scholarly journals Mammillaria Species—Polyphenols Studies and Anti-Cancer, Anti-Oxidant, and Anti-Bacterial Activities

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 131 ◽  
Author(s):  
Hosam O. Elansary ◽  
Agnieszka Szopa ◽  
Marta Klimek-Szczykutowicz ◽  
Karolina Jafernik ◽  
Halina Ekiert ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Sinapic Acid ◽  
Jurkat Cells ◽  
Gentisic Acid ◽  
Natural Product Research ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Mcf 7

Discovering new natural resources of polyphenols is the aim of many recent studies in the field of natural product research. This study tentatively investigated the polyphenols profile of the stems of seven Mammillaria species (M. rhodantha, M. spinosissima, M. hahniana, M. crucigera, M. candida, M. albilanata, and M. muehlenpfordtii) using high performance liquid chromatography with DAD detector (HPLC-DAD) method. Furthermore, the anti-cancer, anti-oxidant, and anti-bacterial potentials of these extracts as well as major identified phenols were explored. The HPLC-DAD study confirmed the availability of six phenolic acids, including gentisic acid, chlorogenic acid, caffeic acid, protocatechuic acid, sinapic acid, and p-hydroxybenzoic acid. The dominant compounds were: gentisic acid in M. rhodantha and M. spinosissima; chlorogenic acid in M. muehlenpfordtii, M. crucigera, and M. rhodantha; and caffeic acid in M. rhodantha, M. crucigera, and M. spinosissima. Stems of Mammillaria sp. showed antiproliferative effects against HeLa, MCF-7, and Jurkat cells. In HeLa and MCF-7 cells, the best antiproliferative activities were found in the treatments with M. rhodantha, M. spinosissima, and M. muehlenpfordtii. The apoptotic assay of M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed accumulation of necrotic cells in the early and late apoptotic phase. M. rhodantha, M. spinosissima, and M. muehlenpfordtii showed the highest anti-oxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), β-carotene bleaching, and ferric reducing anti-oxidant power (FRAP) assays. M. rhodantha was the best source of antioxidants. Mammillaria sp. showed moderate anti-bacterial effects against bacteria and the highest effects were found using the extracts of M. rhodantha, M. spinosissima, M. crucigera and M. muehlenpfordtii against most bacteria. The anti-bacterial activities were attributed to other phenolic compounds (e.g., chlorogenic acid) than gentisic acid, which was not active against most bacteria. Mammillaria sp. could be considered to be an important natural source of phenolic acids with anti-cancer, anti-bacterial, and anti-oxidant activities.

scholarly journals Concentrations of Phenolic Acids Are Differently Genetically Determined in Leaves, Flowers, and Grain of Common Buckwheat (Fagopyrum esculentum Moench)

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1142
Author(s):  
Alena Vollmannová ◽  
Janette Musilová ◽  
Judita Lidiková ◽  
Július Árvay ◽  
Marek Šnirc ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Sinapic Acid ◽  
Fagopyrum Esculentum ◽  
Blood Cholesterol ◽  
Common Buckwheat ◽  
High Concentration ◽  
Phenolic Substances ◽  
Fagopyrum Esculentum Moench

Common buckwheat (Fagopyrum esculentum Moench) is a valuable source of proteins, B vitamins, manganese, tryptophan, phytochemicals with an antioxidant effect, and the natural flavonoid rutin. Due to its composition, buckwheat supports the human immune system, regulates blood cholesterol, and is suitable for patients with diabetes or celiac disease. The study aimed to compare the allocation of selected phenolic acids (neochlorogenic acid, chlorogenic acid, trans-caffeic acid, trans-p-coumaric acid, trans-sinapic acid, trans-ferulic acid) and flavonoids (rutin, vitexin, quercetin, kaempferol) in the leaves, flowers, and grain of buckwheat cultivars of different origin. The content of individual phenolics was determined by the HPLC-DAD method. The results confirmed the determining role of cultivar on the relative content of chlorogenic acid, trans-caffeic acid, trans-sinapic acid, vitexin, and kaempferol in buckwheat plants. A significantly negative correlation among concentrations of phenolic acids in different common buckwheat plant parts shows that there are different mechanisms of genetic influences on the concentration of phenolic substances in common buckwheat flowers, leaves, and grain. These differences should be taken into account when breeding buckwheat for a high concentration of selected phenolic substances.

Involvement of Phenolics, Flavonoids, and Phenolic Acids in High Yield Characteristics of Rice (Oryza Sativa L.)

2018 ◽  
Vol 68 ◽  
pp. 19-26 ◽  
Author(s):  
Tran Dang Xuan ◽  
Do Tuan Bach ◽  
Tran Dang Dat
Keyword(s):  
Ferulic Acid ◽  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Sinapic Acid ◽  
Development Stage ◽  
Vegetative Stage ◽  
High Yield ◽  
Phenolic Contents ◽  
The Difference

The present study examined the correlation between phenolic acids and flavonoids with high rice yield traits of rice. It was observed that the difference of phenolic contents among the tested rice lines occurred only in the vegetative stage. The concentrations of phenolic acids were higher in the rice high yield cultivars than low yield variety in the vegetative stage, but they either decreased dramatically or disappeared during the development stage. Caffeic acid was found only in high yield rice, whereas chlorogenic acid was detected only in low yield rice. Sinapic acid was the dominant phenolic acid in high yield cultivars at vegetative stage (3.7 mg/g), followed by ferulic acid (1.2 mg/g). These findings suggest that caffeic acid, ferulic acid, sinapic acid and chlorogenic acid may play a particular role in forming yield components in rice. The cultivar B3 contained high amount of sinapic acid may be used as a natural source for pharmaceutical use.

METABOLISM OF PHENYLPROPANOID COMPOUNDS IN SALVIA: II. BIOSYNTHESIS OF PHENOLIC CINNAMIC ACIDS

1959 ◽  
Vol 37 (1) ◽  
pp. 537-547 ◽  
Author(s):  
D. R. McCalla ◽  
A. C. Neish
Keyword(s):  
Caffeic Acid ◽  
Phenolic Acids ◽  
Cinnamic Acid ◽  
Shikimic Acid ◽  
Sinapic Acid ◽  
Coumaric Acid ◽  
Cinnamic Acids ◽  
Phenyllactic Acid ◽  
Salvia Splendens ◽  
Specific Activities

p-Coumaric, caffeic, ferulic, and sinapic acids were found to occur in Salvia splendens Sello in alkali-labile compounds of unknown constitution. A number of C14-labelled compounds were administered to leafy cuttings of salvia and these phenolic acids were isolated after a metabolic period of several hours and their specific activities measured. Cinnamic acid, dihydrocinnamic acid, L-phenylalanine, and (−)-phenyllactic acid were found to be good precursors of the phenolic acids. D-Phenylalanine, L-tyrosine, and (+)-phenyllactic acid were poor precursors. A kinetic study of the formation of the phenolic acids from L-phenylalanine-C14 gave data consistent with the view that p-coumaric acid → caffeic acid → ferulic acid → sinapic acid, and that these compounds can act as intermediates in lignification. Feeding of C14-labelled members of this series showed that salvia could convert any one to a more complex member of the series but not so readily to a simpler member. Caffeic acid-β-C14 was obtained from salvia after the feeding of L-phenylalanine-β-C14 or cinnamic acid-β-C14, and caffeic acid labelled only in the ring was obtained after feeding generally labelled shikimic acid.

scholarly journals The effects of plant density and irrigation on phenolic content in cauliflower 

2017 ◽  
Vol 44 (No. 4) ◽  
pp. 178-185 ◽  
Author(s):  
Alina Kałużewicz ◽  
Jolanta Lisiecka ◽  
Monika Gąsecka ◽  
Włodzimierz Krzesiński ◽  
Tomasz Spiżewski ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Ferulic Acid ◽  
Gallic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Plant Density ◽  
Phenolic Content ◽  
Sinapic Acid ◽  
Dry Weight ◽  
Coumaric Acid

This study was conducted to study the influence of plant density and irrigation on the content of phenolic compounds, i.e., phenolic acids and flavonols in cv. ‘Sevilla’ cauliflower curds. Levels of phenolic acids and flavonols were in the range of 3.0–6.2 mg and 25.4–87.8 mg/100 g of dry weight, respectively, depending on plant density and irrigation. Of the phenolic acids, caffeic acid was detected in the highest amount, followed by p-coumaric acid, sinapic acid, gallic acid, and ferulic acid. Of the two flavonols detected, the levels of quercetin were higher than those of kaempferol. The content of the detected phenolic acids (with the exception of ferulic acid) and both flavonols increased with increasing plant density. Furthermore, the concentration of phenolic compounds (with the exception of ferulic acid) was significantly higher under irrigation.

scholarly journals RP-HPLC Analysis of Phenolic Acids of Selected Central European Carex L. (Cyperaceae) Species and Its Implication for Taxonomy

2011 ◽  
Vol 94 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Anna Bogucka-Kocka ◽  
Katarzyna Szewczyk ◽  
Magdalena Janyszek ◽  
Sławomir Janyszek ◽  
Łukasz Cieśla
Keyword(s):  
Cluster Analysis ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Hplc Analysis ◽  
Sinapic Acid ◽  
Plant Tissues ◽  
Coumaric Acid ◽  
Central European ◽  
The Real ◽  
Rp Hplc

Abstract Eighteen species belonging to the Carex genus were checked for the presence and the amount of eight phenolic acids (p-hydroxybenzoic, vanillic, caffeic, syringic, protocatechuic, p-coumaric, sinapic, and ferulic) by means of HPLC. Both the free and bonded phenolic acids were analyzed. The majority of the analyzed acids occurred in the studied species in relatively high amounts. The highest concentrations found were caffeic acid and p-coumaric acid, for which the detected levels were negatively correlated. A very interesting feature was the occurrence of sinapic acid, a compound very rarely detected in plant tissues. Its distribution across the analyzed set of species can be hypothetically connected with the humidity of plants' habitats. Several attempted tests of aggregative cluster analysis showed no similarity to the real taxonomical structure of the genus Carex. Thus, the phenolic acids' composition cannot be considered as the major taxonomical feature for the genus Carex.

scholarly journals Anti-malarial Activity Of Phenolic Acids Is Structurally Related

2020 ◽  
Author(s):  
Prince A Fordjour ◽  
Jonathan P Adjimani ◽  
Bright Asare ◽  
Nancy O Duah-Quashie ◽  
Neils B Quashie
Keyword(s):  
Plasmodium Falciparum ◽  
Ferulic Acid ◽  
Chlorogenic Acid ◽  
Gallic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Rosmarinic Acid ◽  
Protocatechuic Acid ◽  
Antimalarial Activity ◽  
Coumaric Acid

Abstract Background In the absence of an effective vaccine against malaria, chemotherapy remains a major option in the control of the disease. Then, the recent report of the emergence and spread of clones of Plasmodium falciparum resistant to available antimalarial drugs should be of concern as it poses a threat to disease control. Compounds whose pharmacological properties have been determined and touted for other disease can be investigated for antimalarial activity. Phenolic acids (polyphenols) have been reported to exhibit antioxidant, anticancer, anti-inflammatory, antiviral and antibiotic effects. However, information on their antimalarial activity is scanty. Phenolic acids are present in a variety of plant-based foods: mostly high in the skins and seeds of fruits as well as the leaves of vegetables. Systematic assessment of these compounds for antimalarial activity is therefore needed. Method Using the classical in vitro drug test, the antimalarial activities of five hydroxycinnamic acids, (caffeic acid, rosmarinic acid, chlorogenic acid, o-Coumaric acid and ferulic acid) and two hydroxybenzoic acids (gallic acid and protocatechuic acid) against 3D7 clones of Plasmodium falciparum was determined. Results Among the phenolic acids tested, caffeic acid and gallic acid were found to be the most effective, with mean IC 50 value of 17.73µg/ml and 26.59µg/ml respectively for three independent determinations. Protocatechuic acid had an IC 50 value of 30.08 µg/ml. Rosmarinic acid and chlorogenic acid, showed moderate antimalarial activities with IC 50 values of 103.59µg/ml and 105µg/ml respectively. The IC 50 values determined for ferulic acid and o-Coumaric acid were 93.36µg/ml and 82.23µg/ml respectively. Conclusion The outcome of this study suggest that natural occurring phenolic compounds have appreciable level of antimalarial activity which can be exploited for use through combination of actions/efforts including structural manipulation to attain an increase in their antimalarial effect. Eating of natural food products rich in these compounds could provide antimalarial prophylactic effect.

Dietary chlorogenic acid supplementation affects gut morphology, antioxidant capacity and intestinal selected bacterial populations in weaned piglets

2018 ◽  
Vol 9 (9) ◽  
pp. 4968-4978 ◽  
Author(s):  
Yong Zhang ◽  
Yu Wang ◽  
Daiwen Chen ◽  
Bing Yu ◽  
Ping Zheng ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Quinic Acid ◽  
Weaned Piglets ◽  
Gut Morphology ◽  
Bacterial Populations ◽  
Acid Supplementation

Chlorogenic acid (CGA), an ester formed between caffeic acid and quinic acid, is one of the most abundant phenolic acids in plants.

Changes in sugars and phenolics concentrations of Williams pear leaves during the growing season

2006 ◽  
Vol 86 (4) ◽  
pp. 1203-1208 ◽  
Author(s):  
Mateja Colaric ◽  
Franci Stampar ◽  
Metka Hudina
Keyword(s):  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Vanillic Acid ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Sinapic Acid ◽  
Growing Season ◽  
Syringic Acid ◽  
Total Phenolic ◽  
Chromatography Method

Leaves of Williams pear were collected during the growing season from May to October and the contents of sugars and phenolic compounds were analyzed by high-performance liquid chromatography method. Sorbitol was the major sugar (up to 83.8 g kg-1 DW), followed by sucrose (up to 22.1 g kg-1 DW). Concentrations of glucose and fructose were as high as 12.9 and 9.0 g kg-1 DW, respectively. Leaves contained up to 29 471.9 mg kg-1 DW of chlorogenic acid, followed in concentration by rutin (up to 6789.2 mg kg-1 DW), epicatechin (up to 7378.0 mg kg-1 DW), catechin (up to 3846.5 mg kg-1 DW), vanillic acid (up to 1832.1 mg kg-1 DW), syringic acid (up to 1123.5 mg kg-1 DW), caffeic acid (up to 122.5 mg kg-1 DW) and sinapic acid (up to 94.1 mg kg-1 DW). The significant differences in concentration of sorbitol, sucrose, glucose, and in all analyzed phenolics were observed during the growing season (six sampling dates). The lowest concentrations in the leaf were found at the beginning of the growing season in May and June. The highest contents of sugars were in October, with the exception of sorbitol. During the growing season, total phenolic content first increased, then declined. Chlorogenic acid, rutin and caffeic acid contents increased until July, vanillic acid and sinapic acid until August, and catechin, epicatechin and syringic acid until September. However, total phenolic content dropped by 50% from September to October. Key words: Pear leaves, sugars, phenolics, growing season

Characterisation of Polyphenolic Compounds in Viscum album L. and Allium sativum L. extracts

2017 ◽  
Vol 68 (7) ◽  
pp. 1677-1680 ◽  
Author(s):  
Svetlana Trifunschi ◽  
Melania F. Munteanu ◽  
Elena Pogurschi ◽  
Ramona Gligor
Keyword(s):  
Side Effects ◽  
Pharmaceutical Industry ◽  
Phenolic Acids ◽  
Allium Sativum ◽  
Sinapic Acid ◽  
Chemical Compounds ◽  
Viscum Album ◽  
Polyphenolic Compounds ◽  
Coumaric Acid ◽  
Gentisic Acid

There are numerous phytochemicals (isoflavones, flavonoids, catechins, anthocyanins, carotenoids, polyphenols, phenolic acids), which are largely used in the pharmaceutical industry. This research describes the process through which, one can obtain medicinal extracts from mistletoe (Viscum album L.) and garlic (Allium sativum L.) while giving an exact characterisation of the two extracts. The HPLC/MS analysis was employed in order to identify and evaluate the presence of phenolic acids (gentisic acid, chlorogenic acid, p-coumaric acid, ferulic acid and sinapic acid) and of flavonoids (hyperoside, isoquercitrin, rutin and luteolin). The results suggest that these medicinal extracts could replace the chemical compounds used in various therapies and which unfortunately have side effects on patients.

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