Delaying effect of pyrroloquinoline quinone on age-related skin aging in mice and its mechanisms

2021 ◽  
Keyword(s):  
Pyrroloquinoline Quinone ◽  
Skin Aging ◽  
Age Related

scholarly journals Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging Features of Various Plants of the Greek Flora

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1206
Author(s):  
Aimilia D. Sklirou ◽  
Maria T. Angelopoulou ◽  
Aikaterini Argyropoulou ◽  
Eliza Chaita ◽  
Vasiliki Ioanna Boka ◽  
...  
Keyword(s):  
Plant Species ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Ultra Performance Liquid Chromatography ◽  
Skin Aging ◽  
Rosa Damascena ◽  
Phytochemical Study ◽  
Age Related

Skin health is heavily affected by ultraviolet irradiation from the sun. In addition, senile skin is characterized by major changes in the collagen, elastin and in the hyaluronan content. Natural products (NPs) have been shown to delay cellular senescence or in vivo aging by regulating age-related signaling pathways. Moreover, NPs are a preferable source of photoprotective agents and have been proven to be useful against the undesirable skin hyperpigmentation. Greek flora harvests great plant diversity with approximately 6000 plant species, as it has a wealth of NPs. Here, we report an extensive screening among hundreds of plant species. More than 440 plant species and subspecies were selected and evaluated. The extracts were screened for their antioxidant and anti-melanogenic properties, while the most promising were further subjected to various in vitro and cell-based assays related to skin aging. In parallel, their chemical profile was analyzed with High-Performance Thin-Layer Chromatography (HPTLC) and/or Ultra-Performance Liquid Chromatography High-Resolution Mass Spectrometry (UPLC-HRMS). A variety of extracts were identified that can be of great value for the cosmetic industry, since they combine antioxidant, photoprotective, anti-melanogenic and anti-aging properties. In particular, the methanolic extracts of Sideritis scardica and Rosa damascena could be worthy of further attention, since they showed interesting chemical profiles and promising properties against specific targets involved in skin aging.

scholarly journals Longevity strategies in response to light in the reef coral Stylophora pistillata

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alexandre Ottaviani ◽  
Rita Eid ◽  
Didier Zoccola ◽  
Mélanie Pousse ◽  
Jean-Marc Dubal ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Nuclear Translocation ◽  
Human Fibroblasts ◽  
Reef Coral ◽  
Biological Response ◽  
Skin Aging ◽  
Stylophora Pistillata ◽  
Reef Corals ◽  
Effective Interventions ◽  
Age Related

AbstractAging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic stress is a key driver of cellular senescence. Because symbiotic long-lived reef corals experience daily hyperoxic and hypoxic transitions, we hypothesized that these long-lived animals have developed specific longevity strategies in response to light. We analyzed transcriptome variation in the reef coral Stylophora pistillata during the day–night cycle and revealed a signature of the FoxO longevity pathway. We confirmed this pathway by immunofluorescence using antibodies against coral FoxO to demonstrate its nuclear translocation. Through qPCR analysis of nycthemeral variations of candidate genes under different light regimens, we found that, among genes that were specifically up- or downregulated upon exposure to light, human orthologs of two “light-up” genes (HEY1 and LONF3) exhibited anti-senescence properties in primary human fibroblasts. Therefore, these genes are interesting candidates for counteracting skin aging. We propose a large screen for other light-up genes and an investigation of the biological response of reef corals to light (e.g., metabolic switching) to elucidate these processes and identify effective interventions for promoting healthy aging in humans.

scholarly journals Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1529 ◽  
Author(s):  
Yeon Ja Choi
Keyword(s):  
Calorie Restriction ◽  
Skin Diseases ◽  
Skin Aging ◽  
Peroxisome Proliferator ◽  
Extrinsic Factors ◽  
Inflammatory Skin Diseases ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Age Related ◽  
Skin Biology

During the aging process of an organism, the skin gradually loses its structural and functional characteristics. The skin becomes more fragile and vulnerable to damage, which may contribute to age-related diseases and even death. Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation. While calorie restriction (CR) is the most effective intervention to extend the lifespan of organisms and prevent age-related disorders, its effects on cutaneous aging and disorders are poorly understood. This review discusses the effects of CR and its alternative dietary intake on skin biology, with a focus on skin aging. CR structurally and functionally affects most of the skin and has been reported to rescue both age-related and photo-induced changes. The anti-inflammatory, anti-oxidative, stem cell maintenance, and metabolic activities of CR contribute to its beneficial effects on the skin. To the best of the author’s knowledge, the effects of fasting or a specific nutrient-restricted diet on skin aging have not been evaluated; these strategies offer benefits in wound healing and inflammatory skin diseases. In addition, well-known CR mimetics, including resveratrol, metformin, rapamycin, and peroxisome proliferator-activated receptor agonists, show CR-like prevention against skin aging. An overview of the role of CR in skin biology will provide valuable insights that would eventually lead to improvements in skin health.

scholarly journals In VivoAntioxidant and Anti-Skin-Aging Activities of Ethyl Acetate Extraction fromIdesia polycarpaDefatted Fruit Residue in Aging Mice Induced by D-Galactose

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Yang Ye ◽  
Ran-ran Jia ◽  
Lin Tang ◽  
Fang Chen
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Radical Scavenging ◽  
Antioxidant Defense System ◽  
Skin Aging ◽  
Age Related ◽  
Skin Collagen ◽  
Total Antioxidant ◽  
Mda Content

Two different concentrations of D-galactose (D-gal) induced organism and skin aging in Kunming mice were used to examine comprehensively the antioxidant and antiaging activities of ethyl acetate extraction (EAE) fromIdesia polycarpadefatted fruit residue for the first time. The oxygen radical absorbance capacity (ORAC) of EAE was 13.09 ± 0.11 μmol Trolox equivalents (TE)/mg, which showed EAE had greatin vitrofree radical scavenging and antioxidant activity. Biochemical indexes and morphological analysis of all tested tissues showed that EAE could effectively improve the total antioxidant capacity (T-AOC) of the antioxidant defense system of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of tissues and serum, increase glutathione (GSH) content and decrease the malondialdehyde (MDA) content, and maintain the skin collagen, elastin, and moisture content. Meanwhile, EAE could effectively attenuate the morphological damage in brain, liver, kidney, and skin induced by D-gal and its effect was not less than that of the well-known L-ascorbic acid (VC) andα-tocopherol (VE). Overall, EAE is a potent natural antiaging agent with great antioxidant activity, which can be developed as a new medicine and cosmetic for the treatment of age-related conditions.

scholarly journals Skin Aging, Cellular Senescence and Natural Polyphenols

2021 ◽  
Vol 22 (23) ◽  
pp. 12641
Author(s):  
Erika Csekes ◽  
Lucia Račková
Keyword(s):  
Cellular Senescence ◽  
Skin Aging ◽  
The Body ◽  
Skin Changes ◽  
Natural Polyphenols ◽  
Current State ◽  
Age Related ◽  
Aged Skin ◽  
And Function

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli impacting its morphology and function. Senescent cells have been found to accumulate with age and may contribute to age-related skin changes and pathologies. Natural polyphenols exert many health benefits, including ameliorative effects on skin aging. By affecting molecular pathways of senescence, polyphenols are able to prevent or delay the senescence formation and, consequently, avoid or ameliorate aging and age-associated pathologies of the skin. This review aims to provide an overview of the current state of knowledge in skin aging and cellular senescence, and to summarize the recent in vitro studies related to the anti-senescent mechanisms of natural polyphenols carried out on keratinocytes, melanocytes and fibroblasts. Aged skin in the context of the COVID-19 pandemic will be also discussed.

scholarly journals Age-Related Surface Oxidases Shed into Body Fluids as Targets to Prevent Skin Aging and Reduce Cardiovascular Risk

2014 ◽  
Vol 04 (03) ◽  
pp. 119-129 ◽  
Author(s):  
D. James Morré ◽  
Dale Kern ◽  
Christiaan Meadows ◽  
Helen Knaggs ◽  
Dorothy M. Morré
Keyword(s):  
Cardiovascular Risk ◽  
Skin Aging ◽  
Body Fluids ◽  
Age Related

scholarly journals Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Maria Shirshakova ◽  
Elena Morozova ◽  
Daria Sokolova ◽  
Svetlana Pervykh ◽  
Lyailya Kayumova
Keyword(s):  
Connective Tissue ◽  
Soft Tissues ◽  
Skin Condition ◽  
Skin Aging ◽  
Facial Soft Tissue ◽  
Cosmetic Procedure ◽  
Calcium Hydroxylapatite ◽  
Age Related ◽  
Connective Tissue Dysplasia ◽  
Soft Tissue Changes

Undifferentiated connective tissue dysplasia is one of the most common diseases of nowadays, which does not fit into the group of hereditary syndromes. This condition is diagnosed in 20–50% of the population at any age. The study aimed to correct the facial soft tissues of patients with undifferentiated connective tissue dysplasia through the cosmetic procedure of calcium hydroxylapatite injection. In 2018, a 36-year-old patient addressed the beauty salon with signs of undifferentiated connective tissue dysplasia, such as severe asymmetry of the face, infraorbital and nasolabial sulci, and thin and easily folding skin. Signs were observed from the age of 22, i.e., for 14 years. The therapy was performed using special features of the correction of facial soft tissue changes in patients with connective tissue dysplasia (CTD) using calcium hydroxylapatite-based products (Radiesse®, Merz North America, Inc., USA). Particular attention is given to the need for early correction to prevent premature skin aging related to this condition. After 14 days, a significant improvement of the patient’s skin condition was noted after the passing of two procedures. Her condition was estimated as consistent with T1-2P0G0A1Zh1 P1M1K1 and corresponded to grade I age-related changes in the superficial soft tissues. The performed treatment showed high efficacy in case of mild connective tissue dysplasia diagnosis. The results showed that when collecting information from anamnesis, the diagnostic criteria for dysplasia should be considered. If the criteria are met, the cosmetological correction with collagen stimulators becomes possible.

scholarly journals Age-related changes in the lower third of the face considering anatomical and physiological aspects and morphotypes of skin aging

2020 ◽  
Vol 23 (4) ◽  
pp. 258-264
Author(s):  
N. P. Teplyuk ◽  
Serafima V. Lebedeva
Keyword(s):  
Subcutaneous Fat ◽  
Skin Aging ◽  
Facial Aging ◽  
Chronological Aging ◽  
Age Related ◽  
The Face ◽  
Deep Layers ◽  
Bone Structures ◽  
Age Related Changes

All areas and tissues of the face will go through age-related changes; however, aging occurs at a faster rate in the lower third of the face than in other areas. This study presents the anatomical and physiological aspects of age-related changes in all areas and tissues of the face, mainly in the lower third, such as the skin, subcutaneous fat, muscular-aponeurotic system, deep layers of adipose tissue, and bone structures of the face. Involutional changes were differentiated by taking into account the constitutional and architectonic features of the face. Heterochronous and heterotopic characteristics of age-related changes, cutaneous, and treatment components of facial aging were identified. The most commonly used visual scales to assess cosmetic effects and determine chronological aging included global aesthetic improvement scale, Glogau scale, Fitzpatrick wrinkle classification, and Merz visual 5-point aging scale. According to the classification of age-related changes proposed by Kolgunenko, five morphotypes of aging are distinguished: tired, wrinkled, deformation, mixed, and muscular. Understanding the pathogenesis of involutional changes in the lower third of the face in patients with different morphotypes of aging allows for an objective and individualized choice of optimal therapy methods.

scholarly journals Segregation of age-related skin microbiome characteristics by functionality

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hye-Jin Kim ◽  
Jin Ju Kim ◽  
Nu Ri Myeong ◽  
Taeyune Kim ◽  
DooA Kim ◽  
...  
Keyword(s):  
Chinese Women ◽  
Age Groups ◽  
Amplicon Sequencing ◽  
Skin Aging ◽  
Future Research ◽  
Rrna Gene ◽  
Skin Microbiome ◽  
Age Related ◽  
Functional Pathways ◽  
Two Age Groups

AbstractAlthough physiological changes are the most evident indicators of skin aging by alteration of the skin’s structure and function, we question whether skin aging is also affected by the structure and assembly process of the skin microbiome. We analysed the skin microbiomes of 73 healthy Chinese women in two age groups (25–35 years old and 56–63 years old) using 16S rRNA gene amplicon sequencing; the overall microbiome structure was significantly different between the two age groups. An analysis using ecological theory to evaluate the process of microbial community assembly processes revealed that the microbiomes of the older group were formed under a greater influence of the niche-based process, with the network of microbes being more collapsed than that of the younger group. Inferred metagenomic functional pathways associated with replication and repair were relatively more predominant in the younger group whereas, among the various metabolism-related pathways, those associated with biodegradation were more predominant in the older group. Interestingly, we found two segregated sub-typing patterns in the younger group which were also observed in the skin microbiomes of young Chinese women living in four other cities in China. The results of our study highlights candidate microbes and functional pathways that are important for future research into preventing skin aging and which could lead to a comprehensive understanding of age-related skin microbiome characteristics.

scholarly journals Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals

2020 ◽  
Vol 10 (5) ◽  
pp. 1594 ◽  
Author(s):  
Eliana B. Souto ◽  
Ana Rita Fernandes ◽  
Carlos Martins-Gomes ◽  
Tiago E. Coutinho ◽  
Alessandra Durazzo ◽  
...  
Keyword(s):  
Topical Administration ◽  
Skin Aging ◽  
Pharmaceutical Products ◽  
Skin Delivery ◽  
Naturally Occurring ◽  
Age Related ◽  
Efficient Delivery ◽  
Aged Skin ◽  
Chemical Products ◽  
Interesting Alternative

Skin aging is described as dermatologic changes either naturally occurring over the course of years or as the result of the exposure to environmental factors (e.g., chemical products, pollution, infrared and ultraviolet radiations). The production of collagen and elastin, the main structural proteins responsible for skin strength and elasticity, is reduced during aging, while their role in skin rejuvenation can trigger a wrinkle reversing effect. Elasticity loss, wrinkles, dry skin, and thinning are some of the signs that can be associated with skin aging. To overcome skin aging, many strategies using natural and synthetic ingredients are being developed aiming to reduce the signs of aging and/or to treat age-related skin problems (e.g., spots, hyper- or hypopigmentation). Among the different approaches in tissue regeneration, the use of nanomaterials loaded with cosmeceuticals (e.g., phytochemicals, vitamins, hyaluronic acid, and growth factors) has become an interesting alternative. Based on their bioactivities and using different nanoformulations as efficient delivery systems, several cosmeceutical and pharmaceutical products are now available on the market aiming to mitigate the signs of aged skin. This manuscript discusses the state of the art of nanomaterials commonly used for topical administration of active ingredients formulated in nanopharmaceuticals and nanocosmeceuticals for skin anti-aging.

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