scholarly journals Caralluma europaea (Guss.) N.E.Br.: Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 636
Author(s):  
Fatima Ez-Zahra Amrati ◽  
Mohammed Bourhia ◽  
Hamza Saghrouchni ◽  
Meryem Slighoua ◽  
Andriy Grafov ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Chemical Characterization ◽  
Antibacterial Activities ◽  
Antibiotic Resistant ◽  
Traditional Medicines ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
The Family ◽  
Anti Inflammatory ◽  
Antibacterial And Antifungal

Caralluma europaea (Guss.) N.E.Br.: (C. europaea) is a wild medicinal plant belonging to the family Apocynaceae. It is commonly used in traditional medicines for treating several diseases. The present work aims to evaluate the anti-inflammatory, antibacterial, and antifungal potentials of C. europaea fractions including hydro ethanol (ET CE), n-butanol (But CE), and polyphenol (Poly CE). The chemical composition of hydroethanol, n-butanol, and polyphenol-rich fractions from C. europaea were determined using GC-MS after silylation. The anti-inflammatory effect of hydroethanol, n-butanol, and polyphenol-rich fractions was studied by carrageenan-induced paw edema. Antibacterial and antifungal activities of hydroethanol, n-butanol, and polyphenol-rich fractions against Gram-positive bacteria, Gram-negative bacteria, and yeasts were assessed using the disc diffusion and micro-dilution assays. The findings of the chemical characterization affirmed the presence of interesting bioactive compounds in C. europaea fractions. The polyphenol-rich fraction was the best inhibitor of edema by75.68% after 6 h of treatment. The hydroethanol fraction was the most active against both bacteria and yeasts. This study contributes to society as it provides potential bioactive compounds in C. europaea extract, which may help in fighting nosocomial antibiotic-resistant microbes.

scholarly journals Valorization of Sicanaodorifera (Vell.) Naudin Epicarp as a Source of Bioactive Compounds: Chemical Characterization and Evaluation of Its Bioactive Properties

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 700
Author(s):  
Bianca R. Albuquerque ◽  
Maria Inês Dias ◽  
Carla Pereira ◽  
Jovana Petrović ◽  
Marina Soković ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
Food Additives ◽  
Chemical Characterization ◽  
Dry Weight ◽  
Bioactive Molecules ◽  
High Concentration ◽  
Minimal Inhibitory Concentrations ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Fruit bio-residues can be interesting for the recovery of bioactive molecules, such as phenolic compounds, tocopherols, vitamins, among others. These compounds can be targeted at the food industry and used for the development of functional foods or as food additives. In some cases, fruit epicarps are converted into by-products with non-commercial value, and generally, these fruit parts have a higher content in bioactive compounds than the fruit pulp. From this perspective, S. odorifera, a Brazilian fruit, has an inedible epicarp that could be explored to obtain biological compounds. Therefore, the aims of this study were to evaluate the chemical composition and the antioxidant, anti-proliferative, anti-inflammatory, and antimicrobial bioactivities of this by-product. S. odorifera epicarp showed a total of four organic acids, four phenolic compounds, highlighting the high concentration of anthocyanins (24 ± 1 mg/g dry weight (dw)) and high content of tocopherols (366 ± 2 mg/100 g dw). The hydroethanolic extract showed considerable antioxidant activity (EC50 values of 48.2 ± 0.5 and 27 ± 1 µg/mL for TBARS and OxHLIA assays, respectively), as also antibacterial and antifungal activities (minimal inhibitory concentrations (MICs) ≤ 2.2 mg/mL). The results obtained in this study suggest that Sicana odorifera epicarp represents a reliable option for the development of novel natural-based colorants with functional/bioactive proprieties.

scholarly journals Ferrocene Derivatives Carrying Urea, Thiourea, and Sulfonamide Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Serkan Yavuz ◽  
Hilal Yıldırım
Keyword(s):  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Klebsiella Pneumonia ◽  
Gram Negative Bacteria ◽  
Ferrocene Derivatives ◽  
Antifungal Activities ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

In the present study, some novel ferrocene derivatives carrying urea, thiourea, and sulfonamide groups were synthesized, and all compounds were characterized by spectral and elemental analyses. These compounds were screened for their antibacterial activities and also their minimum inhibitory concentration (MIC) against Gram-positive bacteria (Staphylococcus aureusandBacillus subtilis) and Gram-negative bacteria (Klebsiella pneumoniaandEscherichia coli) and antifungal activities againstSaccharomyces cerevisiaeandCandida albicans. Amongst the tested compounds,4b,4c,5b, and6bdisplayed excellent antimicrobial activity.

scholarly journals Antimicrobial Activity of Indigofera suffruticosa

2006 ◽  
Vol 3 (2) ◽  
pp. 261-265 ◽  
Author(s):  
Sônia Pereira Leite ◽  
Jeymesson Raphael Cardoso Vieira ◽  
Paloma Lys de Medeiros ◽  
Roberta Maria Pereira Leite ◽  
Vera Lúcia de Menezes Lima ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Skin Diseases ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Microsporum Canis ◽  
Aqueous Extracts ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Solid Diffusion ◽  
Antibacterial And Antifungal

Various organic and aqueous extracts of leaves ofIndigofera suffruticosaMill (Fabaceae) obtained by infusion and maceration were screened for their antibacterial and antifungal activities. The extracts were tested against 5 different species of human pathogenic bacteria and 17 fungal strains by the agar-solid diffusion method. Most of the extracts were devoid of antifungal and antibacterial activities, except the aqueous extract of leaves ofI. suffruticosaobtained by infusion, which showed strong inhibitory activity against the Gram-positive bacteriaStaphylococcus aureuswith a minimal inhibitory concentration (MIC) of 5000 µg ml−1. The MIC values to dermatophyte strains were 2500 µg ml−1 againstTrichophyton rubrum(LM-09, LM-13) andMicrosporum canis. This study suggests that aqueous extracts of leaves ofI. suffruticosaobtained by infusion can be used in the treatment of skin diseases caused by dermatophytes.

scholarly journals Antimicrobial compounds from the Kenyan Ganoderma adspersum (Schulz.) Donk species

2020 ◽  
Vol 13 (7) ◽  
pp. 3390-3397
Author(s):  
Regina Kemunto Mayaka ◽  
Alice Wanjiku Njue ◽  
Moses Kiprotich Langat ◽  
Peter Kiplagat Cheplogoi ◽  
Josiah Ouma Omolo
Keyword(s):  
Antimicrobial Activity ◽  
Ethyl Acetate ◽  
Gram Positive ◽  
Streptococcus Pneumonia ◽  
Antibiotic Resistant ◽  
1H And 13C Nmr ◽  
Gram Positive Bacteria ◽  
Chemical Structures ◽  
Zones Of Inhibition ◽  
Antibacterial And Antifungal

The emergence of antibiotic resistant pathogens has continuously increased, leading to a growing worldwide health threat due to infectious diseases. And therefore in our search for antibacterial and antifungal compounds from the polypore Ganoderma adspersum, the dried, ground fruiting bodies of G. adspersum were extracted with methanol and solvent removed in a rotary evaporator. The extract was suspended in distilled water, then partitioned using ethyl acetate solvent to obtain an ethyl acetate extract. The extract was fractionated and purified using column chromatographic method and further purification on sephadex LH20. The chemical structures were determined on the basis of NMR spectroscopic data from 1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, and NOESY experiments. Antimicrobial activity against clinically important bacterial and fungal strains was assessed and zones of inhibition were recorded. Compound (1), ergosta-7,22-dien-3-one weakly inhibited the growth of Gram positive bacteria Streptococcus pneumonia and a fungus Cryptococcus neoformans. Compounds ergosta-7,22-dien-3-ol (2) and ergosta-5,7,22-trien-3-ol (3) also inhibited gram positive Streptococcus pyogenes bacteria.Keywords: Polypores, steroid compounds, antimicrobial activity.

scholarly journals Chemistry, Antioxidant, Antibacterial and Antifungal Activities of Volatile Oils and their Components

2009 ◽  
Vol 4 (12) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Laura De Martino ◽  
Vincenzo De Feo ◽  
Florinda Fratianni ◽  
Filomena Nazzaro
Keyword(s):  
Essential Oils ◽  
Antibacterial Activities ◽  
Penicillium Citrinum ◽  
Volatile Oils ◽  
Foeniculum Vulgare ◽  
Antibacterial And Antifungal Activities ◽  
Components Analysis ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Natural Preservatives

The present paper reports the chemical composition, antioxidant and antibacterial activities of several essential oils and their components. Analysis showed that three oils (Carum carvi L., Verbena officinalis L. and Majorana hortensis L.) contained predominantly oxygenated monoterpenes, while others studied (Pimpinella anisum L., Foeniculum vulgare Mill.) mainly contained anethole. C. carvi, V. officinalis and M. hortensis oils exhibited the most potent antioxidant activity, due their contents of carvacrol, anethole and estragol. Antibacterial action was assessed against a range of pathogenic and useful bacteria and fungi of agro-food interest. V. officinalis and C. carvi oils proved the most effective, in particular against Bacillus cereus and Pseudomonas aeruginosa. Carvacrol proved most active against Escherichia coli, and completely inhibited the growth of Penicillium citrinum. The oils proved inactive towards some Lactobacilli strains, whereas single components showed an appreciable activity. These results may be important for use of the essential oils as natural preservatives for food products.

scholarly journals Physico-chemical characterization and biological screening of metal complexes with Cyanex 301

1970 ◽  
Vol 34 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Tarun Kumar Pal ◽  
Md Ashraful Alam ◽  
Suchitra Rani Paul
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Chemical Characterization ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Physico Chemical ◽  
Dithiophosphinic Acid ◽  
Cyanex 301 ◽  
Antibacterial And Antifungal

New metal complexes of Mg(II), VO(II), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Pd(II) with cyanex 301(L) i.e., bis(2,4,4-trimethylpentyl) dithiophosphinic acid were synthesized. The complexes have been characterized by elemental analysis, molar conductivity, molecular mass determination, magnetic measurements, infrared and electronic spectral studies. The prepared metal complexes have the compositions: 2. [MgL2].H2O, 3. [VOL2], 4. K[MnL3].H2O, 5. [FeL3], 6. K[CoL3].H2O, 7. K[NiL3], 8. K[CuL3] and 9. [PdL2]. The complexes 2, 3 and 9 are assumed to have tetrahedral, square pyramidal and square planar geometries, respectively but the complexes 4 - 8 are octahedral based on experimental data. From magnetic measurements the complexes 2 and 9 are found to be diamagnetic and others are paramagnetic. Measured molar conductance showed that the complexes 2, 3, 5 and 9 are non-electrolytes and rest are electrolytes. Besides, some complexes have shown good antibacterial and antifungal activities. Key words: Cyanex 301; Antibacterial; Antifungal; DMSO; Bis (2, 4, 4-trimethylpentyl) dithiophosphinic acid DOI: 10.3329/jbas.v34i2.6859Journal of Bangladesh Academy of Sciences, Vol. 34, No. 2, 153-161, 2010

scholarly journals Antibacterial and Antifungal Activities of Rumex Confertus Willd

2021 ◽  
Vol 9 (12) ◽  
pp. 855-856
Author(s):  
G. D. Shermatova
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Gram Positive ◽  
Antifungal Activities ◽  
Gram Positive Bacteria ◽  
Root Part ◽  
Fungal Activity ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Abstract: The leaves and roots of Rumex confertus Willd were tested in vitro for antibacterial and fungal activity in the fractions of gasoline, chloroform, ethyl acetate and butanol. As a result, it was found that the leaves of the Rumex confertus Willd plant, chloroform and ethyl acetate fractions of the root part have antibacterial activity against fungi and gram-positive bacteria. Keywords: Rumex confertus Willd, fractions, extracts, antibacterial, antifungal

scholarly journals BIOACTIVE COMPOUNDS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF TWO Cirsium SPECIES

2019 ◽  
Vol 18 (5) ◽  
pp. 213-221 ◽  
Author(s):  
Dumrul Gulen ◽  
Temine Sabudak ◽  
Hakime H. Orak ◽  
Hilmican Caliskan ◽  
Merve Ozer
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Bioactive Compounds ◽  
Antifungal Activities ◽  
E Coli ◽  
Inhibition Effect ◽  
Antibacterial And Antifungal Activities ◽  
Hexane Extracts ◽  
Phytochemical Compounds ◽  
Antibacterial And Antifungal

In the GC-MS analysis, 81 bioactive phytochemical compounds were identified in the hexane extracts of Cirsium creticum and Cirsium italicum. Terpenoids constituted the main fractions of C. italicum (70.95 %) while hydrocarbons were most abundant compounds of C. creticum (41.11 %). The antibacterial activity and antifungal activity of extracts from two Cirsium species was tested by using microdilution methods. According to the results of antibacterial activity, highest inhibition effect of C. creticum was found on B. subtilis, E. coli and P. aeruginosa. The highest inhibition effect of C. italicum was found on B. subtilis. In the results of antifungal activity, highest inhibition effect of C. creticum was found on P. chrysogenum and highest inhibition effect of C. italicum was found on C. krusei. The present work is the first report on hexane extracts compounds of two Cirsium species as well as the antibacterial and antifungal activities.

scholarly journals Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Dereje Nigussie ◽  
Gail Davey ◽  
Takele Beyene Tufa ◽  
Malcolm Brewster ◽  
Belete Adefris Legesse ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Meta Analysis ◽  
Fungal Species ◽  
Antifungal Activities ◽  
Traditional Medicines ◽  
Antibacterial And Antifungal Activities ◽  
Wide Range ◽  
Antibacterial And Antifungal

Background: Podoconiosis and lymphatic filariasis are the most common causes of lower limb lymphoedema in the tropics. Many sufferers experience frequent painful episodes of acute bacterial infection. Plant based traditional medicines are used to treat infections in many countries and are culturally established in Ethiopia. Ethiopian medicinal plants found to have antibacterial and antifungal activities were reviewed with the aim of increasing information about the treatment of wound infections in patients with lymphoedema.Methods: This study collates data from published articles on medicinal plants with antibacterial and antifungal activities in Ethiopia. A systematic search of Scopus, EMBASE, PUBMED/MEDLINE and Google Scholar was undertaken. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed. The protocol was registered on PROSPERO with registration number CRD42019127471. All controlled studies of in vitro antibacterial and antifungal activities were considered. All articles containing the descriptors published until June 28, 2019 were included. The outcome was measured as percent inhibition of microbial growth. For quality assessment of individual in vitro studies, OECD guidelines and the WHO-Good Laboratory Practice (GLP) handbook were used.Results: Seventy-nine studies met the inclusion criteria. A total of 150 plant species and three compounds had been tested against 42 species of bacteria, while 43 plant species had been tested against 22 species of fungus.Conclusion: Materials derived from several Ethiopian medicinal plants have been shown to have promising activity against a variety of bacteria and fungi. Those derived from Azadiractha indica A. Juss. and Lawsonia inerms L. are the most extensively studied against a wide range of gram-negative and positive bacteria, and fungal species.

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