Physical development and idiopathic nephrotic syndrome in children

2020 ◽  
Vol 24 (3) ◽  
pp. 79-89
Author(s):  
O. A. Zhdanova ◽  
T. L. Nastausheva ◽  
G. A. Batischeva ◽  
A. P. Savchenko ◽  
E. V. Stenshinskaya ◽  
...  
Keyword(s):  
Body Weight ◽  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Body Height ◽  
Physical Development ◽  
Overweight And Obesity ◽  
Healthy Children ◽  
Z Score ◽  
Before And After ◽  
Steroid Sensitive Nephrotic Syndrome

INTRODUCTION. Study of physical development (PD) of children with idiopathic nephrotic syndrome (INS) includes mainly assessment of body height and weight during corticosteroid (CS) therapy; specifics of these criteria before and after the treatment are not sufficiently studied. THE AIM: to study PD of children with INS debut during CS therapy and upon its completion.PATIENTS AND METHODS. A retrospective analysis of PD was performed in 89 patients with INS in Voronezh Regional Children's Clinical Hospital No.1 during 1998-2014 using method of Z-score of body height and weight in comparison with regional standards.RESULTS. At the INS debut body height of 38.2% of the children and body weight of 41.2% accordingly were less than those of healthy children, p<0.001. Children with steroid-sensitive nephrotic syndrome (SSNS) had no difference in body height Z-score during CS therapy (0.17±1.06) and upon its completion (0.28±1.22), p=0.794. Body height was less in steroiddependent patients (SDNS) compared to SSNS patients. Z-score body weight values in children with SSNS were higher during maximum doses of CS (0.94±1.59) and returned to previous values after the therapy (-0.24±1.33), р=0,040. Patients with a frequent relapsing SSNS and SDNS had overweight and obesity remained after prednisone treatment (p=0.009).CONCLUSION. Physical development of children with INS has differences associated with CS therapy. Since body height and weight of children with INS were different from the norms before CS therapy, this could be influenced by genetic factors, which to be studied further. The results can be used to prognose CS therapy influence on PD of patients and assess prognosis of INS.

Is overweight/obesity a risk factor for atopic allergic disease in prepubertal children? A case–control study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aysel Vehapoglu ◽  
Zeynep Ebru Cakın ◽  
Feyza Ustabas Kahraman ◽  
Mustafa Atilla Nursoy ◽  
Ali Toprak
Keyword(s):  
Body Weight ◽  
Allergic Disease ◽  
Weight Status ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
University Hospital ◽  
Healthy Children ◽  
Prepubertal Children ◽  
Body Weight Status ◽  
Increased Risk

Abstract Objectives It is unclear whether body weight status (underweight/normal weight/overweight/obese) is associated with allergic disease. Our objective was to investigate the relationship between body weight status (body mass index; BMI) and atopic allergic disease in prepubertal children, and to compare children with atopic allergic diseases with non atopic healthy children. Methods A prospective cross sectional study of 707 prepubertal children aged 3–10 years was performed; the participants were 278 atopic children with physician-diagnosed allergic disease (allergic rhinitis and asthma) (serum total IgE level >100 kU/l and eosinophilia >4%, or positivity to at least one allergen in skin test) and 429 non atopic healthy age- and sex-matched controls. Data were collected between December 2019 and November 2020 at the Pediatric General and Pediatric Allergy Outpatient Clinics of Bezmialem Vakıf University Hospital. Results Underweight was observed in 11.6% of all participants (10.8% of atopic children, 12.2% of healthy controls), and obesity in 14.9% of all participants (18.0% of atopic children, 12.8% of controls). Obese (OR 1.71; 95% CI: 1.08–2.71, p=0.021), and overweight status (OR 1.62; 95% CI: 1.06–2.50, p=0.026) were associated with an increased risk of atopic allergic disease compared to normal weight in pre-pubertal children. This association did not differ by gender. There was no relationship between underweight status and atopic allergic disease (OR 1.03; 95% CI: 0.63–1.68, p=0.894). Conclusions Overweight and obesity were associated with an increased risk of atopic allergic disease compared to normal weight among middle-income and high-income pre pubertal children living in Istanbul.

scholarly journals Effects of Three Different Family-Based Interventions in Overweight and Obese Children: The “4 Your Family” Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 341
Author(s):  
Panagiotis Varagiannis ◽  
Emmanuella Magriplis ◽  
Grigoris Risvas ◽  
Katerina Vamvouka ◽  
Adamantia Nisianaki ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Screen Time ◽  
Overweight And Obesity ◽  
Z Score ◽  
Obese Children ◽  
Group 3 ◽  
Group 2 ◽  
Family Based ◽  
Family Based Interventions

Childhood overweight and obesity prevalence has risen dramatically in the past decades, and family-based interventions may be an effective method to improve children’s eating behaviors. This study aimed to evaluate the effectiveness of three different family-based interventions: group-based, individual-based, or by website approach. Parents and school aged overweight or obese children, 8–12 years of age, were eligible for the study. A total of 115 children were randomly allocated in one of the three interventions, and 91 completed the study (79% compliance); Group 1 (n = 36) received group-based interventions by various experts; Group 2 (n = 30) had interpersonal family meetings with a dietitian; and Group 3 (n = 25) received training through a specifically developed website. Anthropometric, dietary, physical activity, and screen time outcomes were measured at baseline and at the end of the study. Within-group comparisons indicated significant improvement in body weight, body mass index (BMI)-z-score, physical activity, and screen time from baseline in all three study groups (p < 0.05). Furthermore, total body fat percentage (%TBF) was also decreased in Groups 2 and 3. Between-group differences varied with body weight and %TBF change, being larger in Group 3 compared to Groups 1 and 2, in contrast to BMI-z-score, screen time, and health behaviors, which were significantly larger in Group 2 than the other two groups. In conclusion, personalized family-based interventions are recommended to successfully improve children’s lifestyle and body weight status.

scholarly journals „Z”-scores of anthropometric and motor parameters of girls in aerobic gymnastics

2014 ◽  
Vol 61 (2) ◽  
pp. 55-58
Author(s):  
M. Tibenská ◽  
H. Medeková
Keyword(s):  
Body Weight ◽  
Body Height ◽  
Sport Performance ◽  
Z Score ◽  
Anthropometric Parameters ◽  
Percentage Of Body Fat ◽  
Standing Long Jump ◽  
Z Scores ◽  
Long Jump ◽  
Shuttle Run

Abstract This study presents the evaluation of chosen anthropometric and motor parameters in group of female junior competitors throughout the course of 2-year preparation of aerobic gymnastics by means of Z-scores. The observed group consisted of 12 girls (average age at the beginning of observance 14.08 ± 1.19 years). Evaluation of anthropometric (body height, body weight, body mass index, percentage of body fat, acting body weight) and motor parameters (sit-ups in 30 seconds and 60 seconds, pull-ups to bar, modified push-ups, standing long jump, backwards tandem walking, shuttle run 4×10 m, Jacík’s test) was carried out in standard conditions in nine girls at 3-month intervals. It has been confirmed that female probands with higher Z-score of motor parameters together with lower Z-score of anthropometric parameters achieved higher sport performance during the 2-year observance at competitions, with an exception of one such proband.

scholarly journals Somatic development and some motor performances of young girls based on age and birth season

2013 ◽  
Vol 7 (1) ◽  
pp. 117-123
Author(s):  
Eszter Szabó ◽  
Danica Keczeli ◽  
István Farmosi ◽  
Sándorné Gaál ◽  
Katalin Keresztesi
Keyword(s):  
Body Weight ◽  
Body Height ◽  
Physical Development ◽  
Mean Value ◽  
Birth Season ◽  
Mean Values ◽  
Somatic Development ◽  
Young Girls ◽  
Study Results ◽  
Continuous Running

There are numerous publications in the literature reporting physical development and motor performances of children of different ages based on sex and various environmental factors. However, there are not many publications on the birth season effect. The aim of the study was to evaluate the differences among children in physical development and motor performances based on age and birth season. Physical development described by body height and body weight, in addition to motor performance indicators including the twenty-metre dash, standing broad jump, six minutes of continuous running, throwing with a stuffed ball, and obstacle race-tests were studied. The survey included the participation of 426 girls. From the group the seven-, eight-, and nine-year olds numbered 148, 191, and 87 respectively. The group of girls who were born in winter, spring, summer and autumn numbered 114, 110, 89 and119 respectively. The tested data were evaluated with unitrate analyses of variance using SPSS statistical package. Mean value, standard error, standard deviation and coefficient of variation were calculated. The significance of differences between mean values was evaluated using “t” test. Differences with an error below 5% were considered to be significant. Furthermore, a correlation analysis was used to evaluate the relationship between season of birth, body development and motor-related performance data. Age, body height, body weight, throwing a stuffed ball in one hand, twenty-metre dash, six minutes of continuous running, and obstacle race-test are interdependent variables of development and motor performances of young girls of this age. Data from the study results show that the children group included in the tests was quite homogenous in body height, but heterogeneous in body weight and motor performances. Physical development and four of the five evaluated sport skills were affected by the birth season. Development and motor performances of the summer- and autumn-born girls are generally better than those born in winter or spring. Differences are significant except for the obstacle race-test. Age, body height, body weight, throwing with a stuffed ball in one hand, twentymetre dash, six minutes of continuous running, and the obstacle race-test seem to be interdependent variables of development and motor performances of young girls of this age.

scholarly journals Comparative analysis of children’s physical development in different age groups in Voronezh region 15 years apart (1997-1999 and 2011-2014)

2017 ◽  
Vol 98 (3) ◽  
pp. 433-439
Author(s):  
O A Zhdanova
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Height ◽  
Age Groups ◽  
Physical Development ◽  
World Health ◽  
Who Standards ◽  
Voronezh Region ◽  
Health Organization

Aim. To investigate physical development of children in Voronezh region in different age groups in 2011-2014 in comparison with the regional studies data in 1997-1999. Methods. The study was performed on 5644 children aged 1-18 years of health groups I and II in comparison with the data of 10 247 children aged 1-14 years examined in 1997-1999. Body height, weight and body mass index Z-scores, calculated using WHO AnthroPlus software, were evaluated. Results. Children’s Z-score values for body height in 2011-2014 were higher than in 1997-1999 in all age groups and at the age of 1-9 years these values exceeded World Health Organization (WHO) standards. Girls’ height approached the standards in 10-14 and 15-18 years, and boys’ height - in 15-18 years. Body weight of children aged 2-8 years was higher than the regional data in 1997-1999 and WHO standards approaching them at the age of 9. Body mass index increase compared to WHO standards was revealed in children aged 1-4 years (p=0.000), and in 2011-2014 the reported differences were less prominent than in 1997-1999. In 2011-2014 among 15-18-years-old girls the shift of body mass index values to the lack of body weight was noted, in 1997-1999 the same changes were found out for 10-14-years-old girls. Conclusion. In 2011-2014 specific attention was required to be paid to physical development of children at the age from 1 to 4 years due to overweight risk of and girls aged 15-18 years due to probable underweight risk.

Gut Microbiota Dysbiosis in Children with Relapsing Idiopathic Nephrotic Syndrome

2018 ◽  
Vol 47 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Shoji Tsuji ◽  
Chikushi Suruda ◽  
Masaki Hashiyada ◽  
Takahisa Kimata ◽  
Sohsaku Yamanouchi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gut Microbiota ◽  
Butyric Acid ◽  
Idiopathic Nephrotic Syndrome ◽  
Flow Cytometric Analysis ◽  
Metagenomic Analysis ◽  
Healthy Children ◽  
Cd4 Cells ◽  
Acid Producing Bacteria ◽  
Gut Microbiota Dysbiosis

Background: While the etiology of idiopathic nephrotic syndrome (idiopathic nephrotic syndrome [INS]; characterized by repeated relapses and comorbid allergic conditions) remains unknown, recent evidence suggests that dysfunction in regulatory T cells (Tregs) plays an important role in the development of INS as well as allergic diseases. We hypothesized that dysbiosis involving decreased butyric acid-producing gut microbiota leads to defective induction and differentiation of peripherally induced Tregs, resulting in INS relapse. Methods: Study subjects were 12 children with INS, 8 classified as relapsing (R group; median age: 3.0 years) and 4 as non-relapsing (NR group; median age: 4.3 years), and 11 healthy children (HC group; median age: 5.1 years) serving as normal controls. Measurement of microbiota was performed using 16S ribosomal RNA metagenomic analysis, and fecal butyric acid was measured using high performance liquid chromatography. Flow-cytometric analysis of Tregs and CD4-positive (CD4+) cells in peripheral blood was also performed. Results: Metagenomic analysis of gut microbiota using feces showed that the proportion of butyric acid-producing bacteria was significantly lower in R (median 6.36%) than HC (median 18.84%; p = 0.0013), but no different between NR (median 16.71%) and HC (p = 0.29). Fecal organic acid analysis revealed significantly lower butyric acid quantities in R than HC (medians: 0.48 vs. 0.99 mg/g, p = 0.042). Circulating Tregs as a proportion of CD4+ cells were decreased in 75% of R and NR. Conclusion: Pediatric relapsing INS patients show gut microbiota dysbiosis, characterized by a decreased proportion of butyric acid-producing bacteria and lower fecal butyric acid quantities, concomitant with reduced circulatory Tregs.

Bone mineral density and its influencing factors in children with idiopathic nephrotic syndrome: a prospective observational study

2019 ◽  
Vol 49 (4) ◽  
pp. 292-298
Author(s):  
Indar K Sharawat ◽  
Lesa Dawman ◽  
Merabhai V Kumkhaniya ◽  
Kusum Devpura ◽  
Amarjeet Mehta
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Bone Mineral ◽  
Idiopathic Nephrotic Syndrome ◽  
Serum Vitamin ◽  
Z Score ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Glucocorticoids are first-line therapy for children with idiopathic nephrotic syndrome (INS). These children are at risk of deranged bone metabolism and low bone mineral density (BMD). We studied 60 children with INS and divided them into two groups. Group 1 included 21 children (initial and infrequent relapsing) and group 2 included 39 children (frequent relapsing, steroid dependent and steroid resistant). Dual-energy X-ray absorptiometry of the lumbar spine was performed to assess BMD. Mean BMD Z-score was compared in both groups; this correlated significantly on univariate analysis with cumulative steroid dose, serum vitamin D levels and calcium supplementation. However, on multivariate analysis, serum vitamin D level was the only factor significantly predictive of low z-score.

scholarly journals Weight status and body composition analysis among Polish boys with autism spectrum disorders

2021 ◽  
Vol 84 (2) ◽  
pp. 151-161
Author(s):  
Sylwia Trambacz-Oleszak
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Autism Spectrum Disorders ◽  
Weight Status ◽  
Body Height ◽  
Autism Spectrum ◽  
Overweight And Obesity ◽  
Z Scores ◽  
Spectrum Disorders ◽  
Standard Deviations

Abstract Currently, autism spectrum disorders (ASD) are one of the main health care problems in both Poland and in other countries. There are limited studies on the physical growth and body composition among children and adolescents with ASD. Several studies have indicated that the prevalence of unhealthy weight is high among autistic patients. Therefore, the main aim of this study was to assess the prevalence of underweight, overweight and obesity of Polish boys with ASD and to analyse body composition. A cross-sectional study was performed on 29 Polish boys aged 3–11 with autism. Anthropometric measurements were taken. Bioelectrical impedance analysis (BIA) was used to evaluate body composition. The percentile values and z-scores for body height, body weight and BMI were calculated. The CDC cut–points were used to determine weight status. Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 25. 16.1% autistic boys had z-scores for body weight above two standard deviations, 12.9% had z-scores for body height above two standard deviations and z-scores for BMI above two standard deviations were found in 19.4% of the boys. 13.8% of autistic boys were underweight, 48.3% had healthy weight, 20.7% were overweight, and 17.2% were obese. The mean value of body fat percentage was 18.46%, and 16.1% of the boys with ASD had higher than normal fat tissue. There is a high prevalence of overweight and obesity among Polish boys with autism.

scholarly journals A descriptive retrospective study on children with newly diagnosed nephrotic syndrome presented to Tripoli Children Hospital during the period between Jan. to Dec. 2014

2016 ◽  
Author(s):  
Naziha Ramadan Rhuma ◽  
Awatif S El Boeshi ◽  
Laila T Sabei ◽  
Azza M Kara
Keyword(s):  
Nephrotic Syndrome ◽  
Retrospective Study ◽  
Family History ◽  
Steroid Therapy ◽  
Idiopathic Nephrotic Syndrome ◽  
Newly Diagnosed ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
Group 2 ◽  
Group 1

Introduction: Nephrotic syndrome is a clinical picture characterized by severe proteinuria, hypoalbuminemia, edema and hypercholesterolemia. A retrospective study was carried out in order to describe disease pattern in newly diagnosed nephrotic syndrome of children admitted to Tripoli children hospital during the year 2014.Methods: The medical data of 56 patients aged between 1 year and 11 years diagnosed with idiopathic nephrotic syndrome were analysed using SPSS software. The data included gender differences, sensitivity to steroid therapy, relapses during six months of follow up and the effect of variable factors such as family history, hypertension, hematuria, serum urea on the degree of relapse.Results: Out of 56 patients with newly diagnosed nephrotic syndrome (NS), 60.7% were boys and 39.3% were girls, with a mean age 4.2±2.2 years. Age  was related significantly to the response to steroid therapy, where 79.5% of patients aged between 2-8 years (group 1) had steroid sensitive nephrotic syndrome (SSNS) compared with only 41.7% of patients aged less than 2 years or more than 8 years (group 2)  (P<0.001).  Although girls relapsed more than boys (70.5% versus 57.1%) during six months of therapy, this difference was not statistically significant. Similarly, no other factors measured such as family history of NS, hypertension, hematuria, serum complement and urea had any effect on the percentage of relapse in patients with newly diagnosed NS.  Conclusion: NS is one of the commonest reasons for admission to nephrology ward. It is more common in boys than girls. The age at presentation related significantly to the response to steroidal therapy. Regarding relapses, girls seems to relapse more frequent than boys and relapses was seen more in age group 1 than group 2, however, these differences were not significant. Other factors studied seems to have no effect on the relapse rate of children with newly diagnosed NS.Key-words: Idiopathic nephrotic syndrome, Steroid sensitive nephrotic syndrome, Steroid resistant nephrotic syndrome, Proteinuria.

scholarly journals Influence of prednisone therapy on physical development of children with nephrotic syndrome

2019 ◽  
Vol 23 (5) ◽  
pp. 88-95 ◽  
Author(s):  
T. L. Nastausheva ◽  
E. E. Boeva ◽  
T. G. Zvyagina ◽  
E. N. Kulakova ◽  
N. S. Nastausheva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Nephrotic Syndrome ◽  
Body Mass ◽  
Cumulative Dose ◽  
Physical Development ◽  
The Body ◽  
Prednisone Therapy ◽  
Steroid Sensitive ◽  
Relationship Of

THE AIM: to compare the parameters of physical development (PD) in children with idiopathic nephrotic syndrome (INS), depending on the treatment with prednisone.PATIENTS AND METHODS. The effect of treatment with prednisone on PD was analyzed in 60 children with INS aged from 2 to 17 years. The children were divided into 2 groups: 30 children who did not receive prednisone, and 30 children who received it during the last 6 months before the study (1st and 2nd group, respectively). The groups compared the anamnestic parameters and the risk factors of children in terms of length, weight, and body mass index.RESULTS. When comparing the characteristics of the risk factors of children of the above 2 groups, differences in body mass and BMI were established. In children who received prednisone for the last 6 months, body weight and BMI were significantly exceeded compared to WHO standards and similar patients who did not receive prednisone for the last 6 months. We have established a reliable association of the Z-BMI criterion with the cumulative dose of prednisone in the last 6 months: r = 0.49, p <0.05. At the same time, no reliable association of body weight with a cumulative dose of prednisone, which the child received before 6 months, has been identified. When analyzing the effectiveness of different doses of prednisone therapy for stopping relapses in children with steroid-sensitive INS, it was found that the onset and duration of remission did not significantly differ when taking standard (60mg/m2/day or 2 mg/kg/day) and half as much (1mg/kg/day) doses of prednisone.CONCLUSION. The relationship of the body mass of children with INS and the cumulative dose of prednisone in the last 6 months has been established. When treating a recurrent steroid-sensitive non-relapsing INS, a decrease in the daily dose of prednisone from 2 mg/kg/day to 1 mg/kg/day is possible in adolescents who are afraid of steroid obesity or who have had severe complications during previous courses of prednisone therapy.

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