Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action

Malaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherapies. One strategy is the repurposing of existing drugs. Herein, we reviewed the antimalarial effects of marketed antibiotics, and described in detail the fast-acting antibiotics that showed activity in nanomolar concentrations. Antibiotics have been used for prophylaxis and treatment of malaria for many years and are of particular interest because they might exert a different mode of action than current antimalarials, and can be used simultaneously to treat concomitant bacterial infections.

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Prevention and Treatment of Early Childhood Caries (ECC)

Journal Of Medicine & Health ◽

10.28932/jmh.v1i3.525 ◽

2016 ◽

Vol 1 (3) ◽

Author(s):

Jeffrey .

Keyword(s):

Early Childhood ◽

Health Problem ◽

Early Childhood Caries ◽

Health Providers ◽

Missing Teeth ◽

Optimal Basis ◽

Major Health Problem ◽

Major Health ◽

Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

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Profile of Organophosphorus Poisoning

KYAMC Journal ◽

10.3329/kyamcj.v9i3.38786 ◽

2018 ◽

Vol 9 (3) ◽

pp. 133-135

Author(s):

Joya Debnath ◽

Arpan Kumar Basak ◽

Md Zubaidur Rahman ◽

Anujit Saha

Keyword(s):

Organophosphorus Compound ◽

Economic Status ◽

Frequency Pattern ◽

Major Health Problem ◽

Major Health ◽

The Public ◽

Medical College ◽

Phosphorus Poisoning ◽

Life Threatening ◽

The Government

Background : Self poisoning with organophosphate pesticides is a major health problem in world wide. Organophosphorus compound poisoning is a very common toxicological emergency encountered at Mirzapur in Tangail. It is particularly common among the rural agricultural worker's which comprise a substantial group of the population of this region.Objective: The objective of this study was to find out the incidence, frequency, pattern of poisoning, outcome and aetiological aspect of Organo phosphorus poisoning patient admitted in Kumudini Women's Medical college Hospital.Methods: A total 366 cases of OPC poisoning were analysed during 1 year from January 2015 to December 2015. The emphasis was given on age, sex, socio-economic status, occupation, motive of poisoning, types of compound consumed its quality, place, distance from referral place and the ultimate outcome.Results: Young population of rural background, particularly agricultural workers were the commonest patients (51.91%). The most common motive of poisoning was with a suicidal intent, both in males (27.59%) and females (66.39%). Financial crisis was one of the most common reasons analysed as the motive behind the poisoning (54.20%). Three hundred forty four Patients recovered and 22 were expired. The major cause of death in these cases was respiratory failure followed by multi-organ failure.Conclusion : Strict of the pesticide act and involving a new policy by the government to educate the public and youth in large about the dangerous, life threatening effects of Organophosphorus compound could help amelerioating the harmful effects of such poisoning.KYAMC Journal Vol. 9, No.-3, October 2018, Page 133-135

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Acute Cholecystitis Caused by Ceftriaxone Stones in an Adult

Case Reports in Medicine ◽

10.1155/2009/132452 ◽

2009 ◽

Vol 2009 ◽

pp. 1-2 ◽

Cited By ~ 6

Author(s):

Christian D. Becker ◽

Robert A. Fischer

Keyword(s):

Adult Patient ◽

Acute Cholecystitis ◽

Health Problem ◽

Medical Literature ◽

Early Recognition ◽

Gallstone Formation ◽

Sludge Formation ◽

Major Health Problem ◽

Major Health ◽

First Case

Acute cholecystitis is a major health problem. There are multiple etiologies to be considered and early recognition of the condition is important to optimize management and outcome. We report the first case in the medical literature of symptomatic acute cholecystitis triggered by ceftriaxone-associated gallbladder sludge formation and, importantly, solid ceftriaxone gallstone formation in an adult patient with underlying mineral and pigment cholecystolithiasis, necessitating cholecystectomy. This case serves as a reminder for physicians to keep this uncommon cause of cholecystolithiasis and cholecystitis in mind in patients who receive prolonged ceftriaxone therapy. These patients should be cautioned to promptly report to their physicians any signs or symptoms of cholecystitis in order to ensure timely and appropriate evaluation.

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New Drugs for Acute Heart Failure

University Heart Journal ◽

10.3329/uhj.v7i1.10208 ◽

2012 ◽

Vol 7 (1) ◽

pp. 35-38

Author(s):

Mohammad Salman ◽

Syed Allahsan ◽

Manzoor Mahmood ◽

Md Khairul Anam ◽

Shahed Mohammad Anwar ◽

...

Keyword(s):

Heart Failure ◽

Renal Failure ◽

Acute Heart Failure ◽

Health Problem ◽

Standard Therapy ◽

New Drugs ◽

European Medicines Agency ◽

Major Health Problem ◽

Major Health ◽

Long Time

Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year. Standard therapy has not changed for long time and includes diuretics and variable use of vasodilators or inotropes. Recently Nesiritide and Levosimendan are two drugs for the treatment of acute heart failure which have been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMEA), respectively. There was little concern that Nesiritide can worsen the renal failure but recent trials had abolished this concern. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10208 UHJ 2011; 7(1): 35-38

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A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210413 ◽

2021 ◽

Vol 11 (4) ◽

pp. 102-105

Author(s):

Lalita Sharma ◽

Sudama Singh Yadav

Keyword(s):

Fungal Infection ◽

Health Problem ◽

Skin Diseases ◽

Modern Science ◽

Treatment Modalities ◽

Major Health Problem ◽

Psychological Burden ◽

Major Health ◽

Almost All ◽

Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

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Cancer in Africa: Is It a Genetic or Environmental Health Problem?

Frontiers in Oncology ◽

10.3389/fonc.2020.604214 ◽

2020 ◽

Vol 10 ◽

Author(s):

Abeer A. Bahnassy ◽

Mona S. Abdellateif ◽

Abdel-Rahman N. Zekri

Keyword(s):

Health Problem ◽

African Ancestry ◽

Survival Rates ◽

Mortality Rates ◽

Sociocultural Factors ◽

Major Health Problem ◽

Major Health ◽

Incidence And Mortality ◽

Environmental Health Problem ◽

African Patients

Patients of African ancestry have the poorest outcome and the shortest survival rates from cancer globally. This could be attributed to many variables including racial, biological, socioeconomic and sociocultural factors (either single, multiple or combined), which may be responsible for this major health problem. We sought to assess the most common types of cancer that endanger the health of the African people, and tried to investigate the real differences between African and other Non-African patients regarding incidence, prevalence and mortality rates of different cancers. Therefore, identifying the underlying aetiological causes responsible for the increased incidence and mortality rates of African patients will allow for changing the current plans, to make optimized modalities for proper screening, diagnosis and treatment for those African patients, in order to improve their survival and outcomes.

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Protein S Deficiency - An Uncommon Cause with Common Presentation

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v35i2.13616 ◽

2016 ◽

Vol 35 (2) ◽

pp. 192-194

Author(s):

Nabanita Kora ◽

Rajib Das ◽

Sabyasachi Som ◽

Sumanta Laha ◽

Nayan Bannerji ◽

...

Keyword(s):

Health Problem ◽

Rare Case ◽

Protein S ◽

Protein S Deficiency ◽

Major Health Problem ◽

Major Health ◽

Young Stroke ◽

Common Presentation ◽

S Deficiency

Correction: The correct PDF for this article was loaded on 9th March 2017. We offer our sincere apologies for having the wrong PDF loaded for this article.Stroke in child poses a major health problem. Thrombophilic factors have been implicated in 4-8% of young stroke worldwide. Protein S deficiency is a very rare cause of stroke. A few cases have been reported in literature. We are reporting a rare case of protein S deficiency causing stroke in a two year old child.J Nepal Paediatr Soc 2015;35(2):192-194

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Editorial: Nutrition Management for Chronic Kidney Disease

Nutrients ◽

10.3390/nu12123852 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3852

Author(s):

Vassilios Liakopoulos ◽

Evangelia Dounousi

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Health Problem ◽

Major Health Problem ◽

Major Health ◽

Nutrition Management

Chronic kidney disease (CKD) constitutes a major health problem worldwide [...]

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Chemical Dependence in Anaesthetic Registrars in Australia and New Zealand

Anaesthesia and Intensive Care ◽

10.1177/0310057x9302100203 ◽

1993 ◽

Vol 21 (2) ◽

pp. 151-155 ◽

Cited By ~ 28

Author(s):

A. M. Weeks ◽

M. R. Buckland ◽

E. B. Morgan ◽

P. S. Myles

Keyword(s):

New Zealand ◽

Health Problem ◽

Chemical Dependence ◽

Chemically Dependent ◽

Major Health Problem ◽

Major Health

The Supervisors of Anaesthetic Training in Australia and New Zealand were surveyed and asked to report any cases of chemical dependence from anaesthetic registrars at their hospital from 1981 to 1991. From 83 questionnaires there were 65 (78%) returned. There were 14 departments (22%) with experience of one or more cases during this interval. Only five (7%) reported conducting a lecture or tutorial on the problem. The departmental reports covered 4425 registrar years of training and there were 17 cases reported. Of these, 13 were complete and are considered in detail. It is estimated that 1.3 % of those who entered anaesthetic training during the interval were recognised to become chemically dependent during their training. Follow-up was available on only six of the 13 registrars and only one was reported to have completed training. The results of this survey indicate that chemical dependence is already a major health problem amongst anaesthetic registrars in Australia and New Zealand.

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