scholarly journals The Fatty Acid Species and Quantity Consumed by the Breastfed Infant Are Important for Growth and Development

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4183
Author(s):  
Alexandra D. George ◽  
Melvin C. L. Gay ◽  
Mary E. Wlodek ◽  
Kevin Murray ◽  
Donna T. Geddes
Keyword(s):  
Total Lipid ◽  
Growth And Development ◽  
Infant Health ◽  
Building Blocks ◽  
Infant Growth ◽  
Gas Chromatography Mass Spectrometry ◽  
Maternal Characteristics ◽  
Fa Composition ◽  
Health And Development ◽  
Fatty Acid Species

The fatty acids (FAs) of human milk (HM) are the building blocks of the HM lipidome, contributing to infant health and development; however, this has not been comprehensively characterised with respect to infant intake. Eighteen Western Australian mother–infant dyads provided monthly longitudinal HM samples during six months of exclusive breastfeeding. Monthly anthropometric measurements, health data and basic maternal food frequency data were also collected. At three months, infant 24 h milk intake and total lipid intake were measured. The FA profile was analysed using gas chromatography–mass spectrometry. Linear regression and Pearson’s correlation were used to identify associations between HM FA composition, HM FA intake, maternal characteristics and infant growth and developmental outcomes. Mean infant intake of total lipids was 29.7 ± 9.4 g/day. HM FA composition exhibited wide variation between dyads and throughout lactation. Infant intake of a number of FAs, including C15:0, C18:1, C18:2 and C20:3, was positively related to infant growth (all p < 0.001). There were no relationships detected between C22:5 and C20:5 and infant head circumference. Infant total lipid intake and the infant intake of many FAs play essential roles in infant growth and development. This study highlights the important relationships of many HM FAs not previously described, including C15:0 and C18:2 species. Infant outcomes should be considered in the context of intake in future HM studies.

scholarly journals Free and Total Amino Acids in Human Milk in Relation to Maternal and Infant Characteristics and Infant Health Outcomes: The Ulm SPATZ Health Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2009
Author(s):  
Joris H.J. van Sadelhoff ◽  
Linda P. Siziba ◽  
Lisa Buchenauer ◽  
Marko Mank ◽  
Selma P. Wiertsema ◽  
...  
Keyword(s):  
Amino Acids ◽  
Health Outcomes ◽  
Human Milk ◽  
Infant Development ◽  
Infant Health ◽  
Child Growth ◽  
Health Study ◽  
Maternal Characteristics ◽  
Tract Infections ◽  
Total Amino Acids

Free amino acids (FAAs) are important regulators of key pathways necessary for growth, development, and immunity. Data on FAAs in human milk (HM) and their roles in infant development are limited. We investigated the levels of FAAs and total amino acids (TAA, i.e., the sum of conjugated amino acids and FAAs) in HM in relation to infant and maternal characteristics and immunological conditions. FAA and TAA levels in HM sampled at 6 weeks (n = 671) and 6 months (n = 441) of lactation were determined using high-performance liquid chromatography. Child growth was ascertained at 4–5 weeks and at 6–7 months of age. Child allergy and lower respiratory tract infections were assessed in the first years of life. Associations of amino acid (AA) levels in HM with child growth and health outcomes were determined by Spearman correlation and modified Poisson regression, respectively. Free glutamine, glutamate, and serine in 6-week HM positively correlated with infant weight gain in the first 4–5 weeks of age. Maternal pre-pregnancy weight and body mass index (BMI) were negatively correlated with free glutamine and asparagine in 6-week and 6-month HM and positively correlated with the sum of TAAs in 6-month HM, but significance was lost following confounder adjustment. Free glutamine was lower in 6-month HM of mothers with an allergy (either active or non-active). No consistent associations were found between FAAs in HM and child health outcomes. However, potential negative associations were observed between specific FAAs and the risk of food allergy. These results suggest that specific FAAs play a role in infant growth. Moreover, these findings warrant further investigations into the relation of FAAs in HM with infant health outcomes and maternal allergy.

scholarly journals Lipidomics of facial sebum in the comparison between acne and non-acne adolescents with dark skin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Obumneme Emeka Okoro ◽  
Adebomi Adenle ◽  
Matteo Ludovici ◽  
Mauro Truglio ◽  
Federico Marini ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Building Blocks ◽  
Carbon Chain ◽  
Gas Chromatography Mass Spectrometry ◽  
Lower Percentage ◽  
Void Space ◽  
Straight Chain ◽  
Dark Skin ◽  
Cross Sectional ◽  
Weight Percentage

AbstractLipidomics is advantageous in the study of sebum perturbations occurring in acne. An extended evaluation of the sebum lipid profiles in acne-prone sebaceous areas is lacking in dark skin. Yet, there is a void space in understanding how the building blocks of sebum lipids, i.e. individual fatty acids (FAs), are intertwined with acne-prone skin. We aimed to determine the sebum lipidome in facial areas of adolescents with and without acne in Nigeria. A cross-sectional analytical study was conducted in 60 adolescents/young adults divided in 30 acne patients (15F, 15M) and 30 age and sex-matched controls. Sebum samples obtained from foreheads and cheeks were analysed separately by gas chromatography–mass spectrometry (GCMS) and thin layer chromatography (HPTLC). Distributions of sebum components were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). Sebum incretion in acne was paralleled by significantly higher abundance of triglycerides, wax esters, and squalene together with monounsaturated FAs (MUFAs), and straight chain saturated FAs (SFAs), especially those with odd-carbon chain, i.e. C13:0, C15:0, and C17:0. Profiling weight/weight percentage of individual components revealed that, in acne, the free FAs (FFAs) array was shifted towards higher relative abundance of the SFAs C15:0, C16:0, and C17:0 and lower percentage of the anteiso-branched FFAs with 12, 14, 16, and 18 carbons. In acne patients, MUFAs and PUFAs were quantitatively increased and decreased on foreheads and cheeks, respectively. Relative abundance of fatty alcohols was decreased in acne independent on the site. The results indicated that acne associates with site-specific derangement of the pathways regulating the balance among odd straight-chain and branched-chain SFAs, MUFAs, which included sapienate (C16:1n-10), PUFAs, and squalene.

scholarly journals Odor-active volatile compounds in preterm breastmilk

2021 ◽  
Author(s):  
Mariana Muelbert ◽  
Laura Galante ◽  
Tanith Alexander ◽  
Jane E. Harding ◽  
Chris Pook ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Volatile Compounds ◽  
Solid Phase ◽  
Relative Concentration ◽  
Gas Chromatography Mass Spectrometry ◽  
List Type ◽  
Maternal Characteristics ◽  
Medium Chain ◽  
Lactation Stage ◽  
Cephalic Phase

Abstract Background Volatile compounds in breastmilk (BM) likely influence flavor learning and, through the cephalic phase response, metabolism, and digestion. Little is known about the volatile compounds present in preterm BM. We investigated whether maternal or infant characteristics are associated with the profile of volatile compounds in preterm BM. Methods Using solid-phase microextraction coupled with gas chromatography/mass spectrometry, we analyzed volatile compounds in 400 BM samples collected from 170 mothers of preterm infants. Results Forty volatile compounds were detected, mostly fatty acids and their esters (FA and FAe), volatile organic compounds (VOCs), aldehydes, terpenoids, alcohols, and ketones. The relative concentration of most FA and FAe increased with advancing lactation and were lower in BM of most socially deprived mothers and those with gestational diabetes (p < 0.05), but medium-chain FAs were higher in colostrum compared to transitional BM (p < 0.001). Infant sex, gestational age, and size at birth were not associated with the profile of volatile compounds in preterm BM. Conclusions Sensory-active volatile FA and FAe are the major contributors to the smell of preterm BM. The associations between lactation stage, maternal characteristics, and volatile compounds, and whether differences in volatile compounds may affect feeding behavior or metabolism, requires further research. Impact Sensory-active volatile FAs are major contributors to the smell of preterm BM and are influenced by the lactation stage and maternal characteristics. Longitudinal analysis of volatile compounds in preterm BM found that FAs increased with advancing lactation. Colostrum had a higher concentration of medium-chain FAs compared to transitional BM and the concentration of these is associated with socioeconomic status, gestational diabetes, and ethnicity.

scholarly journals Protocol for iGrow (Infant Growth and Development Study): biopsychosocial predictors of childhood obesity risk at 2 years

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Esther M. Leerkes ◽  
Cheryl Buehler ◽  
Susan D. Calkins ◽  
Lenka H. Shriver ◽  
Laurie Wideman
Keyword(s):  
Weight Gain ◽  
Childhood Obesity ◽  
Growth And Development ◽  
Maternal Sensitivity ◽  
Feeding Practices ◽  
Infant Growth ◽  
Obesity Risk ◽  
Development Study ◽  
Early Weight Gain ◽  
Infant Weight Gain

Abstract Background Childhood obesity remains a significant public health problem. To date, most research on the causes and correlates of obesity has focused on a small number of direct predictors of obesity rather than testing complex models that address the multifactorial nature of the origins of obesity in early development. We describe the rationale and methods of iGrow (Infant Growth and Development Study) which will test multiple pathways by which (a) prenatal maternal psychobiological risk predicts infant weight gain over the first 6 months of life, and (b) this early weight gain confers risk for obesity at age 2. Infant hormonal and psychobiological risk are proposed mediators from prenatal risk to early weight gain, though these are moderated by early maternal sensitivity and obesogenic feeding practices. In addition, higher maternal sensitivity and lower obesogenic feeding practices are proposed predictors of adaptive child self-regulation in the second year of life, and all three are proposed to buffer/reduce the association between high early infant weight gain and obesity risk at age 2. Methods iGrow is a prospective, longitudinal community-based study of 300 diverse mothers and infants to be followed across 5 data waves from pregnancy until children are age 2. Key measures include (a) maternal reports of demographics, stress, well-being, feeding practices and child characteristics and health; (b) direct observation of maternal and infant behavior during feeding, play, and distress-eliciting tasks during which infant heart rate is recorded to derive measures of vagal withdrawal; (c) anthropometric measures of mothers and infants; and (d) assays of maternal prenatal blood and infant saliva and urine. A host of demographic and other potential confounds will be considered as potential covariates in structural equation models that include tests of mediation and moderation. Efforts to mitigate the deleterious effects of COVID-19 on study success are detailed. Discussion This study has the potential to inform (1) basic science about early life processes casually related to childhood obesity and (2) development of targeted intervention and prevention approaches that consider mother, infant, and family risks and resources.

scholarly journals Australian Foster Carers’ Views and Concerns Regarding Maternal Drug Use and the Safety of Breastmilk

Children ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 284
Author(s):  
Stacy Blythe ◽  
Kath Peters ◽  
Emma Elcombe ◽  
Elaine Burns ◽  
Karleen Gribble
Keyword(s):  
Home Care ◽  
Child Protection ◽  
Online Survey ◽  
Infant Health ◽  
Health Issues ◽  
Child Protection Workers ◽  
Out Of Home Care ◽  
Maternal Caregiving ◽  
Health And Development ◽  
Major Factors

Parental substance misuse and mental health issues are major factors associated with infant placement into out-of-home care. Such placements may result in disruption and/or cessation of breastfeeding. Provision of breastmilk to infants in out-of-home care (OOHC) is desirable in terms of infant health and development, and also in supporting maternal caregiving. However, little is known about how breastfeeding is supported for infants in out-of-home care. This study used an online survey to explore the facilitation of breastfeeding in the context of OOHC and foster carers’ management of expressed breastmilk (EBM). Foster carers were generally open to the idea of maternal breastfeeding and infants in their care receiving EBM from their mothers. However, the majority of respondents expressed concern regarding the safety of EBM for infant consumption due to the possibility of harmful substances in the milk. Concerns regarding the safety of handling EBM were also prevalent. These concerns caused foster carers to discard EBM. Findings suggest foster carers’ may lack knowledge related to maternal substance use and breastmilk. Better integration between health care and social service systems, where the voices of mothers, foster carers and child protection workers are heard, is necessary to develop solutions enabling infants living in OOHC access to their mother’s breastmilk.

Aspergillus flavusgrowth and aflatoxin production as influenced by total lipid content during growth and development of cottonseed

2017 ◽  
Vol 31 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Kanniah Rajasekaran ◽  
Greg Ford ◽  
Kandan Sethumadhavan ◽  
Carol Carter-Wientjes ◽  
John Bland ◽  
...  
Keyword(s):  
Total Lipid ◽  
Lipid Content ◽  
Growth And Development ◽  
Total Lipid Content ◽  
Aflatoxin Production

scholarly journals Hydroponic Basil Production: Temperature Influences Volatile Organic Compound Profile, but Not Overall Consumer Preference

Horticulturae ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 76
Author(s):  
Kellie J. Walters ◽  
Roberto G. Lopez
Keyword(s):  
Organic Compound ◽  
Volatile Organic Compound ◽  
Growth And Development ◽  
Consumer Preference ◽  
Gas Chromatography Mass Spectrometry ◽  
Methyl Chavicol ◽  
Sweet Basil ◽  
Visual Attribute ◽  
Volatile Organic ◽  
Production Temperature

Altering the growing temperature during controlled-environment production not only influences crop growth and development, but can also influence volatile organic compound (VOC) production and, subsequently, sensory attributes of culinary herbs. Therefore, the objectives of this study were to (1) quantify the influence of mean daily temperature (MDT) and daily light integral (DLI) on key basil phenylpropanoid and terpenoid concentrations, (2) determine if differences in sensory characteristics due to MDT and DLI influence consumer preference, and (3) identify the sweet basil attributes consumers prefer. Thus, 2-week-old sweet basil ‘Nufar’ seedlings were transplanted into deep-flow hydroponic systems in greenhouses with target MDTs of 23, 26, 29, 32, or 35 °C and DLIs of 7, 9, or 12 mol·m−2·d−1. After three weeks, the two most recently mature leaves were harvested for gas chromatography–mass spectrometry (GC–MS) and consumer sensory analysis. Panel evaluations were conducted through a sliding door with samples served individually while panelists answered Likert scale and open-ended quality attribute and sensory questions. The DLI did not influence VOC concentrations. Increasing MDT from 23 to 36 °C during production increased 1,8 cineole, eugenol, and methyl chavicol concentrations linearly and did not affect linalool concentration. The increases in phenylpropanoid (eugenol and methyl chavicol) were greater than increases in terpenoid (1,8 cineole) concentrations. However, these increases did not impact overall consumer or flavor preference. The MDT during basil production influenced appearance, texture, and color preference of panelists. Taken together, MDT during production influenced both VOC concentrations and textural and visual attribute preference of basil but did not influence overall consumer preference. Therefore, changing the MDT during production can be used to alter plant growth and development without significantly affecting consumer preference.

scholarly journals UTILIZATION OF CORK AS COOLER BAG MAKING MATERIALS FOR DAIRY BREAST MILK AS AN EXCLUSIVE BREAST MILK COVERAGE ON WORKING MOTHER

2019 ◽  
Vol 4 (1) ◽  
pp. 38-44
Author(s):  
Bina Melvia Girsang ◽  
Farida Linda Sari ◽  
Nur Afi Darti
Keyword(s):  
Breast Milk ◽  
Community Service ◽  
Growth And Development ◽  
Working Mothers ◽  
Infant Health ◽  
Health Workers ◽  
Working Mother ◽  
Health Counseling ◽  
Self Learning ◽  
Made In

Working mother factors, lack of knowledge about the benefits of breast milk, and the low support of assisting health workers are factors that influence the achievement of exclusive breast milk targets. The method of implementing community service activities was carried out with health counseling and assistance in the manufacture of milk bag milk milk cooler for 20 breastfeeding working mothers. Making cooler bags using cork as a material that is easily available and economical, is a breakthrough that can be made in helping to achieve exclusive breastfeeding programs. The purpose of this community service is to empower mothers through making cooler bags that are expected to improve the skills and confidence of working mothers in providing breast milk. The implementation of community service shows the results that mothers understand about the benefits of breast milk (80%), the statement of the attitude of mothers who are willing to milk breast milk in the workplace (80%), and all mothers are able to play a role in making cooler bags independently. Communities can learn independently (self learning) and can share experiences in preventing and tackling infant health, especially in fulfilling breast milk for infant growth and development

ERRATA

PEDIATRICS ◽  
1993 ◽  
Vol 92 (1) ◽  
pp. 190-190
Keyword(s):  
Infant Health ◽  
United States Public Health ◽  
Development Program ◽  
Health Resources ◽  
Failure To Thrive ◽  
Robert Wood Johnson Foundation ◽  
Stanford University ◽  
Department Of Health ◽  
Health And Development ◽  
Additional Support

"Risk Factors and Outcomes for Failure to Thrive in Low Birth Weight Preterm Infants," by Kelleher et al, was published in the May issue of Pediatrics (1993;91:941-948). The acknowledgments that follow should have appeared at the end of that text: The Infant Health and Development Program is supported by grants to the Department of Pediatrics, Stanford University; The Frank Porter Graham Child Development Center, University of North Carolina; and the eight participating universities by the Robert Wood Johnson Foundation. Additional support was provided to the Department of Pediatrics, Stanford University, from the Pew Charitable Trusts; the Bureau of Maternal and Child Health and Resources Development, Health Resources Services Administration, United States Public Health Service, Department of Health and Human Services (grant MCJ-060515); and the Stanford Center for the Study of Families, Children and Youth.

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