scholarly journals Effect of Mixer Type on Particle Coating by Magnesium Stearate for Friction and Adhesion Modification

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1211
Author(s):  
Wei Pin Goh ◽  
Ana Montoya Sanavia ◽  
Mojtaba Ghadiri
Keyword(s):  
Flow Resistance ◽  
Flow Characteristics ◽  
Magnesium Stearate ◽  
Shear Strain Rate ◽  
Mixing Conditions ◽  
Particle Coating ◽  
Powder Characteristics ◽  
Interparticle Friction ◽  
Sharp Corners

Glidants and lubricants are often used to modify interparticle friction and adhesion in order to improve powder characteristics, such as flowability and compactability. Magnesium stearate (MgSt) powder is widely used as a lubricant. Shear straining causes MgSt particles to break, delaminate, and adhere to the surfaces of the host particles. In this work, a comparison is made of the effect of three mixer types on the lubricating role of MgSt particles. The flow behaviour of α-lactose monohydrate, coated with MgSt at different mass percentages of 0.2, 0.5, 1, and 5 is characterised. The mixing and coating process is carried out by dry blending using Turbula, ProCepT, and Mechanofusion. Measures have been taken to operate under equivalent mixing conditions, as reported in the literature. The flow resistance of the coated samples is measured using the FT4 rheometer. The results indicate that the flow characteristics of the processed powders are remarkably similar in the cases of samples treated by Turbula and Mechanofusion, despite extreme conditions of shear strain rate. The least flow resistance of samples is observed in the case of samples treated by the ProCepT mixer. High-velocity collisions of particles round off the sharp corners and edges, making them less resistant to flow. The optimal percentage of magnesium stearate is found to be approximately 1% by weight for all mixer types, as the addition of higher amounts of lubricant does not further improve the flowability of the material.

scholarly journals Water-Worked Gravel Bed: State-of-the-Art Review

Water ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 694 ◽  
Author(s):  
Ellora Padhi ◽  
Subhasish Dey ◽  
Venkappayya R. Desai ◽  
Nadia Penna ◽  
Roberto Gaudio
Keyword(s):  
State Of The Art ◽  
Flow Characteristics ◽  
Streamwise Velocity ◽  
Secondary Currents ◽  
Gravel Bed ◽  
Natural Stream ◽  
Art Research ◽  
The Comparative Study ◽  
Water Work

In a natural gravel-bed stream, the bed that has an organized roughness structure created by the streamflow is called the water-worked gravel bed (WGB). Such a bed is entirely different from that created in a laboratory by depositing and spreading gravels in the experimental flume, called the screeded gravel bed (SGB). In this paper, a review on the state-of-the-art research on WGBs is presented, highlighting the role of water-work in determining the bed topographical structures and the turbulence characteristics in the flow. In doing so, various methods used to analyze the bed topographical structures are described. Besides, the effects of the water-work on the turbulent flow characteristics, such as streamwise velocity, Reynolds and form-induced stresses, conditional turbulent events and secondary currents in WGBs are discussed. Further, the results form WGBs and SGBs are compared critically. The comparative study infers that a WGB exhibits a higher roughness than an SGB. Consequently, the former has a higher magnitude of turbulence parameters than the latter. Finally, as a future scope of research, laboratory experiments should be conducted in WGBs rather than in SGBs to have an appropriate representation of the flow field close to a natural stream.

scholarly journals In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ
Keyword(s):  
Drug Carrier ◽  
Magnesium Stearate ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Powder Inhalation ◽  
Particle Coating ◽  
Lower Drug ◽  
Dry Particle Coating ◽  
Coarse Model ◽  
Carrier Systems

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.

Role of Dissipation Characteristics in Predicting Flow from Dissimilar Centrifugal Pumps

1994 ◽  
Vol 208 (4) ◽  
pp. 285-294 ◽  
Author(s):  
E A Bunt ◽  
B Parsons ◽  
F Holtzhausen
Keyword(s):  
Flow Characteristics ◽  
Maximum Flow ◽  
Centrifugal Pumps ◽  
Graphical Solution ◽  
Dissipative Flow ◽  
In Series ◽  
Lower Maximum ◽  
Output Field ◽  
High Series

Examination of flows in a particular case of dissimilar pumps coupled in series or in parallel (without check valves) showed that the ‘classical’ graphical solution of combined characteristics in the [+H, +Q] quadrant did not accord with the output field in certain regions. To predict the full flow fields, it was necessary to take into account dissipative flow characteristics in two other quadrants: for low-output parallel flow (when there is still flow available from the pump of higher head when the ‘weaker’ pump's flow has been reduced to zero), that in the [+H, –Q] quadrant; and for high series flow (after the output head of the pump of lower maximum flow has been reduced to zero), that in the [–H, +Q] quadrant. This problem does not arise when the pumps have identical characteristics.

scholarly journals Numerical Study of Heat Transfer Intensification in a Circular Tube Using a Thin, Radiation-Absorbing Insert. Part 1: Thermo-Hydraulic Characteristics

Energies ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4596
Author(s):  
Piotr Bogusław Jasiński
Keyword(s):  
Heat Transfer ◽  
Flow Resistance ◽  
Numerical Study ◽  
Flow Characteristics ◽  
Cylindrical Tube ◽  
Radiation Absorption ◽  
Fluid Temperature ◽  
Gas Temperature ◽  
Insert Size ◽  
Channel Diameter

The presented paper, which is the first of two parts, shows the results of numerical investigations of a heat exchanger channel in the form of a cylindrical tube with a thin insert. The insert, placed concentrically in the pipe, uses the phenomenon of thermal radiation absorption to intensify the heat transfer between the pipe wall and the gas. Eight geometric configurations of the insert size were numerically investigated using CFD software, varying its diameter from 20% to 90% of the pipe diameter and obtaining the thermal-flow characteristics for each case. The tests were conducted for a range of numbers Re = 5000–100,000 and a constant temperature difference between the channel wall and the average gas temperature of ∆T = 100 °C. The results show that the highest increase in the Nu number was observed for the inserts with diameters of 0.3 and 0.4 of the channel diameter, while the highest flow resistance was noted for the inserts with diameters of 0.6–0.7 of the channel diameter. The f/fs(Re) and Nu/Nus(Re) ratios are shown on graphs indicating how much the flow resistance and heat transfer increased compared to the pipe without an insert. Two methods of calculating the Nu number are also presented and analysed. In the first one, the average fluid temperature of the entire pipe volume was used to calculate the Nu number, and in the second, only the average fluid temperature of the annular portion formed by the insert was used. The second one gives much larger Nu/Nus ratio values, reaching up to 8–9 for small Re numbers.

Role of Plaque Morphology in Altering the Flow Characteristics in Diseased Coronary Artery

2012 ◽  
Author(s):  
Carlos Moreno ◽  
Kiran Bhaganagar
Keyword(s):  
Coronary Artery ◽  
Nonlinear Response ◽  
Flow Characteristics ◽  
Proximal Region ◽  
Patient Specific ◽  
Plaque Morphology ◽  
Mean Velocity ◽  
Peak Location ◽  
The Mean

Patient specific simulations of a single patient based on an accurate representation of the plaque in a diseased coronary artery with 35% stenosis are performed to understand the effect of inlet forcing frequency and amplitude on the wall shear stress (WSS). Numerical simulations are performed with unsteady flow conditions in a laminar regime. The results have revealed that at low amplitudes, WSS is insensitive to forcing frequency and is it in phase with Q. The maximum WSS is observed at the proximal region of the stenosis, and WSS has highest negative values at the peak location of the stenosis. For higher pulsatile amplitude (a > 1.0), WSS exhibits a strong sensitivity with forcing frequencies. At higher forcing frequency the WSS exhibits nonlinear response to the inlet forcing frequency. Furthermore, significant differences in the mean velocity profile are observed during maximum and minimum volumetric flow rates.

Analysis of Flow Resistance Inside Microchannels With Different Inlet Configurations Using Micro-PIV System

2003 ◽  
Author(s):  
Sang-Joon Lee ◽  
Guk-Bae Kim
Keyword(s):  
Flow Resistance ◽  
Reduction Rate ◽  
Flow Characteristics ◽  
Entrance Region ◽  
Curvature Radius ◽  
Microfluidic Chips ◽  
Mean Velocity ◽  
Dimethyl Siloxane ◽  
Micro Piv ◽  
Macro Scale

Most microfluidic chips consist of several microchannels inside. In order to design microfluidic chips efficiently, it is important to predict the flow passage and to understand the flow characteristics on the chip. In this study, the flow structure inside microchannels has been investigated using a micro-PIV system. We focused on the flow resistance with respect to the inlet configuration of microchannels. The microchannels made of poly-dimethyl-siloxane (PDMS) material were fabricated by a micro-molding technique using SU-8 (photoresist) master. The width (w) and depth of the microchannels were fixed as 100 μm and 58 μm, respectively. Six different inlet configurations with curvature radii in the ranges from r = 0.2w to 1.5w were tested in this study. As a result, with increasing the curvature radius of the inlet corner, the streamwise mean velocity develops slowly in the entrance region, but the fully developed velocity at further downstream is increased. When the curvature radius is larger than r = 0.6w, the reduction rate of flow resistance is not so significant. For the microchannels with r = 0.6w, 0.8w and 1.0w the downstream mean velocity at channel center has nearly the same value of about 276 mm/sec, 10.5% larger than that of r = 0.2w. The simple rounding of microchannel inlet corner reduces flow resistance effectively by smoothing the incoming flow. The length of entrance region is much smaller than that of macro-scale channel.

Flow Resistance Characteristics of a Specific Fuel RP-3 in Helical Tubes at Supercritical Pressure With Uniform Heat Flux

2017 ◽  
Author(s):  
Nan Zhang ◽  
Yanchen Fu ◽  
Haoran Huang ◽  
Jie Wen ◽  
Nigeer Te
Keyword(s):  
Heat Flux ◽  
Friction Factor ◽  
Mass Flux ◽  
Flow Resistance ◽  
Flow Characteristics ◽  
Supercritical Pressure ◽  
Uniform Heat Flux ◽  
Inlet Temperature ◽  
Uniform Heat ◽  
Helical Tubes

The flow resistance characteristics of aviation kerosene RP-3 in horizontal helical tubes at the supercritical pressure under heating condition are investigated. Both pressure drop and friction factor were examined under uniform heat flux of 50kW/m2−300kW/m2, mass flux from 786kg/m2s to 1375kg/m2s, and helical diameter from 20mm to 40mm. The influence of viscous factors on the resistance is analyzed to explore flow characteristics in a helical tube and provide a reference for the design of heat exchangers. Friction factor decreases with the increase of heat flux at low inlet temperatures 323K and 423K. It is explained that the viscosity changes more dramatically than the density. When the fluid inlet temperature is 523K and the fluid mean temperature Tb is close to pseudo-critical temperature, frictional flow resistance becomes significantly larger Tpc due to huge variations in thermal properties in the radical direction. The effect of centrifugal force makes the friction factor decline slowly. The friction factor goes up with the enlargement of mass flux when Tb>0.81Tpc. This phenomenon is caused by the larger radial velocity gradient under the large mass flux. Different helical diameters play the leading roles for the bending flow in the tubes.

Laser sintering of cryogenically ground polymer powders into high-performance parts: The role of dry particle coating with a conductive flow agent

Polymer ◽  
2020 ◽  
Vol 186 ◽  
pp. 122044
Author(s):  
Shuting Xi ◽  
Peiyao Zhang ◽  
Yajiang Huang ◽  
Miqiu Kong ◽  
Qi Yang ◽  
...  
Keyword(s):  
High Performance ◽  
Laser Sintering ◽  
Particle Coating ◽  
Dry Particle Coating ◽  
Polymer Powders

On the Role of Enduring Contact in Powder Lubrication

2005 ◽  
Vol 128 (1) ◽  
pp. 168-175 ◽  
Author(s):  
J. Y. Jang ◽  
M. M. Khonsari
Keyword(s):  
Analytical Solution ◽  
Flow Velocity ◽  
Volume Fraction ◽  
Flow Characteristics ◽  
Kinetic Regime ◽  
Governing Equations ◽  
Wide Range ◽  
Fraction Distribution ◽  
Powder Lubrication

This paper is devoted to a study of the enduring contact between granules of powder lubricants in an effort to better understand the flow characteristics of powder lubricants. Appropriate formulation of the governing equations is reported that can be used for prediction of the flow velocity, pseudo temperature, and volume fraction distribution of powders for a wide range of operating speeds. A set of parametric simulations and a limiting analytical solution is presented for predicting the behavior of a powder lubricant under low operating speeds when the enduring contact tends to dominate the kinetic regime. The limiting solution shows that below a certain sliding speed the volume fraction remains unchanged due to the effect of the enduring contact. It is also shown that below this limiting speed the enduring contact plays a major role and should not be neglected.

Pilot Pipe and Damping Orifice Arrangements Analysis of a Pilot-Control Globe Valve

2020 ◽  
Vol 142 (10) ◽  
Author(s):  
Jin-yuan Qian ◽  
Jia-yi Wu ◽  
Zhi-xin Gao ◽  
Zhi-jiang Jin
Keyword(s):  
Energy Consumption ◽  
Pressure Distribution ◽  
Lower Energy ◽  
Flow Resistance ◽  
Flow Characteristics ◽  
Incoming Flow ◽  
Local Flow ◽  
Flow Capacity ◽  
Bottom Face ◽  
Globe Valve

Abstract Compared to conventional globe valves, the pilot-control globe valve (PCGV) possesses advantages of lower energy consumption and higher space utilization. In order to analyze the effects of pilot pipe and damping orifice arrangements, this work proposes four PCGVs and conducts simulations to compare their overall performances, overall flow characteristics, and local flow characteristics around the valve core. In general, the arrangement of the pilot pipe has larger effects on the hydroperformances of PCGVs than the arrangement of the damping orifice. The pipe-parallel-mounted type PCGV performs better in hydroperformance than the pipe-perpendicular-mounted type PCGV, and thus is recommended in practice. As the specified valve core travel increases, the flow resistance of PCGVs decreases and the flow capacity of PCGVs increases. However, overlarge specified valve core travel has little effects on the flow resistance and flow capacity of PCGVs. Besides, the increased specified valve core travel could effectively reduce the wear induced by the uneven pressure distribution on the external lateral face of valve core, but it has little effect on the wear induced by the uneven pressure distribution on the bottom face. For all pipe-perpendicular-mounted type PCGVs, the variation of axial force imposed on the valve core relative to the specific valve core travel presents similar tendencies under different incoming flow velocity within the scope of the investigation, which could be concluded into a fitting equation. This work could be referred for the optimization of PCGVs and other similar valves.

Sign in / Sign up

Export Citation Format

Share Document