PROSPECTS OF USING ANTI-IDIOTYPIC ANTIBODIES TO TWO MORPHINE DERIVATIVES IN THE FORM OF LIPOSOMAL FORM FOR THE DEVELOPMENT OF A VACCINE AGAINST OPIATE ADDICTION

Author(s):  
R. Ageldinov ◽  
M. Nesterov ◽  
T. Klimova ◽  
N. Gamaleya ◽  
L. Ulyanova

The prospects of using liposomes in the creation of a pharmaceutical form of liposomal preparation of antiidiotypic Ab2 antibodies to two derivatives of morphine, which leads to the production of Ab3 antibodies capable of preventing the action of morphine in the body, are considered.

2019 ◽  
Vol 24 (2) ◽  
pp. 343-367
Author(s):  
Roberto Paura

Transhumanism is one of the main “ideologies of the future” that has emerged in recent decades. Its program for the enhancement of the human species during this century pursues the ultimate goal of immortality, through the creation of human brain emulations. Therefore, transhumanism offers its fol- lowers an explicit eschatology, a vision of the ultimate future of our civilization that in some cases coincides with the ultimate future of the universe, as in Frank Tipler’s Omega Point theory. The essay aims to analyze the points of comparison and opposition between transhumanist and Christian eschatologies, in particular considering the “incarnationist” view of Parousia. After an introduction concern- ing the problems posed by new scientific and cosmological theories to traditional Christian eschatology, causing the debate between “incarnationists” and “escha- tologists,” the article analyzes the transhumanist idea of mind-uploading through the possibility of making emulations of the human brain and perfect simulations of the reality we live in. In the last section the problems raised by these theories are analyzed from the point of Christian theology, in particular the proposal of a transhuman species through the emulation of the body and mind of human beings. The possibility of a transhumanist eschatology in line with the incarnationist view of Parousia is refused.


Geophysics ◽  
1952 ◽  
Vol 17 (2) ◽  
pp. 344-364 ◽  
Author(s):  
Fraser S. Grant

A method is developed for determining the approximate size and shape of the three‐dimensional mass distribution that is required to produce a given gravitational field. The first few reduced multipole moments of the distribution are calculated from the derivatives of the surface field, and the approximative structure is determined from the values of these moments and a knowledge of the density contrast between the body and its surroundings. A system of classification of problems by symmetry is introduced and its practical usage discussed. A relaxation method is described which may be used to adjust the initial solution systematically to give agreement over the whole field. A descriptive discussion is appended.


2004 ◽  
pp. 147-176
Author(s):  
Stanimir Rakic

In this paper I examine compound names of plants, animals, human beings and other things in which at least one nominal component designates a part of the body or clothes, or some basic elements of houshold in Serbian and English. The object of my analysis are complex derivatives of the type (adjective noun) + suffix in Serbian and componds of the type noun's + noun, noun + noun and adjective + noun in English. I try to show that there is a difference in metaphorical designation of human beings and other living creatures and things by such compound nouns. My thesis is that the metathorical designation of human beings by such compounds is based on the symbolic meaning of some words and expressions while the designation of other things and beings relies on noticed similarity. In Serbian language such designation is provided by comples derivatives praznoglavac 'empty-headed person', tupoglavac 'dullard' debolokoiac 'callos person', golobradac 'young, inexperienced person' zutokljunac 'tledling' (fig), in English chicken liver, beetle brain birdbrain, bonehead, butterfingers, bigwig, blackleg, blue blood bluestocking, eat's paw, deadhead,fat-guts,fathead, goldbrick (kol) hardhat, hardhead, greenhorn, redcoat (ist), redneck (sl), thickhead, etc. Polisemous compounds like eat's paw lend support for this thesis because their designation of human beings is based on symbolic meaning of some words or expressions. I hypothesize that the direction and extend of the possible metaphorization of names may be accounted for by the following hierarchy (11) people - animals - plants - meterial things. Such hierarchy is well supported by the observations of Lakoff (1987) and Taylor (1995) about the role of human body in early experience and perception ofthe reality. Different restrictions which may be imposed in the hierarchy (11) should be the matter of further study, some of which have been noted on this paper. The compounds of this type denoting people have metaphorically meaning conected with some pejorative uses. These compounds refer to some psychological or characteral features, and show that for the classification of people such features are much more important than physical properties. While the animals and plants are classified according to some charecteristics of their body parts, people are usually classified according to psychollogical characteristics or their social functions. I have also noted a difference in structure between compounds designation animals and those designating plants and other things. The designation of animals relies more on metonymy, and that of plants and other things on metaphor based on comparision of noticed similarities. In the compounds designating animals, the nominal component relatively seldom refers to the parts of plants or other things. I guess that the cause may be the fact that the anatomy of plants is very different from the anatomy of animals. As a consequence the structure adjective + noun is much more characteristic of the compounds designating animals in English than the structure noun's + noun, and the same holds, although in a lesser degree for the compounds designating humans. It is also noticeable that in English compounds whose second component a part of body or clothes the first component rarely designates animals. On the other hand the compounds (9), in which the nominal head refers to some superordinate species, the first component often designates animal species, but usually of a very different kind. These data seem to lend support for Goldvarg & Gluksberg's thesis (1998) that metaforical interpretation is favoured if the nominal constituents denote quite different entities.


Author(s):  
Gennady M. Aldonin ◽  
◽  
Vasily V. Cherepanov ◽  

In domestic and foreign practice, a great deal of experience has been accumulated in the creation of means for monitoring the functional state of the human body. The existing complexes mainly analyze the electrocardiogram, blood pressure and a number of other physiological parameters. Diagnostics is often based on formal statistical data which are not always correct due to the nonstationarity of bioprocesses and without taking into account their physical nature. An urgent task of monitoring the state of the cardiovascular system is the creation of effective algorithms for computer technologies to process biosignals based on nonlinear dynamic models of body systems since biosystems and bioprocesses have a nonlinear nature and fractal structure. The nervous and muscular systems of the heart, the vascular and bronchial systems of the human body are examples of such structures. The connection of body systems with their organization in the form of self-similar fractal structures with scaling close to the “golden ratio” makes it possible to diagnose them topically. It is possible to obtain detailed information about the state of the human body’s bio-networks for topical diagnostics on the basis of the wavelet analysis of biosignals (the so-called wavelet-introscopy). With the help of wavelet transform, it is possible to reveal the structure of biosystems and bioprocesses, as a picture of the lines of local extrema of wavelet diagrams of biosignals. Mathematical models and software for wavelet introscopy make it possible to extract additional information from biosignals about the state of biosystems. Early detection of latent forms of diseases using wavelet introscopy can shorten the cure time and reduce the consequences of disorders of the functional state of the body (FSO), and reduce the risk of disability. Taking into account the factors of organizing the body’s biosystems in the form of self-similar fractal structures with a scaling close to the “golden ratio” makes it possible to create a technique for topical diagnostics of the most important biosystems of the human body.


REPERTÓRIO ◽  
2017 ◽  
pp. 298
Author(s):  
Regina Miranda

<p class="p1">Resumo:</p><p class="p2">Ao tomar como contexto teórico as pesquisas em Harmonias Espaciais desenvolvidas pelo teórico de movimento Rudolf Laban na primeira metade do século XX, este artigo considera o longo predomínio da visão de um <em>alguém</em> que habitava um <em>espaço vazio </em>separado do corpo e aponta perspectivas contemporâneas, que<em> </em>tornaram o<em> </em>espaço entre/em ambos mais fluido e plástico. A contribuição teórica aqui apresentada indicou a necessidade da inclusão de configurações geométricas mais instáveis no campo Labaniano e também a criação de percursos para a encarnação de conceitos, que pudessem representar essas novas interações. Como um dos territórios da pesquisa artística que fundamenta esta narrativa, o encontro com a tecnologia foi explorado, inicialmente, como uma forma de ampliar a experiência corpo-espacial dos atuantes formais e informais de uma performance, oferecendo a possibilidade de um desenho cênico que incluía a articulação entre espaços físicos e virtuais e de conexões espaciais de livre escolha. Mais recentemente, a relação se ampliou em uma experiência interdisciplinar de criação cênica e coreográfica em interatividade com processos computacionais. Nos exemplos apontados, o que rege a escolha das tecnologias é o interesse artístico e conceitual de investigar como cada tecnologia pode colaborar na criação, deslocamento e distorção de espaços performáticos.</p><p class="p3"><span class="s1">Palavras-chave: </span>Arte e tecnologia. Artes cênicas. Campo labaniano. Corpo-espaço. Performance imersiva.</p><p class="p3"> </p><p>SHIFTING SPACES: POETICS OF INTERACTION BETWEEN ART AND TECHNOLOGY</p><p class="p1"><em>Abstract:</em></p><p class="p5"><em>Embracing as theoretical context the Space Harmonies’ research developed by movement theorist Rudolf Laban during the first half of the 20th century, this paper considers the long predominance of the vision of someone who inhabited an empty space separated from the body, and points toward contemporary perspectives, which have made the space between/in both more fluid and plastic. The theoretical contribution presented here indicated the need to include more unstable geometric configurations in the Labanian field and the creation of paths for the incarnation of concepts, which could represent these new interactions. As one of the areas of artistic research that underlies this narrative, the encounter with technology was initially explored as a way to broaden the body-space experience of the formal and informal participants of a performance. It offered the possibility of a scenic design that included the articulation between physical and virtual spaces and free-choice spatial connections. More recently, the relationship expanded in an interdisciplinary experience of scenic and choreographic creation in interactivity with computational processes. In the mentioned examples, what defines the choice of the technologies is the artistic and conceptual interest to investigate how each technology can collaborate in the creation, displacement and distortion of performative spaces.</em></p><p class="p3"><span class="s1"><em>Keywords: </em></span><em>Art and technology. Performing arts. Labanian field. Body-space. Immersive performance.</em></p>


2021 ◽  
Author(s):  
◽  
Catherine Falconer-Gray

<p>In 1844, George French Angas, the English traveller, artist, natural historian and ethnographer spent four months travelling in New Zealand. He sought out and met many of the most influential Maori leaders of the time, sketching and recording his observations as he went. His stated intention was to provide a ‘more correct idea’ of New Zealand and the New Zealanders. In Australia and then Britain he held exhibitions of his work and in 1847 he published two works based on this time in New Zealand: a large volume of full-colour lithographs, The New Zealanders Illustrated and a travel narrative based on his journal, Savage Life and Scenes in Australia and New Zealand. These exhibitions and publications comprised the nineteenth century’s largest collection of works about Maori and Maori culture. This thesis is a study of the ‘more correct idea’ that Angas sought to provide: his creation of colonial knowledge about Maori. Angas is most commonly described in New Zealand as being an unremarkable artist but as providing a window onto New Zealand in the 1840s. This thesis opens the window wider by looking at Angas’s works as a record of a cultural encounter and the formation of a colonial identity. The works were shaped by numerous ideological and intellectual currents from Britain and the empire, including humanitarianism and the aesthetic of the picturesque. Ideas about gender and the body form a central part of the colonial knowledge created in Angas’s work. Particularly notable is what this thesis terms ‘sartorial colonisation’ – a process of colonisation through discourse and expectations around clothes. Angas also travelled and worked in a dynamic middle ground in New Zealand and Maori played a vital role in the creation of his works. Angas represented Maori in a sympathetic light in many ways. Ultimately however, he believed in the superiority of the British culture, to the detriment of creating colonial knowledge that placed Maori as equal partners in the recently signed Treaty of Waitangi. This thesis also examines the ways in which Angas’s body of work has been engaged with by the New Zealand public through to the present. As a study of the products of a British traveller who spent time in other parts of the empire as well as in New Zealand, this thesis contributes to histories of New Zealand, and British imperial and transcolonial history.</p>


2017 ◽  
Vol 7 (4) ◽  
pp. 536-541 ◽  
Author(s):  
M. Khariv ◽  
B. Gutyj ◽  
N. Ohorodnyuk ◽  
O. Vishchur ◽  
I. Khariv ◽  
...  

The results of research on the influence of the elaborated complex immunotropic drug containing butafosfan, interferon, thistle and fat-soluble vitamins A, D3, E in the form of a liposomal emulsion on the activity of T- and B-cell chains of immunity in rats under the conditions of action on the body of oxidative stress are presented. It has been established that the introduction of 50% tetrachloromethane into the rats of the first and second experimental groups, with a dose of 0.25 ml per 100 g of body weight, causes oxidative stress in them which negatively affects the cellular immunity and functional activity of immunocompetent blood cells. Immunosuppressive effects of oxidative stress were manifested by a decrease in the blood of rats in the first and second experimental groups of the number of T- and B-lymphocytes and their regulatory subpopulations mainly on the 2nd and 5th day of the study. At the same time, in the blood of rats of the first experimental group in all research periods a decrease in the relative number of common, active and theophylline-resistant T-lymphocytes, as well as B-lymphocytes was observed with a noticeable increase in the number of their undifferentiated forms. At the same time, the obtained data suggest the positive effect of butafosfan, interferon, thistle and vitamins A, D3, E in the liposomal preparation on the relative amount of T- and B-lymphocytes and on the redistribution of avidity in the direction of strengthening the receptor field of plasma membranes immunocompetent cells. It was found that the normalization on the 2nd day of blood level in the second experimental group of common T-lymphocytes occurred due to the secondary forms of the blood and active T-lymphocytes by changes in the number of low-avid forms. In addition to the indicators characterizing the cellular immunity of rats, the components of the liposomal preparation showed regulatory influence on the humoral link of the immune response. In particular, on the 10th day of research in blood of rats of the second experimental group a tendency towards an increase in the relative number of B-lymphocytes and an increase in the number of cells with low and medium density of receptors was found, which, under the conditions of oxidative stress, indicates an increase in the body's ability to actively synthesize protective antibodies


2018 ◽  
Vol 20 (10) ◽  
pp. 3858-3878 ◽  
Author(s):  
Mark A Rademacher

How people with ostomies—a surgically created opening in the body that expels bodily wastes—use social media to challenge ostomy stigma represents a growing area of research, especially the creation, posting, and circulation of ostomy selfies within online health communities. This project contributes to this research by examining reactions by a mass audience to news stories about a viral ostomy selfie posted by ostomate Bethany Townsend to a Crohn’s disease Facebook page. By analyzing the user-generated comments associated with this news coverage, this study illuminates how ostomy selfies are interpreted outside the highly sympathetic audiences that populate online health communities. Analysis reveals positive and negative reactions, posted by ostomates and non-ostomates alike, coexist within the comments. Implications of the conflicting reactions to ostomies, in general, and ostomy selfies, in particular, are discussed with regard to the effort to destigmatize ostomies in society.


2021 ◽  
Vol 32 (5) ◽  
pp. 50
Author(s):  
Oleg Aronson

The article is devoted to an analysis of the creative work of the Russian philosopher Valery Podoroga. It focuses on the special discipline he created, namely, “analytical anthropology”, and the book “Anthropograms”, in which Valery Podoroga sets out the basic principles and analytical tools of his philosophical work. Examining the books of the philosopher that preceded the creation of analytical anthropology and those that were written later, it is possible to single out two important lines of his research. First, the philosophy of literature and second, research in the field of the political. Podoroga’s understanding of literature is broader than that of a cultural practice or a social institution. For him, it is the space of the corporal experience of contact with the world, in which the affective aspect of thinking is realized. This line of analysis points to the “poetic” dimension of the experience of thinking, since the emphasis here is on what Jakobson called the “poetic function of language”, its orientation toward itself. It is precisely the literary aspect that becomes important when analyzing the texts of philosophers (Kierkegaard, Nietzsche, Heidegger); however, what is even more important is that in the very experience of fiction Podoroga is trying to find new means for philosophy. His “poetic line” is closely connected with the poetics of space (Bachelard) and the phenomenology of the body (Merleau-Ponty, Henry). It is the combination of poetics and phenomenology that allows Podoroga to overcome both the orientation of poetics exclusively toward language and the categorical apparatus of philosophy. The main result of Valery Podoroga’s work is the creation of an “anthropogram”, a special kind of scheme in which the action of the Work (a literary work, but not only) is immanent to the dynamics of the world. Is it possible to create such anthropograms outside the field of literature? Podoroga does not specify. The article attempts to show how Podoroga’s ways of working with literary texts correlate with his works dealing with the technologies of power and violence, transforming separate political and ethical terms into anthropograms, that is, forms of thought immanent to life itself.


2020 ◽  
pp. 164-188
Author(s):  
Gerard O'Daly

The chapter discusses Augustine’s presentation in Books 11–14 of the origins of the two cities, heavenly and earthly. The focus is on the creation of the universe, the angels and the rebellion of some of them, and Adam, Eve, and the Fall. Specific themes include: Genesis exegesis; the elaboration of the history theme, with good and bad angels as ‘prologues’ to the two historical human cities; good and evil in the universe; angelic rebels and the nature of the will; death and resurrection; Platonist and Christian views on the body; Pauline flesh and spirit; emotions and passions; sexual desire in paradise and since the Fall; love of self and love of God, and the application of this contrast to the two cities.


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