scholarly journals Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2346
Author(s):  
Theresa Greupner ◽  
Elisabeth Koch ◽  
Laura Kutzner ◽  
Andreas Hahn ◽  
Nils Helge Schebb ◽  
...  
Keyword(s):  
Single Dose ◽  
Young Male ◽  
Stearidonic Acid ◽  
Omega 3 ◽  
Alternative Source ◽  
Promising Alternative ◽  
Echium Oil ◽  
Epa And Dha ◽  
Overnight Fasting ◽  
N3 Polyunsaturated Fatty Acids

The omega-3 (n3) polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with health benefits. The primary dietary source of EPA and DHA is seafood. Alpha-linoleic acid (ALA) has not been shown to be a good source for EPA and DHA; however, stearidonic acid (SDA)—which is naturally contained in echium oil (EO)—may be a more promising alternative. This study was aimed at investigating the short-term n3 PUFA metabolism after the ingestion of a single dose of EO. Healthy young male subjects (n = 12) ingested a single dose of 26 g of EO after overnight fasting. Plasma fatty acid concentrations and relative amounts were determined at baseline and 2, 4, 6, 8, 24, 48, and 72 h after the ingestion of EO. During the whole examination period, the participants received standardized nutrition. Plasma ALA and SDA concentrations increased rapidly after the single dose of EO. Additionally, EPA and DPAn3 concentrations both increased significantly by 47% after 72 h compared to baseline; DHA concentrations also significantly increased by 21% after 72 h. To conclude, EO increases plasma ALA, SDA, EPA, DPAn3, and DHA concentrations and may be an alternative source for these n3 PUFAs.

scholarly journals Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1627
Author(s):  
Ramesh Kumar Saini ◽  
Parchuri Prasad ◽  
Reddampalli Venkataramareddy Sreedhar ◽  
Kamatham Akhilender Naidu ◽  
Xiaomin Shang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Oxidative Stability ◽  
Stearidonic Acid ◽  
The Body ◽  
Lepidium Sativum ◽  
Omega 3 ◽  
Epa And Dha ◽  
Microbial Sources ◽  
Effective Source

The omega−3 (n−3) polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) acid are well known to protect against numerous metabolic disorders. In view of the alarming increase in the incidence of chronic diseases, consumer interest and demand are rapidly increasing for natural dietary sources of n−3 PUFAs. Among the plant sources, seed oils from chia (Salvia hispanica), flax (Linum usitatissimum), and garden cress (Lepidium sativum) are now widely considered to increase α-linolenic acid (ALA) in the diet. Moreover, seed oil of Echium plantagineum, Buglossoides arvensis, and Ribes sp. are widely explored as a source of stearidonic acid (SDA), a more effective source than is ALA for increasing the EPA and DHA status in the body. Further, the oil from microalgae and thraustochytrids can also directly supply EPA and DHA. Thus, these microbial sources are currently used for the commercial production of vegan EPA and DHA. Considering the nutritional and commercial importance of n−3 PUFAs, this review critically discusses the nutritional aspects of commercially exploited sources of n−3 PUFAs from plants, microalgae, macroalgae, and thraustochytrids. Moreover, we discuss issues related to oxidative stability and bioavailability of n−3 PUFAs and future prospects in these areas.

scholarly journals Intake of Calanus finmarchicus oil for 12 weeks improves omega-3 index in healthy older subjects engaging in an exercise programme

2020 ◽  
pp. 1-8
Author(s):  
Paulina Wasserfurth ◽  
Josefine Nebl ◽  
Tim Konstantin Boßlau ◽  
Karsten Krüger ◽  
Andreas Hahn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Controlled Trial ◽  
Exercise Programme ◽  
Stearidonic Acid ◽  
Calanus Finmarchicus ◽  
Wax Ester ◽  
Blood Levels ◽  
Omega 3 ◽  
Epa And Dha ◽  
Randomised Controlled

Abstract The n-3 PUFA, EPA and DHA, play an important role in human health. As the intake of EPA and DHA from the diet is often inadequate, supplementation of those fatty acids is recommended. A novel source of n-3 PUFA is Calanus finmarchicus oil (CO) which contains fatty acids mainly bound in wax esters. To date, no data are available on the effects of long-term intake of this marine oil on n-3 PUFA blood levels. Therefore, the aim of this study was to evaluate the effect of CO on the n-3 PUFA blood levels using the omega-3 index (O3I). The data originate from a larger randomised controlled trial. For this analysis, samples from seventy-two participants (59·2 (sd 6·2) years, BMI 27·7 (sd 5·28) kg/m2) were analysed. Of those, thirty-six performed 2×/week exercise and received 2 g of CO, which provided 124 mg stearidonic acid (SDA), 109 mg EPA and 87 mg DHA daily (EXCO group), while the other group performed exercise only (EX group) and served as a control for this analysis. The O3I increased from 6·07 (sd 1·29) % at baseline to 7·37 (sd 1·10) % after 12 weeks within the EXCO group (P < 0·001), while there were no significant changes in the EX group (6·01 (sd 1·26)–6·15 (sd 1·32) %, P = 0·238). These data provide first evidence that wax ester-bound n-3 PUFA from CO can significantly increase the O3I despite relatively low EPA + DHA amounts. Further, the effects of exercise could be excluded.

Aspirin and Omega-3 Polyunsaturated Fatty Acid Use and Their Interaction in Cardiovascular Diseases and Colorectal Adenomas

2021 ◽  
pp. 1-34
Author(s):  
Ivan E. Wang ◽  
Shana Yi ◽  
Robert C. Block ◽  
Shaker A. Mousa
Keyword(s):  
Synergistic Effects ◽  
Colorectal Adenomas ◽  
Diabetic Patients ◽  
High Dose ◽  
Low Doses ◽  
Omega 3 ◽  
Pufa Supplementation ◽  
Epa And Dha ◽  
Specific Manner ◽  
N3 Polyunsaturated Fatty Acids

Abstract Aspirin (acetylsalicylic acid, ASA) is inexpensive and is established in preventing cardiovascular disease (CVD) and colorectal adenomas. Omega-3 (n3) polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have also shown benefit in preventing CVD. The combination could be an effective preventative measure in patients with such diseases. ASA and n3 PUFA reduced the risk of CVD in ASA resistant or diabetic patients. EPA and DHA deficient patients also benefited the most from n3 PUFA supplementation. Synergistic effects between ASA and EPA and DHA are “V-shaped” such that optimal ASA efficacy is dependent on EPA and DHA concentrations in blood. In colorectal adenomas, ASA (300 mg/d) and EPA reduced adenoma burden in a location and subtype specific manner. Low doses of ASA (75-100 mg/d) were used in CVD prevention; however ultra-low doses (30 mg/d) can also reduce thrombosis. EPA to DHA ratio is also important with regards to efficacy. DHA is more effective in reducing blood pressure and modulating systemic inflammation, however high dose EPA can lower CVD events in high-risk individuals. Although current literature has yet to examine ASA and DHA in preventing CVD, such combination warrants further investigation. To increase adherence to ASA and n3 PUFA supplementation, combination dosage form may be required to improve outcomes.

scholarly journals Prenatal Nutritional Strategies to Reduce the Risk of Preterm Birth

2021 ◽  
pp. 1-9
Author(s):  
Karen Patricia Best ◽  
Judith Gomersall ◽  
Maria Makrides
Keyword(s):  
Preterm Birth ◽  
Large Scale ◽  
Cochrane Review ◽  
Cost Effective ◽  
Omega 3 ◽  
Promising Alternative ◽  
Nutritional Interventions ◽  
Dietary Nutrients ◽  
Preterm Babies ◽  
Nutritional Strategies

Worldwide, around 15 million preterm babies are born annually, and despite intensive research, the specific mechanisms triggering preterm birth (PTB) remain unclear. Cost-effective primary prevention strategies to reduce PTB are required, and nutritional interventions offer a promising alternative. Nutrients contribute to a variety of mechanisms that are potentially important to preterm delivery, such as infection, inflammation, oxidative stress, and muscle contractility. Several observational studies have explored the association between dietary nutrients and/or dietary patterns and PTB, often with contrasting results. Randomized trial evidence on the effects of supplementation with zinc, multiple micronutrients (iron and folic acid), and vitamin D is promising; however, results are inconsistent, and many studies are not adequately powered for outcomes of PTB. Large-scale clinical trials with PTB as the primary outcome are needed before any firm conclusions can be drawn for these nutrients. The strongest evidence to date for a nutritional solution exists for omega-3 long-chain polyunsaturated fatty acids (LCPUFAs), key nutrients in fish. In 2018, a Cochrane Review (including 70 studies) showed that prenatal supplementation with omega-3 LCPUFAs reduced the risk of PTB and early PTB (EPTB) compared with no omega-3 supplementation. However, the largest trial of omega-3 supplementation in pregnancy, the Omega-3 to Reduce the Incidence of Prematurity (ORIP) trial (<i>n</i> = 5,544), showed no reduction in EPTB and a reduction in PTB only in a prespecified analysis of singleton pregnancies. Exploratory analyses from the ORIP trial found that women with low baseline total omega-3 status were at higher risk of EPTB, and that this risk was substantially reduced with omega-3 supplementation. In contrast, women with replete or high baseline total omega-3 status were already at low risk of EPTB and additional omega-3 supplementation increased the risk of EPTB compared to control. These findings suggest that determining an individual woman’s PUFA status may be the most precise way to inform recommendations to reduce her risk of PTB.

scholarly journals Cost-Effectiveness of Black Soldier Fly Larvae Meal as Substitute of Fishmeal in Diets for Layer Chicks and Growers

2021 ◽  
Vol 13 (11) ◽  
pp. 6074
Author(s):  
Esther Khayanga Sumbule ◽  
Mary Kivali Ambula ◽  
Isaac Maina Osuga ◽  
Janice Ghemoh Changeh ◽  
David Miano Mwangi ◽  
...  
Keyword(s):  
Weight Gain ◽  
Live Weight ◽  
Daily Weight Gain ◽  
Feed Conversion ◽  
Alternative Source ◽  
Black Soldier Fly ◽  
Promising Alternative ◽  
Black Soldier Fly Larvae ◽  
Fly Larvae ◽  
The Impact

The acceptance of eco-friendly black soldier fly larvae meal (BSFLM) as sustainable alternative protein ingredient in poultry feeds continues to gain momentum worldwide. This study evaluates the impact of BSFLM in layer chick and grower diets on the growth, carcass quality and economic returns. Mean weekly weight gain and total live weight per chick and grower varied significantly. The highest final weight gain was achieved when birds were provided diet with 25.6% BSFLM. Average daily feed intake (ADFI), average daily weight gain (ADG) and overall weight gain of the chick varied significantly, except for the feed conversion ratio (FCR). For grower birds, ADFI, ADG, FCR and overall weight gain did not vary significantly across the various feeding regimes. The weight of the wings and drumsticks had a quadratic response with a maximum weight obtained at 33% inclusion of BSFLM. The weight of the internal organs were not significantly affected by dietary types. Positive cost–benefit ratio and return on investment was recorded for diet types with higher BSFLM inclusion levels (>75%). Diets with 25% and 100% BSFLM inclusion were the most suitable and cost-effective, respectively. Thus, BSFLM represents a promising alternative source of protein that could be sustainably used in the poultry industries.

Comparative study of tissue deposition of omega-3 fatty acids from polar-lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats

2015 ◽  
Vol 6 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Michael L. Kagan ◽  
Aharon Levy ◽  
Alicia Leikin-Frenkel
Keyword(s):  
Fatty Acids ◽  
Comparative Study ◽  
Polar Lipid ◽  
Rat Plasma ◽  
Nannochloropsis Oculata ◽  
Polar Lipids ◽  
Omega 3 Fatty Acids ◽  
Krill Oil ◽  
Omega 3 ◽  
Epa And Dha

An oil from micro-algae rich in EPA with no DHA and consisting of 15% polar lipids (phospholipids and glycolipids) showed equivalent uptake of EPA into rat plasma and organs as omega-3 krill oil consisting of EPA and DHA and 40% phospholipids.

Uptake by man of aluminium in a public water supply

1998 ◽  
Vol 17 (6) ◽  
pp. 296-301 ◽  
Author(s):  
N D Priest ◽  
R J Talbot ◽  
D Newton ◽  
J P Day ◽  
S J King ◽  
...  
Keyword(s):  
Gamma Ray ◽  
Tap Water ◽  
Young Male ◽  
Gamma Ray Spectrometry ◽  
Public Water Supply ◽  
Intestinal Uptake ◽  
Blood Samples ◽  
Al Content ◽  
Daily Uptake ◽  
Overnight Fasting

1 After overnight fasting, two young male adults each received a single oral dose of 100 Bq 26Al in tap water. Coincidence gamma-ray spectrometry and accelerator mass spectrometry were used to determine the 26Al content of excretion collections and of blood samples. 2 Close to 100% of the intake was recovered in faeces during the first 7 days. Gastro-intestinal uptake, determined by comparing urinary excretion with patterns previously established following intravenous administration of 26Al, averaged 0.22% in the two subjects. 3 Uptake fractions based on comparisons of blood concentration following ingestion and injection were much lower, but were judged to be unreliable. It is concluded that aluminium present in most water supplies is unlikely to contribute as much as 1% of a typical daily uptake of 10 mg from food.

Insulin Secretion and Sensitivity after Single-Dose Amisulpride, Olanzapine or Placebo in Young Male Subjects: Double Blind, Cross-Over Glucose Clamp Study

2012 ◽  
Vol 45 (06) ◽  
pp. 223-228 ◽  
Author(s):  
D. Kopf ◽  
M. Gilles ◽  
G. Paslakis ◽  
F. Medlin ◽  
F. Lederbogen ◽  
...  
Keyword(s):  
Single Dose ◽  
Insulin Secretion ◽  
Young Male ◽  
Glucose Clamp ◽  
Double Blind ◽  
Clamp Study ◽  
Male Subjects

scholarly journals Solar PV Fed Irrigation Pump

2019 ◽  
Vol 8 (4) ◽  
pp. 8616-8620
Keyword(s):  
Hardware Implementation ◽  
Advanced Technology ◽  
Simple Design ◽  
Solar Pv ◽  
Alternative Source ◽  
Promising Alternative ◽  
Agricultural Growth ◽  
Dc Voltage ◽  
Irrigation Technology ◽  
Solar Powered

Agricultural growth has been severely affected due to the constraints in irrigation-energy deficits. Due to the availability of abundant solar energy especially in India for all days, solar powered irrigation technology has been a promising alternative source compared to canonical electricity and diesel focused pumping systems. How to furnish an electric power suitable to drive an irrigation pump for agricultural purposes in isolated areas using solar PV panels is the problem. This project deals with solving a local irrigation problem in countries. In this proposed project a simple design of simulation and analysis of a PMSM fed by a solar PV, modelled through DC/DC converter controlled by a MPPT and for utilizing the power from Solar. Compared to all converters, luo converters is the advanced technology. POSL luo converter are of new DC-DC step-up converter. This POSL luo converter performs positive to positive DC-DC voltage increasing conversion. The hardware implementation has been done for positive output super-lift luo converter respectively.

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