scholarly journals Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 251
Author(s):  
Mehreen Zeb ◽  
Chow H. Lee
Keyword(s):  
Drug Discovery ◽  
North America ◽  
Bioactive Compounds ◽  
Ecological Systems ◽  
Good Source ◽  
Mushroom Species ◽  
Long Time ◽  
Bioactive Ingredients ◽  
Medicinal Properties ◽  
Different Cultures

Mushrooms, the fruiting bodies of fungi, are known for a long time in different cultures around the world to possess medicinal properties and are used to treat various human diseases. Mushrooms that are parts of traditional medicine in Asia had been extensively studied and this has led to identification of their bioactive ingredients. North America, while home to one of the world’s largest and diverse ecological systems, has not subjected its natural resources especially its diverse array of mushroom species for bioprospecting purposes: Are mushrooms native to North America a good source for drug discovery? In this review, we compile all the published studies up to September 2020 on the bioprospecting of North American mushrooms. Out of the 79 species that have been investigated for medicinal properties, 48 species (60%) have bioactivities that have not been previously reported. For a mere 16 selected species, 17 new bioactive compounds (10 small molecules, six polysaccharides and one protein) have already been isolated. The results from our literature search suggest that mushrooms native to North America are indeed a good source for drug discovery.

scholarly journals A REVIEW ON ALOE VERA-THE WONDER MEDICINAL PLANT

2018 ◽  
Vol 8 (5-s) ◽  
pp. 94-99 ◽  
Author(s):  
Suseela Lanka
Keyword(s):  
Amino Acids ◽  
Medicinal Plant ◽  
Genital Herpes ◽  
Bioactive Compounds ◽  
Seborrheic Dermatitis ◽  
Aloe Vera ◽  
Medicinal Uses ◽  
Succulent Plant ◽  
Long Time ◽  
Medicinal Properties

Aloe vera, a succulent plant that grows in arid and subtropical climates is best known for its medicinal properties and is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine. It has been in use for a long time by people of varied cultures and traditional uses include applications to reduce perspiration, oral dosing for diabetes and to get rid of a range of gastrointestinal ailments. It is also used to treat burn wounds, minor cuts, genital herpes, and seborrheic dermatitis. The leaves of this wonderful medicinal plant contain numerous vitamins, minerals, natural sugars, enzymes, amino acids, and as well rich in various bioactive compounds that exhibit emollient, purgative, anti-inflammatory, antioxidant, antimicrobial, anti-helmenthic, antifungal, aphrodisiac, antiseptic and cosmetic values. Many cosmetic industries widely use this plant owing to its healing and nourishing properties.  Keywords: Aloe vera, Medicinal Uses, bioactive compounds, Cosmetic industries

scholarly journals A Comprehensive Review on Anti-Inflammatory Activity of The Traditional Plants Plumbago zeylanica(Chitra)

2021 ◽  
Vol 22 (1) ◽  
Keyword(s):  
Bioactive Compounds ◽  
Pharmacological Action ◽  
Comprehensive Understanding ◽  
High Demand ◽  
Plumbago Zeylanica ◽  
Wide Range ◽  
Anti Cancer ◽  
Long Time ◽  
Medicinal Properties ◽  
Anti Inflammatory

Medicinal plants have long been utilised as a source of medicine and are in high demand throughout the world. They've been around for a long time, and they've been utilised to cure and prevent ailments. Plumbago zeylanica is a medicinal plant that is frequently utilised for its medicinal properties. It contains several bioactive compounds like napthoquinones, flavonoids, alkaloids, glycosides, steroids, tri-terpenoids, tannins, fixed oils, fats, proteins, etc. among all plumbagin is most important bioactive compounds. It possesses wide range of pharmaceutical activities such as anti-inflammatory, antimicrobial, anti-cancer, anti-ulcer, antidiabetic etc. Several investigations on its pharmacological activity have been conducted. The goal of this review is to provide a comprehensive understanding of P. zeylanica's chemical composition and pharmacological action.

Effects of insecticides on adults and eggs of Drosophila suzukii (Diptera, Drosophilidae)

2017 ◽  
Vol 43 (2) ◽  
pp. 208 ◽  
Author(s):  
Daniele Cristine Hoffmann Schlesener ◽  
Jutiane Wollmann ◽  
Juliano De Bastos Pazini ◽  
Anderson Dionei Grützmacher ◽  
Flávio Roberto Mello Garcia
Keyword(s):  
North America ◽  
South America ◽  
Chemical Control ◽  
Stone Fruits ◽  
Drosophila Suzukii ◽  
Ovicidal Effect ◽  
Mere Presence ◽  
South Of Brazil ◽  
Different Cultures ◽  
First Time

Drosophila suzukii (Diptera, Drosophilidae) is an exotic species, endemic to Asia and currently a pest to small and stone fruits in several countries of North America and Europe. It was detected in 2013 for the first time in South America, in the south of Brazil. Unlike most drosophilids, this species deserves special attention, because the females are capable of oviposit inside healthy fruits, rendering their sale and export prohibited. Despite the confirmed existence of this species in different states of Brazil, this insect is yet been to be given the pest status. Nevertheless, the mere presence of this species is enough to cause concern to producers of small fruits and to justify further investigation for it’s control, especially chemical control for a possible change in status. Therefore, the goal of this work was to evaluate, in laboratory, mortality of D. suzukii adults and ovicidal effect when exposed to different insecticides registered for species of the Tephritidae and Agromyzidae families in different cultures. The insecticides deltamethrin, dimethoate, spinosad, fenitrothion, phosmet, malathion, methidathion, and zeta-cypermethrin resulted in mortality to 100 % of the subjects three days after the treatment (DAT). Regarding the effects over eggs, it was  established that the insecticides fenitrothion, malathion, and methidathion deemed 100 % of the eggs not viable, followed by phosmet and diflubenzuron, which also caused elevated reduction in the eclosion of larvae two DAT.

The 14th Annual AMSE Conference

1988 ◽  
Vol 5 (2) ◽  
pp. 311
Author(s):  
Mozaffar Partowmah
Keyword(s):  
North America ◽  
Nuclear Physics ◽  
Agricultural Research ◽  
Social Scientists ◽  
Electronic Engineering ◽  
Student Paper ◽  
Long Time ◽  
Continuous Support ◽  
And Performance ◽  
Sizable Number

The 14th Annual Conferknce of the Association of Muslim Scientistsand Engineers (ASME) was held during the weekend of qufur 2628,1409/0ctober 7-9, 1988, at the Islamic Center of North America in Plainfield,Indiana. Papers presented at the Conference dealt with a variety of subjectsranging from agriculture and health sciences to car manufacturing tips,computers, industrial, civil and electronic engineering, as well as resourcemanagement and organizational behavior.Members of the AMSS (Association of Muslim Social Scientists) whoattended the AMSE Conference, participated in the sessions with undividedattention. Dr. AbdulHamid AbuSulayman, the AMSS President, in his banquetspeech, stressed the need for an active AMSE that will eventually attracta more sizable number of Muslims in North America and coordinate theirscientific efforts for their common benefit.In a session entitled “Technology Transfer,” the Japanese and Koreanapproaches were contrasted with the Muslim world approach. A highlightof the Conference was the announcement of the A1 Khwarazmi Award thatthe AMSE will award annually to a distinguished Muslim scientist or engineer.The first Al Khwarazmi Award went to Dr. M.A.K. Lodhi of Texas A&MUniversity in appreciation of his continuous support for Muslim studentsand his long-time involvement in the AMSE in addition to his scientific interestand achievements in nuclear physics and field theory.The Best Student Paper Award went to the following: 1) Abdullah M.Elramsisi of Rochester Hill, Michigan for his paper “On Model-based ImageRestoration and Performance Evaluation;” and 2) Khatib Rajab of Morgantown,West Virginia for his paper on “Agricultural Research Needs and Prioritiesin Zanzibar as perceived by Administrators and Extension Workers.”Copies of all of the presented papers were distributed at the Conferenceand will be ppblished in the conference proceedings. Preprints and reprintsmay be obtained by writing to the AMSE office at P.O. Box 38, Plainfield,Indianna, 46168 ...

Unraveling the action mechanism of Buyang Huanwu Tang (BYHWT) for Cerebral Ischemia by Systematic Pharmacological Methodology

2020 ◽  
Vol 23 ◽  
Author(s):  
Shi-tang Ma ◽  
Ning Zhang ◽  
Ge Hong ◽  
Cheng-tao Feng ◽  
Sheng-wei Hong ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Virtual Screening ◽  
Signaling Pathways ◽  
Bioactive Compounds ◽  
Enrichment Analysis ◽  
Material Base ◽  
Lead Discovery ◽  
Binding Effect ◽  
Bioactive Ingredients ◽  
Compound Target

Background: Buyang Huanwu Tang (BYHWT) and relevant Traditional Chinese medicine (TCM) has its unique advantages in the treatment of cerebral ischemia. However, its pharmacological mechanism have not been fully explained. Objective: Base on the multi-component, also the entire disease network targets, the present study set out to identify major bioactive ingredients, key disease targets, and pathways of BYHWT against cerebral ischemia disease by systematic pharmacological methodology. Methods: Both the bioactive compounds from the BYHWT and the positive drugs against cerebral ischemia were fully investigated. The binding targets of the positive drugs were then obtained. A virtual screening protocol was then used to highlight the compound-target interaction. And network was constructed to visual the compound-target binding effect after docking analysis. Moreover，the targets enrichment analysis for biological processes and pathways were revealed to further explore the function of bio-targets protein gene and its role in the signal pathway. Results: A total of 382 active ingredients of the BYHWT and 23 candidate disease targets were identified. Virtual screening results indicated that multiple bioactive compounds targeted multiple proteins. Each compounds act on one or more targets. The mechanisms were linked to 20 signaling pathways, and the key mechanism was related to serotonergic synapse, calcium signaling pathway and camp signaling pathways. Conclusion: The present study explored the bioactive ingredients and mechanisms of BYHWT against cerebral ischemia by systematic pharmacological methodology. the novel methodology would provide a reference for the lead discovery of precursors, disease mechanism and material base for TCM.

Decoding Protein-protein Interactions: An Overview

2020 ◽  
Vol 20 (10) ◽  
pp. 855-882
Author(s):  
Olivia Slater ◽  
Bethany Miller ◽  
Maria Kontoyianni
Keyword(s):  
Drug Discovery ◽  
Protein Interactions ◽  
Drug Repurposing ◽  
Protein Docking ◽  
Target Space ◽  
Protein Protein Interactions ◽  
X Ray Crystallography ◽  
Protein Protein Interaction ◽  
Interaction Sites ◽  
Long Time

Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and given advances in X-ray crystallography, protein-protein interactions have become an emerging focus area of drug discovery enterprises. Proteins interact with other biomolecules and it is this intricate network of interactions that determines the behavior of the system and its biological processes. In this review, we briefly discuss networks in disease, followed by computational methods for protein-protein complex prediction. Computational methodologies and techniques employed towards objectives such as protein-protein docking, protein-protein interactions, and interface predictions are described extensively. Docking aims at producing a complex between proteins, while interface predictions identify a subset of residues on one protein that could interact with a partner, and protein-protein interaction sites address whether two proteins interact. In addition, approaches to predict hot spots and binding sites are presented along with a representative example of our internal project on the chemokine CXC receptor 3 B-isoform and predictive modeling with IP10 and PF4.

scholarly journals Bioactivity of Medicinal Plants and Extracts

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 634
Author(s):  
Francisco Les ◽  
Guillermo Cásedas ◽  
Víctor López
Keyword(s):  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Medicinal Properties

Nature is an inexhaustible source of bioactive compounds and products with interesting medicinal properties and technological applications [...]

scholarly journals Diverse resourcing of Nerium indicum leaves for bio-utilization

2020 ◽  
Vol 24 (3 Part A) ◽  
pp. 1785-1793
Author(s):  
Dongli Ma ◽  
Yuanyuan Chen ◽  
Yong Lai ◽  
Zanpei Zhang ◽  
Ximei Li ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Organic Solvents ◽  
Raw Materials ◽  
Chemical Constituents ◽  
Food Additives ◽  
Ornamental Plant ◽  
Bioactive Ingredients ◽  
Ft Ir ◽  
Medicinal Properties ◽  
Alcohol Benzene

Nerium indicum is an ornamental plant that is widely distributed in tropical and subtropical regions wordwide. It has toxic and medicinal properties which is closely related to the bioactive ingredients contained in Nerium indicum. In our research, the leaves of Nerium indicum was used as raw materials to study the chemical constituents and their effects. The chemical constituents of the leaves were analyzed by FT-IR and GC-MS with alcohol, benzene and acetone as organic solvents. A total of 73 compounds were obtained by acetone organic solvent, 25 compounds were extracted from benzene and 146 compounds were obtained from alcohol. Rich bioactive and bioenergy components were found in all three kinds of extract, suggesting that Nerium indicum leaves are of great significance for the diverse resourcing of bio-utilization including biomedicine, bioenergy, aroma, food additives.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential oils of 14 known Ficus species – A Concise Review

2021 ◽  
Vol 12 (6) ◽  
pp. 8003-8034
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Bioactive Compounds ◽  
Volatile Oils ◽  
Good Source ◽  
Concise Review ◽  
Living Organisms

Compounds useful for drugs, cosmetics, and food have been obtained directly or indirectly from living organisms over the years. However, there has been a renewed interest in getting useful compounds from living organisms, especially plants. Essential oils, interchangeably called volatile oils, are bioactive compounds found in minute quantities in some plants. Essential or volatile oils have been known for years to find usefulness in foods, drugs (antimicrobial, antifungal), and cosmetics. This review attempts to summarize information on the essential oil from Ficus species concerning their morphology, pharmacology, bioactivity, and application. This was achieved by gathering information on essential oils from different Ficus species. Essential oils from Ficus species are a good source of bioactive compounds for use in drug, food, and cosmetic industries. It is worthy to note that Nigerian Figs were characterized by the high presence of phytol and 6,10,14-trimethyl-2-pentadecanone, and these compounds are, therefore, seen as markers. Furthermore, this review presents numerous insights on how to best harness the different potentials of the essential oils and possibilities to be examined.

scholarly journals Evolution of andrenine bees reveals a long and complex history of faunal interchanges between the Americas during the Mesozoic and Cenozoic

2021 ◽  
Author(s):  
Kelli S Ramos ◽  
Aline C Martins ◽  
Gabriel A R Melo
Keyword(s):  
North America ◽  
South America ◽  
Time Window ◽  
Distributional Pattern ◽  
Long Distance ◽  
Early Diversification ◽  
Palearctic Region ◽  
Long Time ◽  
The Times ◽  
Dated Phylogeny

Bees are presumed to have arisen in the early to mid-Cretaceous coincident with the fragmentation of the southern continents and concurrently with the early diversification of the flowering plants. Among the main groups of bees, Andreninae sensu lato comprise about 3000 species widely distributed with greatest and disjunct diversity in arid areas of North America, South America, and the Palearctic region. Here, we present the first comprehensive dated phylogeny and historical biogeographic analysis for andrenine bees, including representatives of all currently recognized tribes. Our analyses rely on a dataset of 106 taxa and 7952 aligned nucleotide positions from one mitochondrial and six nuclear loci. Andreninae is strongly supported as a monophyletic group and the recovered phylogeny corroborates the commonly recognized clades for the group. Thus, we propose a revised tribal classification that is congruent with our phylogenetic results. The time-calibrated phylogeny and ancestral range reconstructions of Andreninae reveal a fascinating evolutionary history with Gondwana patterns that are unlike those observed in other subfamilies of bees. Andreninae arose in South America during the Late Cretaceous around 90 Million years ago (Ma) and the origin of tribes occurred through a relatively long time-window from this age to the Miocene. The early evolution of the main lineages took place in South America until the beginning of Paleocene with North American fauna origin from it and Palearctic from North America as results of multiple lineage interchanges between these areas by long-distance dispersal or hopping through landmass chains. Overall, our analyses provide strong evidence of amphitropical distributional pattern currently observed in Andreninae in the American continent as result at least three periods of possible land connections between the two American landmasses, much prior to the Panama Isthmus closure. The andrenine lineages reached the Palearctic region through four dispersal events from North America during the Eocene, late Oligocene and early Miocene, most probably via the Thulean Bridge. The few lineages with Afrotropical distribution likely originated from a Palearctic ancestral in the Miocene around 10 Ma when these regions were contiguous, and the Sahara Desert was mostly vegetated making feasible the passage by several organisms. Incursions of andrenine bees to North America and then onto the Old World are chronological congruent with distinct periods when open-vegetation habitats were available for trans-continental dispersal and at the times when aridification and temperature decline offered favorable circumstances for bee diversification.

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