Biological effects of uremic toxins

2015 ◽  
Vol 18 (4) ◽  
pp. 125-130
Author(s):  
Corina Daniela Ene ◽  
◽  
Mircea Penescu ◽  
Emanoil Ceauşu ◽  
Ilinca Nicolae ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Human Body ◽  
Scientific Community ◽  
Biological Effects ◽  
Therapeutic Strategies ◽  
The Body ◽  
Uremic Toxins ◽  
Major Goal ◽  
International Scientific Community ◽  
Progressive Accumulation

Progressive accumulation of uremic toxins in the body exerts a variety of adverse effects on all organs, tissues and systems. The elimination of these compounds from the body is a major goal in the international scientific community. The objectives of this study are: uremic toxins classification, presentation of nocive effects of uremic toxins in human body. This paper is focused on identifying the disorders induced by uremic toxins on metabolism and microcirculation and on finding new therapeutic strategies to prevent the development of complications in uremic patients.

Maiden Voyage

Nuncius ◽  
2011 ◽  
Vol 26 (1) ◽  
pp. 21-49
Author(s):  
Dario De Santis
Keyword(s):  
Eighteenth Century ◽  
Human Body ◽  
Scientific Community ◽  
Microscopic Investigation ◽  
The Body ◽  
Natural Phenomena ◽  
Scientific Debate

AbstractThe scientific debate which developed during the eighteenth century, proposed and diffused new theories on the generation not only within the scientific community. Microscopic investigation and various experimental campaigns fostered daring models attempting to unveil the natural phenomena from which life originates. Besides the famous scientific and philosophical works that marked the age, in the second part of the century two pamphlets appeared that well represent the importance of the querelle about embryological systems defining the concept of generation as a voyage within the human body. Lucina sine concubitu and Juno abortans, respectively published in England and in Germany between 1750 and 1760, narrate the odd and imaginary adventures of two doctors who are trying to interrupt and modify the embryos' journey towards the body of the mother.

scholarly journals Amidoximes and Oximes: Synthesis, Structure, and Their Key Role as NO Donors

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2470 ◽  
Author(s):  
Tanya Sahyoun ◽  
Axelle Arrault ◽  
Raphaël Schneider
Keyword(s):  
Nitric Oxide ◽  
Cytochrome P450 ◽  
Arterial Pressure ◽  
Human Body ◽  
Biological Effects ◽  
Biological Pathways ◽  
The Body ◽  
No Donors ◽  
External Sources

Nitric oxide (NO) is naturally synthesized in the human body and presents many beneficial biological effects; in particular on the cardiovascular system. Recently; many researchers tried to develop external sources to increase the NO level in the body; for example by using amidoximes and oximes which can be oxidized in vivo and release NO. In this review; the classical methods and most recent advances for the synthesis of both amidoximes and oximes are presented first. The isomers of amidoximes and oximes and their stabilities will also be described; (Z)-amidoximes and (Z)-oximes being usually the most energetically favorable isomers. This manuscript details also the biomimetic and biological pathways involved in the oxidation of amidoximes and oximes. The key role played by cytochrome P450 or other dihydronicotinamide-adenine dinucleotide phosphate (NADPH)-dependent reductase pathways is demonstrated. Finally, amidoximes and oximes exhibit important effects on the relaxation of both aortic and tracheal rings alongside with other effects as the decrease of the arterial pressure and of the thrombi formation

scholarly journals Gıdalarda Bulunan L-Triptofan, Serotonin, Melatonin Profilleri ve Sağlık Üzerine Etkileri

2015 ◽  
Vol 3 (11) ◽  
pp. 877
Author(s):  
Seda Kurtulmuş ◽  
Tuğba Kök Taş
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Human Health ◽  
Human Body ◽  
Biological Effects ◽  
Essential Amino Acids ◽  
The Body ◽  
Human Nutrition ◽  
Pressure Balance

Nowadays, depending on the progress of science and technology, our eating habits have changed. The shape and quality of nutrition is important for human health. Especially, some food components have various effect on central nervous system such as depression, anxiety, sleep, appetite. Food constituents are transported into the central nervous system via the neutral amino acids such as phenylalanine, leucine, isoleucine, tyrosine and valine. Amino acids have an important role in human nutrition. It cannot be synthesized in the body and one of the essential amino acids that must be taken outside, trytophan, is indispensable in human nutrition because of it has the many functions. In recent years, scientific community concentrated on the various functions of L-Trytophan (L-Trp) as pioneer in the secretion of the hormones serotonin and melatoninin in the human body. The hormones serotonin and melatonin is responsible for activities such as psychology, sleep, body temperature, blood pressure balance, antioxidant effect, cancer inhibitor, sexuality, autism and circadian rhythms in human body that they are available in various foods such as milk, kefir, yogurt, orange, strawberry, grape, olive oil, walnut, prune, nut, pomegranate, coffee, kiwi and banana. In this study, L-Trp, serotonin and melatonin biosynthesis and metabolism, food profiles and in terms of their physiological and biological effects on human health has been compiled.

The International Action “Open Access Week — 2009”

2009 ◽  
pp. 97-98
Author(s):  
Yulia V. Samodova
Keyword(s):  
Open Access ◽  
Scientific Community ◽  
International Scientific Community ◽  
International Action ◽  
The World

Information on the coming Open Access Week which will be held from 19 to 23 October 2009. Interest in the results of scientific researches all over the world has led to consolidation of forces of the international scientific community and to expand the now-annual event from a single day to seven days.

Correction of Posture Deviations in the Sagittal Plane Using the Pilates Method

2019 ◽  
pp. 3-13
Author(s):  
Alexandru Cîtea ◽  
George-Sebastian Iacob
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Postural Control ◽  
Human Body ◽  
Sagittal Plane ◽  
The Body ◽  
Lower Limbs ◽  
Low Back ◽  
Pilates Method ◽  
The Relationship

Posture is commonly perceived as the relationship between the segments of the human body upright. Certain parts of the body such as the cephalic extremity, neck, torso, upper and lower limbs are involved in the final posture of the body. Musculoskeletal instabilities and reduced postural control lead to the installation of nonstructural posture deviations in all 3 anatomical planes. When we talk about the sagittal plane, it was concluded that there are 4 main types of posture deviation: hyperlordotic posture, kyphotic posture, rectitude and "sway-back" posture.Pilates method has become in the last decade a much more popular formof exercise used in rehabilitation. The Pilates method is frequently prescribed to people with low back pain due to their orientation on the stabilizing muscles of the pelvis. Pilates exercise is thus theorized to help reactivate the muscles and, by doingso, increases lumbar support, reduces pain, and improves body alignment.

Representation of a Human Body: A Comparison Study between Balinese and Javanese Traditional House

Humaniora ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 83-90
Author(s):  
Anak Agung Ayu Wulandari ◽  
Ade Ariyani Sari Fajarwati
Keyword(s):  
Comparative Study ◽  
Human Body ◽  
Qualitative Method ◽  
Descriptive Analysis ◽  
The Body ◽  
Comparison Study ◽  
Architectural Drawing ◽  
Study Approach ◽  
The Comparative Study ◽  
Head Area

The research would look further at the representation of the human body in both Balinese and Javanese traditional houses and compared the function and meaning of each part. To achieve the research aim, which was to evaluate and compare the representation of the human body in Javanese and Balinese traditional houses, a qualitative method through literature and descriptive analysis study was conducted. A comparative study approach would be used with an in-depth comparative study. It would revealed not only the similarities but also the differences between both subjects. The research shows that both traditional houses represent the human body in their way. From the architectural drawing top to bottom, both houses show the same structure that is identical to the human body; head at the top, followed by the body, and feet at the bottom. However, the comparative study shows that each area represents a different meaning. The circulation of the house is also different, while the Balinese house is started with feet and continued to body and head area. Simultaneously, the Javanese house is started with the head, then continued to body, and feet area.

Towards Breast Cancer Vaccines, Progress and Challenges

2019 ◽  
Vol 16 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Javad Behravan ◽  
Atefeh Razazan ◽  
Ghazal Behravan
Keyword(s):  
Breast Cancer ◽  
Adverse Effects ◽  
Cancer Vaccine ◽  
Cancer Vaccines ◽  
Weight Control ◽  
The Body ◽  
Phase Iii ◽  
Current Therapy ◽  
Surgical Ablation ◽  
Breast Cancer Vaccine

Breast cancer is the second leading cause of cancer death among women. National cancer institute of the US estimates that one in eight women will be diagnosed with breast cancer during their lifetime. Considering the devastating effects of the disease and the alarming numbers many scientists and research groups have devoted their research to fight breast cancer. Several recommendations are to be considered as preventing measures which include living a healthy lifestyle, regular physical activity, weight control and smoking cessation. Early detection of the disease by annual and regular mammography after the age of 40 is recommended by many healthcare institutions. This would help the diagnosis of the disease at an earlier stage and the start of the treatment before it is spread to other parts of the body. Current therapy for breast cancer includes surgical ablation, radiotherapy and chemotherapy which is often associated with adverse effects and even may lead to a relapse of the disease at a later stage. In order to achieve a long-lasting anticancer response with minimal adverse effects, development of breast cancer vaccines is under investigation by many laboratories. The immune system can be stimulated by a vaccine against breast cancer. This approach has attracted a great enthusiasm in recent years. No breast cancer vaccines have been approved for clinical use today. One breast cancer vaccine (NeuVax) has now completed clinical trial phase III and a few preventive and therapeutic breast cancer vaccines are at different steps of development. We think that with the recent advancements in immunotherapy, a breast cancer vaccine is not far from reach.

scholarly journals Complications of intravesical BCG therapy in non-muscle invasive bladder cancer: our tertiary care centre experience

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Vivek Sharma ◽  
Avinash P. S. Thakur ◽  
Vasantharaja Ramasamy ◽  
Pushpendra Kumar Shukla ◽  
Fanindra Singh Solanki ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Adverse Effects ◽  
Bladder Carcinoma ◽  
Bladder Tumour ◽  
The Body ◽  
Bcg Therapy ◽  
Intravesical Bcg ◽  
Urothelial Bladder ◽  
Muscle Invasive ◽  
Intravesical Bcg Therapy

Abstract Background Urothelial bladder carcinoma accounts for around 3.9% cases of all the male cancers in India. Non-muscle-invasive bladder carcinoma (NMIBC) is predominant group which constitute approximately three fourth of the urothelial bladder cancer. Intravesical BCG immunotherapy is the corner stone of today’s NMIBC management. However, as with any other therapy it has its own complications and its interruption due to these adverse effects is a major cause of suboptimal efficacy. The aim of this study was to assess the complications of intravesical BCG therapy and their management in NMIBC patients. Methods This was a retrospective descriptive study conducted between October 2016 and November 2019; a backward review of 149 patients with diagnosis of NMIBC that undergone intravesicle BCG therapy was performed. Patient’s demographical, clinical, diagnostic and procedural data regarding bladder tumour, BCG therapy, its complications and management were collected and analysed. Results Total 149 patients were analysed, comprising 116 males and 33 females. The mean age was of 57.2 ± 6.7 years. Total 85.23% were primary and 14.76% were recurrent tumours. Total 96 patients (64.42%) completed the planned course, while 53 (35.57%) interrupted. The reasons for BCG interruption includes adverse effects (15.4%), progression of disease (6.7%), disease refractory to BCG (4.6%) and disease recurrence during BCG (3.3%). Most of the adverse events occurred in first 6 months and most interruptions occurred after the induction period. Cystitis was the most common observed adverse effect seen in 39.6% patients. Frequency, urgency, haematuria were common presentation. Radical cystectomy was the most common (16.10%) further treatment with patients whose treatment was interrupted. Conclusion BCG is an indispensable therapy available for NMIBC, but it is associated with array of adverse effects and complications, which are the main reasons for poor compliance to BCG therapy. Although BCG-related complications can affect any organ in the body, potentially life-threatening systemic BCG-related infections are encountered in only < 5% of patients. There are some difficulties in diagnosis of the BCG complications because acid-fast staining, culture and PCR test are not always positive; tissue biopsies should be indicated sometimes to evaluate histopathology and presence of M. bovis. A persistently monitored multidisciplinary approach with high index of suspicion and prompt anti-TB therapy can help to derive the maximum benefits while keeping the complications at check.

German labour market data – Data provision and access for the international scientific community

2020 ◽  
Vol 21 (3) ◽  
pp. 313-333
Author(s):  
Dana Müller ◽  
Stefanie Wolter
Keyword(s):  
Labour Market ◽  
Survey Data ◽  
Scientific Community ◽  
Market Research ◽  
Research Data ◽  
International Scientific Community ◽  
High Quality ◽  
Data Centre ◽  
Integrated Employment ◽  
Data Provision

AbstractThe Research Data Centre at the Institute for Employment Research (RDC-IAB) has been offering high-quality administrative and survey data on the German labour market for 15 years and has become one of the most important locations worldwide for researchers interested in data for labour market research. This article provides an overview of the RDC-IAB, including its data and access modes. The article presents two datasets in more detail: the Sample of Integrated Employment Biographies, a classic dataset, and the Linked Personnel Panel, a new dataset. Finally, this article provides insights into future infrastructure and data developments.

Embodying the culture of achievement: Culture between illness and perfection is a ‘thin line’ – obtaining the ideal female body as an act of achievement

2021 ◽  
pp. 1354067X2110040
Author(s):  
Josefine Dilling ◽  
Anders Petersen
Keyword(s):  
Experimental Study ◽  
Human Body ◽  
Female Body ◽  
The Body ◽  
Thin Line ◽  
Complex Processes ◽  
The Individual ◽  
Different Levels ◽  
The Ideal ◽  
Body Ideals

In this article, we argue that certain behaviour connected to the attempt to attain contemporary female body ideals in Denmark can be understood as an act of achievement and, thus, as an embodiment of the culture of achievement, as it is characterised in Præstationssamfundet, written by the Danish sociologist Anders Petersen (2016) Hans Reitzels Forlag . Arguing from cultural psychological and sociological standpoints, this article examines how the human body functions as a mediational tool in different ways from which the individual communicates both moral and aesthetic sociocultural ideals and values. Complex processes of embodiment, we argue, can be described with different levels of internalisation, externalisation and materialisation, where the body functions as a central mediator. Analysing the findings from a qualitative experimental study on contemporary body ideals carried out by the Danish psychologists Josefine Dilling and Maja Trillingsgaard, this article seeks to anchor such theoretical claims in central empirical findings. The main conclusions from the study are used to structure the article and build arguments on how expectations and ideals expressed in an achievement society become embodied.

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