scholarly journals Short Review: Phytofabrication of Zinc Oxide Nanoparticles for Anticancer Applications

2021 ◽  
Vol 3 (1) ◽  
pp. 82-89
Author(s):  
Siti Nur Amalina Mohamad Sukri ◽  
Kamyar Shameli ◽  
Sin-Yeang Teow ◽  
Eleen Dayana Mohamed Isa ◽  
Mostafa Yusefi ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Short Review ◽  
Review Article ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Inhibition Activity ◽  
Zno Nps ◽  
Cancerous Cells ◽  
High Inhibition

Zinc oxide nanoparticles (ZnO NPs) are one of the most well-known materials in the field of nanotechnology. Adopting a more environmentally friendly synthesis methods of ZnO NPs have been the focus in the last few decades. Of all green synthesis methods of ZnO NPs, fabrication with the help of plant extracts has been the most popular due to its many benefits. The use of phytofabricated ZnO NPs in anticancer studies has been conducted increasingly over the last decade because of its high inhibition activity against various types of cancerous cells. This short review article will present the current update on the phytofabrication of ZnO NPs in recent years and discuss on their cytotoxicity mechanism against cancer cells.

scholarly journals Green versus Chemical Precipitation Methods of Preparing Zinc Oxide Nanoparticles and Investigation of Antimicrobial Properties

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Bulcha Bekele ◽  
Anatol Degefa ◽  
Fikadu Tesgera ◽  
Leta Tesfaye Jule ◽  
R. Shanmugam ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Chemical Synthesis ◽  
Zinc Oxide Nanoparticles ◽  
Antimicrobial Properties ◽  
Chemical Precipitation ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Zno Nps ◽  
Precipitation Synthesis

Comparison of green and chemical precipitation method syntheses of zinc oxide nanoparticles (ZnO NPs) was performed, and antimicrobial properties were investigated. Avocado, mango, and papaya fruit extracts were carried out for the green synthesising methods, while the chemical precipitation method was chosen from chemical synthesis methods. Zinc nitrate was used as a salt precursor, whereas leaf extract was served as a reducing agent for green synthesising methods. In addition, sodium hydroxide, polyvinyl alcohol, and potassium hydroxide were used as reducing agents in the case of chemical precipitation synthesis methods. ZnO NPs were characterised by characterizing techniques such as Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The antimicrobial activities of prepared nanoparticles were evaluated on Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), and Salmonella typhimurium (S. typhimurium). The particle sizes of the prepared samples which were evaluated by the Scherrer equation were in the range of 11-21 nm for green synthesis, while 30-40 nm for chemical precipitation synthesis methods. Small agglomerations were observed from SEM results of prepared ZnO NPs from both methods. Prepared ZnO NPs were showed strong antimicrobial properties. From the result, the inhibition zone was in the range of 15-24 mm for the green route and 7–15 mm for chemical precipitation methods, where the standard drugs have 25 mm of the zone of inhibition. A green synthesised method of preparing ZnO NPs gives promising antimicrobial properties compared to chemical synthesis and is also eco-friendly and safe compared to the chemical synthesis.

scholarly journals Plant-Mediated Biosynthesis and Photocatalysis Activities of Zinc Oxide Nanoparticles: A Prospect towards Dyes Mineralization

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Mohamed Awad Fagier
Keyword(s):  
Zinc Oxide ◽  
Green Synthesis ◽  
Zinc Oxide Nanoparticles ◽  
Vital Role ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
High Electron ◽  
Zno Nps ◽  
Factors Affecting ◽  
Photodegradation Efficiency

In recent years, nanoparticles synthesis by green synthesis has gained extensive attention as a facile, inexpensive, and environmentally friendly method compared with chemical and physical synthesis methods. This review covered the biosynthesis of zinc oxide nanoparticles (ZnO NPs), including the procedure and mechanism. Factors affecting the formation of ZnO NPs are discussed. The presence of active bioorganic molecules in plant extract played a vital role in the formation of ZnO NPs as a natural green medium in the metallic ion reduction processes. ZnO NPs exhibit attractive photocatalysis properties due to electrochemical stability, high electron mobility, and large surface area. In this review, the procedure and mechanism of the ZnO photocatalysis process are studied. The effects of dyes amount, catalysts, and light on photodegradation efficiency are also considered. This review provides useful information for researchers who are dealing with green synthesis of ZnO NPs. Moreover, it can provide investigators with different perceptions towards the efficiency of biosynthesized ZnO NPs on dyes degradation and its restrictions.

scholarly journals Zinc oxide nanoparticles: potential novel applications in cellular physiology, pathology, neurosciences and cancer research

2019 ◽  
Vol 58 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Senka Pantic ◽  
Sanja Radojevic Skodric ◽  
Zlatibor Loncar ◽  
Igor Pantic
Keyword(s):  
Cancer Research ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Rapid Development ◽  
Short Review ◽  
Consumer Products ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Cellular Physiology ◽  
Anticancer Properties

Abstract With the rapid development of nanotechnology during the past several years, attention has been focused on metallic nanomaterials, due to their specific physical and chemical characteristics. Zinc oxide nanoparticles (ZnO NPs) have numerous potential applications in industry, as a part of various consumer products, but also in medical research. Anticancer properties of ZnO NPs have been suggested in cell cultures, however, the precise mechanism responsible for their activity in these conditions remains elusive. Cytotoxicity and genotoxicity of ZnO NPs are also unclear. Apart from cancer research, ZnO NPs are today widely researched in almost all areas of fundamental medicine. In this short review, we discuss recently published articles on ZnO NPs applications in cellular physiology, pathology, neurosciences and oncology.

Evaluation of the Effect of Nanoparticles Zinc Oxide/Camellia sinensis Complex on the Kidney of Rats Treated with Monosodium Glutamate: Antioxidant and Histological Approaches

2019 ◽  
Vol 20 (7) ◽  
pp. 542-550 ◽  
Author(s):  
Nahla S. El-Shenawy ◽  
Reham Z. Hamza ◽  
Fawziah A. Al-Salmi ◽  
Rasha A. Al-Eisa
Keyword(s):  
Zinc Oxide ◽  
Camellia Sinensis ◽  
Zinc Oxide Nanoparticles ◽  
Morphological Changes ◽  
Monosodium Glutamate ◽  
Oxide Nanoparticles ◽  
High Dose ◽  
Enzymatic Antioxidants ◽  
Zno Nps ◽  
Tea Extract

Background: Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study has been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis (green tea extract, GTE) on kidneys of rats treated with monosodium glutamate (MSG). Methods: Therefore, the objective of the research was designed to explore the possible defensive effect of GTE/ZnO NPs against MSG-induced renal stress investigated at redox and histopathological points. Results: The levels of urea and creatinine increased as the effect of a high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates were elevated significantly with the high dose of MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased sharply in MSG-treated rats as compared to the normal group. Conclusion: The data displayed that GTE/ZnO NPs reduced the effects of MSG significantly by reduction of the level peroxidation and enhancement intracellular antioxidant. These biochemical findings were supported by histopathology evaluation, which showed minor morphological changes in the kidneys of rats.

Zinc oxide nanoparticles help to enhance plant growth and alleviate abiotic stress: A review

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohammad Faizan ◽  
Fangyuan Yu ◽  
Chen Chen ◽  
Ahmad Faraz ◽  
Shamsul Hayat
Keyword(s):  
Zinc Oxide ◽  
Plant Growth ◽  
Abiotic Stresses ◽  
Zinc Oxide Nanoparticles ◽  
Growth And Yield ◽  
Oxide Nanoparticles ◽  
Main Concern ◽  
Negative Effects ◽  
Zno Nps ◽  
Agricultural Yield

: Abiotic stresses arising from atmosphere change belie plant growth and yield, leading to food reduction. The cultivation of a large number of crops in the contaminated environment is a main concern of environmentalists in the present time. To get food safety, a highly developed nanotechnology is a useful tool for promoting food production and assuring sustainability. Nanotechnology helps to better production in agriculture by promoting the efficiency of inputs and reducing relevant losses. This review examines the research performed in the past to show how zinc oxide nanoparticles (ZnO-NPs) are influencing the negative effects of abiotic stresses. Application of ZnO-NPs is one of the most effectual options for considerable enhancement of agricultural yield globally under stressful conditions. ZnO-NPs can transform the agricultural and food industry with the help of several innovative tools in reversing oxidative stress symptoms induced by abiotic stresses. In addition, the effect of ZnO-NPs on physiological, biochemical, and antioxidative activities in various plants have also been examined properly. This review summarizes the current understanding and the future possibilities of plant-ZnO-NPs research.

scholarly journals Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 713
Author(s):  
Nina Melnikova ◽  
Alexander Knyazev ◽  
Viktor Nikolskiy ◽  
Peter Peretyagin ◽  
Kseniia Belyaeva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Bacterial Cellulose ◽  
Zinc Oxide Nanoparticles ◽  
Wound Dressings ◽  
Oxide Nanoparticles ◽  
Burn Wound ◽  
Zno Nps ◽  
Wound Model ◽  
And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

scholarly journals Biosynthesis of Zinc Oxide Nanoparticles from Acacia nilotica (L.) Extract to Overcome Carbapenem-Resistant Klebsiella Pneumoniae

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1919
Author(s):  
Elsayim Rasha ◽  
AlOthman Monerah ◽  
Alkhulaifi Manal ◽  
Ali Rehab ◽  
Doud Mohammed ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Zinc Oxide ◽  
Klebsiella Pneumoniae ◽  
Zinc Oxide Nanoparticles ◽  
Acacia Nilotica ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
X Ray ◽  
Carbapenem Resistant

Recently, concerns have been raised globally about antimicrobial resistance, the prevalence of which has increased significantly. Carbapenem-resistant Klebsiella pneumoniae (KPC) is considered one of the most common resistant bacteria, which has spread to ICUs in Saudi Arabia. This study was established to investigate the antibacterial activity of biosynthesized zinc oxide nanoparticles (ZnO-NPs) against KPC in vitro and in vivo. In this study, we used the aqueous extract of Acacia nilotica (L.) fruits to mediate the synthesis of ZnO-NPs. The nanoparticles produced were characterized by UV-vis spectroscopy, zetasizer and zeta potential analyses, X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM). The antimicrobial activity of ZnO-NPs against KPC was determined via the well diffusion method, and determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the results showed low MIC and MBC when compared with the MIC and MBC of Imipenem and Meropenem antibiotics. The results of in vitro analysis were supported by the results upon applying ZnO-NP ointment to promote wound closure of rats, which showed better wound healing than the results with imipenem ointment. The biosynthesized ZnO-NPs showed good potential for use against bacteria due to their small size, applicability, and low toxicity to human cells.

scholarly journals Scolicidal activity of biosynthesized zinc oxide nanoparticles by Mentha longifolia L. leaves against Echinococcus granulosus protoscolices

2021 ◽  
Author(s):  
Bushra H. Shnawa ◽  
Samir M. Hamad ◽  
Azeez A. Barzinjy ◽  
Payman A. Kareem ◽  
Mukhtar H. Ahmed
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Public Health Problem ◽  
Analytical Techniques ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Leaf Extracts ◽  
X Ray ◽  
Morphological Alterations ◽  
Mentha Longifolia

AbstractCystic echinococcosis is a public health problem in developing countries that practice sheep breeding extensively. In the current study, the protoscolicidal activity of biosynthesized zinc oxide nanoparticles (ZnO NPs) derived from Mentha longifolia L. leaf extracts was investigated. The resultant ZnO NPs were characterized by means of various analytical techniques, such as ultraviolet–visible (UV–Vis) spectrometry, Fourier transform infrared (FT-IR) spectrophotometry, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis. The results showed that the ZnO NP had the highest scolicidal activity at 400 ppm concentration after 150 min of exposure time, showing 100% mortality rate. The treated protoscolices exhibited loss of viability with several morphological alterations. Hence, an easy and effective green synthesis of ZnO NPs, with efficient scolicidal potential, is reported in this study.

scholarly journals Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pandiyan Amuthavalli ◽  
Jiang-Shiou Hwang ◽  
Hans-Uwe Dahms ◽  
Lan Wang ◽  
Jagannathan Anitha ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Mosquito Control ◽  
Xrd Analysis ◽  
Microbial Pathogens ◽  
Oxide Nanoparticles ◽  
Lawsonia Inermis ◽  
Zno Nps ◽  
Vector Borne Diseases ◽  
Substantial Problem

AbstractMicrobes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized by UV–vis, FT-IR, SEM with EDX, and XRD analysis. Green synthesized ZnO NPs were highly toxic against Anopheles stephensi, whose lethal concentrations values ranged from 5.494 ppm (I instar), 6.801 ppm (II instar), 9.336 ppm (III instar), 10.736 ppm (IV instar), and 12.710 ppm (pupae) in contrast to L. inermis treatment. The predation efficiency of the teleost fish Gambusia affinis and the copepod Mesocyclops aspericornis against A. stephensi was not affected by exposure at sublethal doses of ZnO NPs. The predatory potency for G. affinis was 45 (I) and 25.83% (IV), copepod M. aspericornis was 40.66 (I) and 10.8% (IV) while in an ZnO NPs contaminated environment, the predation by the fish G. affinis was boosted to 71.33 and 34.25%, and predation of the copepod M. aspericornis was 60.35 and 16.75%, respectively. ZnO NPs inhibited the growth of several microbial pathogens including the bacteria (Escherichia coli and Bacillus subtilis) and the fungi (Alternaria alternate and Aspergillus flavus), respectively. ZnO NPs decreased the cell viability of Hep-G2 with IC50 value of 21.63 µg/mL (R2 = 0.942; P < 0.001) while the concentration increased from 1.88 to 30 µg/mL. These outcomes support the use of L. inermis mediated ZnO NPs for mosquito control and drug development.

Sign in / Sign up

Export Citation Format

Share Document