scholarly journals Benzene Exposure Analysis through S-Phenylmercapturic Acid in Urine at Platelet Levels in Footwear Workers in Sukajaya Village, Bogor Regency

2021 ◽  
Vol 9 (E) ◽  
pp. 260-264
Author(s):  
Siti Norjannah ◽  
Ririn Arminsih Wulandari ◽  
Al Asyary
Keyword(s):  
Mass Spectrometry ◽  
Alcohol Consumption ◽  
Blood Cells ◽  
White Blood Cells ◽  
Individual Characteristics ◽  
Negative Effects ◽  
Cross Sectional ◽  
Benzene Exposure ◽  
Platelet Counts ◽  
Automated Hematology Analyzer

BACKGROUND: Benzene is a toxic and carcinogenic compound whose presence in glue is endangering the health of workers in footwear workshops. One of its negative effects is its disruption of the bone marrow, which is where red blood cells, white blood cells, and platelets are produced. AIM: The purpose of this study was to analyze the relationship of benzene exposure with platelet levels in workers through examination of S-phenylmercapturic acid (S-PMA) concentrations in urine. METHODS: The design of the study was cross sectional, with 73 workers used as samples. The concentration of S-PMA was measured using Liquid chromatography-Mass Spectrometry/Mass Spectrometry and platelet counts using an automated hematology analyzer. Direct interview was used to retrieve workers’ individual characteristics. RESULTS: The results showed an odds ratio (OR) value of 2.28 for correlation between S-PMA concentration and platelet levels. The results also showed an OR value of 1.58 for correlation between non-routine exercise habits and platelet levels and an OR value of 1.78 for correlation between alcohol consumption and platelet levels. Multivariable logistic regression test results showed an OR of 2.59 for workers with S-PMA concentration (>0.67 μg/g creatinine) on platelet counts after controlling for the variables of age and alcohol consumption. CONCLUSION: The study’s main recommendation is that information about the dangers of benzene in glue to health and how to avoid it should be disseminated to prevent benzene exposure.

scholarly journals STAT3 methylation in white blood cells as a novel sensitive biomarker for the toxic effect of low-dose benzene exposure

2016 ◽  
Vol 5 (3) ◽  
pp. 800-807 ◽  
Author(s):  
Di Liu ◽  
Yujiao Chen ◽  
Pengling Sun ◽  
Wenlin Bai ◽  
Ai Gao
Keyword(s):  
Dna Methylation ◽  
Toxic Effect ◽  
Health Effects ◽  
Blood Cells ◽  
Low Dose ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Benzene Exposure

A cross-sectional study was conducted in a sample of 571 workers to explore the toxic effect and early sensitive biomarker of the health effects of low-dose benzene exposure (LDBE), as well as the correlation between DNA methylation and the toxic effect of LDBE.

The situation of antibiotic use for diarrhea treatment on pediatric inpatient at Pediatrics - Kien Giang General Hospital in 2019-2020

2020 ◽  
pp. 15-24
Author(s):  
Nhon Tran Van ◽  
Mai Do Van ◽  
Hien Ha Minh
Keyword(s):  
General Hospital ◽  
Blood Cells ◽  
Antibiotic Prescription ◽  
White Blood Cells ◽  
Antibiotic Use ◽  
Cross Sectional Study ◽  
Loose Stool ◽  
Cross Sectional ◽  
Watery Stool ◽  
Pediatric Inpatient

Background: To survey for evaluation the use of antibiotic for diarrhea treatment on pediatric inpatient in compliance with MOH, WHO or treatment regimen. Objectives: (1) To describe the situation of antibiotic use for diarrhea treatment and (2) to determine factors that affected on indication of antibiotic for pediatric inpatient under 15 years at Kien Giang General Hospital in 2019. Subjects and methods: A cross-sectional study on 251 medical records of pediatric inpatients who treated by one of any drug from 01/2019 to 12/2019. Results: one antibiotic was prescribed in 71.7% in comparison with 17.1% on two antibiotics. The antibiotic prescription was based on the results of blood test including examinations of white blood cells (WBC), the percentage of neutrophils (Neu%) and/or C-reactive protein (CRP) (59.4%), stool with white blood cells and/or red blood cells (1.6%), high fever without causes (27.9%), watery stool (86.3%), loose stool with blood (100%), loose stool (97.9%). The most used antibiotics are ceftriaxone (53.4%), ciprofloxacin (12.4%). Duration of antibiotic use is 5 days in median. Conclusion: The rate of antibiotic prescription that met MOH and WHO guidelines was 88.3% in comparison with 11.7% of non-conformance. The compliance prescriptions based on antibiogram were 77.8%, non-compliance were 22.5%. The compliance dosage refered to guideline was 86.4%, non-conpliance was 2.4%. The duration of hospitalization and neutrophil are factors that affected the use of antibiotics (p < 0.05). Keywords: diarrhea, pediatric inpatient, antibiotic, Pediatrics-Kien Giang General Hospital

Associations between white blood cells count and obesity in apparently healthy young adults

2020 ◽  
Vol 50 (6) ◽  
pp. 1013-1019
Author(s):  
Fatemeh Ghannadiasl
Keyword(s):  
Young Adults ◽  
Cardiovascular Diseases ◽  
Blood Cells ◽  
White Blood Cells ◽  
Cross Sectional Study ◽  
The Body ◽  
Sectional Study ◽  
Cross Sectional ◽  
Content Type ◽  
Apparently Healthy

Purpose The elevated white blood cells (WBCs) count has been reported to be a predictor of cardiovascular diseases, diabetes, hypertension and metabolic syndrome. This study aims to determine the associations between WBCs count and obesity in apparently healthy young adults. Design/methodology/approach In this cross-sectional study, the authors evaluated the body mass index (BMI) in 392 apparently healthy young adults of both sexes. The WBCs count was measured using standard counter techniques. The inclusion criteria were the agreement to participate in the study, between 18 and 25 years of age, lack of self-reported diseases such as cardiovascular diseases, hypertension, kidney and infectious diseases. Findings According to the BMI classification, underweight and overweight or obesity were observed in 14.58 and 11.48 per cent of young adults, respectively. The mean WBC was 6.5 ± 1.5 (×10³ cells/µL). Higher values of WBCs were found in women than in men (p = 0.02). The young adults with higher BMI had a higher WBCs count. There was a positive correlation between WBCs count and weight and BMI (r = 0.19 and r = 0.22, p < 0.001, respectively). Research limitations/implications This research was a cross-sectional study. Future studies are suggested using longitudinal studies to examine more relationships between obesity and WBCs count in apparently healthy young adults. Practical implications The results of this study provide evidence for weight management in this age group to reduce diseases associated with increased WBCs count. Originality/value The WBCs count was related to increasing levels of BMI per cent 2 C even in the normal range.

scholarly journals Hematologic Changes in Patients with Graves’ disease in Gorgan During 2014-2015

2017 ◽  
Vol 2 (3) ◽  
pp. 106
Author(s):  
Maryam Zahedi ◽  
Farzam Mirkamali ◽  
Sharabeh Hezarkhani ◽  
Armineh Motiee ◽  
Arash Rezaei Shahmirzadi ◽  
...  
Keyword(s):  
Blood Cells ◽  
Complete Blood Count ◽  
Statistical Significance ◽  
White Blood Cells ◽  
P Value ◽  
Graves Disease ◽  
Thyroid Disorder ◽  
Cross Sectional ◽  
Mild Anemia ◽  
Before And After

Background: The most common cause of hyperthyroidism in areas without iodine deficiency is Graves’ disease. There are reports of some hematological alterations in hyperthyroidism. This study was designed to measure the hematologic profile in the patients with Graves’ disease before and after the treatment.Methods: In this cross-sectional study, 100 patients were selected with convenience sampling that diagnosed as autoimmune Graves’ disease in our academic endocrinology clinic during 2014-2015. Inclusion criteria included autoimmune hyperthyroidism in patients who were referred to this center during the study period. Patients who refused to take part in the research, had recent infections disease, malignancies, surgical procedures, severe trauma, received immunosuppressive drugs or corticosteroids, high erythrocyte sedimentation rate (ESR) values during the last six months, and not responded to treatment with methimazole were excluded from the study. The simple sampling technique was used to select the patients.   A complete blood count (CBC) was taken before and after treatment. The P-value less than 0.05 was considered as the statistical significance level. All data were analyzed using the Statistical Package for the Social Sciences 16.0 (SPSS Inc., Chicago, IL, USA) software.Results: One hundred patients with a mean age of 38 ± 9.8 years were included. There were no significant changes in the white blood cells (WBC) count, red blood cells (RBC) count, and platelets. Mild anemia (Hb=12.16±1.23) present before treating the hyperthyroidism that was significantly improved after treatment (P= 0.000). Conclusions: Our results showed that the only significant hematologic change in patients with Graves’ disease was mild anemia that improves after treating the underlying thyroid disorder. 

scholarly journals Haematological Changes in Donors Post Apheresis

2021 ◽  
Author(s):  
. Nikhil ◽  
Subhashish Das ◽  
. Snigdha
Keyword(s):  
Platelet Count ◽  
Blood Cells ◽  
Complete Blood Count ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
Point Of View ◽  
Haematological Parameters ◽  
Cross Sectional ◽  
Wbc Count ◽  
Rbc Count

Introduction: The productivity, quality of platelet apheresis collection has improved because of the considerable advancement in the automated cell separators. Automated cell separators have lot of sizeable scientific advances, but the alertness has been centered to Platelet Concentrates (PCs) quality than on safety of donor. Aim: To find the changes in haematological parameters and the consequences of apheresis and plateletpheresis on donor’s health. Materials and Methods: It was observational cross-sectional study done in laboratory at RL Jalappa Blood Bank, Tamaka, Kolar, Karnataka, India. The study was done from March 2019 to August 2020. A total of 300 healthy donors (plateletpheresis donors) were involved in the study. The plateletpheresis (Haemonetics MCS), predonation and postdonation haematological parameters such as haemoglobin concentration, Haematocrit (Hct), platelet, white and red blood cell count were calculated in all donors. The samples for Complete Blood Count (CBC) were secured from the donors, at the beginning and end of the procedure. Postdonation haematological parameters such as platelet count, haemoglobin, haematocrit, White Blood Cells (WBC), Red Blood Cells (RBC) counts of the donor was inscribed and comparison was done with the pre donation haematological parameters. Quality control of all Single Donor Platelet (SDP) products was done. All donors were evaluated for adverse donor reactions. The mean pre and post plateletpheresis values comparison was done utilising paired t-test. Statistical analysis was accomplished utilising Statistical Package for the Social Sciences (SPSS) software version 16.0. Results: Platelet count, haemoglobin, WBC count, RBC count and haematocrit were jotted down from 262 donors and a significant decrease was noticed in these parameters postdonation. Donor parameter platelet count (lac/mL) value was decreased from 273.57-224.28 whereas WBC count (cu/mm) predonation value decreased from 9.91-8.86 Postdonation, haemoglobin (g/dL) value decreased from 14.46-12.91, haematocrit (%) decreased slightly from 45.19-44.19, RBC count (million/mm3) decreased from 5.21-5.01. This concluded that the values decreased postdonation. Conclusion: The study conducted was safe from donor’s point of view. SDP is very effective in treatment of thrombocytopenia and is safe from recipient’s point of view.

scholarly journals Malaria-attributable fraction of fever episodes among HIV-seropositive patients in the Western highland area of Cameroon

2019 ◽  
Author(s):  
Timoléon TCHUINKAM ◽  
François Fopa ◽  
Anna Maria Doro-Altan ◽  
Innocent Djikolbe-Gondje ◽  
Maria Angeles Mendaza ◽  
...  
Keyword(s):  
Blood Cells ◽  
White Blood Cells ◽  
Attributable Fraction ◽  
Cross Sectional ◽  
Highland Area ◽  
Viral Loads ◽  
Significant Difference ◽  
Hiv Seropositive ◽  
Plasmodial Infection ◽  
Hiv Aids

Abstract Background: Fever is the most frequent symptom for Malaria and HIV/AIDS, but it is non-specific; therefore it can’t be used efficiently in clinical diagnosis of malaria in hyperendemic zones. In hypoendemic areas of malaria, this assertion is not obvious, since people lack naturally acquired immunity. The present study aims at determining the Malaria-attributable fraction of fever episodes (MAFE) among HIV-positive patients in a hypoendemic highland area. Methods: During two-years prospective cross-sectional study, blood samples were collected from outpatients of an HIV/AIDS clinic and examined for the presence and density of malaria parasites. In addition to malaria related symptoms, some other patients’ data were recorded: sexe, age, body mass index (BMI), T-lymphocyte CD4 counts, viral loads, haemograms and transaminases measurements. Results: A total of 729 HIV-seropositive patients were enrolled into the study. Their mean Plasmodial infection rate and parasitaemia were: 0.823% and 1.050 parasites/µl of blood respectively; and were both significantly lower, compared to the control seronegative group, in contrast to our hypothesis. No significant difference was observed when the mean values of transaminases were compared between those with and without plasmodial infection. For the 119 (16.32%) febrile individuals found, the calculated MAFE was almost null (0.15%). Their mean CD4 count, red blood cells (RBC) count and haemoglobin rate were: 226 cell/µl, 3.83x10 6 RBC/µl and 10.4 g/dl respectively; and were all significantly lower than in the non-febrile group. However, malaria parasite infection rates and mean densities were similar in both groups. Likewise, there was no difference between: sex ratios, mean ages, BMI, total white blood cells counts and viral loads between the two groups. Conclusion: HIV infection in spite of the immunodeficiency induced does not enhance the risk of Plasmodium infection in hypoendemic highland settings. Even in the scarce cases of co-infection occurring here, malaria is rarely responsible for fever episodes. These fevers are indeed associated with higher anaemia and immunodeficiency, and likely due instead to opportunistic infectious diseases.

scholarly journals Reliable assessment of bone marrow and bone marrow concentrates using automated hematology analyzer

2019 ◽  
Vol 14 (7) ◽  
pp. 639-646 ◽  
Author(s):  
Venkata P Mantripragada ◽  
Nicolas S Piuzzi ◽  
Jaiben George ◽  
Wesley Bova ◽  
Mitchell Ng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Red Blood Cells ◽  
Blood Cells ◽  
White Blood Cells ◽  
Limiting Factor ◽  
Cell Therapies ◽  
Reliable Assessment ◽  
Hematology Analyzer ◽  
Automated Hematology Analyzer

Aim: A limiting factor in advancement of bone marrow based cell therapies is the lack of characterization of cell products delivered to patients. Methods: Using an automated hematology analyzer that can be implemented in clinical setting, the composition of bone marrow aspirates (n = 17 patients) and bone marrow concentrates (n = 12 patients) were assessed. ICC estimates were calculated for measuring reliability. Results: Bone marrow aspirates assessment resulted in excellent reliability for determining white blood cells (ICC – 0.96; 95% CI: 0.92–0.99), red blood cells (ICC – 0.9; 95% CI: 0.77–0.96), platelets (ICC – 0.93; 95% CI: 0.85–0.97) composition. Bone marrow concentrate assessment resulted in excellent reliability for determining white blood cells (ICC – 0.97; 95% CI: 0.93–0.99), platelets (ICC – 0.95; 95% CI: 0.89–0.99) and moderate reliability for red blood cells (ICC – 0.66; 95% CI: 0.36–0.87) composition. Conclusion: Modern automated hematology analyzers could assist to better characterize the cell therapy products to provide reliable and consistent outcomes.

scholarly journals Effects of Chahuangjing on Decorporation and Radiation Protection Against Tritiated Water

Dose-Response ◽  
2018 ◽  
Vol 16 (4) ◽  
pp. 155932581881065 ◽  
Author(s):  
Xueyong Zuo ◽  
Qiu Chen ◽  
Houwen Li ◽  
Ke Zhang ◽  
Kongzhao Wang ◽  
...  
Keyword(s):  
Radiation Protection ◽  
Blood Cells ◽  
Tritiated Water ◽  
White Blood Cells ◽  
Sod Activity ◽  
Specific Pathogen ◽  
Mda Content ◽  
Automated Hematology Analyzer ◽  
Commercial Kits ◽  
Male Specific

The purpose of this study was to investigate the effects of Chahuangjing, a novel traditional Chinese medicinal compound, on decorporation and radiation protection against tritiated water (HTO). Sixty male specific-pathogen-free-grade C57BL/6J mice were randomly divided into 12 groups: mice in 4 control groups were intraperitoneally injected with sterile water; mice in 4 HTO groups were intraperitoneally injected with 11.1 × 105 Bq/g of HTO; and mice in the other 4 groups were administered with HTO and a Chahuangjing compound (0.2 mL, once daily). After 1, 7, 14, and 21 days, the mice were killed and samples were collected. A liquid scintillation counting method was used for tritium measurement. A fully automated hematology analyzer was used to assess blood samples. The superoxide dismutase (SOD) and malondialdehyde (MDA) content was analyzed using commercial kits. Chahuangjing significantly increased decorporation and shortened the effective half-life of tritium. To a certain extent, Chahuangjing alleviated the HTO-induced reduction in white blood cells and elevated red blood cells after HTO exposure. Moreover, Chahuangjing alleviated the HTO-induced reduction in SOD activity and reduced MDA. Our study demonstrated that Chahuangjing can enhance the elimination of tritium and reduce free radicals to alleviate HTO-induced radiation injury.

scholarly journals Predictors of Alcohol Consumption Among Younger Adults During the First Phase of the COVID-19 Pandemic

2021 ◽  
Vol 12 ◽  
Author(s):  
Lasse Brandt ◽  
Ricarda Evens ◽  
Simon Reiche ◽  
Roman M. Marek ◽  
Daa Un Moon ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Primary Outcome ◽  
Primary Outcome Measure ◽  
Negative Effects ◽  
Cross Sectional ◽  
Younger Adults ◽  
Guilty Feeling ◽  
Mental Health Effects ◽  
Number Of Individuals ◽  
Frequent Drinking

Background: The COVID-19 pandemic may lead to negative mental health effects but the effect on alcohol consumption among younger adults is unclear. We assess predictors of change in alcohol consumption during the first phase of the COVID-19 pandemic among younger adults.Methods: This cross-sectional internet-based survey was part of an overarching project, the Corona Drug Survey, which was conducted from April 30 to August 4, 2020. Participants of any sex and ≥18 years old were included. The primary outcome measure was change in alcohol consumption during the early COVID-19 pandemic. We implemented an ordinal logistic regression to assess the effect (odds ratio [OR] and 95% confidence interval [CI]) of the following predictors: quarantine restrictions on leaving the residence, number of individuals in the household, problematic alcohol consumption before the pandemic (CAGE [cutting down, annoyance by criticism, guilty feeling, and eye-opener] score), personal concern regarding the pandemic, age, and sex.Results: 3,321 participants with a mean age of 32 (SD: 13) years were included in this study. 70.4% of participants reported less or unchanged alcohol consumption in the recent 4 weeks of the pandemic compared to before the pandemic. A higher number of individuals in the household was associated with a reduced alcohol consumption (OR = 0.869; 95% CI = 0.815–0.927). No quarantine restrictions on leaving the residence (OR = 1.593; 95% CI = 1.397–1.817), a higher age (1.006; 1.001-1.011), and female sex (compared to males: 1.206; 1.062–1.371) were associated with an increase in alcohol consumption. The CAGE score before the pandemic (OR = 0.983; 95% CI = 0.931–1.037) and the pandemic concern (0.927; 0.857–1.003) were not associated with a significant change in alcohol consumption. Celebrations were no longer frequent drinking occasions during the pandemic compared to before the pandemic. The majority of participants (60.9%) did not use alcohol drinking as a coping mechanism to mitigate negative effects of the pandemic.Interpretation: In this cohort of younger adults with fewer celebratory drinking occasions, restrictions on leaving the residence and the number of persons in the household were the strongest predictors of reduced alcohol consumption during the early phase of the pandemic.

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