Higher Habitual Nuts Consumption Is Associated with Better Cognitive Function among Qatari Adults

The association between nuts intake and cognitive function is inconclusive. We aimed to investigate the association between habitual nuts consumption and cognition among Qatari adults. Data from 1000 participants aged >20 years who attended Qatar Biobank (QBB) were used. Nuts consumption was assessed by a food frequency questionnaire (FFQ). Blood samples were measured for magnesium, lipids and glucose. Mean reaction time (MRT) was used as an indicator of cognitive function. Linear regression was used to assess the association. A total of 21.1% of the participants reported consuming nuts ≥4–6 times/week (high consumption) while 40.2% reported consuming ≤1 time/month (low consumption). The mean MRT was 715.6 milliseconds (SD 204.1). An inverse association was found between nuts consumption and MRT. Compared to those with a low consumption, high consumption of nuts had a regression coefficient of −36.9 (95% CI −68.1 to −5.8) after adjusting for sociodemographic and lifestyle factors. The inverse association between nuts and MRT was mainly seen among those >50 years. There was an interaction between nuts consumption and hypertension. The association between nuts consumption and MRT was not mediated by hypertension, diabetes, or serum magnesium. Habitual higher consumption of nuts is positively associated with cognitive function, especially among old adults.

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Nuts consumption and cognitive function

10.29117/quarfe.2021.0142 ◽

2021 ◽

Author(s):

Zainab Abdulmoayed Abdulwahab ◽

Sara Qaddourah ◽

Hajer Nafea ◽

Omnia Abdelmegid

Keyword(s):

Cognitive Function ◽

Regression Coefficient ◽

Serum Magnesium ◽

Positive Association ◽

Inverse Association ◽

Old Adults ◽

High Consumption ◽

The Mean ◽

Mean Reaction Time ◽

Low Consumption

Background: Cognitive impairments has become a global public concern. A limited number of studies suggest a positive association between nuts intake and cognitive function. Objectives: The aim of this study is to investigate the association between nuts consumption and cognitive function and to test whether hypertension and diabetes mediate this association among adults in Qatar. Methods: Data from 1000 participants aged 20 and above who attended Qatar Biobank (QBB) were used. Nuts consumption was assessed by a Food Frequency Questionnaire (FFQ). Blood samples were measured for magnesium and glucose. Cognitive function was assessed using computer self-administrated test to measure Mean Reaction Time (MRT). Linear regression was used to assess the association. Results: A total of 21.1% of the sample reported consuming nuts more than 4-6 times/week (high consumption) while 40.2% reported the consumption ≤1 time/month (low consumption). The mean MRT was 715.6 millisecond (SD 204.1). An inverse association was found between nuts consumption and MRT. Compared with those with a low consumption, high consumption of nuts had a regression coefficient of -36.95 (-68.09 to -5.82) after adjusting for sociodemographic and lifestyle factors. The inverse association between nuts and MRT was mainly seen among those aged >50 years. There was an interaction between nuts consumption and hypertension. The association between nuts consumption and MRT was not mediated via hypertension, diabetes, and serum magnesium. Conclusion: There is a positive association between nuts consumption and cognitive function, especially among old adults.

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Serum Magnesium and Cognitive Function among Qatari Adult

University of the Future: Re-Imagining Research and Higher Education ◽

10.29117/quarfe.2020.0207 ◽

2020 ◽

Author(s):

Kateba Al Ghazali ◽

Sana El Tayeb ◽

Ayesha Musleh ◽

Tamara Al-Abdi ◽

Zumin Shi

Keyword(s):

Cognitive Function ◽

Serum Magnesium ◽

Positive Association ◽

Regression Coefficients ◽

Low Magnesium ◽

Wide Range ◽

Computer Based ◽

Low Levels ◽

Mean Reaction Time ◽

Low Serum

Background: Previous studies found that low levels of magnesium can increase the risk of several diseases including cardiovascular diseases, diabetes, and hypertension which are associated with cognitive dysfunction. Objective: Examine the association between serum magnesium and cognitive function among Qatari adults. In addition to assessing the interaction relation between low serum magnesium, hypertension, and diabetes in relation to cognitive function. Methods: Data from 1000 Qatari participants aged ≥20 years attending the Qatar Biobank Study were analyzed. Serum magnesium was measured by an automated calorimetric method and suboptimal magnesium was characterized by <0.85 mmol/L. Cognitive function was measured by a computer-based selfadministered test focusing on mean reaction time (MRT). Multivariable linear regression and logistic regression were used. Results: The prevalence of suboptimal magnesium was 57.1%. Across the quartiles of serum magnesium from high to low, the regression coefficients (95% CI) for MRT were 0, -17.79, -18.27, and -31.93 (95%CI 2.38–3.05), respectively (p for trend <0.033). The presence of hypertension and diabetes significantly increased the MRT along with a wide range of low serum magnesium. Women with diabetes or hypertension were affected the greatest by low magnesium levels. Conclusion: There was a positive association between serum magnesium and cognitive function. Low magnesium levels were associated with a longer MRT.

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The Association between Fish Consumption and Risk of Metabolic Syndrome in Adults: Tehran Lipid and Glucose Study

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000561 ◽

2019 ◽

Vol 89 (3-4) ◽

pp. 192-199

Author(s):

Parvin Mirmiran ◽

Golaleh Asghari ◽

Alireza Dizavi ◽

Hossein Farhadnejad ◽

Fereidoun Azizi

Keyword(s):

Metabolic Syndrome ◽

Fish Consumption ◽

Odds Ratio ◽

Population Based ◽

Food Frequency ◽

High Consumption ◽

Canned Fish ◽

Consumption Data ◽

The Mean ◽

Adjusted Model

Abstract. Objective: Although fish consumption may play a role in prevention of the risk of metabolic syndrome (MetS), results of studies available on this topic are controversial. In this study, we have examined the association of fish consumption and 3.6-year incidence of MetS in Tehranian adults. Methods: We conducted a population based cohort study of 3382 adult subjects, aged 19-55 years, from the Tehran Lipid and Glucose Study (TLGS). Fish consumption data were collected using a valid and reliable food-frequency questionnaire. The consumption of fish, in the form of canned and non-canned fish was designated for all subjects, and was classified into three categories (< 30, 30-45, and > 45 g/week). Odds ratio (OR) for the occurrence of MetS according to categories of fish consumption was assessed by multivariable logistic regression. Results: The mean age of participants (35% male) at baseline was 35 years. Mean fish consumption was 11.3 g/d and incidence of MetS was 13.1%. In the fully adjusted model, subjects, who consumed > 45 g/week of fish had lower incidence of MetS, compared to those who consumed < 30 g/week (OR = 0.73; CI: 0.56-0.95). However, there were no associations between consumption of non-canned fish (OR = 0.86; 95% CI: 0.67-1.10) and canned fish (OR = 0.91; 95% CI: 0.64-1.29) and the incidence of MetS. Conclusion: Our findings suggest that high consumption of fish can reduce the incidence of MetS among adults.

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Habitual Tea and Coffee Consumption and Mean Reaction Time Among Qatari Adults

Journal of Alzheimer s Disease ◽

10.3233/jad-215130 ◽

2021 ◽

pp. 1-10

Author(s):

Alaa Heggy ◽

Aisha Masoumi ◽

Maryam Al-Yafei ◽

Fatima Al-Bader ◽

Tamara Al-Abdi ◽

...

Keyword(s):

Reaction Time ◽

Cognitive Function ◽

Low Density Lipoprotein ◽

Coffee Consumption ◽

Density Lipoprotein ◽

Inverse Association ◽

Drinking Patterns ◽

Herbal Tea ◽

Coffee Drinking ◽

Mean Reaction Time

Background: Tea and coffee consumption is associated with cognitive function in some studies. Objective: We aimed to identify tea and coffee drinking patterns and their association with mean reaction time among Qatari adults. Method: The study included 1,000 adults aged 20 years and above attending the Qatar Biobank Study (QBB). Habitual tea and coffee consumption during the previous year was assessed by questionnaire. Tea and coffee drinking patterns were identified using factor analysis. In a computer-based self-administered touch screens test, mean reaction time (MRT) was used as an indicator of cognitive function. Results: The mean age of the participants was 35.8 (SD 10.3) years. Herbal tea and regular coffee consumption was inversely associated with MRT. In the multivariable model, compared with non-consumers, the regression coefficients for MRT were –34.3 (–65.4, –3.3) and –37.9 (–71.0, –4.7) for daily consumers of herbal tea and regular coffee, respectively. Of the two tea and coffee drinking patterns identified, pattern 1 (high consumption of tea, Arabic coffee, and herbal tea) was not associated with MRT but pattern 2 (high loadings of instant coffee, regular coffee, and Karak) was inversely associated with MRT in the unadjusted model. There was a significant interaction between pattern 2 and low-density lipoprotein (LDL) in relation to MRT. Pattern 2 was inversely associated with MRT among those with a low LDL. Conclusion: There was an inverse association between regular coffee and herbal tea consumption with mean reaction time. There was an interaction between Western coffee pattern and LDL.

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Consumption of Lactose, Other FODMAPs and Diarrhoea during Adjuvant 5-Fluorouracil Chemotherapy for Colorectal Cancer

Nutrients ◽

10.3390/nu12020407 ◽

2020 ◽

Vol 12 (2) ◽

pp. 407

Author(s):

Reetta Holma ◽

Reijo Laatikainen ◽

Helena Orell ◽

Heikki Joensuu ◽

Katri Peuhkuri ◽

...

Keyword(s):

Colorectal Cancer ◽

Adjuvant Therapy ◽

Gastrointestinal Symptoms ◽

Mucosal Injury ◽

Dietary Carbohydrates ◽

Food Diary ◽

High Consumption ◽

Increased Risk ◽

Symptom Diary ◽

Low Consumption

Chemotherapy-induced mucosal injury of the small intestine may interfere with the enzymes and transporters responsible for the hydrolysis and absorption of dietary carbohydrates causing diarrhoea, abdominal discomfort and pain. The aim of this study was to investigate the association between the consumption of foods rich in FODMAPs (fermentable oligo-, di- and monosaccharides and polyols) and gastrointestinal symptoms in patients receiving adjuvant therapy for colorectal cancer. The patients (n = 52) filled in a 4-day food diary at baseline and during therapy and kept a symptom diary. The intakes of FODMAP-rich foods were calculated as portions and the intakes were divided into two consumption categories. Patients with high consumption of FODMAP-rich foods had diarrhoea more frequently than those with low consumption (for lactose-rich foods the odds ratio (OR) was 2.63, P = 0.03; and for other FODMAP-rich foods 1.82, P = 0.20). Patients with high consumption of both lactose-rich and other FODMAP-rich foods had an over 4-fold risk of developing diarrhoea as compared to those with low consumption of both (OR, 4.18; P = 0.02). These results were confirmed in multivariate models. Conclusion: Consumption of lactose-rich foods results in an increased risk of diarrhoea during adjuvant therapy for colorectal cancer, especially when the consumption of other FODMAP-rich foods is also high.

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High Adherence to the Mediterranean Diet Is Associated with a Reduced Risk of Obesity among Adults in Gulf Countries

Nutrients ◽

10.3390/nu13030995 ◽

2021 ◽

Vol 13 (3) ◽

pp. 995

Author(s):

Israa M. Shatwan ◽

Eiman A. Alhinai ◽

Balqees Alawadhi ◽

Shelini Surendran ◽

Najlaa M. Aljefree ◽

...

Keyword(s):

Mediterranean Diet ◽

Total Sample ◽

Cross Sectional Study ◽

Inverse Association ◽

Protective Effects ◽

Hip Circumference ◽

Cross Sectional ◽

Gulf Countries ◽

The Mean ◽

The Mediterranean

The Mediterranean diet (MedDiet) is considered as a good example of a healthy dietary pattern that has protective effects on obesity. The aim of the present study was to assess the adherence of adults from three Gulf countries (Saudi Arabia, Oman, and Kuwait) to the MedDiet and its association with obesity risk. A cross-sectional study was conducted on 961 men and women (75.7%) aged 20–55 years old. Waist circumference (WC), and hip circumference (HC) were measured waist/hip ratio (WHR) and body mass index (BMI) were calculated. A validated 14-item Questionnaire was used to measure adherence to MedDiet. The mean of the adherence to MedDiet score was 5.9 ± 2.03 for the total sample. An inverse association was observed between the adherence to MedDiet and BMI after adjusting for potential confounders (p = 0.0003 in total participants, and p = 0.001 in women only). A protective effect was seen with a higher adherence to the MedDiet on HC, suggesting that a greater adherence to the MedDiet was associated with a decreased HC (p = 0.04 in total participants, and p = 0.01 in women only). In conclusion, low adherence to the MedDiet among participants from three gulf countries was associated with increased obesity indicators, BMI, and HC.

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The association of insulinemic potential of diet and lifestyle with the risk of insulin-related disorders: a prospective cohort study among participants of Tehran Lipid and Glucose Study

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00674-z ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Ebrahim Mokhtari ◽

Hossein Farhadnejad ◽

Farshad Teymoori ◽

Parvin Mirmiran ◽

Fereidoun Azizi

Keyword(s):

Insulin Resistance ◽

Dietary Intakes ◽

Β Cells ◽

Β Cell ◽

Food Frequency ◽

Cell Dysfunction ◽

The Mean ◽

Diet And Lifestyle ◽

Activity Information ◽

Insulin Insensitivity

Abstract Background We aim to assess the association of empirical dietary (EDIH) and lifestyle (ELIH) index for hyperinsulinemia with the risk of insulin resistance, hyperinsulinemia, insulin sensitivity, and β-cell dysfunction in Iranian adults. Methods In this prospective study, a total of 1244 men and women aged ≥ 20 years were selected among participants of the Tehran lipid and glucose study and followed for 3.2 years. Dietary intakes were assessed using a valid semi-quantitative food frequency questionnaire. Dietary and lifestyle insulinemic potential indices were calculated using dietary intake, body mass index, and physical activity information. Multivariable logistic regression was used to estimate the associated risk of a 3-year incidence of insulin-related disorders. Results The mean ± SD age and BMI of all eligible participants (42.7% males) were 43.0 ± 13.0 and 27.4 ± 4.9 in the study's baseline. After adjusting for all potential confounders, participants in the highest tertile of ELIH score had a greater risk of developing hyperinsulinemia (OR:2.42, 95%CI:1.52–3.86, P for trend = < 0.001), insulin resistance (OR:2.71, 95%CI:1.75–4.18, P for trend = < 0.001) and insulin insensitivity (OR:2.65, 95%CI: 1.72–4.10, P for trend = < 0.001) compared with those in the lowest tertile. However, the risk of incident β-cell dysfunction was lower in individuals with a higher score of ELIH in comparison to those with the lowest score (OR:0.30, 95%CI:0.19–0.45, P for trend = < 0.001). Conclusions Empirical lifestyle index for hyperinsulinemia was directly associated with insulin resistance, insulin insensitivity, and hyperinsulinemia and was inversely associated with β-cells dysfunction.

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Abstract P014: Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study

Circulation ◽

10.1161/circ.135.suppl_1.p014 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Akira Fujiyoshi ◽

Takayoshi Ohkubo ◽

Katsuyuki Miura ◽

Akihiko Shiino ◽

Naoko Miyagawa ◽

...

Keyword(s):

Cognitive Function ◽

Cognitive Abilities ◽

Estimated Glomerular Filtration Rate ◽

Subclinical Atherosclerosis ◽

Community Dwelling ◽

Community Based ◽

Lower Egfr ◽

The Mean ◽

The Relationship

Introduction: The relationship between chronic kidney disease (CKD) and cognitive function remains to be determined. Existing studies focused primarily on estimated glomerular filtration rate (eGFR) but not proteinuria in relation to cognitive function. Hypothesis: In a community-based sample, lower eGFR and presence of proteinuria are cross-sectionally independently associated with lower cognition. Methods: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) randomly recruited and examined participants from Shiga, Japan in 2006-08 at baseline. Among 824 male participants in the follow-up exam (2010-12), we restricted our analyses to those who underwent the Cognitive Abilities Screening Instrument (CASI), age ≥65 years-old, free of stroke, with no missing pertinent covariates. We calculated eGFR (creatinine-based) according to the 2012-guideline by the Japanese Society of Nephrology. We then divided the participants into three groups by eGFR of ≥60, 59-40, and <40 (mL/min/1.73m 2 ), and separately divided into three groups according to proteinuria using urine dipstick: (-), (-/+), and ≥(1+). We defined CKD as either eGFR <60 or proteinuria ≥ (-/+). In linear regression with CASI score being a dependent variable, we computed the score adjusted for age, highest education attained, smoking, drinking, body mass index, hypertension, diabetes, and dyslipidemia. Results: We analyzed 541 men. The mean [standard deviation] of age and unadjusted score were 72.6 [4.3] years and 89.7 [6.0]. Prevalence of CKD was 56%. The score was significantly lower in participants with CKD than those without it (P=0.03). eGFR and proteinuria categories were separately and jointly associated with lower CASI score in a graded fashion (Ps for trend <0.05 in all the models tested. Table 1 ). Conclusions: Lower eGFR and higher degree of proteinuria were independently associated with lower cognitive function in the community-based men. CKD even in its early phase may predispose to lower cognitive function.

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Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders

Neurology ◽

10.1212/wnl.0000000000012025 ◽

2021 ◽

pp. 10.1212/WNL.0000000000012025

Author(s):

Shahram Oveisgharan ◽

Ana W. Capuano ◽

Sukriti Nag ◽

Sonal Agrawal ◽

Lisa L. Barnes ◽

...

Keyword(s):

Severity Score ◽

Hemoglobin A1c ◽

Oldest Old ◽

Brain Regions ◽

Inverse Association ◽

Community Based ◽

Cytoplasmic Inclusions ◽

The Mean ◽

High Level ◽

Relationship Of

Objective.We tested the hypothesis that an inverse association exists between diabetes mellitus (DM) and hemoglobin A1C (A1C) with Transactive response DNA binding protein 43 (TDP-43) levels in older adults.Methods.We leveraged antemortem and postmortem data of decedents from three community-based clinical-pathological studies. DM status, A1C levels, and medications for DM were documented annually. TDP-43 cytoplasmic inclusions, evaluated in 6 brain regions using immunohistochemistry, were used to obtain a semiquantitative TDP-43 score (0-5) in each region, and scores were averaged across regions to obtain a TDP-43 severity score. We used linear regressions to test the association of DM and A1C with the TDP-43 severity score.Results.On average, participants (n=817) were 90 years old at the time of death, three fourth were women, and one fourth had DM. The mean A1C was 6.0% (SD=0.6). TDP-43 was observed in 54% of participants, and the mean TDP-43 score was 0.7 (range 0-4.5). A higher level of A1C was associated with a lower TDP-43 score (estimate=-0.156, S.E.=0.060, p=0.009) while DM had a borderline inverse association with the TDP-43 score (estimate=-0.163, S.E.=0.087, p=0.060). The association of higher levels of A1C with lower TDP-43 scores persisted after further adjustment by Apolipoprotein ε4, vascular risk factors, stroke, and hypoglycemic medications. Exclusion of the oldest old participants did not change the results.Conclusion.Overall, the results suggest that a high level of A1C is associated with less TDP-43 proteinopathy in older persons while the relationship of DM with TDP-43 needs further study.

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A Study on Some Serum Biological Constituents during Different Days of Normal Oestrous Cycle of Manipuri Pony Mares

Indian Journal of Animal Research ◽

10.18805/ijar.b-4476 ◽

2021 ◽

Author(s):

Ningthoukhongjam Linda ◽

Fazal Ali Ahmed ◽

J.K. Chaudhary ◽

Mohammad Ayub Ali ◽

Jagan Mohanarao Gali

Keyword(s):

Total Protein ◽

Serum Magnesium ◽

Serum Levels ◽

Oestrous Cycle ◽

Serum Magnesium Level ◽

Calcium Phosphorus ◽

Serum Biochemical ◽

The Mean ◽

Hormonal Assay ◽

Apparently Healthy

Background: The aim of this study was to estimate the serum biochemical (glucose, cholesterol, total protein, calcium, phosphorus and magnesium) and hormonal constituents (estrogen and progesterone) in female Manipuri pony mares during the different days of oestrous cycle. Methods: A total of 50 numbers of blood samples were collected from 10 numbers of apparently healthy, non-pregnant on the different days of oestrous cycle i.e. day 0, 4, 8, 14 and 18 by using commercial diagnostic kits. Result: The mean serum levels of glucose, cholesterol and phosphorus were found to be non-significant on the different days of oestrous cycle whereas the mean serum level of total protein and calcium was found significantly different (P less than 0.01). The serum magnesium level differed significantly (P less than 0.05) amongst the different days of oestrous cycle. Both estrogen and progesterone were also found to be significant (P less than 0.01) between the different days of oestrous cycle. The results showed significant influence on serum biochemical and hormonal assay during different days of oestrous cycle in female Manipuri pony.

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