COMPONENTS OF MILK OF SIMMENTAL BREED BELONGING TO VARIOUS GENOTYPES

2020 ◽  
pp. 14-18
Author(s):  
Г.Н. ЛЕВИНА ◽  
А.И. НАЗАРЕНКО
Keyword(s):  
Milk Yield ◽  
Mass Fraction ◽  
Freezing Temperature ◽  
Energy Value ◽  
Group Iii ◽  
Holstein Breed ◽  
Group I ◽  
Milk Components ◽  
Beta Hydroxybutyrate ◽  
Stage 1

Изучены удой, калорийность и компоненты молока по трем лактациям у коров, имеющих разную кровность по породам: I группа — ¾ голштинской породы красно-пестрой масти (КГШ); ¼ симментальской породы (СИМ), II группа — ¾ СИМ; ¼ КГШ и III группа — ½ монбельярдской породы (МБ); ¼ СИМ; ¼ КГШ. Исследования проводили с 2014 по 2020 год на базе племенного завода ООО «Сапфир-Агро» Курской области. Удой коров был более 7000 кг молока за лактацию. Цель исследований заключалась в сравнительной оценке по удою и компонентам молока дочерей от маточного поголовья симментальской породы, имеющего кровность ½ по голштинской и быков монбельярдской, симментальской и голштинской пород для определения рационального приема дальнейшего совершенствования симментальской породы. В каждую группу отбирали животных по принципу пар-аналогов, с учетом возраста и даты отела, по 70 коров, полученных не менее чем от 3 быков-производителей. Животные находились в одинаковых условиях кормления и содержания. Установлено, что по суммарному удою за три лактации коровы разных генотипов равноценны (21,3—21,8 тыс. кг молока). Однако по калорийности молоко дочерей быков монбельярдской (72,7—74,7 ккал в 100 г) и симментальской (73,2—75,0 ккал) пород достоверно выше, чем в группе коров, имеющей кровность ¾ по КГШ породе (70,9—71,6 ккал), достоверное превосходство над коровами с ¾ КГШ было и по МДБ и казеину. МДЖ у всех животных была значительно выше 4,0% (4,12—5,01%). Достоверное превосходство коров II и III групп над сверстницами I группы наблюдалось на 1 и 3 стадиях, а по лактозе — на всех стадиях 1-й лактации. Температура замерзания молока была минимальной на 1 стадии всех лактаций. Максимальные величины бета-гидроксибутирата (БГБ) и ацетона в молоке были в 1 стадию всех лактаций. Изменчивость этих показателей была высокой у коров всех групп (57,0—217,0%). С учетом величины удоя и компонентов молока за три лактации снижение кровности по голштинам для потомства симментальской породы рационально, кроме того использование быков монбельярдской и симментальской породы на маточном голштинизированном поголовье симментальской породы способствует сохранению и развитию ее оригинальных качеств. Milk yield, energy value and milk components according to three lactations in cows with various pedigree by breeds were studied: Group I — ¾ of Holstein breed of red-and-white color (KGSh); ¼ of Simmental breed (SIM); Group II — ¾ SIM; ¼ KGSh; and group III — ½ of Montbéliarde breed (MB); ¼ SIM; ¼ KGSh. Research was carried out from 2014 until 2020 at OOO Sapfir-Agro stud farm located in the Kursk Region. Milk yield amounted to more than 7000 kg of milk per lactation. The purpose of study was to carry out comparative evaluation of pedigree stock calves belonging to Simmental breed with ½ pedigree of Holstein breed and bulls of Montbéliarde, Simmental, and Holstein breeds by milk yield and milk components to determine the rational method of further improvement of Simmental breed. Animals were chosen for each group according to the pair-analogue principle taking into account their age and date of calving. 70 cows from not less than 3 seed bulls were included. All of the animals were provided with the same feeding conditions and husbandry. It was determined that the cows with various genotypes are equivalent by total milk yield per three lactations (21.3—21.8 thousand kilograms of milk). However, energy value of milk obtained from the daughters of Montbéliarde (72.7—74.7 kcal per 100 g) and Simmental (73.2—75.0 kcal) bulls was reliably higher than that of the group of cows with ¾ pedigree of KGSh breed (70.9—71.6 kcal), and the reliable superiority over cows with ¾ KGSh was seen both in mass fraction of protein and casein. Mass fraction of fat was significantly higher than 4.0% (4.12—5.01%) in all animals. Reliable superiority of cows belonging to groups II and III over their counterparts belonging to group I was observed during stages 1 and 3, and superiority according to lactose was seen in all stages of the 1st lactation. Freezing temperature of milk was minimal on stage 1 of all lactations. Maximum values of beta-hydroxybutyrate (BHB) and acetone in milk were observed during stage 1 of all lactation. Variability of these parameters was high in cows belonging to all groups (57.0—217.0%). Taking milk yield and milk components values for three lactations into account, the decrease of pedigree by Holstein breed for Simmental offspring is rational. Also, the use of Montbéliarde and Simmental bulls on Holsteinised breeding stock of Simmental breed facilitates the preservation and development of its original qualities.

Vincristine (V), dactinomycin (A), and lower doses of cyclophosphamide (C) with or without radiation therapy for patients with newly diagnosed low-risk embryonal rhabdomyosarcoma (ERMS): A report from the Children’s Oncology Group (COG).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9509-9509 ◽  
Author(s):  
David Walterhouse ◽  
Alberto S. Pappo ◽  
Jane L Meza ◽  
John C. Breneman ◽  
Andrea Anita Hayes-Jordan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Complete Response ◽  
Low Risk ◽  
Phase Iii ◽  
Newly Diagnosed ◽  
Group Iii ◽  
Group I ◽  
Phase Iii Study ◽  
Stage 1

9509 Background: Intergroup Rhabdomyosarcoma Study (IRS) trials showed improved survival with VAC compared with VA for patients with Stage 1 Group III (non-orbit) or Stage 3 Group I/II ERMS (see table). In COG ARST0331, we hypothesized that VA in combination with lower doses of C (total cumulative dose=4.8 g/m2) would produce the benefit of IRS-IV VAC with less toxicity for patients with Stage 1 Group III (non-orbit) or Stage 3 Group I/II low-risk ERMS. Methods: This single arm, non-inferiority, phase III study enrolled newly diagnosed patients with Stage 1 Group III (non-orbit) ERMS or Stage 3 Group I/II ERMS onto Subset 2. Therapy was 4 cycles of VAC followed by 12 cycles of VA over 46 weeks (total cumulative doses: V=54 mg/m2, A=21.6 mg/m2, C=4.8 g/m2). The radiation therapy dose was 36 Gy for Group IIA patients, 41.4 Gy for Group IIB/C patients, and 50.4 Gy for Group III patients. From 2004–2008 girls with Group III vaginal RMS did not receive radiotherapy if a complete response was achieved with chemotherapy with or without delayed resection. The primary endpoint was failure-free survival (FFS), and results were compared with a fixed expected outcome. Results: With a median follow-up of 3.0 yrs, we observed 16 failures vs. 7.8 expected failures. Estimated 3-yr FFS was 63% (95% CI: 46%, 75%) (n=60), and overall survival (OS) was 84% (95% CI: 68%, 93%). Estimated 3-yr FFS was 46% (95% CI: 23%, 67%) for girls with non-bladder genitourinary tract ERMS (n=21) and 75% (95% CI: 53%, 88%) for all other Subset 2 patients (n=39). Conclusions: We observed suboptimal FFS of patients with Subset 2 low-risk RMS using reduced total cyclophosphamide (4.8 g/m2). Results were complicated by the choice of no radiation therapy for girls with vaginal tumors. Future studies for low-risk RMS Subset 2 patients could investigate a dose of C between 4.8 and 26.4 g/m2 with VA and local radiotherapy. [Table: see text]

scholarly journals Formation features of humoral immunity in newborn calves in case of including haylage with bio-preservative into the diet of cows

2021 ◽  
Vol 273 ◽  
pp. 02008
Author(s):  
Anna Karamaeva ◽  
Larisa Bakaeva ◽  
Natalia Soboleva ◽  
Sergey Karamaev
Keyword(s):  
Blood Serum ◽  
Milk Yield ◽  
Humoral Immunity ◽  
Immune Status ◽  
The Body ◽  
Group Iii ◽  
First Feeding ◽  
Group I ◽  
Newborn Calves ◽  
Group Ii

The peculiarities of the formation of colostrum in the udder of cows and the immune status in the body of calves in the first hours and days after birth, when included in the diet of cows, haylage from eastern goat’s rue prepared with the use of bio-preservatives “Silostan” (group II) and “GreenGrass 3 × 3”(Group III). The study of colostrum of the first milk yield showed that feeding cows with silage with the bio-preservative “Silostan” contributed to an increase in the content of immunoglobulins by 4.0% (Р<0,001), with bio-preservative “GreenGras 3 × 3” - by 5.3% (Р<0,001). After drinking the first portion of colostrum, immunoglobulins appear in the blood serum of calves after 2 hours. After 6 hours, the content of immunoglobulins in the blood serum of calves of group II was 21.9% higher than in group I (haylage without preservative) (P < 0.05), group III - by 27.1% (P <0.001). The proportion of calves with an immunoglobulin content 6 hours after the first feeding with colostrum not more than 6.0 mg / ml, decreased in group II by 12.0%, in group III - by 20.0%.

ДИНАМИКА МОЛОЧНОЙ ПРОДУКТИВНОСТИ ПЕРВОТЕЛОК ЧЕРНО-ПЕСТРОЙ ПОРОДЫ В ЗАВИСИМОСТИ ОТ СПОСОБА СОДЕРЖАНИЯ И СЕЗОНА ОТЕЛА

2019 ◽  
Author(s):  
S.A. OVODKOV ◽  
Ah.S. DELYAN
Keyword(s):  
Milk Yield ◽  
Group Iv ◽  
Milk Productivity ◽  
Group Iii ◽  
Black And White ◽  
Agricultural Enterprise ◽  
Group I ◽  
White Breed ◽  
Group Ii ◽  
Calving Season

Изучено влияние способа содержания и сезона отела на лактационную деятельность голштинизированных коров-первотелок черно-пестрой породы. Исследования проведены в условиях сельскохозяйственного предприятия Тверской области на 4 группах животных: I группа — привязное содержание, летние отелы; II — привязное содержание, зимние отелы; III — беспривязное содержание, летние отелы; IV — беспривязное содержание, зимние отелы. Максимальные удои у коров I, III и IV групп были получены на 3-м мес лактации, II — на 2-м. Удой в I, II, III и IV группах составил, соответственно, 7714, 8717, 7682 и 7930 кг молока за 305 дней лактации. Удой коров за первые 3 мес в % к удою за 305 дней лактаций: I группа — 33,7%, II — 35,8, III — 34,4, IV — 35,9%. Максимальный суточный удой в I группе равнялся 30,8 кг, во II — 36,5, в III —29,7 и в IV — 35,3. Среднесуточный удой за 305 дней лактации в I группе составил 21,2 кг, во II — 23,6, в III группе — 19,4 и в IV группе — 21,7. Коэффициент постоянства лактации в I II III и IV группах равнялся 93,2, 94,2, 89,2 и 98%, соответственно. Независимо от способа содержания более высокие показатели молочной продуктивности и устойчивости лактационной деятельности имели коровы, отелившиеся в зимний период.The influence of the method of keeping and calving season on the lactation activity of Holstein cows-heifers of black-and-white breed is studied. Studies were conducted in the agricultural enterprise of the Tver region on 4 groups of animals: I group — tethered content, summer calving; 2 — tethered content, winter calving; III — loose content, summer calving; 4 — loose content, winter calving. Maximum milk yield in cows I and III and IV groups were obtained on the 3rd month of lactation, the second — at the 2nd. Milk Yield in I, II and III and in IV groups made, respectively, 7714, 8717, 7682 and 7930 kg of milk for 305 days of lactation. Milk yield of cows for the first 3% to milk yield for 305 days of lactation: group I-33,7%, II — 35,8, III-34,4, IV-35,9%. The maximum daily yield in group I was 30.8 kg, in group II — 36.5, in group III — 29.7 and in group IV — 35.3. The average daily yield for 305 days of lactation in group I was 21.2 kg, in group II — 23.6, in group III — 19.4 and in group IV — 21.7. The coefficient of persistence of lactation in I, II, III and IV groups was equal to 93.2 per cent, 94,2, to 89.2 and 98%, respectively. Regardless of the method of maintenance, cows calving in winter had higher indicators of milk productivity and stability of lactation activity.

Milk productivity of cows depending on their origin on genealogical line

2021 ◽  
pp. 21-30
Author(s):  
M. V. Voronov ◽  
N. A. Fedoseeva ◽  
T. N. Pimkina ◽  
O. V. Gorelik
Keyword(s):  
Milk Yield ◽  
Mass Fraction ◽  
Positive Association ◽  
Specific Weight ◽  
Milk Productivity ◽  
Black And White ◽  
Holstein Breed ◽  
Significant Difference ◽  
White Breed ◽  
The Difference

The improvement of cattle of Black-and-White breed by mating of maternal stock with the sires of Holstein breed continues at the present time. Therefore, breeding in pedigree farms for the production of milk is carried out including the use of Holstein lines. The purpose of the work was to assess the milk productivity of cows of Black-and-White breed, with a high proportion of blood in Holstein breed, depending on their linear origin. In the herd of the breeding farm where the research has been carried out, the lines Reflection Sovereign 198998 and Wes Ideal 933122 occupy the dominant position in terms of the specific weight of cattle, followed by the line Montwick Chieftain 95679. The difference in milk yield between groups of cows of different lines was from 3,0 to 354 kg or 0,04 to 4,6 %. The highest milk yield was shown by the first-calf heifers of the line Wes Ideal 933122 – 7787±123,21 kg. In the milk of the first-calf heifers of the line Pabst Governor 882933 compared with herdmates of other lines the increased content of fat and protein has been noted,. The difference in the mass fraction of fat in milk was significant in favor of Pabst Governor 882933 cows (P ≤ 0,01–0,001). There was also the significant difference in the mass fraction of fat in milk between the groups of cows of the lines Montwick Chieftain 95679, Reflection Sovereign 198998 and Wes Ideal 933122 in favor of the latter at P ≤ 0,05–0,01. A definite association between milk yield and the mass fraction of fat in milk has not been established. There is a pattern of the positive association between the mass fraction of fat and the mass fraction of protein in milk and it is clearly seen that with the increase in the mass fraction of fat in milk, there is the increase in the mass fraction of protein.

scholarly journals Results of the Intergroup Rhabdomyosarcoma Study Group D9602 Protocol, Using Vincristine and Dactinomycin With or Without Cyclophosphamide and Radiation Therapy, for Newly Diagnosed Patients With Low-Risk Embryonal Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group

2011 ◽  
Vol 29 (10) ◽  
pp. 1312-1318 ◽  
Author(s):  
R. Beverly Raney ◽  
David O. Walterhouse ◽  
Jane L. Meza ◽  
Richard J. Andrassy ◽  
John C. Breneman ◽  
...  
Keyword(s):  
Survival Rates ◽  
Embryonal Rhabdomyosarcoma ◽  
Study Group ◽  
Free Survival ◽  
Group Iii ◽  
Group I ◽  
Risk Patients ◽  
Group Ii ◽  
Stage 1

Purpose Patients with localized, grossly resected, or gross residual (orbital only) embryonal rhabdomyosarcoma (ERMS) had 5-year failure-free survival (FFS) rates of 83% and overall survival rates of 95% on Intergroup Rhabdomyosarcoma Study Group (IRSG) protocols III/IV. IRSG D9602 protocol (1997 to 2004) objectives were to decrease toxicity in similar patients by reducing radiotherapy (RT) doses and eliminating cyclophosphamide for the lowest-risk patients. Patients and Methods Subgroup A patients (lowest risk, with ERMS, stage 1 group I/IIA, stage 1 group III orbit, stage 2 group I) received vincristine plus dactinomycin (VA). Subgroup B patients (ERMS, stage 1 group IIB/C, stage I group III nonorbit, stage 2 group II, stage 3 group I/II) received VA plus cyclophosphamide. Patients in group II/III received RT. Compared with IRS-IV, doses were reduced from 41.4 to 36 Gy for stage 1 group IIA patients and from 50 or 59 to 45 Gy for group III orbit patients. Results Estimated 5-year FFS rates were 89% (95% CI, 84% to 92%) for subgroup A patients (n = 264) and 85% (95% CI, 74%, 91%) for subgroup B patients (n = 78); median follow-up: 5.1 years. Estimated 5-year FFS rates were 81% (95% CI, 68% to 90%) for patients with stage 1 group IIA tumors (n = 62) and 86% (95% CI, 76% to 92%) for patients with group III orbit tumors (n = 77). Conclusion Five-year FFS and OS rates were similar to those observed in comparable IRS-III patients, including patients receiving reduced RT doses, but were lower than in comparable IRS-IV patients receiving VA plus cyclophosphamide. Five-year FFS rates were similar among subgroups A and B patients.

scholarly journals Comparative evaluation of russian black pied and holstein cattle breeds of foreign breeding

2021 ◽  
Vol 282 ◽  
pp. 03009
Author(s):  
O.V. Gorelik ◽  
А.S. Gorelik ◽  
M.A. Tokoreva ◽  
N.I. Sorokina ◽  
G.V. Mkrtchyan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Milk Yield ◽  
Mass Fraction ◽  
Essential Amino Acids ◽  
Comparative Assessment ◽  
Holstein Cows ◽  
Holstein Breed ◽  
Ideal Protein ◽  
The Difference ◽  
The Ideal

A related Holstein breed has recently been used to improve domestic dairy cattle and create highly productive herds by purchasing semen from breeding bulls, as well as a large number of heifers and calves of foreign breeding. The purpose of the work is a comparative assessment of the productive qualities of Black Pied and Holstein cows of foreign breeding. Purebred Holstein cows differ from animals of Black Pied breed in milk yield per lactation by 1064 kg or 15.2% (P≤0.01, in favor of Holstein cows). In terms of quality indicators of milk, that are the content of fat and protein in milk, the superiority remained with Black Pied cows. The difference was significant at P≤0.05 for fat content in milk and at P≤0.001 for protein content. Both groups of cows exceeded the breed standard for milk yield per lactation, mass fraction of fat and mass fraction of protein in milk. The milk of the Russian Black Pied cattle contains more essential amino acids. The milk of cows of both breeds can be considered complete, since the amount of limited amino acids in the milk of purebred Holstein cows of foreign breeding is over 95% of their content in the ideal protein.

Realization of the potential of cows of Holstein breed of different generations in terms of productive traits

2021 ◽  
pp. 28-35
Author(s):  
O. V. Nazarchenko ◽  
A. N. Rusanov
Keyword(s):  
Milk Yield ◽  
Mass Fraction ◽  
First Generation ◽  
Live Weight ◽  
High Productivity ◽  
Black And White ◽  
Holstein Breed ◽  
Genetic Potential ◽  
White Breed ◽  
Productive Traits

Breeding work with dairy cattle in the Kurgan region is aimed at breeding animals that combine the adaptive properties and valuable traits of cattle of Black-and-White breed with a high proportion of genes of Holstein breed. Such animals are characterized by high productivity and suitability for intensive technology of their housing. The purpose of the research was to determine the indicators of milk productivity of first-calf heifers of different generations of Holstein breed, imported to the pedigree farms of the Kurgan region, as well as to determine the degree of realization of the genetic potential of animals. Scientific research has been carried out in the herd of CJSC “Glinka” (Kurgan), where highly productive cattle of Black-and-White and Holstein breeds are bred. The subject of research was the first-calf heifers of the imported Holstein breed of German selection of different generations, as well as the herdmates of Black-and-White breed. It has been found that the realization of the genetic potential for milk yield in Holstein cows of German breeding was higher and amounted to 76,4 %, in cows of Black-and-White breed 69,9 %. The highest milk yield for 305 days of lactation has been observed in the second generation of Holstein heifers 8905 kg, which exceeded the milk yield of herdmates of the second and third generations by 113 kg or 1,26 % and 174 kg or 1,95 %, respectively. The mass fraction of fat in German Holsteins of different generations ranged from 3,99 to 4,21 % (P < 0,001), while the mass fraction of protein in the milk of first-calf heifers varied slightly in the range from 3,18 to 3,20 %. In terms of live weight, the animals of the third generation slightly exceeded the herdmates of the 1st and 2nd generations by 19 kg or 3,25 % and 20 kg or 3,43 %, respectively. The largest profit has been received from the first-generation first-calf heifers of Holstein breed of German selection, where the level of profitability of milk production was 50,7 %, which was higher than that of the herdmates of the second and third generations by 3,9 and 7,9 %, respectively.

Analysis of Prognostic Factors in Patients With Nonmetastatic Rhabdomyosarcoma Treated on Intergroup Rhabdomyosarcoma Studies III and IV: The Children's Oncology Group

2006 ◽  
Vol 24 (24) ◽  
pp. 3844-3851 ◽  
Author(s):  
Jane L. Meza ◽  
James Anderson ◽  
Alberto S. Pappo ◽  
William H. Meyer
Keyword(s):  
Regional Lymph Node ◽  
Oncology Group ◽  
Anatomic Site ◽  
Primary Tumors ◽  
Undifferentiated Sarcoma ◽  
Group Iii ◽  
Disease Characteristics ◽  
Group I ◽  
Node Disease ◽  
Stage 1

Purpose The outcome for localized rhabdomyosarcoma (RMS) or undifferentiated sarcoma (UDS) is affected by age, histology, primary anatomic site, extent of disease, and therapy. Patients and Methods We evaluated patient and disease characteristics for their ability to predict outcome for patients with nonmetastatic RMS or UDS treated on Intergroup Rhabdomyosarcoma Study (IRS) -III (1984 to 1991) or IRS-IV (1991 to 1997). Results The estimated 5-year failure-free survival (FFS) rate was 90% for patients with embryonal RMS (ERMS) stage 1, group I or IIa; stage 2, group I; or group III orbit. The estimated 5-year FFS rate was 87% for patients with ERMS stage 1, group IIb or IIc; stage 1, group III nonorbit; stage 2, group II; and stage 3, group I or II; and 73% for patients with ERMS stage 2 or 3, group III. The estimated 5-year FFS rate was poor for patients with stage 2 or 3, group III ERMS with invasive (T2) tumors who were age younger than 1 year or 10 years or older (56%) and patients with stage 2 or 3, group III extremity primary tumors (43%). Overall, outcomes for patients with alveolar RMS (ARMS) or UDS were worse than for patients with ERMS. However, the 5-year FFS rate was good for patients with ARMS/UDS at favorable sites with group I or II (80%) or group III (76%) disease. The FFS rate was poorer for patients with ARMS/UDS at unfavorable sites with group I or II (66%) or group III (45%) disease. The estimated 5-year FFS rate was 31% for patients with group III ARMS/UDS at unfavorable sites with regional lymph node disease, which is similar to metastatic RMS. Conclusion Patient and disease characteristics identify distinct subsets with different outcomes, allowing the Soft Tissue Sarcoma Committee of the Children's Oncology Group to refine risk-adapted therapy assignment.

scholarly journals Vincristine, Actinomycin, and Cyclophosphamide Compared With Vincristine, Actinomycin, and Cyclophosphamide Alternating With Vincristine, Topotecan, and Cyclophosphamide for Intermediate-Risk Rhabdomyosarcoma: Children's Oncology Group Study D9803

2009 ◽  
Vol 27 (31) ◽  
pp. 5182-5188 ◽  
Author(s):  
Carola A.S. Arndt ◽  
Julie A. Stoner ◽  
Douglas S. Hawkins ◽  
David A. Rodeberg ◽  
Andrea A. Hayes-Jordan ◽  
...  
Keyword(s):  
Local Therapy ◽  
Risk Groups ◽  
Intracranial Extension ◽  
Primary Study ◽  
Intermediate Risk ◽  
Undifferentiated Sarcoma ◽  
Group Iii ◽  
Group I ◽  
Α Level ◽  
Stage 1

PurposeThe purpose of this study was to compare the outcome of patients with intermediate-risk rhabdomyosarcoma (RMS) treated with standard VAC (vincristine, dactinomycin, and cyclophosphamide) chemotherapy to that of patients treated with VAC alternating with vincristine, topotecan, and cyclophosphamide (VAC/VTC).Patients and MethodsPatients were randomly assigned to 39 weeks of VAC versus VAC/VTC; local therapy began after week 12. Patients with parameningeal RMS with intracranial extension (PME) were treated with VAC and immediate x-ray therapy. The primary study end point was failure-free survival (FFS). The study was designed with 80% power (5% two-sided α level) to detect an increase in 5-year FFS from 64% to 75% with VAC/VTC.ResultsA total of 617 eligible patients were entered onto the study: 264 were randomly assigned to VAC and 252 to VAC/VTC; 101 PME patients were nonrandomly treated with VAC. Treatment strata were embryonal RMS, stage 2/3, group III (33%); embryonal RMS, group IV, less than age 10 years (7%); alveolar RMS or undifferentiated sarcoma (UDS), stage 1 or group I (17%); alveolar RMS/UDS (27%); and PME (16%). At a median follow-up of 4.3 years, 4-year FFS was 73% with VAC and 68% with VAC/VTC (P = .3). There was no difference in effect of VAC versus VAC/VTC across risk groups. The frequency of second malignancies was similar between the two treatment groups.ConclusionFor intermediate-risk RMS, VAC/VTC does not significantly improve FFS compared with VAC.

scholarly journals Shorter-Duration Therapy Using Vincristine, Dactinomycin, and Lower-Dose Cyclophosphamide With or Without Radiotherapy for Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group

2014 ◽  
Vol 32 (31) ◽  
pp. 3547-3552 ◽  
Author(s):  
David O. Walterhouse ◽  
Alberto S. Pappo ◽  
Jane L. Meza ◽  
John C. Breneman ◽  
Andrea A. Hayes-Jordan ◽  
...  
Keyword(s):  
Residual Disease ◽  
Incidence Rates ◽  
Low Risk ◽  
Newly Diagnosed ◽  
Oncology Group ◽  
Group Iii ◽  
Group I ◽  
Risk Patients ◽  
Stage 1 ◽  
Length Of Therapy

Purpose Intergroup Rhabdomyosarcoma Study Group (IRSG) studies III and IV showed improved failure-free survival (FFS) rates with vincristine, dactinomycin, and cyclophosphamide (VAC; total cumulative cyclophosphamide dose, 26.4 g/m2) compared with vincristine and dactinomycin (VA) for patients with subset-one low-risk embryonal rhabdomyosarcoma (ERMS; stage 1/2 group I/II ERMS or stage 1 group III orbit ERMS). The objective of Children's Oncology Group ARST0331 was to reduce the length of therapy without compromising FFS for this subset of low-risk patients by using VA in combination with lower-dose cyclophosphamide (total cumulative dose, 4.8 g/m2) plus radiotherapy (RT). Patients and Methods This noninferiority prospective clinical trial enrolled newly diagnosed patients with subset-one clinical features. Therapy included four cycles of VAC followed by four cycles of VA over 22 weeks. Patients with microscopic or gross residual disease at study entry received RT. Results With a median follow-up of 4.3 years, we observed 35 failures among 271 eligible patients versus 48.4 expected failures, calculated using a fixed outcome based on the FFS expected for similar patients treated on the IRSG D9602 protocol. The estimated 3-year FFS rate was 89% (95% CI, 85% to 92%), and the overall survival rate was 98% (95% CI, 95% to 99%). Patients with paratesticular tumors had the most favorable outcome. Three-year cumulative incidence rates for any local, regional, or distant failures were 7.6%, 1.5%, and 3.4%, respectively. Conclusion Shorter-duration therapy that included lower-dose cyclophosphamide and RT did not compromise FFS for patients with subset-one low-risk ERMS.

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