Clinical and Demographic Predictors of Mortality due to COVID-19 Pandemic: A Retrospective Study

The alarming statistics of COVID-19 surges up in 2021 throwing an enormous burden on the healthcare system across the world. According to WHO reports on 14th April 2021, globally 136,996,364 confirmed COVID-19 cases are reported across the continents, including 2,951,832 deaths. The state of Maharashtra reported the maximum number of cases of India including high mortality rate. This study was conducted to identify and describe the relation of different predictors (Age, gender, duration of hospital stay, presence of co morbidities) of mortality among the COVID-19 deceased patients by retrospectively analyzing the medical case records of 121 patients from a dedicated COVID hospital at Aurangabad from July 2020 to December 2020. Chi-square test was performed to assess the association between causes of death with different cluster of variables and their significance. This study helps us to identify risk factors that show association between various predictors and mortality rate in COVID-19 patients. Out of 121 deaths, 96 (79%) were male, 61 (49.6%) were in age group between 60-79 years, ARDS was one of the major complication in the deceased patients accounting 29.8% and cardio respiratory arrest was the common cause of death among the deceased patients with 85%. It was also observed that mortality rate was very higher in the initial five days of hospitalization with critical care support. Our result findings provide clinical inferences for physicians to identify high-risk factors with COVID-19 at a very early stage. Key words: COVID-19, Mortality rate, Demographic predictors, Co-morbidities, Cardio respiratory arrest.

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Clinical Characteristics And Analysis Of Risk Factors For Disease Progression Of COVID-19 Among Patients Within Wad Medani Isolation Centers, Gezira State: A Prospective Cohort Study From Sudan

10.21203/rs.3.rs-967313/v1 ◽

2021 ◽

Author(s):

Mohammed Yousif Elnaeem Yousif ◽

Moh.Mah.Fadel Allah Eljack ◽

Osman Amir ◽

Mohammed Alfatih ◽

Akram Khalid Al Tigany Al Shiekh ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Mortality Rate ◽

Clinical Characteristics ◽

Severe Disease ◽

Severe Infection ◽

Chi Square ◽

Factors Associated ◽

Glucose Levels ◽

Chi Square Test

Abstract Background : (COVID-19) had a great impact on the world’s health systems since December 2019. A little is known about the clinical characteristics and risk factors associated with COVID-19 severity in Sudanese Patients; therefor it is necessary to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors associated with COVID-19 severity. Methods : A one-year retrospective cohort study (May 2020- May2021) was done at three isolation centers in Wad Medani. Sample contained all COVID-19 patients who are over 18 years old and were confirmed to be COVID-19 by nucleic acid testing or features Suggestive of Covid19 on Chest CT scan. Results : This study included 418 patients confirmed COVID-19 cases with a median age of 66.3±13years. 179 (64.2%) patients were men. Hypertension (n=195; 46.7%) and diabetes (n=187; 44.7%) were the most common comorbidities. The most common symptoms at COVID-19 onset were fever (n=303; 72.5%), cough (n=278; 66.5%) and dyspnea (n= 256; 61.2%). the overall mortality rate was 35.4% (n=148). The morality rate was 42.3% (n=118) among patients with severe disease. The Chi-square test and ANOVA analysis revealed that older age, anemia, neutrophilia and lymphcytopenia, higher glucose levels, HbA1c levels and creatinine levels were variables associated with severe COVID-19. In inflammatory markers, the levels of CRP and d-dimer were elevated in severe infection more than moderate and mild infections. Conclusion : Patients with these factors are more likely to deteriorate into severe infection and have higher mortality rate than those without these factors.

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Better Prediction of Neuro - Developmental Outcome in Babies Using Combined Vojta’s Neurokinesiological Examination, Amiel Tison Angles and Head Holding Grades

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v41i1.29993 ◽

2021 ◽

Vol 41 (1) ◽

pp. 17-22

Author(s):

Ashish Jain ◽

H Veerabhadrappa ◽

SW Shrikant ◽

Nisha Kumari

Keyword(s):

Risk Factors ◽

High Risk ◽

Predictive Value ◽

Risk Category ◽

Chi Square ◽

Maternal Risk ◽

High Risk Factors ◽

Chi Square Test ◽

One Year ◽

A Prospective Study

Introduction: With the advances in medical technology, the survival rate has increased amongst the high-risk neonates. Changes occurring in the neuro-motor function during the first year of life are closely related to the maturation of the central nervous system of babies and the presence or absence of injury to brain. These should be detected as early as possible, so that intervention programmes can be started. Methods: A prospective study was done in NICU of a teaching hospital, to find the predictive value of combined assessment by three neuro-developmental examinations Viz. Vojta’s Neurokinesiological examination, Amiel-Tison angles and head holding grades. Total 375 babies with various high risk category were included, out of which only 114 infants completed one-year follow-up. On the first visit a detailed neurological examination was performed using Vojtas Neurokinesological postures, Amiel- Tison angles and head holding grades based on Trivandrum Developmental Screening Chart (TDSC). At one year, the milestones attained were plotted against the BSID percentiles and babies assigned as developmentally delayed, if it was below 97% pass level. Sensitivity and specificity were calculated and propositions evaluated by chi-square test. Results: 23% babies had developmental delay at one year. The important high risk factors were maternal risk factors 39%, HIE with MAS, HIE stage-III, complications during NICU stay. Conclusions: Vojta’s Neurokinesiological examination is an effective screening test that can be applied to all high-risk neonates. The predictive value could be enhanced to 100%, by using other simple tests, like Amiel-Tison Angles and Head holding grades by TDSC.

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CARBAPENEM-RESISTANT ENTEROBACTERIACEAE: NEW MENACE TO OUR ANTIBIOTIC ARMAMENTARIUM!

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i9.19448 ◽

2017 ◽

Vol 10 (9) ◽

pp. 335

Author(s):

Ankita Porwal ◽

Sevitha Bhat

Keyword(s):

Risk Factors ◽

Polymyxin B ◽

Isolation Rate ◽

Chi Square ◽

Carbapenem Resistant ◽

Chi Square Test ◽

Vitek 2 ◽

The Common ◽

Common Infection ◽

Carbapenem Resistant Enterobacteriaceae

Objective: To study the risk factors, clinical characteristics, and outcome in patients with infections due to CRE infections.Methods: Retrospective study was carried out in a microbiology laboratory for 6 months. 152 CRE isolates identified by the Vitek 2 compact system were included in the study. The risk factors, antibiotic treatment and clinical outcome were studied from the case sheets, Chi-square test was used for statistical analysis.Results: Of the 2520 positive cultures for Enterobacteriaceae, isolation rate of CRE was 152 (6%). 76 (50%) belonged to exudates, 22 (14.1%) blood culture, 90 (59.2%) urine. The common infection was UTI. The risk factors were prior exposure to antimicrobials, admission to intensive care unit, indwelling devices and prior hospitalization. The effective antibiotic was colistin, polymyxin B, tigecycline, cefoperazone-sulbactum, piperacillin-tazobactum. The mortality was 19.7%.Conclusion: We have demonstrated the value of understanding local epidemiology to help modify our risk-based screening as a strategy to limit the spread of CRE.

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COMPARISON OF POLYMORPHISM rs2070672 CYP2E1 GENE PROPORTION IN EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE

INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) ◽

10.32734/ijnpc.v2i01.2652 ◽

2020 ◽

Vol 2 (01) ◽

pp. 10-12

Author(s):

I Ketut Suanda ◽

I Gde Ardika Nuaba ◽

Ni Putu Ayu Wiarni Susanthi

Keyword(s):

Risk Factors ◽

Nasopharyngeal Carcinoma ◽

Early Stage ◽

Advanced Stage ◽

Chi Square ◽

Cross Sectional ◽

Cyp2e1 Gene ◽

Undifferentiated Type ◽

Chi Square Test ◽

Common Malignancy

Introduction: Nasopharyngeal carcinoma is the most common malignancy in the ENT field. The cause of nasopharyngeal carcinoma is multifactorial. One of the risk factors for an increase in nasopharyngeal carcinoma is the rs2070672 polymorphism of the CYP2E1gene. Purpose: To determine the rs2070672 CYP2E1gene polymorphism proportion in early and advanced stage undifferentiated type NPC subjects in Balinese. Method: This research is a cross sectional comparative study. The case population were all subjects with undifferentiated type NPC in the ENT outpatient clinic at Sanglah General Hospital Denpasar. This study uses 65 samples. Data collected in the form of subject characteristics and rs2070672 CYP2E1gene polymorphisms which examined by ARMS-PCR technique. Results: The average age of the sample was 48.1 years, the most were male as many as 48 subjects (73.8%), and the highest was advanced stage as many as 56 subjects (86.2%). In the chi square test the proportion of polymorphisms in the advanced stage was 2.357 times higher than the early stages. The results of multivariate analysis using logistic regression proved that the rs2070672 CYP2E1gene polymorphism at advanced stage was 7.469 times higher than early stage. Conclusion: There is a difference in the proportion of rs2070672 CYP2E1gene polymorphism in undifferentiated type NPC of Balinese, where advanced stage is higher than early stage.

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Prevalence and risk factors of apical periodontitis in endodontically treated teeth in a selected population of Brazilian adults

Brazilian Dental Journal ◽

10.1590/s0103-64402008000100006 ◽

2008 ◽

Vol 19 (1) ◽

pp. 34-39 ◽

Cited By ~ 34

Author(s):

Carlos Estrela ◽

Cláudio Rodrigues Leles ◽

Augusto César Braz Hollanda ◽

Marcelo Sampaio Moura ◽

Jesus Djalma Pécora

Keyword(s):

Risk Factors ◽

Confidence Intervals ◽

Odds Ratio ◽

Apical Periodontitis ◽

Endodontic Treatment ◽

Technical Quality ◽

Endodontically Treated Teeth ◽

Chi Square ◽

Chi Square Test

The aim of this study was to assess the prevalence and risk factors of apical periodontitis in endodontically treated teeth in a selected population of Brazilian adults. A total of 1,372 periapical radiographs of endodontically treated teeth were analyzed based on the quality of root filling, status of coronal restoration and presence of posts associated with apical periodontitis (AP). Data were analyzed statistically using odds ratio, confidence intervals and chi-square test. The prevalence of AP with adequate endodontic treatment was low (16.5%). This percentage dropped to 12.1% in cases with adequate root filling and adequate coronal restoration. Teeth with adequate endodontic treatment and poor coronal restoration had an AP prevalence of 27.9%. AP increased to 71.7% in teeth with poor endodontic treatment associated with poor coronal restoration. When poor endodontic treatment was combined with adequate coronal restoration, AP prevalence was 61.8%. The prevalence of AP was low when associated with high technical quality of root canal treatment. Poor coronal restoration increased the risk of AP even when endodontic treatment was adequate (OR=2.80; 95%CI=1.87-4.22). The presence of intracanal posts had no influence on AP prevalence.

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Bacteriological Safety of Blood Collected for Transfusion at University of Gondar Hospital Blood Bank, Northwest Ethiopia

ISRN Hematology ◽

10.1155/2013/308204 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Hailegebriel Wondimu ◽

Zelalem Addis ◽

Feleke Moges ◽

Yitayal Shiferaw

Keyword(s):

Risk Factors ◽

Bacterial Contamination ◽

Standard Procedure ◽

Cross Sectional Study ◽

Northwest Ethiopia ◽

Blood Bank ◽

Bacterial Isolation ◽

Chi Square ◽

Cross Sectional ◽

Chi Square Test

Background. Transfusion associated bacterial infection has remained more frequent with a sever risk of morbidity and mortality. This study assessed the bacteriological safety of blood collected for transfusion. Method. A cross-sectional study was conducted at University of Gondar hospital blood bank from December 2011 to June 2012. Bacterial isolation, identification, and antimicrobial susceptibility tests were done as per the standard procedure. Chi-square test and P value were used to assess associations between risk factors and the bacterial isolation rate. Results. Twenty-one (15.33%) blood units were found contaminated with bacteria, and 95.24% contamination was due to external sources. The commonly isolated bacteria were Staphylococcus aureus, Coagulase negative Staphylococci, Escherichia coli, Klebsiella species, Streptococci species, Enterobacter species, and Citrobacter species. All of the bacteria isolated were 100% sensitive to Gentamicin, Chloramphenicol, Amoxicillin, and Doxycycline. Multiple antimicrobial resistances were observed in 66.7% of the isolates. Not using glove by phlebotomist, touching disinfected phlebotomy site and double puncture at the same hand or both hands of a donor were found to be risk factors for bacterial contamination. Conclusion. Bacterial contamination of blood to be transfused is a common problem in the hospital. So attention should be given to activities performed at the blood bank for safe transfusion practices.

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Social assessment of children dental health and its determining factors

Стоматология детского возраста и профилактика ◽

10.33925/1683-3031-2021-21-2-123-131 ◽

2021 ◽

Vol 21 (2) ◽

pp. 123-131

Author(s):

T. G. Svetlichnaya ◽

A. S. Mityagina ◽

T. M. Burkova ◽

N. M. Ogorelkova

Keyword(s):

Risk Factors ◽

Oral Hygiene ◽

Primary Teeth ◽

Dental Health ◽

Tooth Decay ◽

Chi Square ◽

Significance Level ◽

Pediatric Dentist ◽

Chi Square Test ◽

Decay Risk

Relevance. The high prevalence of tooth decay requires investigation of its risk factors. The aim was to study tooth decay risk factors among six-year-old children according to the level of dental health (based on parents’ assessment).Materials and methods. The research evaluated the dental health of six-year-olds and factors defining their oral health; The study surveyed 515 parents of six-year-old children from 7 kindergartens in Arkhangelsk. Pearson chi-square test assessed the differences in the frequency of tooth decay factors among six-year-old children according to the level of dental health. The accepted significance level was 0.05.Results. The Arkhangelsk parents evaluated the dental health of their six-year-olds as relatively favourable: good (41.2%) and satisfactory (46.6%). Only 9.5% of children had poor health. Children generally had good oral hygiene skills: 86.8% liked brushing their teeth; 60.2% squeezed the optimal amount of toothpaste on the toothbrush; 56.7% brushed their teeth twice a day. The dental literacy of parents was satisfactory: 67.0% purchased toothpaste for children; 90.8% considered necessary to treat primary teeth; 69.2% replaced toothbrush every three months; 59.7% visited a pediatric dentist twice a year. The children with poor dental health had insufficient oral hygiene skills: 46.9% did not like teeth cleaning; 51.1% brushed their teeth once a day. Their diet was not healthy: 100.0% did not eat hard food; 65.3% frequently consumed sweets. The parents of children with poor dental health had low medical literacy and poor oral hygiene: 46.9% did not know that treatment of primary teeth was necessary; 42.9% considered the treatment of primary teeth as unnecessary; 32.6% purchased whatever toothpaste. The general negative trend is to use toothpaste without fluoride (68.1%).Conclusions. The results of the study demonstrated a significantly higher frequency of cariogenic factors in children with poor dental health.

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Risk Factors for Typhoid Fever Occurrence and Recurrence in Gombe Metropolis, Gombe State, Nigeria

Journal of University of Shanghai for Science and Technology ◽

10.51201/jusst/21/11914 ◽

2021 ◽

Vol 23 (11) ◽

pp. 381-401

Author(s):

Umar Abdullahi Tawfiq ◽

◽

Shohaimi Shamarina ◽

Syafinaz Amin Nordin ◽

Mohd Noor Hisham Mohd Nadzir ◽

...

Keyword(s):

Risk Factors ◽

Epidemiological Data ◽

Simple Random Sampling ◽

Chi Square ◽

Long Time ◽

Chi Square Test ◽

The Government ◽

Set Up ◽

Associated Risk Factors ◽

At Home

Typhoid is a life-threatening disease that has remained endemic in parts of Africa and Asia where its burden is elevated by the inefficiency of control efforts which have been hampered by lack of epidemiological data, among others. In Nigeria, such data is absent in most of the States like Gombe where the disease has been rife for a long time, hence, to bridge that knowledge gap, this study was set up to determine the host-associated risk factors for typhoid occurrence and recurrence in Gombe. A questionnaire that was designed and validated for this location was used to obtain data from 663 respondents using simple random sampling and analyzed using the Chi-square test for association and binomial logistic regression to obtain risk factors for typhoid occurrence and recurrence, respectively. The study revealed that occurrences were statistically significantly associated with the variables for vaccination (χ2 = 39.729, p < 0.01), having houseboy/girl (χ2 = 16.909, p < 0.01), typhoid patient at home (χ2 = 13.393, p < 0.01), hand washing before handling food (χ2 = 22.856, p < 0.01), consuming iced/frozen items (χ2 = 16.805, p < 0.01), boiling drinking water (χ2 = 49.633, p < 0.01), and eating commercially available foods/drinks (χ2 = 27.864, p < 0.01), while recurrences were statistically significantly predicted by „not sure of been vaccinated‟ (OR = 2.962, CI = 1.290 to 6.802, p < 0.01), „not having another typhoid patient at home‟ (OR = 1.799, CI = 0.998 to 3.244, p < 0.01), and „drinking unboiled water sometimes‟ (OR = 2.130, CI = 1.023 to 4.434, p < 0.01). It is believed that these findings will guide efforts by the Government for health interventions against typhoid in the study area, thus improving the quality of life for the population.

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Clinical implication of surgically treated early-stage cervical cancer with multiple high-risk factors

Journal of Gynecologic Oncology ◽

10.3802/jgo.2015.26.1.3 ◽

2015 ◽

Vol 26 (1) ◽

pp. 3 ◽

Cited By ~ 11

Author(s):

Koji Matsuo ◽

Seiji Mabuchi ◽

Mika Okazawa ◽

Mahiru Kawano ◽

Hiromasa Kuroda ◽

...

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

High Risk ◽

Clinical Implication ◽

Early Stage ◽

High Risk Factors ◽

Early Stage Cervical Cancer

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Our experience of clinico-pathological study of thyroid swelling

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20183396 ◽

2018 ◽

Vol 4 (5) ◽

pp. 1156

Author(s):

Vilas R. Kirdak ◽

Sambhaji G. Chintale ◽

Sonali P. Jatale ◽

Kaleem A. Shaikh

Keyword(s):

Cost Effective ◽

Safe Procedure ◽

Chi Square ◽

Radiological Investigation ◽

Statistical Tool ◽

Fourth Decade ◽

Chi Square Test ◽

The Common ◽

Thyroid Swelling ◽

High Index Of Suspicion

Background: Diseases of thyroid gland are extremely common. Majority of palpable thyroid swellings are asymptomatic occurs in 5% of the population. The main objective of present study is to know the accuracy of FNAC in preoperative diagnosis of clinically palpable thyroid swelling and evaluate the efficiency of FNAC, USG, and TFT in differentiating between benign and malignant thyroid swelling and their confirmation by histopathological reports after operation.Methods: This prospective study is carried out in 120 cases of thyroid swelling attending to the ENT opd at our hospital. Pearson chi square test used as statistical tool to analyse the data. All patients informed written consent taken. The patients are subjected to detailed history with thorough clinical examination, pathological and radiological investigation. FNAC, USG and TFT were done in each case. The result of FNAC was interpreted. Results: The present study includes 120 cases. All patient examined clinically, pathologically and radiological. The common age group of presentation of thyroid swelling is between second to fourth decade. Youngest patient is of 15 yrs. old and oldest is being 68 yrs of age. All 120 cases were evaluated preoperatively and provisional diagnosis was made on the basis of FNAC, TFT and USG. 111 Cases were operated out of total 120 cases. So, the overall accuracy of FNAC in comparisons to HPR is 99.15% with no false positive reports.Conclusions: The overall incidence of the malignancy in thyroid swelling varies from 10% to 30% according to various studies, in our study the overall incidence of malignancy in thyroid swelling was 5.8%. High index of suspicion should be kept in mind during physical examination for detection of malignancy. FNAC should be done in all cases preoperatively FNAC is safe procedure and cost effective.

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