TO STUDY THE SIGNIFICANCE OF VARIOUS BIOCHEMICAL AND ND HEMATOLOGICAL PARAMETERS IN COVID CASES IN INDIA IN 2 WAVE OF COVID-19 PANDEMIC: STUDY FROM PUNE, MAHARASHTRA

2021 ◽  
pp. 14-17
Author(s):  
Aruna Chhikara
Keyword(s):  
Middle Age ◽  
Hematological Parameters ◽  
Clinical Manifestations ◽  
Control Group ◽  
Surrogate Markers ◽  
Rt Pcr ◽  
Course Of Disease ◽  
Indian Context ◽  
Infectivity Rate ◽  
D Dimer

COVID -19 infection is an ongoing pandemic. The world has already witness two waves and a third one is imminent. Also the COVID 19 infection is now presenting with numerous manifestation besides respiratory symptom. Thus it becomes essential to study surrogate markers or various biochemical and hematological parameters and their signicance in these cases. Data available so far is mostly from other nations with only a limited number of studies from Indian context. Thus the present study was conducted to evaluate the signicance of laboratory parameters in predicting cases infected with COVID 19 and also the correlation of these parameters with gender and course of disease. 557 subjects were included in this study from Pune, Maharashtra. The groups were divided into cases and controls on basis of RT PCR results and clinical manifestations. The control group had 442 subjects and the cases were 135 in number. The inammatory markers (CRP, D-dimer and ferritin) were signicantly high in cases as compared to controls. Among cases 40 % patients belonged to young age (<45 years), 38% to middle age (45 -59 years) and 22 % to elderly group (>60 years). This shows high infectivity rate in st younger group as compared to 1 wave. NLR was higher in cases as compared to controls. CRP, D-dimer and ferritin were signicantly higher in cases as compared to controls

scholarly journals Hematological abnormalities and comorbidities are associated with COVID-19 severity among hospitalized patients: Experience from Bangladesh

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0255379
Author(s):  
Md. Ashrafur Rahman ◽  
Yeasna Shanjana ◽  
Md. Ismail Tushar ◽  
Tarif Mahmud ◽  
Ghazi Muhammad Sayedur Rahman ◽  
...  
Keyword(s):  
Hematological Parameters ◽  
Treatment Protocol ◽  
Blood Parameters ◽  
Rt Pcr ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hematological Abnormalities ◽  
Positive Correlations ◽  
Patients Experience ◽  
D Dimer

Background The hematological abnormalities are assumed to be involved in the disease progression of COVID-19. However, the actual associations between specific blood parameters and COVID-19 are not well understood. Here we aimed to assess the correlations between hematological parameters and the severity of COVID-19. Methods We included COVID-19 patients who were admitted to Evercare Hospital Ltd, Dhaka, Bangladesh, between November 10, 2020, to April 12, 2021, with a confirmed case of RT-PCR test. We recorded demographic information, clinical data, and routine hematological examination results of all COVID-19 patients. We performed statistical analyses and interpretation of data to compare severe COVID-19 patients (SCP) and non-severe COVID-19 patients (NSCP). Results The age and BMI of the admitted COVID-19 patients were 48.79±8.53 years and 25.82±3.75 kg/m2. This study included a total of 306 hospitalized COVID-19 patients. Among them, NSCP and SCP were 198 and 108, respectively. And we recorded 12 deaths from SCP. We observed the alterations of several hematological parameters between SCP and NSCP. Among them, we noticed the increased levels of C-reactive protein (CRP), d-dimer, and ferritin showed good indicative value to evaluate the severity of COVID-19. Also, there were positive correlations among these parameters. Moreover, we found correlations between the outcomes of COVID-19 patients with patient’s demographics and comorbid diseases. Conclusion Based on our results, CRP, d-dimer, and ferritin levels at admission to hospitals represent simple assessment factors for COVID-19 severity and the treatment decisions at the hospital setup. These blood parameters could serve as indicators for the prognosis and severity of COVID-19. Therefore, our study findings might help to develop a treatment protocol for COVID-19 patients at the hospital setup.

scholarly journals DETERMINATION OF HEMATOLOGICAL PARAMETERS AND D-DIMER AMONG SUDANESE CHILDREN INFECTED WITH PLASMODIUM FALCIPARUM IN KHARTOUM STATE – SUDAN.

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Fatima H. Abdallah ◽  
Abuzar Elnager ◽  
Safa Wdidi ◽  
Alneil M. Hamza ◽  
Abdalla E. Ali
Keyword(s):  
Plasmodium Falciparum ◽  
Platelet Count ◽  
Hematological Parameters ◽  
Hematological Parameter ◽  
Control Group ◽  
Healthy Children ◽  
Parameter Measuring ◽  
Hematological Changes ◽  
D Dimer

Background: Falciparum malaria is one of the causes of morbidity and mortality in third world , the pathogenesis of the infection results from the sequestration of infected hematological change in vital organs. Aim:  this study aim to measuring  hematological changes and  D- dimer among children affected with P falciparum. Methods: The total study group100 children, 60 as case study infected with Plasmodium Falciparum and 40 as control group healthy children. Hematological parameter measuring by hematological analyzer and D dimer measured by fluorescence Immunoassay used I. Chroma instrument. Results: Statistical analysis results of sixty children infected with malaria falciparum participated in the study the mean±SD had a significantly lower Hb (8.14gm/dl  ± 2.2) and haematocrit (24.4% ± 6.6) than control children (p <0.001), Thrombocytopenia was found in 59.3% of enrolled patients. Platelet count (98.53% ± 48.9) , D. dimer (7397.58 ng/ml ± 5867.07)  (p <0.001). D. dimer showed correlation with parasite density, Platelet count and Haematocrit correlated (r = 0.4, p <0.0001); (p <0.001). Conclusion: Malaria infection by plasmodium falciparum had major effects on hematological parameters such as thrombocytopenia , anemia and hyper coagulation   have been significantly associated with severity of malaria falciparum.  Keywords: Plasmodiu, Falciparum, D-dimer, Hematological parameters

scholarly journals Validation of the "Six Step Spot Test" for gait among patients with multiple sclerosis in Brazil

2010 ◽  
Vol 68 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Karina Pavan ◽  
Charles Peter Tilbery ◽  
Sergio Lianza ◽  
Bruna Eriko Matsuda Marangoni
Keyword(s):  
Multiple Sclerosis ◽  
Healthy Subjects ◽  
Clinical Manifestations ◽  
Spot Test ◽  
Lower Limbs ◽  
Control Group ◽  
Study Group ◽  
Course Of Disease ◽  
Time Performance ◽  
Gradual Accumulation

The clinical manifestations of multiple sclerosis (MS) are variable among patients, and the course of disease is not linear. Different symptoms are presented, with gradual accumulation of disability. These variations are difficult to quantify in clinical practice, and several studies have attempted to create instruments capable of measuring these disabilities. The Six Step Spot Test (SSST) was developed for quantitative evaluation of the lower limbs (LL) over time. Performance in this test reflects the complexity of sensory-motor function, including LL strength, spasticity, coordination and balance, going beyond vision and cognition. The aim of the present study was to validate the SSST in a population of MS patients in Brazil. This prospective study included 75 patients with MS, with EDSS 0 to 6.5 in the study group. Ninety-one healthy subjects were randomly selected for the control group. The results showed that the groups were similar, and that the SSST is a reliable and reproducible test. According to the statistical analysis on the data in this study, the SSST is a valid, reliable and reproducible tool for use in the Brazilian MS patient population.

scholarly journals Alteration of biomarkers of expired and cured COVID- 19 ICU patients in a tertiary care hospital

2021 ◽  
Vol 7 (2) ◽  
pp. 1031-1037
Author(s):  
Abu Hasan ◽  
Rummana Rahim ◽  
Mizanur Rahman
Keyword(s):  
Biochemical Parameters ◽  
Target Genes ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr ◽  
C Reactive Protein ◽  
Protein Ratio ◽  
Reactive Protein ◽  
D Dimer

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2). This is a retrospective observational study aimed to find the alteration of some biochemical and hematological parameters of 121 COVID-19 patients admitted in intensive care unit (ICU) of Evercare Hospital Dhaka during May to December 2020. Methods: Retrospective biochemical, hematological and molecular (COVID-19 RT-PCR Ct value) markers were analyzed on COVID-19 patients in ICU and compared on those who died in the ICU and those cured. Results: Comparison of viral titer assessed by RT-PCR Ct values of target genes of SARS-CoV-2 among cured and expired patients did not show any significant differences. However, biochemical parameters such as CRP, Ferritin and hematological parameters such as WBC, absolute neutrophil, absolute lymphocyte, D-dimer showed significant differences among cured and expired patients. Patients who died in ICU mean CRP, Ferritin, D-dimer, WBC, absolute neutrophil were 10.39, 7694.30, 3196, 16.38, 15.12 respectively, compared to cured patients 0.93, 457.57, 773, 11.24, 8.86 respectively, with 95% confidence interval (95% CI). Platelets and absolute lymphocytes were observed decreased in expired patients compared to cured. Further, elevated level of neutrophil to lymphocyte ratio (NLR) and reduced level of lymphocyte to C-reactive protein ratio (LCR) has significant correlation with disease severity. Conclusion: These findings indicate that biochemical parameters such as CRP, Ferritin and hematological parameters such as CBC, D-Dimer, NLR, LCR can be monitored to identify severity and fatality of COVID-19 patients and thus, may help in improving disease outcome. Bioresearch Commu. 7(2): 1031-1037, 2021 (June)

scholarly journals Assessment of Macrophage Inflammatory Biomarkers and Neutrophil Extracellular Traps Associated Proteins in COVID-19 Patients

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4193-4193
Author(s):  
Laura Lopez de Frutos ◽  
Irene Serrano-Gonzalo ◽  
Barbara Menendez-Jandula ◽  
Esther Franco-Garcia ◽  
Carlos Lahoz ◽  
...  
Keyword(s):  
Health System ◽  
Macrophage Activation ◽  
Conflicts Of Interest ◽  
Clinical Manifestations ◽  
Neutrophil Extracellular Traps ◽  
Endothelial Damage ◽  
Control Group ◽  
P Value ◽  
Extracellular Traps ◽  
D Dimer

Abstract Background : The SARS-CoV-2 infection activates both innate and adaptive immune responses and induces an exaggerated cytokine storm leading to causes septic shock, acute respiratory distress syndrome, and/or multiple organ failure in critically ill patients. The knowledge of this dysregulated immune response is not well explained. One hypothesis is that the response of macrophages and neutrophils to infection is disproportionate, resulting in overproduction of cytokines and activation of neutrophils leading to the most severe complications of infection, including the production of multiple microthrombi and endothelial damage. Aim of the study: To evaluate the activation levels of macrophage biomarkers as well as indicators of the development of neutrophil extracellular traps (NET) in the first phase of infection in hospitalized patients with COVID19. Patients and Methods: We selected dry blood spot from a total of 60 previously identified SARS-CoV-2 infected subjects. Plasma samples were provided by the Aragon Health System Biobank's collection and were extracted within 5 days of symptom onset. Plasma from 60 healthy controls were used to stablish the control range for NETosis determination. The study was authorized by the Ethics Committee of the Aragon Health System and complies with the European General Data Protection Regulation (GDPR 2016/679) and LO 3/2018. Demographic characteristics, clinical manifestations, follow-up during hospitalization, associated comorbidities, and thrombotic complications were obtained from the database. Chitotriosidase activity (ChT), YKL40 chitinase and CCL18/PARC cytokine were measured as markers of macrophage activation. Myeloperoxidase (MPO), Neutrophil Elastase (NE), and S100A8/S100A9 Heterodimer (MPR) were immuno-quantified, levels of circulating free DNA (cfDNA) were measured as well as the presence of DNAsases by fluorimetry as indicators of Netosis. For the comparative analysis, we stratified patients by age groups and disease severity and used the Mann-Whitney U test for statistical comparison, considering a p-value &lt; 0.05 as statistically significant. Results : A statistically significant increase in ChT (p=0.032) and CCL18/PARC (p=0.0001) was observed in the patients´ group. A comparative study with clinical variables and other inflammation markers as ferritin, D-dimer will be shown upon acceptance. Concerning NET markers, we found a statistically significant increase in MPO, NE, and MRP in COVID-19 patients (p=0.0001; p=0.0290; p=0.0001 respectively), as well as a statistically significant decrease in DNAsa (p=0.0001). No differences in cfDNA levels were observed. The table shows the median (quartile1-quartile3) for each marker in the control group and in the patient group. Conclusions : In this study, biomarkers of macrophage activation do not appear to be more sensitive than the indicators of inflammation in routine clinical practice (ferritin, D-dimer). Clinical cases of severe COVID-19 disease show an excessive NET formation, which contributes to vascular damage and the development of thrombosis. This work was supported by a research grant from FEETEG Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Extrapulmonary Manifestations of COVID-19: A Call to Extra Vigilance and Tribute to Dr Li Wenliang

2020 ◽  
Vol 1 (1) ◽  
pp. xi-xiv ◽  
Author(s):  
AM Onoja ◽  
GTA Jombo ◽  
AT Onoja ◽  
AI Nwannadi ◽  
IH Aba
Keyword(s):  
Degradation Products ◽  
Clinical Manifestations ◽  
Fulminant Myocarditis ◽  
Severe Thrombocytopenia ◽  
Disseminated Intravascular Coagulopathy ◽  
Course Of Disease ◽  
Fibrin Degradation Products ◽  
Intravascular Coagulopathy ◽  
Life Threatening ◽  
D Dimer

COVID-19 pandemic has covered all continents and virtually all countries of the world infecting millions of people with several hundred thousands of death. It was first brought to the attention of a Chinese ophthalmologist Dr Li Wenliang. The disease which was first believed to be solely associated with the lungs and respiratory system has now shown that the spectrum of organ involvement of the disease is much larger than earlier believed.  While lung and pulmonary features still account for a much larger presentation of the disease, other clinical manifestations such as  fulminant myocarditis, arteriovenous thromboembolism, disseminated intravascular coagulopathy, intracerebral haemorrhage, diarrhea, hypoxic encephalopathy, septicaemia and detection of SARS-CoV-2 particles in stool, saliva and semen of infected individuals are also becoming less infrequent. Haematologic manifestations of hypercoagulable blood are commonly reported among hospitalized COVID‐19 patients.  An elevated  D‐Dimer, that is rising  in the course of disease may signifies disease deterioration. Prolonged PT and aPTT and increased fibrin degradation products with severe thrombocytopenia have been associated with life-threatening disseminated intravascular coagulation (DIC). Physicians should therefore be on a watch out for these features in the management of patients and be ready to spot out other new surprises by the disease. This should be through deepening of curiosity by health personnel in the assessment and management of patients to spot out early surprises of COVID-19 to strengthen the sustenance of the ongoing control of the pandemic

Laboratory assessment of fibrinolysis markers at coronary artery bypass surgery

2017 ◽  
Author(s):  
Н. Самсонова ◽  
М. Рыбка ◽  
Е. Рогальская ◽  
И. Ворожка ◽  
Д. Хинчагов ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Clinical Manifestations ◽  
Control Group ◽  
Type I ◽  
D Dimer

Введение. При операциях аортокоронарного шунтирования (АКШ) клинические проявления фибринолиза выражены слабо. Цель исследования: оценка возможности использования биохимических маркеров для определения степени активации фибринолиза на различных этапах АКШ. Материалы и методы. Обследовано 40 больных ишемической болезнью сердца, которым выполнялась операция реваскуляризации миокарда на работающем сердце в условиях искусственного кровообращения. Пациенты были поделены на 4 группы, 3 из которых, в зависимости от применяемого антифибринолитика, обозначены как группа «ε-аминокапроновая кислота» («ЕАКК»), группа «транексамовая кислота» («ТК»), группа «аминометилбензойная кислота» («АМБК»). В четвертой группе антифибринолитик не применялся, эта группа использована в качестве контрольной. У всех пациентам исследовали уровень маркеров активации системы гемостаза и фибринолиза, регистрировали тромбоэластограмму (ТЭГ). Результаты. Между группами не найдено различий в активности плазминогена, ингибитора плазмина, показателя LY 30 в ТЭГ. Уровень активности ингибитора активатора плазминогена I типа снижался от этапа к этапу исследования в группе контроля и последовательно увеличивался в группах, где применялись антифибринолитики. В группе контроля наблюдался максимальный рост содержания Д-димера, в группе «ТК» – минимальный. Заключение. Наиболее информативным лабораторным маркером активации системы фибринолиза является уровень Д-димера. Introduction. Clinical manifestations of fibrinolysis are weakly expressed during coronary artery bypass surgery (CABS). The aim of study: to assess the possibility of biochemical markers usage for determination of fibrinolysis activation at various CABS stages. Materials and methods. We examined 40 patients with ischemic heart disease during myocardial revascularization surgery on working heart under cardiopulmonary bypass. Patients were divided into four groups; depending on applied antifibrinolytics three of them were denoted as «ε-aminocaproic acid» («EAСА») group, «tranexamic acid» («TА») group and «aminomethylbenzoic acid» («AMBА») group. In fourth group antifibrinolytic was not applied, this group was used as a control. In all patients we examined markers level of hemostasis and fibrinolysis activation and registered tromboelastogram parameters (TEG). Results. We didn’t found any differences in activities of plasminogen and plasmin inhibitor, LY 30 parameter (in TEG) between groups. Inhibitor of plasminogen activator type I activity reduced from stage to stage of CABS in control group and consistently increased in study groups. We observed maximal increasing of D-dimer content in control group and minimal rising of D-dimer concentration in «TА» group. Conclusion. D-dimer level is the most informative laboratory marker of fibrinolysis activation.

scholarly journals ASSESSMENT OF THE DEPENDENCE OF THE CLINICAL MANIFESTATION OF ACUTE GASTROENTERITIS CAUSED BY ROTAVIRUS ON ITS GENOTYPES

2020 ◽  
pp. 52-59
Author(s):  
Mariia Teslenko ◽  
Lyudmila Chernyshova
Keyword(s):  
Acute Gastroenteritis ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Severe Illness ◽  
Rt Pcr ◽  
Severe Dehydration ◽  
Course Of Disease ◽  
Immunoenzymatic Assay ◽  
Children Under 5

The leading cause of acute gastroenteritis (AGE) in children is rotavirus. In different countries, different rotavirus genotypes prevail and are associated with different severity of disease. The purpose of our study was to identify the distribution of rotavirus genotypes in Kyiv, Ukraine, and to determine the correlation between the genotypes and course of disease. Materials and methods. 978 children under 5 years of age were examined with АGE symptoms and not vaccinated against rotavirus. Determination of rotavirus antigen and genotype were performed using the immunoenzymatic assay and real-time RT-PCR. We assessed the demographics, clinical manifestations of AGE, the Vesikari scale AGE severity. Results. The G4P[8] genotype prevailed in Ukraine during 2014-2018. The G1P[8] was the second most common. G9P8 was the third, the fourth place was shared by G2P[4] and G3P[8]. Fever, as a manifestation, was more pronounced in G1P[8] and G3P[9]. The highest number of vomiting episodes per day occurred in the G1P[8] and G4P[8]-related cases. Maximum of diarrhea episodes per day was observed in genotypes G1P[8], G3P[8], G4P[8] and G9P[8]. Mucus and blood in stool were found in genotypes G3P[8] (1/33.33 %), G4P[8] – blood (1/2.27 %). The children with genotypes G1P[8] and G4P[8] had catarrhal symptoms. More cases of moderate and severe dehydration, occurred in the G4P[8]. The Vesikari scale analysis showed that only G1P[8] led to mild cases(3.57 %). The most widespread genotypes, G1P[8] and G4P[8], led to a moderate illness in 14.29 % and 13.56 % cases, respectively, and to a severe illness in 82.14 % and 86.44 % cases, respectively. Conclusions. G4P[8] was associated with the most severe disease due to more frequent and prolonged vomiting, febrile fever and bloody diarrhea. G1P[8] and G4P[8] were associated with catarrh.

scholarly journals Clinical manifestations, CT features and outcome of 39 patients with COVID-19: retrospective case analysis

2020 ◽  
Author(s):  
Haohao Lu ◽  
Chuansheng Zheng ◽  
Qiaoxia Tong ◽  
Jin Tian
Keyword(s):  
Early Stage ◽  
Clinical Manifestations ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Rt Pcr ◽  
Retrospective Case ◽  
Recovery Stage ◽  
Discharged Patients ◽  
D Dimer ◽  
Pulmonary Ct

Abstract 1. BackgroundTo explore the manifestations and evolution of the pulmonary CT in COVID-19, and to analyze the causes and countermeasures of “Recurrent positive” in discharged patients.2. MethodsData of 39 patients with COVID-19 were collected. RT-PCR was positive at admission.From onset to discharge, pulmonary CT was performed regularly.During the treatment,Blood-RT,CRP and D-dimer were detected.3.ResultFrom the onset to 14 days, the lesions in pulmonary CT increased significantly.After treatment, pulmonary CT before discharge showed that some patients' lesions were completely absorbed, and some residual strip like lesions or ground glass opacity with reduced density.Two weeks after discharge, there were 2 patients with new ground glass opacity.There were 20 patients with D-dimer increased.4.ConclusionIn the early stage of COVID-19, the pulmonary CT has the characteristic manifestations, which is helpful for early diagnosis.In the middle stage, pulmonary lesions changed rapidly.In the recovery stage, some of the patients remained strip like lesions.It is necessary to pay attention to the possibility of pulmonary fibrosis after recovery.The discharge standard of COVID-19 needs to be more strict to avoid “Recurrent positive”,the discharged patients should continue to be observed.D-dimer was increased in some patients, it is safe to use heparin in anticoagulation without contraindications.

QUANTITATIVE ANALYSIS OF BIOCHEMICALAND HEMATOLOGICAL MARKERS IN COVID 19 PATIENTS AT DEDICATED COVID CARE HOSPITAL IN SOUTHERN RAJASTHAN

2021 ◽  
pp. 55-59
Author(s):  
Manju Lata Gupta ◽  
Namita Goyal ◽  
Dharmendra Garg ◽  
Anju Mishra ◽  
Priyanka Kumari ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Virus Disease ◽  
Hematological Parameters ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr ◽  
Icu Patients ◽  
Hematological Markers ◽  
High Dependency ◽  
D Dimer

Introduction: - Corona virus disease (COVID-19) is an emerging disease that threatens the biosecurity of all countries and spreading rapidly worldwide. Early diagnosis of the disease is essential because of high infectivity and mortality rates of COVID-19. Aims and objective: -The study was to observe and compare the clinical, biochemical and hematological proles between high dependency unit (HDU), Intensive care unit (ICU) and pregnant women with conrmed COVID 19 positive RT-PCR. Material and methods: - This study is conducted in COVID-19 dedicated Tertiary Care Hospital attached to RNT Medical College, Udaipur of Southern Rajasthan. Data of all patients with conrmed positive RT-PCR was collected during April 26, 2021 to May 31, 2021 from respective Lab Coordinator appointed for this purpose. SPSS statistics software was used for data statistics and mapping. Continuous variables were expressed as median and IQR (Inter Quarentile Range). Results:- Out of 428 patients 174 patients were in ICU, 235patients were in HDU and 19 patients were pregnant women. Mean age of 428 is 47.32 year ranging 18-86yrs. Among these 428 patients 267(62.38%) patients were males and 161(37.62%) patients were females. The biochemical, coagulation and hematological parameters such as Serum Ferritin, Lactate Dehydrogenase, C-Reactive Protein, Blood Sugar, D-Dimer, Prothrombin Time & INR, ESR, WBC, and Absolute Neutrophil Count were statistically signicant(p<0·05) across all comparisons(ICU,HDU and pregnant women). IL6 (Interleukin-6) and Hemoglobin were signicantly (p<0·05) lower in pregnant women as compare to ICU patients. Absolute lymphocyte count, Platelet, Platelet lymphocyte ratio were signicantly (p<0·05) lower in HDU patients as compare to ICU patients. Conclusion:- The present study has evaluated the clinical utility of biochemical parameter such as Ferritin, CRP, LDH, D-Dimer, and hematological markers like WBC, Neutrophils and Lymphocytes as signicant predictors of COVID-19 outcome.

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