◽  
Better Than

<p class="Default"><em>The purpose of this research is to know whether or not there are differences of learning outcomes of students of class X TKJ 1 and X TKJ 2 between those using a constructivism approach and those using an open-ended approach in learning mathematics in statistics chapter. The research method used is a quasi-experiment with population of students of SMK TERPADU HUTAMA and with samples of 68 people simply and randomly taken by using a self-developed instrument in the form of test about Mathematics Learning Outcomes. The research data for the experimental and controlled classes are collected by analyzing the test using t test, while the normality analysis requirement is analyzed by testing with chi-square test and homogeneity with F test. The result of the research shows that there is a significant difference between students’ learning outcomes through constructivism approach and through an open-ended approach to mathematics learning in SMK TERPADU HUTAMA. From the research results, it can be concluded that the constructivism approach is better than the open-ended approach in statistics learning because the former can encourage the development of individual’s skill in the classroom.</em></p>

scholarly journals Trends in oxygen therapy in patients with moderate to severe COVID-19 admitted to the ICU

2021 ◽  
Vol 8 (4) ◽  
pp. 10-14
Author(s):  
Raghunath S S ◽  
Bheema Devanand ◽  
Mohammed Nizamuddeen B ◽  
Bala Bhaskar S ◽  
Pradnya Kothari ◽  
...  
Keyword(s):  
Oxygen Therapy ◽  
Prospective Observational Study ◽  
Severe Disease ◽  
Comfort Level ◽  
Chi Square ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Chi Square Test ◽  
Polymerase Chain ◽  
Ethical Clearance

The most concerning complication of severe acute respiratory syndrome corona virus 2 (SARSCoV-2) pneumonia is acute hypoxemic failure. Though various antivirals, steroids, immunomodulators have been tried, oxygen therapy remains the mainstay of treatment. After obtaining institutional ethical clearance, a prospective observational study was conducted on 102 COVID-19 positive patients aged 20 years and above, admitted in the ICU with moderate to severe disease. COVID-19 infection was confirmed by polymerase chain reaction or rapid antigen test. Data of two demographically comparable groups i.e., patients on HFNO and NIV was analysed outcome was defined as discharge from ICU, shift to other non-invasive modes of oxygen therapy, endotracheal intubation or death, and comfort level for each mode. The data was analysed using SPSS-16.0, Chi-square test and “t” value test were applied.Comparison ofthe mean number of invasive ventilator free days of HFNO and NIV was insignificant(p&#62;0.05). Among the patients on HFNO (high flow nasal oxygen) 49.09% were stepped down to NRB (non-rebreathing mask) whereas 7.27% went for intubation which is significant compared to NIV mask (non-invasive ventilation), where 13.64% were stepped down to HFNO and 34.09% were intubated (p=0.000).Oxygen therapy with HFNO is associated with better outcome and less mortality when compared with NIV.

scholarly journals Growth Pattern and Trends in Startup Funding in INDIA

2019 ◽  
Vol 8 (12) ◽  
pp. 3721-3724
Keyword(s):  
Growth Pattern ◽  
Early Stage ◽  
Experimental Phase ◽  
Chi Square ◽  
Professional Qualification ◽  
Funding Sources ◽  
Start Up ◽  
Expansion Stage ◽  
Chi Square Test ◽  
Prime Objective

This paper presents the trend and growth pattern of startup ventures, their types and different stages of funding in India. The prime objective of this research was to study growth pattern of the startups and stages of funding received by these startups. The analysis has shown Indian start-up companies prefer primarily funding in four different stages, such as early stage, growth stage, expansion stage and bridge funding. The result has also shown that maximum funding was received in the expansion stage in the financial years. Bridge funding is becoming more and more prevalent, almost 10 per cent of deals. Further, it is noticed that the entrepreneurs find financial support from other funding sources, after the initial experimental phase. The results of chi-square test revealed that there is no significant association between stages of funding and level of development of startup. Further, the test also revealed no significant association between financing methods and professional qualification of promoters of startup.

scholarly journals Molecular Alterations in Lung Adenocarcinoma With Ground-Glass Nodules: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Zihan Wei ◽  
Ziyang Wang ◽  
Yuntao Nie ◽  
Kai Zhang ◽  
Haifeng Shen ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Early Stage ◽  
Meta Analysis ◽  
Genetic Alterations ◽  
Ground Glass ◽  
Cochrane Library ◽  
Chi Square ◽  
Test Analysis ◽  
Molecular Alterations ◽  
Chi Square Test

Background and AimsNodular ground-glass lesions have become increasingly common with the increased use of computed tomography (CT), while the genomic features of ground-glass opacities (GGOs) remain unclear. This study aims to comprehensively investigate the molecular alterations of GGOs and their correlation with radiological progression.MethodsStudies from PubMed, Embase, Cochrane Library, and Web of Science, using PCR, targeted panel sequencing, whole exosome sequencing, and immunohistochemistry, and reporting genomic alterations or PD-L1 expressions in lung nodules presenting as GGOs until January 21, 2021 were included in this study. Chi-square test, random-effects model, and Z-test analysis were adopted to analyze the data.ResultsA total of 22 studies describing mutations in lung adenocarcinoma (LUAD) with GGOs were analyzed. EGFR was the most frequently mutative gene (51%, 95%CI 47%–56%), followed by TP53 (18%, 95%CI 6%–31%), HER2 (10%, 95%CI 0%–21%), ROS1 (6%, 95%CI 0%–18%), and KRAS (6%, 95%CI 3%–9%). The correlation between the frequency of EGFR mutation and radiological was observed and the differences were found to be not statistically significant in the subgroups, which are listed as below: radiological: gGGO 47.40%, 95%CI [38.48%; 56.40%]; sGGO 51.94%, 95%CI [45.15%; 58.69%]. The differences of the frequency of KRAS mutation in the different subgroups were also consistent with this conclusion, which are listed as: radiological gGGO 3.42, 95%CI [1.35%; 6.13%]; sGGO 12.27%, 95%CI [3.89%; 23.96%]. The pooled estimated rate of PD-L1 was 8.82%, 95%CI [5.20%–13.23%]. A total of 11.54% (3/26) of the SMGGNs were confirmed to be intrapulmonary spread by WES.ConclusionsSomatic genetic alterations are considered in early-stage GGO patients without distinct changes of the frequency following the progress of the tumor. This review sheds insight on molecular alterations in LUAD with GGOs.

scholarly journals Childhood dental fear in children aged 7-11 years old by using the Children’s Fear Survey Schedule-Dental Subscale

2021 ◽  
Vol 14 (1) ◽  
pp. 45-49
Author(s):  
Sujata Rath ◽  
◽  
◽  
◽  
Debasmita Das ◽  
...  
Keyword(s):  
Behavior Modification ◽  
Dental Treatment ◽  
Early Stage ◽  
Dental Fear ◽  
Chi Square ◽  
Chi Square Test ◽  
Male Patients ◽  
Fear Survey Schedule ◽  
Separation From Parents ◽  
First Time

In children, dental fear is not only associated with fear of pain or invasive procedures, but it is also correlated with separation from parents or confronting unfamiliar people or environments. The Children’s Fear Survey Schedule-Dental Subscale (CFSS-DS) was developed to evaluate dental fear in children, and this scale is now used across the world for evaluating dental fear. The aim of this study was to evaluate dental fear in children between 7–11 years of age and to find out the association between caries and fear of dental treatment. A total of 300 subjects of both sexes were enrolled in the study. Prior to the oral examination, all patients’ attendants were informed about the study, and the subjects were asked to fill in a questionnaire regarding the CFSS-DS scale. The data obtained through the questionnaires were analyzed using the Chi-Square test. Fear scores were highest for “injections” (3.91±0.17), “dentist drilling” (3.91±0.10) and “choking” (3.65±0.82). It was also observed that subjects who had already visited a dental clinic or those who were familiar with the dental environment at an early stage of life were less anxious than patients who were receiving dental treatment for the first time. In this study, we found that female subjects were more anxious in comparison to male patients. Once the child’s fear is identified, the dentist can use various behavior modification techniques to eliminate fear, explain the steps, and use the instruments accordingly until fear has vanished.

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