BLOOD GROUP RELATIONSHIP WITH CORONARY HEART DISEASE

2021 ◽  
Vol 4 (1) ◽  
pp. 40-46
Author(s):  
Samuel Ginting ◽  
Pitriani . ◽  
Juni Mariati Simarmata ◽  
Chaidir Saputra Harahap
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Clinical Symptoms ◽  
Black Population ◽  
Developed Countries ◽  
Blood Type ◽  
P Value ◽  
Chi Square ◽  
The Relationship

  Coronary heart disease is a heart disease caused by narrowing of the coronary arteries, starting from the occurrence of atherosclerosis (arterial stiffness) or the accumulation of fat or plaque (plague) on the walls of the coronary arteries, either accompanied by clinical symptoms or without symptoms. Coronary heart disease (CHD) is widely reported in developed countries. The incidence of CHD in European men was recorded by WHO in 1976 as 2-14 per 1000 population and CHD is mostly found in Finland. In developing countries, the prevalence of CHD is generally rare. In South Africa in 1970 the death rate from CHD was 0.05 per 1000 black population and 1.9 per 1000 white population. In Ujung Pandang, the average treatment for CHD is 0.3 per 1000 patients. The type of research used is a quantitative study with a descriptive correlation research design, which is a study or study that describes the relationship between two variables in a situation or group of subjects. This is done to see the relationship between one variable with another variable. This study aims to see the relationship between blood type and the incidence of coronary heart disease in the CVCU room at Haji Adam Malik General Hospital Medan in 2010. The population of this study was 11 people using incidental sampling. From the statistical test using the Chi-Square test analysis, it was found that p (value) = 0.012 where p (value) < 0.05. So the results of these tests found a very close and real relationship between the relationship between blood type and the incidence of coronary heart disease. The results of this study can be used as information and increase knowledge for nursing services in hospitals about the relationship between blood type and the incidence of coronary heart disease.

scholarly journals Hubungan antara Jenis Kelamin dan Kejadian Kematian Mendadak di RSUP Prof. Dr. R. D Kandou Manado

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Gerrit J. Pangemanan ◽  
Djemi Tomuka ◽  
Nola T.S. Mallo
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sudden Death ◽  
Analytical Study ◽  
Sampling Method ◽  
P Value ◽  
Chi Square ◽  
Common Cause ◽  
Chi Square Test ◽  
The Relationship

Abstract: Sudden death could occur in anyone regardless of gender either male or female. This study was aimed to determine the relationship between gender and the incidence of sudden death at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study with across sectional design using total sampling method. The results showed 345 cases of sudden deaths consisted of 209 males and 136 females. The age ranges were 0-1 years (7 cases), 1-18 years (7 cases), 18-40 years (38 cases), 40-60 years (138 cases), and >60 years (155 cases). Coronary heart disease was the leading cause of sudden deaths (40 cases). Data analyzed by using Chi-square test showed a P value of 0.838. Conclusion: There was no relationship between gender and the incidence of sudden death. Sudden deaths were most common among males, age >60 years, with coronary heart disease as the most common cause of sudden death.Keywords: gender, sudden death Abstrak: Kematian mendadak dapat terjadi pada siapa saja, tidak memandang jenis kelamin baik laki-laki maupun perempuan. Penelitian ini bertujuan untuk mengetahui hubungan antara jenis kelamin dan kejadian kematian mendadak di RSUP Prof. Dr. R. D Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang menggunakan metode total sampling. Hasil penelitian mendapatkan 345 kasus kematian mendadak terdiri dari 209 laki-laki dan 136 perempuan. Rentang usia 0-1 tahun berjumlah 7 kasus, usia 1-18 tahun berjumlah 7 kasus, usia 18-40 tahun berjumlah 38 kasus, usia 40-60 tahun berjumlah 138 kasus, dan usia >60 tahun berjumlah 155 kasus. Penyakit jantung koroner merupakan penyebab kematian mendadak terbanyak dengan jumlah 40 kasus. Analisis data menggunakan uji chi-kuadrat mendapatkan P=0,838. Simpulan: Tidak terdapat hubungan antara jenis kelamin dengan kejadian kematian mendadak. Sebagian besar kematian mendadak ditemukan pada laki-laki, kelompok usia >60 tahun, dengan penyebab penyakit jantung koroner.Kata kunci: jenis kelamin, kematian mendadak

scholarly journals The Relationship Between Vegetarian Diet and The Risk of Coronary Heart Disease

2020 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
A. Andrianto ◽  
R. I. Gunadi
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Framingham Heart Study ◽  
Developed Countries ◽  
Vegetarian Diet ◽  
P Value ◽  
Spearman Correlation ◽  
Chd Risk ◽  
Heart Study ◽  
The Relationship

Background. Coronary heart disease (CHD) is a major cause of death in developed countries whereas most cases can be prevented by addressing behavioral risk factors, such as unhealthy diet. Vegetarian dietary patterns reduce CHD risk and mortality by 40%. The Framingham Heart Study on Hard CHD calculates a 10-year risk assessment with six predictors, two of which are lipid profile types. Aims. To discover the relationship between vegetarian diet and the risk of coronary heart disease, we did a cross-sectional analytical observation in North Jakarta using 30 healthy vegetarians and 30 healthy non-vegetarians aged of 20-34 years in 2010. Framingham Heart Study on Hard CHD 10-year risk assessments were done on both groups. Methods. Results were compared and analyzed using Mann-Whitney U and Spearman correlation tests. Results. Mann-Whitney U test showed significant differences on total cholesterol and total FHS risk points (p-value 0.000; pvalue 0.000). Spearman correlation analysis on total risk points confirms a moderate negative degree for vegetarian diet and CHD risk (r = -0.525, p-value 0.000). In conclusion, there is a significant relationship between vegetarian diet and a reduced risk of coronary heart disease in 20-34 years of age.

scholarly journals HUBUNGAN KARAKTERISTIK PERAWAT DENGAN PEMAHAMAN PENERAPAN RESUSITASI JANTUNG PARU (RJP) DI RUANGAN IGD DAN ICU RSUD DR. ACHMAD MOCHTAR BUKITTINGGI TAHUN 2017

2018 ◽  
Vol 5 (1) ◽  
pp. 91-98
Author(s):  
Aldo Yuliano ◽  
Misye Herlindawati ◽  
Ida Suryati
Keyword(s):  
Coronary Heart Disease ◽  
Developing Countries ◽  
Heart Disease ◽  
P Value ◽  
Chi Square ◽  
Chi Square Test ◽  
Work Relationship ◽  
Study Designs ◽  
Relationship Of ◽  
The Relationship

              Cases of coronary heart disease are increasing in developed and developing countries and it is estimated that by 2020 cases of coronary heart disease have reached 82 million cases. More than 60% of coronary heart disease burden globally occurs in developing countries. The purpose of this study was to determine the relationship Understanding Application Characteristics Nurse With Cardiac Pulmonary Resuscitation (CPR) in the ER and ICU hospital room Dr.Achmad Mochtar Bukittinggi Year 2017. This research method used descriptive analytic study designs Correlation approach, then the data is processed by using Chi Square test. The sample in this study as many as 33 people responden. Obtained statistical test p value = 0.014 (p <α), it can be concluded the Relationship Age Nurse With Application Understanding Cardiac Pulmonary Resuscitation (CPR), the value of p value = 0.003 (p <α ), It can be concluded that there is a relationship of Nurses education with the understanding of Implementation of Pulmonary Heart Resuscitation (RJP), obtained p value = 0,031 (p <α) it can be concluded the existence of work relationship Nurses With Understanding Implementation of Pulmonary Heart Resuscitation (RJP) value = 0.010 (p <α), it can be concluded their tenure gender relations nurse With Application understanding Cardiac Pulmonary Resuscitation (CPR). Suggestion in this research is The result of this research can be picture in improving health service especially in application of Lung Heart Resuscitation (RJP).

Hubungan Kadar Kolesterol Total Dan Hipertensi Dengan Kejadian Penyakit Jantung Koroner DI RSUD dr. Soedarso Pontianak

2018 ◽  
Vol 1 (2) ◽  
pp. 99
Author(s):  
Laila Kamila ◽  
Maulidiyah Salim
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Blood Vessels ◽  
Public Hospital ◽  
Sampling Technique ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling

Abstract: Coronary heart is a disease that offense to blood vessels and heart attack due to constriction of blood vessels. A high level of cholesterol in blood or exceeds the normal limit can form sediment in wall of blodd vessels which cause blood vessels constriction or blockage. This research object to determine whether there is a correlation between cholesterol level total and hypertension with coronary heart disease in patients who hospitalized in Regional Public Hospital of dr. Soedarso Pontianak. This study was used cross sectional design, purposive sampling technique, it gained 50 people as samples. The measurement of blood pressure was done in heart poly and cholesterol total level in clinic laboratory of Regional Public Hospital of dr. Soedarso by using enzymatic CHOD-PAP method. It can be obtained that 10 people had hypertension and 40 people did not.the average of total cholesterol was 224 mg/dl. Maximum value of total cholesterol was 224 mg/dl and 152 mg/dl as minimum value. Data has been analyzed by using statistical test, Chi-Square, to determine the correlation of total cholesterol wit coronary heart disease, obtained p value=0,024 (less than α=0,05). Correlation of hypertension and coronary heart disease gained p value=0,923 (more than α=0,05), it can be concluded that total cholesterol correlated with coronary heart disease, and there was not a correlation between hypertension and coronary heart disease.Abstrak: Jantung koroner adalah penyakit yang  menyerang pembuluh darah dan serangan jantung, karena penyempitan pada pembuluh darah. Kadar kolesterol yang tinggi dalam darah melebihi normal dapat membentuk endapan pada dinding pembuluh darah sehingga menyebabkan penyempitan dan tersumbatnya pembuluh darah. Penelitian ini bertujuan untuk mengetahui hubungan kadar kolesterol total dan hipertensi dengan penyakit jantung koroner pada pasien di RSUD dr. Soedarso Pontianak. Disain penelitian  ini menggunakan cross sectional, teknik pengambilan sampel yaitu purposive sampling, didapat jumlah sampel 50 orang. Pengukuran Tensi Darah dilakukan di poli Jantung dan pemeriksaan kadar kolesterol total di laboratorium klinik RSUD dr. Soedarso Pontianak dengan metode enzimatik CHOD-PAP. Hasil penelitian didapatkan 10 orang mengalami hipertensi dan 40 orang non hipertensi. Rata-rata kadar kolesterol total 224 mg/ dl. Nilai maksimum kadar kolesterol total yaitu 224 mg/dl dan nilai minimum yaitu 152 mg/dl. Analisa data dengan uji statistik Chi-square untuk mengetahui hubungan kolesterol total dengan penyakit jantung koroner didapatkan nilai p = 0,024 (lebih kecil dari  α 0,05). Uji hubungan hipertensi dengan penyakit jantung koroner didapat nilai p = 0,923 (lebih besar dari α 0,05), dapat disimpulkan terdapat hubungan kadar kolesterol total dengan penyakit jantung koroner dan tidak ada hubungan hipertensi dengan penyakit jantung koroner.

Antioxidant potential of diet: Association between dietary antioxidant index and odds of coronary heart disease: A case-control study

2021 ◽  
pp. 1-13
Author(s):  
Farhad Vahid ◽  
Zahra Nasiri ◽  
Amir Abbasnezhad ◽  
Ezatollah Fazeli Moghadam
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
P Value ◽  
Dietary Antioxidants ◽  
Dietary Antioxidant ◽  
The Relationship ◽  
Control Study

BACKGROUND: Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE: This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS: In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS: Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION: Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.

scholarly journals Hubungan Antara Aktivitas Fisik Dan Riwayat Keluarga Dengan Kejadian Penyakit Jantung Koroner Di Puskesmas Banjarsari Kota Metro

2021 ◽  
Vol 3 (2) ◽  
pp. 181-191
Author(s):  
Rika Yulendasari ◽  
Usastiawaty Cik Ayu Saadiah Isnainy ◽  
Rima Ary Pradisca
Keyword(s):  
Physical Activity ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Self Care ◽  
Care Quality ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

ABSTRACT: RELATIONSHIP BETWEEN PHYSICAL ACTIVITY AND FAMILY HISTORY WITH CORONARY HEART DISEASE AT PUSKESMAS  BANJARSARI METRO Introduction: Based on data in coronary heart events Metro City 2018 total which is 1,309 new cases. For new diseases 190 men and 22 for women cases,  for old cases 369 men and 528 women in 2019 have a very drastic decrease, with total of new and old 229 patients with heart disease , for new diseases which is 32 men and 57 cases and women, for an old cases which is 60 cases for men and 80 cases for women.Purpose:  to known relations between physical activity and family history with coronary heart disease at Puskesmas Banjarsari Metro in 2020.Method: quantitative research type, analytical survey research plan with cross sectional approach, population and sample in research patients with heart failure are22 respondents. Univariate and bivariate data analysis used chi square test.Result : From 23 respondents, 13 respondents (56,5%) with low activity, families at risk which is 14 respondents (55,0%),  12 respondent (52,2%) with coronary heart, results of statistical tests using the chi square test obtained p-value = 0,022(< 0.05) , p-value = 0,006(< 0.05).Conclusion : Results of using the chi square test obtained p-value = 0,022(< 0.05) that means there is a relations between physical actiivity with occurrence coronary heart disease in Puskesmas Banjarsari Kota Metro 2020. Results of using the chi square test obtained p-value = 0,006(< 0.05) that means there is a relations between history of family with occurrence coronary heart disease in Puskesmas Banjarsari Kota Metro 2020. For peoples who risk of coronary heart disease (CHD) to behave healthy living by maintaining a diet by consuming foods that conform to diet coronary heart patients, avoid smoking, not consuming alcohol beverages, maintain weight stability and exercise regulary. Keywords : Knowledge, Self Care, Quality of life.       INTISARI:HUBUNGAN ANTARA AKTIVITAS FISIK DAN RIWAYAT KELUARGA DENGAN KEJADIAN PENYAKIT JANTUNG KORONER DI PUSKESMAS RAWAT INAP BANJARSARI KOTA METRO  Pendahuluan: Berdasarkan data kejadian jantung koroner di Kota Metro tahun 2018 pada berdasarkan jumlah kasus baru dan lama  sebanyak 1.309 dengan pembagian penyakit baru, laki-laki sebanyak 190 orang, perempuan sebanyak 22 orang, dan kasus lama, laki-laki sebanyak 369 orang, perempuan sebanyak 528 orang, pada tahun 2019 mengalami penurunan yang sangat drastis, yaitu total pasien jantung baru dan lama sebanyak 229 orang, dengan pembagian penyakit baru, laki-laki sebanyak 32 orang, perempuan sebanyak 57 orang, dan kasus lama, laki-laki sebanyak 60 orang, perempuan sebanyak 80 orang.Tujuan: Diketahui hubungan antara aktivitas fisik dan riwayat keluarga dengan kejadian penyakit jantung koroner di Puskesmas Banjarsari Kota Metro Tahun 2020.Metode: Jenis penelitian kuantitatif, rancangan penelitian survey analitik dengan pendekatan cross sectional, populasi dan sampel dalam penelitian ini adalah pasien gagal jantung sebanyak 22  responden, Analisa data menggunakan univariat dan bivariat menggunakan uji chi square.Hasil : Dari 23 responden dengan aktivitas kurang sebanyak 13 responden (56,5%), riwayat keluarga beresiko sebanyak 14 responden (55,0%),  jantung koroner sebanyak 12 responden (52,2%), Hasil uji statistik menggunakan uji chi square didapat nilai p-value = 0,022 (< 0.05) , p-value = 0,006 (< 0.05).Kesimpulan : Hasil uji statistik menggunakan uji chi square didapat nilai p-value = 0,022 (< 0.05) yang artinya terdapat hubungan antara aktivitas fisik dengan kejadian penyakit jantung koroner di Puskesmas Banjarsari Kota Metro Tahun 2020. Hasil uji statistik menggunakan uji chi square didapat nilai p-value = 0,006 (< 0.05) yang artinya terdapat hubungan antara riwayat keluarga dengan kejadian penyakit jantung koroner di Puskesmas Banjarsari Kota Metro  Tahun 2020Bagi seseorang yang mempunyai resiko terhadap terjadinya Penyakit Jantung Koroner (PJK) untuk berperilaku hidup sehat dengan jalan menjaga pola makan dengan jalan mengkonsumsi makanan yang sesuai dengan pola diit penderita PJK, menghindari merokok, tidak mengkonsumsi minuman beralkohol, menjaga kestabilan berat badan dan berolah raga secara teratur. Kata Kunci      : Pengetahuan, Self Care, Kualitas Hidup 

scholarly journals Relationship Of Food Consumption With Disease Hypertension In Elderly at Panti Jompo Yayasan Guna Budi Bakti Medan Labuhan

2019 ◽  
Vol 1 (1) ◽  
pp. 29-34
Author(s):  
Ihsan Isan Kurniawan
Keyword(s):  
Nursing Home ◽  
Food Consumption ◽  
The Elderly ◽  
Developed Countries ◽  
World Health ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

Based on WHO data (World Health Organition), around 972 million people in the world or 26.4% of people worldwide have hypertension, the figure is likely to increase to 29.2% in 2025. Of the 972 million hypertension, 333 million are in developed countries and the remaining 639 are in developing countries including Indonesia. This research aims to determine the relationship of food consumption with hypertension in the elderly at the Nursing Home in Medan Labuhan Foundation for the Budi Bakti in 2018. The research design is an analytical survey to determine the relationship between two variables with a cross sectional approach. The population in this study were patients who suffered from hypertension in the Nursing Home Foundation Medan Labuhan For Bakti Budi Bakti in 2018 totaling 64 people and a sample of 64 people and using total sampling. The test in this study is Chi-square test. The results of this study showed that 61 (95.3%) of the majority had poor food consumption, and the majority of hypertensive diseases were as heavy as 45 respondents (70.3%), bivariate statistic test results showed that there was a relationship between food consumption and hypertension with p value -Velue = 0.004.     The conclusion in this study is that there is a relationship between food consumption and hypertension is p-velue = 0.004 α 0.05, so Ha is accepted. Suggestions for further researchers to be able to examine the causes and relationship of food consumption with hypertension.

scholarly journals Hubungan periodontitis dengan penyakit jantung koroner pada pasien di RSUP Prof. Dr. R. D. Kandou Manado

e-GIGI ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Jolanda P. Ticoalu ◽  
Billy J. Kepel ◽  
Christy N. Mintjelungan
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Periodontal Disease ◽  
Systemic Disease ◽  
Case Control ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Cross Sectional Design

Abstract: Periodontitis is one of the factors causing systemic disease. It is often associated with increasing signs of inflammation and it is also an indicator of the risk factors of coronary heart disease (CHD). Infection of periodontal structures can accelerate the form of atherosclerosis that causes coronary heart disease due to systemic inflammation through the release of endotoxins, proteins, or acute phase reactors. This was a case control analytical study with a cross sectional design conducted at Prof. Dr. R. D. Kandou Hospital Manado from August to September 2016. There were 40 respondents (20 CHD patients and 20 non-CHD patients) obtained by using total sampling method. Periodontal disease indexes of the samples were evaluated by using periodontal disease index of Ramfjord 1959. The Chi-square test showed a p value of 0.01. Conclusion: There was a significant relationship between periodontitis and coronary heart disease in patients at Prof. Dr. R. D. Kandou Hospital Manado. Keywords: periodontitis, Coronary Heart Disease (CHD) Abstrak: Periodontitis merupakan salah satu faktor penyebab penyakit sistemik. Pada periodontitis sering didapatkan peningkatan tanda-tanda inflamasi yang juga merupakan salah satu indikator dari faktor risiko penyakit jantung koroner (PJK). Infeksi struktur periodontal dapat mempercepat pembentukan aterosklerosis yang menjadi penyebab PJK dengan cara menimbulkan inflamasi sistemik melalui pelepasan endotoksin, protein, atau reaktor fase akut. Jenis penelitian ialah analitik menggunakan case control dengan desain potong lintang. Penelitian dilakukan di RSUP Prof. Dr. R. D. Kandou Manado pada bulan Agustus sampai September 2016. Terdapat 40 responden (20 pasien PJK dan 20 pasien non PJK) diperoleh dengan menggunakan metode total sampling. Pada penelitian ini dilakukan pengukuran indeks penyakit periodontal menggunakan pengukuran PDI Ramfjord 1959. Analisis data menggunakan uji Chi-square. Hasil analisis bivariat menggunakan uji Chi-square menunjukkan nilai p=0,01 (0,01<0,05) yang menyatakan bahwa terdapat hubungan antara periodontitis dengan PJK pada pasien di RSUP Prof. Dr. R. D. Kandou Manado. Simpulan: Terdapat hubungan bermakna antara periodontitis dengan penyakit jantung koroner pada pasien di RSUP Prof. Dr. R. D. Kandou Manado.Kata kunci: periodontitis, penyakit jantung koroner (PJK)

scholarly journals HUBUNGAN ANTARA GOLONGAN DARAH DAN PENYAKIT JANTUNG KORONER

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Yoma Kristiani Tarukbua’ ◽  
Lucia Panda ◽  
Ventje Kawengian
Keyword(s):  
Coronary Heart Disease ◽  
Developing Countries ◽  
Heart Disease ◽  
Mortality Rate ◽  
Cross Sectional Study ◽  
Blood Type ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

Abstract: Coronary heart disease (CHD) is a disease with a high mortality rate in both developed and developing countries. Blood type is a particular feature of human in an individual's blood, such as ABO and Rhesus groups. The purpose of this study to determine the relate of blood type and CHD. Methods Cross sectional study using a study by the number of respondents in this study were 42 patients CHD checks from November to December 2012 at poliklinik Jantung BLU RSUP Prof. Dr. R. D Kandou, Manado. Based on Chi Square test showed the value of Pearson Chi Square, which obtained significance value is 1.000 (significant value <0.05), so it was concluded that there is no significant relate between blood type and CHD. Keywords: CAD, Blood Group, Cross Sectional     Abstrak: Penyakit jantung koroner (PJK) merupakan penyakit dengan angka mortalitas yang tinggi baik di negara maju maupun berkembang. Golongan darah merupakan ciri khusus darah dari suatu individu, seperti golongan ABO maupun Rhesus. Tujuan penelitian ini untuk mengetahui hubungan golongan darah dan PJK. Metode penelitian menggunakan studi Cross Sectional dengan jumlah responden dalam penelitian ini adalah 42 pasien PJK yang melakukan pemeriksaan mulai bulan November hingga Desember 2012 di poliklinik Jantung BLU RSUP Prof. Dr. R. D Kandou, Manado. Berdasarkan uji Chi Square menunjukkan nilai Pearson Chi Square, yang didapatkan nilai signifikansinya adalah 1,000 (nilai signifikan <0,05), sehingga disimpulkan bahwa tidak terdapat hubungan bermakna antara golongan darah dan PJK. Kata kunci: PJK, Golongan Darah, Cross Sectional

scholarly journals Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD

2021 ◽  
Vol 11 (6) ◽  
pp. 506
Author(s):  
Yana V. Polonskaya ◽  
Elena V. Kashtanova ◽  
Ivan S. Murashov ◽  
Evgenia V. Striukova ◽  
Alexey V. Kurguzov ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Relative Risk ◽  
Matrix Metalloproteinases ◽  
Coronary Arteries ◽  
Serum Levels ◽  
Blood Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Potential Biomarkers

This work is aimed at studying the relationship of matrix metalloproteinases with calcification of the coronary arteries. The study included 78 people with coronary heart disease (CHD) and 36 without CHD. Blood and samples of coronary arteries obtained as a result of endarterectomy were examined. Serum levels of metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, and MMP-13 were determined by multiplex analysis. In blood vessel samples, MMP-1, MMP-3, MMP-7, and MMP-9 were determined by enzyme immunoassay; MMP-9 expression was evaluated by immunohistochemistry. Patients with CHD had higher serum levels of MMP-1, MMP-7, and MMP-12. Blood levels of MMP-1 and MMP-3 were associated with calcium levels, MMP-9 with osteoprotegerin and osteonectin, MMP-7 and MMP-10 with osteoprotegerin, MMP-12 with osteocalcin, and MMP-13 with osteopontin. Calcified plaques had higher levels of MMP-1 and MMP-9 compared to plaques without calcification. The relative risk of coronary arteries calcification was associated with MMP-9, which is confirmed by the results of immunohistochemistry. The results obtained indicate the participation of some MMPs, and especially MMP-9, in the calcification processes. The study can serve as a basis for the further study of the possibility of using MMP-1, MMP-7 and MMP-12 as potential biomarkers of CHD.

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