scholarly journals Iron status parameters in preeclamptic women in Gaza, Palestine

2020 ◽  
Vol 28 (1) ◽  
Keyword(s):  
Gestational Age ◽  
Serum Iron ◽  
Biochemical Analysis ◽  
Iron Status ◽  
Gaza Strip ◽  
Hematological Parameters ◽  
Case Control ◽  
The Body ◽  
The Other ◽  
Iron Supplements

Preeclampsia (PE) is a turmoil in the pregnancy appeared with the onset of hypertension and considerable amount of proteinuria. Extra serum iron is a causative component of oxidative stress concerned in the pathogenesis of preeclampsia. This study is a case control, conducted in 2018, and aimed to determine the iron status in preeclamptics as compared to normotensive pregnancies in Gaza strip. About 100 pregnant women with gestational age between 26 to 36 weeks. Fifty of them were preeclamptics and an equal number were without preeclampsia, aged between 18 to 35 years. Interview questionnaires were used to take sociodemographic and clinical data. Anthropometric evaluation and biochemical analysis were conducted. The SPSS version22 was used for data analysis. There was no statistically difference in the gestational age, gestational number and hemoglobin levels in the cases and controls (p≥ 0.05). In contrast, the body mass index (BMI), systolic, diastolic blood pressure (BP), and uric acid (UA) levels were significantly higher in preeclamptics (P<0.001). As well, the majority of cases were have +2 proteinuria on dipstick testing. Further, serum iron and ferritin levels were significantly higher in preeclamptics. On the other hand, ferritin levels had significant direct correlations with gestational number, previous preeclampsia, BMI, systolic BP, diastolic BP, UA, and proteinuria (P<0.05). Likewise, Iron had significant direct correlation with proteinuria (P<0.05). Preeclamptics have higher hematological parameters levels (iron & ferritin) as compared to normotensive women. However, Iron status of preeclamptic women should be assessed before giving iron supplements as these may cause more harm than benefit.

scholarly journals Is Iron Deficiency a Risk Factor for Postpartum Depression? A Case-Control Study in the Gaza Strip, Palestine

2021 ◽  
pp. 1-21
Author(s):  
Samar Hameed ◽  
Ihab A. Naser ◽  
Mohamed A. Ghussein ◽  
Mohammed S. Ellulu
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Postpartum Depression ◽  
Case Control Study ◽  
Iron Status ◽  
Gaza Strip ◽  
Case Control ◽  
Body Iron ◽  
The Gaza Strip ◽  
Control Study

Abstract Objective: This study aims to investigate the association between iron body status and postpartum depression (PPD) among mothers during the postpartum period. Design: This is a Case-Control study. Setting: Governmental primary health care centers in the Gaza Strip, Palestine. Participants: This study involved 300 mothers a month after delivery, with one 150 mothers that were recruited in the Cases group who were diagnosed with PPD based on Edinburgh Postnatal Depression Scale (EPDS) ≥10. The Control group included 150 mothers did not have PPD (EPDS <10). Body iron status represented by the index of sTfR/log Ferritin. Results: Among PPD mothers, 43.3% had low ferritin level vs. 15.3% for controls (P<0.001) and cases vs. controls difference in mean hemoglobin level was -0.61 (95% C.I -0.86, -0.35). The results of the Multiple Logistic Regression reported that there is a statistically significant association between PPD and the body iron status existed, as mothers who suffered from iron deficiency (ID) were three times more likely to have PPD (ORadj 3.25; p = 0.015). Furthermore, the results of the final regression model showed that the other factors that can lead to PPD are; absence of psychological guidance services (ORadj 8.54; p = 0.001), suffering from undesired feeling in the last pregnancy (ORadj 1.77; p = 0.034), in addition to having one of the mental health disorders in the last pregnancy (p = 0.001). Conclusion: Body iron status might be a risk factor for postpartum depression and other possibilities of. reverse causality may worsen the condition.

scholarly journals Assessment of Gastrointestinal Symptoms and Non-transferrin Bound Iron After Oral Ferrous Sulfate and Iron-enriched Aspergillus Oryzae Supplementation in Women (P24-039-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Amanda Bries ◽  
Chong Wang ◽  
Brian Wels ◽  
Isaac Agbemafle ◽  
Olivia Meier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Iron Supplementation ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Supplements

Abstract Objectives Iron deficiency anemia (IDA) is a widespread nutritional deficiency. Iron supplementation with ferrous sulfate (FeSO4) is the most common strategy to treat IDA; however, the compliance with daily FeSO4 administration is poor, due to contraindicating side effects. Previously, we have reported that A. oryzae (Ultimine®; ULT) is a novel iron source. Therefore, the objective of this study was to determine the biochemical assessment, non-transferrin bound iron (NTBI) and commonly related gastrointestinal side effects to assess the safety of A. oryzae compared to FeSO4. Methods Female participants (n = 16) with serum ferritin concentrations 40 µg/L were randomized to a double-blind, 9-wk cross-over study with a 3-wk placebo washout period between treatments. Oral iron supplements (65 mg Fe), FeSO4 and ULT were administered for 21 consecutive days for each subject. Side effect questionnaires were collected 3d/wk over the 9-wk study period. Side effects and biochemical markers (nausea, heartburn, abdominal pain, fatigue, headache, diarrhea, constipation, oxidative stress and liver and kidney function) from iron supplementation were evaluated, along with serum iron, % transferrin saturation (TS) and NBTI 8 h curves. Results Serum iron, TS, and NTBI were all markedly higher with FeSO4 at each time-point from 2–8 hours (P < 0.001) compared to ULT, whereas NTBI was undetected. Among treatments, FeSO4 resulted in higher inflammation, though not statistically significant. Compliance based on returned pills was higher with ULT (97.3%) than placebo and FeSO4 (95.2% and 93.2%, respectively). Subjects taking FeSO4 reported abdominal discomfort 2% more than ULT, which was not significantly different. FeSO4 caused marginally higher incidence of combined nauseation, constipation and diarrhea when subjects were taking FeSO4 (P < 0.07). Iron status was maintained similarly by both oral iron supplements. Oxidative stress, inflammation, kidney and liver function markers were not elevated with ULT supplementation, suggesting safety of its consumption. Conclusions Better compliance and less gastrointestinal related side effects were reported with ULT compared to FeSO4, while maintaining normal iron status. Our data suggests ULT is a safe oral iron supplement for treatment of IDA. Funding Sources Cura Global Health, Inc.

Interaction Between Genotypes for HFE and TFR2 Genes Mutations and Iron Status in Brazilian Blood Donors

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5382-5382
Author(s):  
Rodolfo D Cancado ◽  
Paulo CJL Santos ◽  
Samuel Rostelato ◽  
Cristiane T Terada ◽  
Iris Gonzales ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Blood Donors ◽  
Binding Capacity ◽  
Iron Status ◽  
Hereditary Hemochromatosis ◽  
Transferrin Saturation ◽  
The Body ◽  
Hfe Gene ◽  
Automation System

Abstract Hereditary hemochromatosis (HH) is a disorder characterized by increased intestinal iron absorption, which leads to a progressive accumulation of iron in the body. This iron overload has been associated with mutations in HFE gene (C282Y, H63D and S65C) and other genes. The objectives of this study were to assess the frequencies of functional mutations in HFE and TFR2 genes and to investigate their relationship with the iron status in a sample of blood donors. Blood donors (n=542) were recruited at the Hemocenter of the Santa Casa Hospital, Sao Paulo, Brazil. The genotypes for HFE (C282Y, H63D and S65C) TFR2 (Y250X and Q690P) gene mutations were evaluated by PCR-RFLP. The concentrations of serum iron and total iron-binding capacity (TIBC) were measured by automation system Advia®(Bayer Diagnostics) and serum ferritin by Axsym System®(Abbott Laboratories). The frequencies of HFE 282Y, HFE 63D and HFE 65C alleles were 2.1, 13.6 and 0.6%, respectively. The frequency C282Y allele (2.1%) in Brazilian blood donors is lower than that observed in blood donors from Northern Europe (5.1 to 8.2%, P&lt;0.05). The TFR2 250X and TFR2 690P alleles were not found in these subjects. The iron status was similar between HFE genotypes in women. However, men carrying HFE 282CY genotype had higher serum ferritin and lower TIBC concentrations when compared to the HFE 282CC genotype carriers. HFE 282CY genotype was also associated with higher transferrin saturation in men who donated blood at the first time. Moreover, male donors with HFE 63DD plus 63HD genotypes had higher serum iron and transferrin saturation when compared to those with HFE 63HH genotype. A relationship between HFE CY/HH/SS haplotype and lower TIBC concentrations was also found in men. The HFE 282Y and HFE 65C alleles were rare while the HFE 63D was frequent in blood donors. The mutations in TFR2 gene were not found in this study. The HFE 282Y and HFE 63D alleles were associated with alterations on iron status only in male blood donors.

scholarly journals The significance of haemochromatosis gene mutations in the general population: implications for screening

Gut ◽  
1998 ◽  
Vol 43 (6) ◽  
pp. 830-836 ◽  
Author(s):  
M J Burt ◽  
P M George ◽  
J D Upton ◽  
J A Collett ◽  
C M A Frampton ◽  
...  
Keyword(s):  
General Population ◽  
Serum Iron ◽  
Deoxyribonucleic Acid ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Gene Mutations ◽  
The Other ◽  
Phenotypic Screening ◽  
C282y Mutation ◽  
C282y Homozygosity

Background—Haemochromatosis is associated with mutations in the HFE gene but the significance of these mutations in the general population is unknown.Aims—To determine the frequency ofHFE gene mutations in the general population, their effect on serum iron indexes, and their role in screening for haemochromatosis.Methods—Deoxyribonucleic acid (DNA) from 1064 randomly selected subjects was analysed for the C282Y and H63D mutations in the HFE gene. Serum iron, transferrin saturation, and ferritin were measured and individuals with increased iron indexes were investigated to confirm or exclude a clinical diagnosis of haemochromatosis.Results—Mutations were identified in 409 individuals (38.4%) with heterozygote (carrier) frequencies of 13.2% and 24.3% for the C282Y and H63D mutations respectively. Heterozygosity for either mutation significantly increased serum iron and transferrin saturation but despite a similar trend for ferritin, this was only significant for C282Y homozygotes. Five individuals (0.47%) were homozygous for the C282Y mutation, three of whom had haemochromatosis confirmed by liver biopsy (0.28%). The other two C282Y homozygotes would not have been detected by phenotypic screening alone.Conclusions—HFE mutations are present in 38.4% of the population, affect serum iron indexes, and are important determinants of iron status. The population frequency of genetically defined haemochromatosis (C282Y homozygosity) is approximately one in 200 and is higher than the prevalence of clinically apparent haemochromatosis.

scholarly journals Inflammatory and oxidative status in European captive black rhinoceroses: a link with Iron Overload Disorder?

2020 ◽  
Author(s):  
Hanae Pouillevet ◽  
Nicolas Soetart ◽  
Delphine Boucher ◽  
Rudy Wedlarski ◽  
Laetitia Jaillardon
Keyword(s):  
Oxidative Stress ◽  
Iron Overload ◽  
Serum Iron ◽  
Iron Status ◽  
The Body ◽  
Stress Markers ◽  
Oxidative Markers ◽  
Inflammatory Status ◽  
The Impact ◽  
And Oxidative Stress

AbstractIron Overload Disorder (IOD) is a syndrome developed by captive browsing rhinoceroses like black rhinoceroses (Diceros bicornis) in which hemosiderosis settles in vital organs while free iron accumulates in the body, potentially predisposing to various secondary diseases. Captive grazing species like white rhinoceroses (Ceratotherium simum) do not seem to be affected. The pro-oxidant and pro-inflammatory properties of iron, associated with the poor antioxidant capacities of black rhinoceroses, could enhance high levels of inflammation and oxidative stress leading to rapid ageing and promoting diseases. In this prospective study, 15 black (BR) and 29 white rhinoceroses (WR) originating from 22 European zoos were blood-sampled and compared for their iron status (serum iron), liver/muscle biochemical parameters (AST, GGT, cholesterol), inflammatory status (total proteins, protein electrophoresis) and oxidative stress markers (SOD, GPX, dROMs). Results showed higher serum iron and liver enzyme levels in black rhinoceroses (P<0.01), as well as higher GPX (P<0.05) and dROM (P<0.01) levels. The albumin/globulin ratio was lower in black rhinoceroses (P<0.05) due to higher α2-globulin levels (P<0.001). The present study suggests a higher inflammatory and oxidative profile in captive BR than in WR, possibly in relation to iron status. This could be either a consequence or a cause of iron accumulation, potentially explaining rapid ageing and various diseases. Further investigations are needed to assess the prognostic value of the inflammatory and oxidative markers in captive black rhinoceroses, particularly for evaluating the impact of reduced-iron and antioxidant-supplemented diets.

scholarly journals Saliva Iron Levels to Assess Iron Status in Children

2021 ◽  
Vol 9 (E) ◽  
pp. 843-846
Author(s):  
Rostika Flora ◽  
Mohammad Zulkarnain ◽  
Nur Alam Fajar ◽  
Indah Yuliana ◽  
Risnawati Tanjung ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Diagnostic Test ◽  
Serum Iron ◽  
Iron Status ◽  
The Body ◽  
Test Results ◽  
Long Term Effects ◽  
Normal Children ◽  
Non Invasive ◽  
The Impact

BACKGROUND: Iron plays an essential role in the process of neurotransmitter synthesis and neuron myelination. Iron deficiency impacts low cognitive performance, even involved in long-term effects even though iron deficiency has been overcome. Given the impact caused by iron deficiency, it is necessary to monitor the status of iron in the body. Diagnostic tests carried out so far use blood specimens taken with invasive method. This creates fear for the child because of the pain it causes. AIM: This study aims to obtain a non-invasive alternative diagnostic test in detecting iron deficiency in children using saliva as an examination specimen. METHODS: The design of this study was case control, with a sample of elementary school children aged 9–12 years and for women who had not experienced menstruation. The sample consisted of 40 people who were taken randomly and grouped into iron deficiency and normal. Determine the group of iron deficiency and normal was based on the results of an examination of serum iron levels. Next, saliva samples were taken to determine saliva iron levels. The characteristics of the sample data were obtained through a questionnaire, while the measurement of serum iron levels was carried out by the spectrophotometric method, and the measurement of saliva iron levels was carried out by the ELISA method. Data were analyzed using Spearman’s test. RESULTS: Based on serum iron measurements, it was found that the mean serum iron levels in children with iron deficiency were lower than normal children (38.153 ± 8.99 q/dL vs. 79.198 ± 14.2219 q/dL), on the contrary, on examination of iron levels, it was found that in children with iron deficiency, saliva iron levels were higher than in normal children (5.745 ± 3.04 q/dL vs. 2,576 ± 1.43 q/dL). The correlation test results showed a significant negative correlation between serum iron levels and moderate iron levels (p = 0.000, r = –0.518). CONCLUSION: Saliva iron levels can be used as an alternative non-invasive diagnostic test to assess children’s iron status.

scholarly journals Iron status in breast-fed infants

2001 ◽  
Vol 41 (4) ◽  
pp. 191
Author(s):  
I Gusti Ayu Asih Ratnadi ◽  
Soetjiningsih Soetjiningsih
Keyword(s):  
Serum Ferritin Level ◽  
Iron Status ◽  
Ferritin Level ◽  
The Body ◽  
Inclusion Criteria ◽  
Iron Supplements ◽  
The Status ◽  
Quality Of Food ◽  
Breast Fed

Ninety infants were selected stratified proportionally random sampling and they met the inclusion criteria. Iron status was determined by the serum ferritin level concentration. The nutritional status was determined by the body weight to age based on the standard criteria of WHO NCHS. The quality of food was defined by asking the parents to keep a diary of consumed in the last 7 days minimally for three days. Out of the 90 infants, 50.4 % of them were males and 45.6 % of them were females. Most of them (93.7%) had normal nourished and 8.3 % had undernourished. The prevalence status of low iron was 18.9%. The low iron status began to occur at the age of 4 – 6 months old (6%) and the highest at the age of 9 – 12 months old (65%). Statistically significant differences were found between the iron status and the quality of food supplements over age group. The low quality of food is a risk factor influence the status of low iron. It is suggested that the iron supplements be given to breast-fed infant at the age of 4 – 6 months old.

scholarly journals Hematology and Iron Status Evaluation Based on Donation Characteristics in Dr. Sardjito Hospital, Yogyakarta

2021 ◽  
Vol 27 (3) ◽  
pp. 249
Author(s):  
Fuad Anshori ◽  
Tri Ratnaningsih ◽  
Teguh Triyono
Keyword(s):  
Iron Deficiency ◽  
Blood Donors ◽  
Blood Donation ◽  
Iron Status ◽  
Statistical Significance ◽  
Hematological Parameters ◽  
Short Interval ◽  
The Body ◽  
Iron Storage ◽  
Iron Saturation

Blood donation will reduce iron storage in the body. A high frequency of donations and short interval inter-donations may increase the risk of iron deficiency. In Indonesia, detection of iron deficiency in blood donors is not a routine procedure. Therefore, the comparison of hematology and iron status based on donor characteristics is not widely known. For a month, this study was a cross-sectional study conducted at the Blood Transfusion Service Unit, Dr. Sardjito Hospital. Subjects were routine blood donors who met the criteria for donor selection; however, subjects were excluded if the CRP level was > 10 g/L and had a history of iron supplementation. Subjects were divided based on donation frequency and blood donation interval. The Kruskal-Wallis test was used to compare variables among groups with a statistical significance of p < 0.05. This study involved 145 subjects who met the criteria. Blood donations more than 20 times showed the lowest ferritin levels and iron saturation (16.9 ng/mL and 15.08%). Ferritin levels were also increased in line with the donation interval (35.5 ng/mL; 75.3 ng/mL; 92.7 ng/mL every three months). However, the hematological parameters and iron saturation did not differ significantly based on the donation interval. Hematological parameters are easy and fast procedures but have limitations in the early detection of iron deficiency. Serum ferritin has higher specificity, but its level is affected by inflammatory conditions. Ferritin levels were consistently at the lowest level in the subjects with the highest risk of iron deficiency compared to hematologic and iron saturation parameters.

Perbandingan Efek Suplementasi Tablet Tambah Darah Dengan Dan Tanpa Vitamin C Terhadap Kadar Hemoglobin Pada Ibu Hamil Dengan Usiakehamilan 16-32 Minggu Di Desa Keniten Kecamatan Mojo Kabupaten Kediri

2017 ◽  
Vol 3 (1) ◽  
pp. 76
Author(s):  
Siti Asiyah ◽  
Dwi Estuning Rahayu ◽  
Wiranti Dwi Novita Isnaeni
Keyword(s):  
Treatment Group ◽  
Vitamin C ◽  
Gestational Age ◽  
Group Treatment ◽  
Sampling Technique ◽  
Hemoglobin Level ◽  
The Body ◽  
Control Group ◽  
Fetal Organ ◽  
And Control

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant.  That  cause of  high metabolism at the pregnancy for formed of  fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of  this research in 4 June – 11 July 2014 is for compare the effect of  iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical.  Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is  cluster random sampling is 29 mother pregnant. Comparison analysis of  iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant

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