Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children

Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors, including obesity, hypertension, diabetes, hyperglycemia, and dyslipidemia. This study aimed to investigate the relationship between vitamin D level and lipid profile in non-obese children. A total of 243 non-obese healthy volunteers, aged 9–18 years, were enrolled from March to May 2017. Their height and weight were measured, and body mass index was calculated. Subjects underwent blood tests, including measurements of vitamin D (25(OH)D) level and lipid panels, and were divided into either the vitamin D-deficient group (<20 ng/mL) or normal group. The student’s t-test and a simple linear regression analysis were used to estimate the association between vitamin D level and lipid profile. Overall, 69.5% of non-obese children (n = 169) had a 25(OH)D level of less than 20 ng/mL. The vitamin D-deficient group showed higher triglyceride (TG) level and TG/high-density lipoprotein cholesterol (HDL-C) ratio than the normal group (TG level: 90.27 vs. 74.74 mmol/L, p = 0.003; TG/HDL-C ratio: 1.753 vs. 1.358, p = 0.003). Vitamin D level seems to affect the lipid profile, even in non-obese children, and a low vitamin D level may progress to dyslipidemia or obesity in non-obese children.

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Serum Apelin and Obesity-Related Complications in Egyptian Children

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.312 ◽

2018 ◽

Vol 6 (8) ◽

pp. 1354-1358 ◽

Cited By ~ 3

Author(s):

Maged A. El Wakeel ◽

Ghada M. El-Kassas ◽

Alyaa H. Kamhawy ◽

Essam M. Galal ◽

Maysa S. Nassar ◽

...

Keyword(s):

Blood Pressure ◽

Childhood Obesity ◽

Serum Insulin ◽

Low Density Lipoprotein ◽

Linear Regression Analysis ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Z Score ◽

Obese Children ◽

Egyptian Children

BACKGROUND: The rapidly increasing prevalence of childhood obesity became a major burden on health worldwide, giving an alarm to clinicians and researchers. Adipocytes act as an active endocrine organ by releasing plenty of bioactive mediators (adipokines) that play a major role in regulating metabolic processes. Apelin is a recently identified adipokine that is expressed in adipocytes.AIM: The current work aimed to uncover the relation between serum apelin and childhood obesity and its related complications as hypertension and hyperglycemiaMETHOD: A group of 50 obese and 31 non-obese; sex- and age-matched children were enrolled in our study with a mean age of (9.5 ± 2.1) and (8.7 ± 1.3) respectively. Anthropometric measurements, blood pressure, were assessed in all studied participants, we also determined the lipid profile, serum insulin, fasting blood glucose (FBG) level, HOMA-IR and serum apelin.RESULTS: Obese children had higher levels of HbA1c, FBG, serum insulin, HOMA-IR, total cholesterol, triglycerides, low-density lipoprotein (LDL) and diastolic blood pressure (DBP Z-score); compared to controls (all P < 0.05). Apelin was significantly higher in obese children versus controls and correlated positively with BMI Z-Score (P = 0.008), DBP Z-Score (P = 0.02), cholesterol, TG (both P = 0.02), serum insulin (P = 0.003), FBG and HOMA-IR (both P = 0.001). Linear regression analysis showed that FBG was the most effective factor in predicting the level of serum apelin (P = 0.04).CONCLUSION: This work supports the hypothesis that apelin may have a crucial role in the pathogenesis of health hazards related to obesity in children including insulin resistance, hypertension and a higher risk of occurrence of metabolic syndrome.

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Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid Concentrations and Lipid Parameters Among King Abdulaziz University Hospital Patients

10.21203/rs.3.rs-306744/v1 ◽

2021 ◽

Author(s):

Ranya A. Ghamri ◽

Tala A. Qalai ◽

Raghad A. Ismail ◽

Joud M. Aljehani ◽

Dina S. Alotaibi ◽

...

Keyword(s):

Uric Acid ◽

Lipid Profile ◽

Serum Uric Acid ◽

Acid Concentration ◽

Density Lipoprotein ◽

University Hospital ◽

Uric Acid Concentration ◽

Serum Uric Acid Concentration ◽

King Abdulaziz University ◽

The Relationship

Abstract Background: Hyperuricemia is a metabolic defect caused by high purine consumption, overproduction of uric acid, or reduced uric acid excretion. Hyperuricemia is the second most common metabolic disease after diabetes mellitus and can mediate proinflammatory endocrine imbalance in adipose tissue, which contributed to dyslipidemia. Furthermore, several studies have associated uric acid with dyslipidemia. However, no previous studies have examined patients without chronic illness. Thus, we aimed to assess the relationship between serum uric acid concentration and lipid profile parameters and to estimate the prevalence of hyperuricemia in the city of Jeddah. Methods: A retrospective study was conducted among 1206 patients without chronic illness after applying the exclusion criteria. Patients had undergone laboratory blood testing over a 3-year period (2018–2020) at King Abdulaziz University Hospital, which was ethically approved. We used a predesigned checklist to collect data from electronic hospital records using Google Forms. Bivariate analysis, tables, and graphs were used to represent and identify the relationships between variables. A P-value of <0.05 was considered significant.Results: Our study revealed a prevalence of 12% for hyperuricemia in the study population. Males were more frequently affected than females (8.13% vs. 3.73%, respectively). There was no association between serum uric acid concentration and lipid profile parameters, including total cholesterol (P = 0.92), triglyceride (P = 0.42), high-density lipoprotein (P = 0.47), and low-density lipoprotein (P = 0.66). There was a strong association between serum uric acid concentration and high body mass index (P < 0.001), older age (P = 0.002), male sex (P < 0.001), and nationality (P < 0.001). Furthermore, there was an association between sex and mean erythrocyte sedimentation rate (P = 0.02) and mean triglyceride concentration (P = 0.02).Conclusion: We observed a low prevalence of hyperuricemia, and our results indicate no association between serum uric acid concentration and lipid profile parameters.

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VARIANTS OF HYPERLIPIDEMIA IN CHILDREN WITH INSULIN RESISTANCE

Inter Collegas ◽

10.35339/ic.7.1.23-25 ◽

2020 ◽

Vol 7 (1) ◽

pp. 23-25

Author(s):

T. Chaychenko ◽

M. Kharkova ◽

O. Rybka

Keyword(s):

Insulin Resistance ◽

Lipid Profile ◽

National Cholesterol Education Program ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Overweight Children ◽

Obese Children ◽

Age Assessment ◽

Gender And Age ◽

Adults And Children

Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. Purpose of the study- to analyze the lipid profile in overweight children, depending on the presence of insulin resistance. 247 overweight and obese children aged 2 to 18 were examined, including 160 boys and 87 girls. Obesity was diagnosed if the BMI exceeded 97 percentile, according to gender and age. Assessment of the lipid profile included measurements of total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein. To evaluate the parameters of the lipid profile, we used the National Cholesterol Education Program (NCEP) according to the latest edition (2006). We analyzed lipid values depending on the presence or absence of insulin resistance. BMI was also evaluated according to Z-BMI. Insulin resistance was detected in 69.9% of children. Hyperlipidemia was detected in 24.9% of children and dyslipidemia in 83% of the children examined. A change was found in all indicators of the lipid profile, depending on the presence of insulin resistance. A significant increase in Z-BMI was revealed depending on the presence of insulin resistance. Conclusions: Most overweight children have insulin resistance and dyslipidemia; the type of dyslipidemia in children with obesity directly depends on the presence of insulin resistance.

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Correlation between vitamin D and lipid profile in multiple sclerosis patients

QJM ◽

10.1093/qjmed/hcab102.013 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Azza AbdelNaser AbdelAziz ◽

Prof Dr. Rasha Mamdouh Saleh ◽

Mahmoud Saad Swelam ◽

Janet Masoud Ayad

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Disease Activity ◽

Lipid Profile ◽

Serum Vitamin ◽

Density Lipoprotein ◽

P Value ◽

Serum Vitamin D ◽

The Mean ◽

Multiple Sclerosis Patients

Abstract Background Studies have suggested that vitamin D and lipid profile have been linked to the etiology of multiple sclerosis and have an impact on the activity and progression of the disease. Objectives The aim of the present study was to determine correlation between vitamin D level and lipid profile in multiple sclerosis (MS) patients and their effect on disease activity and progression for better management and control of risk factors. Patients and Methods It is a cross-sectional hospital based study carried on clinically definite 111 Relapsing Remitting MS (RRMS) patients according to McDonald criteria 2010 recruited from Multiple sclerosis unit at Ain Shams University Hospitals, both genders included and aged from 18 to 50 years old. All subjects were assessed regarding their basic demographic data, serum vitamin D level and lipid profile and correlated these data with their state of disease activity and degree of disability. Results The mean level of serum vitamin D was 18.93 ± 9.85 ng/mL. Serum vitamin D level was insufficient (< 30 ng/mL) in 81.08% of patients and sufficient (≥ 30 ng/mL) in 18.92% of patients. The mean level of total cholesterol (TC) was 204.9 ± 50.9 mg/dL, of tri-glycerides (TG) was 105.4 ± 44.6 mg/dL, of low density lipoprotein (LDL) was 122.2 ± 38.8 mg/dL and of high density lipoprotein (HDL) level was 56.2 ± 16.6 mg/dL. High relapse frequency was found to be significantly related to low serum vitamin D level with P-value 0.005. Near all lipid related variables were positively correlated to disease duration. TC and TG were positively related to EDSS while HDL was negatively related with it. Number of brain T2 lesions was significantly correlated with TC and TG levels with P-value 0.001 and 0.002 respectively. Fingolimod was found to be associated with dyslipidemia. We found that each 1 ng/mL increase in vitamin D was associated with decrease in TC of 1.48 mg/dL (95% CI: -2.42 to -0.54, P-value 0.002) and increase in HDL of 0.35 mg/dL (95% CI: 0.04 to -0.66, P-value 0.028). Conclusion Vitamin D deficiency is predominant among Egyptian MS patients. Patients with insufficient vitamin D were found to have higher annualized relapse rate (ARR). Patients with dyslipidemia found to have longer duration, more disability and higher brain T2 lesion load. Vitamin D was correlated positively with HDL and negatively with TC.

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Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

Nutrition & Metabolism ◽

10.1186/s12986-020-00455-x ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Dan Jin ◽

Dao-Min Zhu ◽

Hong-Lin Hu ◽

Meng-Nan Yao ◽

Wan-Jun Yin ◽

...

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

The Relationship

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Empathy and Personality Styles in Medical Students

Revista Colombiana de Psicología ◽

10.15446/rcp.v29n2.82988 ◽

2020 ◽

Vol 29 (2) ◽

pp. 73-87

Author(s):

Yolanda Dávila Pontón ◽

Alejandro Reyes Reyes ◽

Aracelis Calzadilla Núñez ◽

Víctor Patricio Díaz Narváez ◽

Robert Utsman ◽

...

Keyword(s):

Medical Students ◽

Educational Level ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Personality Styles ◽

Empathy Scale ◽

Mean Differences ◽

Student’S T ◽

The Relationship ◽

Student’S T Test

This study aimed to establish the relationship between empathy and personality styles in medical students, considering the differences by gender. The participants were 278 students of the medical career of the Universidad del Azuay, Ecuador. They were evaluated using the Jefferson empathy scale and the Millon Index of Personality Styles. Relationships between empathy and personality styles were examined using Pearson's correlation coefficient and hierarchical multiple linear regression analysis, for comparisons by gender and educational levels; with both Student's t test and analysis of variance used respectively. Results indicated that the factor structure of the empathy scale is invariant between men and women, noticing gender differences in care with compassion and total empathy, with women presenting a higher mean. Differences are observed by educational level, where the general empathy in the first three years grows progressively, and then slightly decrease. In conclusion, female students present a mean score of total empathy greater than men, with differences of empathy according to educational level

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Effect of Helicobacter pylori Infection on Serum Lipid Profile

Journal of Lipids ◽

10.1155/2018/6734809 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Mohamadreza Haeri ◽

Mahmoud Parham ◽

Neda Habibi ◽

Jamshid Vafaeimanesh

Keyword(s):

Helicobacter Pylori ◽

Lipid Profile ◽

Blood Sugar ◽

Serum Lipid ◽

Density Lipoprotein ◽

Population Data ◽

Serum Lipid Profile ◽

Significant Difference ◽

H Pylori ◽

The Relationship

Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were statistically analyzed by SPSS version 16. P values < 0.05 were considered significant. Results. In the current study, 66.5% of the cases were serologically positive for H. pylori. Among male cases, the level of low density lipoprotein (LDL) was higher in patients with H. pylori infection, compared with that of the ones without the infection (P=0.03); although level of triglyceride (TG) was higher and the level of high density lipoprotein (HDL) was lower in the cases with H. pylori infection; there was no statistically significant difference between the cases with and without H. pylori infection regarding the level of HDL and TG. Among female cases, the level of TG was significantly lower in patients with H. pylori infection, compared with that of the ones without the infection (P=0.001); but there was no significant difference between the cases with and without H. pylori infection regarding the level of LDL and HDL. The mean fasting blood sugar (FBS) in the cases with H. pylori infection was significantly higher than that of the ones without the infection (P=0.04). Conclusion. According to the results of the current study, the levels of LDL and FBS were high among the male cases with H. pylori infection. However, in females with H. pylori infection the level of TG was low; hence, it seems that the atherogenicity of H. pylori affected the level of blood sugar more.

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The Effect of Pilates Training on Body Composition, Lipid Profile, and Serum 25-Hydroxy Vitamin D Levels in Inactive Overweight Women

Zahedan Journal of Research in Medical Sciences ◽

10.5812/zjrms.100502 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Mojdeh Khajehlandi ◽

Robabeh Mohammadi

Keyword(s):

Vitamin D ◽

Body Composition ◽

Exercise Training ◽

Lipid Profile ◽

Density Lipoprotein ◽

Training Group ◽

Control Group ◽

Overweight Women ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

Background: The increasing prevalence of overweight and related diseases has gained more scientific attention. Overweight and obesity are known as a threat to health, and low serum 25-hydroxy vitamin D levels is associated with obesity. Objectives: Therefore, we examined the effect of Pilates training on body composition, lipid profile, and serum 25-hydroxy vitamin D levels in inactive overweight women. Methods: In this clinical study, 28 overweight women were randomly divided into a training group (n = 14) and a control group (n = 14). Pilates training was performed three 60-min sessions during 12 weeks. In two stages, blood samples were collected 48 hours before and after the last protocol exercise training session. During the 12 weeks, the control group had no exercise training. For analyzing within- and between-group changes, paired t-test and ANCOVA with the significant level of P < 0.05 were used, respectively. Results: After 12 weeks of Pilates training in the training group compared to the control group, there was a significant decrease in the body mass index (P = 0.005), cholesterol (P = 0.001) and triglyceride (P = 0.001) values, and serum 25-hydroxy vitamin D levels (P = 0.005), while high-density lipoprotein (P = 0.028) increased significantly. However, no significant change was observed in low-density lipoprotein levels (P = 0.435). Conclusions: According to the results, it can be indicated that 12 weeks of Pilates training have improved serum 25-hydroxy vitamin D levels, changed anthropometry, and lipid profile in inactive overweight women.

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The Relationship Between Serum Vitamin D Level and Systemic Lupus Erythematosus Activity

International journal of epidemiologic research ◽

10.34172/ijer.2020.01 ◽

2020 ◽

Vol 7 (1) ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Batool Zamani ◽

Hossein Akbari ◽

Mehrdad Mahdian ◽

Ehsan Dadgostar

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Lupus Erythematosus ◽

Healthy Subjects ◽

Linear Regression Analysis ◽

Serum Vitamin ◽

Control Group ◽

Systemic Lupus ◽

25 Hydroxy Vitamin D ◽

The Relationship

Background and aims: : Systemic lupus erythematosus (SLE) is an autoimmune disease which involves various organs. Vitamin D is an essential ingredient in regulating the immune system. This study aimed to investigate the relationship between vitamin D and the severity of lupus activity. Materials and Methods: This case-control study was carried out on 38 patients with lupus on the basis of the American College of Rheumatology (ACR) criteria and 44 healthy subjects with no history of rheumatologic disease. To measure the level of 25-hydroxy vitamin D, venous blood samples (5 cc) were taken from each participant and the activity of the lupus disease was measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scale. Finally, the chi-square test, independent sample t test, one-way ANOVA, and multiple linear regression analysis were used to measure multivariate effects. The level of significance was set to be P<0.05. Results: Thirty-five lupus patients and 40 healthy subjects were females (P=0.847). Vitamin D deficiency was observed in the case (42.1%) and control (11.4%) groups. The mean value of serum vitamin D3 level was 35.3 ng/mL in the control group, as well as 24.6 ng/mL and 21.3 ng/mL in patients with mild and severe SLE, respectively (P=0.024). Conclusion: In this study, high levels of 25-hydroxy vitamin D were observed among the healthy subjects compared to patients with SLE. Eventually, the level of vitamin D significantly decreased by increasing the severity of SLE activity.

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The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population

Archives of Medical Science ◽

10.5114/aoms.2020.101100 ◽

2020 ◽

Author(s):

Nutjaree Jeenduang ◽

Boonnisa Sangkaew

Keyword(s):

Vitamin D ◽

Body Composition ◽

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Serum Lipids ◽

Density Lipoprotein ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

The Relationship

IntroductionDyslipidaemia is a major risk factor for cardiovascular diseases (CVD). Vitamin D deficiency has been found to be associated with CVD. However, the relationships between vitamin D and lipids are inconsistent. The aim of this study was to investigate the relationship between vitamin D status and serum lipids in Southern Thai subjects.Material and methodsA total of 726 healthy subjects in Southern Thailand were enrolled in the study. Serum 25-hydroxyvitamin D (25(OH)D), lipid profiles, fasting plasma glucose, anthropometric data, blood pressure, and body composition were measured. The relationship between serum 25(OH)D levels and biochemical data was evaluated by partial correlation and multiple linear regression analyses. The association of serum 25(OH)D levels with dyslipidaemia was analysed using multivariate regression analysis.ResultsSerum 25(OH)D levels were negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and body composition parameters after adjusting for age in women. Multiple linear regression analysis showed that TC and BMI were independent predictors for 25(OH)D concentrations in women. Multivariate logistic regression analysis showed that the odds ratio of hypertriglyceridaemia (OR 0.51; 95% CI: 0.32–0.80, p = 0.004) and reduced high-density lipoprotein cholesterol (HDL-C) (OR 0.43; 95% CI: 0.26–0.71, p = 0.001) were significantly lower in vitamin D sufficiency when compared with hypovitaminosis D in women.ConclusionsVitamin D sufficiency could reduce risk of hypertriglyceridaemia and reduced HDL-C, particularly in women, suggesting that vitamin D sufficiency may have beneficial effects on lipids and a decreased risk for CVD in Thai women.

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