Effect of glucomannan on haematological, coagulation and biochemical parameters in male rabbits fed aflatoxin-contaminated ration

2011 ◽  
Vol 4 (2) ◽  
pp. 183-188 ◽  
Author(s):  
A. Eisa ◽  
A. Metwally
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Serum Glucose ◽  
Control Group ◽  
Total Lipids ◽  
Total Proteins ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Calcium Phosphorus ◽  
Aflatoxin B

The main goal of the present work was to explore the effect of glucomannan (GM) as a biological detoxifying agent on haematological, coagulation and biochemical parameters in male rabbits fed aflatoxin B1 (AFB1)-contaminated ration. Thirty male White New Zealand rabbits were used in this study. They were divided into 3 equal groups. The first group was given a ration free from mycotoxins and kept as a control group. Rabbits in the second group were fed a ration naturally contaminated with AFB1 (0.1 mg/kg ration) for 28 days, while rabbits in the third group were fed AFB1-contaminated ration (0.1 mg/kg ration) in addition to GM (1 kg/ton) for 28 days. The results of the present work revealed that aflatoxicosis elicited a picture of microcytic hypochromic anaemia, leukopenia, lymphocytopenia and monocytopenia. Coagulopathy recorded in this work due to aflatoxicosis was characterised by thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time. Hepatotoxicity due to AFB1 recorded in this work was characterised by a significant increase in serum activity of alanine aminotransferase, gammaglutamyl transferase and total bilirubin in addition to a significant decrease in serum total proteins and albumin. Data recorded in this work showed a significant increase in serum urea, creatinine, total lipids and cholesterol in addition to a significant decrease in serum glucose, calcium, phosphorus and iron in rabbits fed aflatoxin-contaminated ration only. Supplementation of rabbit ration with GM resulted in the return of the above-mentioned parameters to normal control values. It could be concluded that GM provides new insights into counteracting the adverse effects of AFB1.

scholarly journals Infection of sheep with Strongyloides papillosus: The effect of intensity of parasitic infection as well as therapy with albendazole on certain biochemical parameters in the blood of sheep

2015 ◽  
Vol 69 (1-2) ◽  
pp. 41-61
Author(s):  
Blagoje Dimitrijevic ◽  
Slavoljub Jovic ◽  
Milanka Jezdimirovic ◽  
Dragan Bacic ◽  
Mila Savic ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Parasitic Infection ◽  
Infection Intensity ◽  
Total Activity ◽  
Control Group ◽  
Growth Trend ◽  
Calcium Phosphorus

The objective of this work was to investigate certain biochemical parameters in the blood of sheep in conditions of different intensity of parasitic infection with Strongyloides papillosus, and also after the therapy with albendazole. The research was carried out on the sheep of Wurtemberg breed (n = 30) in which there was determined low, medium and high intensity of parasitic infection with S. papillosus. The control group (n = 10) consisted of the sheep that were negative to the presence of the parasitic infection. The degree and type of changes were monitored by determining the concentration of glucose, total protein, albumin, Albumin/Globulin ratio, AST, urea, total bilirubin, calcium, phosphorus, lactate dehydrogenase (LDH) total activity and isoenzyme distribution LDH1-5. On the basis of the obtained results it was concluded, through isoenzyme distribution of lactate dehydrogenase, that parasitic infection with S. papillosus can cause damage to the liver, heart muscle and lungs, while after the therapy with albendazole, the most affected organ is the liver. The concentration of glucose, total protein and albumin linearly decreased with the increase of intensity of the parasitic infection (p < 0,05), and after the therapy with albendazole, a drop in concentration of these parameters was at a statistically significantly higher level (p< 0,01). AST activity as well as the concentration of urea and total bilirubin grew linearly along with the intensity of the parasitic infection (p < 0,05). After the therapy with ABZ, AST activity and concentration of total bilirubin were at a statistically significantly higher level (p < 0,001), while urea concentration kept the same level as in the case of the parasitic infection. The values of calcium concentration (p > 0,05) as well as phosphorus (p < 0,05) linearly decreased with the parasitic infection intensity growth. Trend towards the decline of the concentration of these macroelements continues even after the therapy with albendazole (p < 0,001). Considering our previous research in the field of oxidative stress, a phenomenon that is fundamentally related to the changes determined in this work, we strongly recommend that besides antihelmintics, preparations with antioxidative properties should be used in antiparasitic protocols as well. <br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/VETGL190125001E">10.2298/VETGL190125001E</a><u></b></font>

Study on Kidney Function in Female Workers Exposed to Perchlorethylene

1990 ◽  
Vol 9 (6) ◽  
pp. 377-380 ◽  
Author(s):  
A. Vyskočil ◽  
S. Emminger ◽  
J. Tejral ◽  
Z. Fiala ◽  
E. Ettlerova ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Biochemical Parameters ◽  
Renal Damage ◽  
Ambient Air ◽  
Exposed Group ◽  
Control Group ◽  
Total Proteins ◽  
Dry Cleaning ◽  
Female Workers ◽  
Occupationally Exposed

1 Biochemical markers of kidney damage were examined in 16 female workers chronically exposed to tetrachlorethylene (TCE) in five dry-cleaning shops. The results were compared with those obtained in 13 females non-occupationally exposed to organic solvents. 2 The intensity of exposure was monitored by personal environmental monitoring. The time-weighed average exposure to TCE amounted to 157 mg m-3 (range 9-799 mg m-3). A satisfactory agreement was found between the concentration of TCE in ambient air sampled with the charcoal tube method and with a passive dosimeter. 3 The urinary excretion of lysozyme was increased in the exposed group. No difference was found in the urinary excretion of albumin, β2-microglobulin, lactate dehydrogenase, total proteins or glucose. The prevalence of abnormal values of biochemical parameters in the exposed group did not differ from that observed in the control group. No correlation was found between the level of TCE exposure and biochemical parameters. 4 The present study suggests that chronic exposure to TCE does not lead to renal damage.

Reticulocyte Parameters in Microcytic Hypochromic Anaemias Using Beckman Coulter DxH800 – A Study from Kerala, India

2021 ◽  
Vol 8 (14) ◽  
pp. 888-892
Author(s):  
Blessy Mary Thomas ◽  
Sheila Das ◽  
Sunil Antony ◽  
Alice David
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Response To Therapy ◽  
Control Group ◽  
Blood Samples ◽  
Deficiency Anaemia ◽  
Chronic Disorder ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia

BACKGROUND Microcytic hypochromic anaemia is commonly due to iron deficiency, anaemia of chronic disorder [ACD] and thalassaemic syndromes. Reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anaemias and monitoring bone marrow response to therapy METHODS All samples were selected from routine blood counts, and sent for investigation of anaemia, over a period of two years. These samples were run on the DxH800 (Beckman Coulter). 385 cases were selected for the study. Blood analysis for all these cases had been requested by general practitioners to investigate anaemia. These blood samples had been collected in ethylenediaminetetraacetic acid (EDTA) anticoagulant vacutainers and processed within 2 hours of collection. Determination of red cell and reticulocyte parameters in all blood samples, was performed using the Beckman Coulter 7-part analyser [Unicell DxH 800]. RESULTS Of the 156 cases of microcytic hypochromic anaemia studied, iron deficiency anaemia (IDA) was present in 91 cases, anaemia of chronic disorder (ACD) in 50 cases, beta thalassemia trait (BTT) in 15 cases. Of the 50 ACD cases, 37 were associated with IDA. The control group comprised of 229 adult medical students (143 women and 103 men) with a median age of 18.84 ± 0.98 years. We also had 4 cases of other haemoglobinopathies, which were microcytic hypochromic, but were not included in our study as the number of cases was too less to be analysed. CONCLUSIONS New reticulocyte parameters are useful for evaluation of iron status and diagnosing iron deficiency anaemias. They also are reliable parameters for recognising subsets of anaemic patients thereby improving the management of anaemia. KEYWORDS Reticulocyte, Microcytic, Hypochromic, Anaemia, Beckman Coulter

scholarly journals Biochemical responses to ocean acidification contrast between tropical corals with high and low abundances at volcanic carbon dioxide seeps

2015 ◽  
Vol 73 (3) ◽  
pp. 897-909 ◽  
Author(s):  
J. Strahl ◽  
D. S. Francis ◽  
J. Doyle ◽  
C. Humphrey ◽  
K. E. Fabricius
Keyword(s):  
Carbon Dioxide ◽  
Fatty Acids ◽  
Biochemical Parameters ◽  
Cell Damage ◽  
Biomass Energy ◽  
Elevated Pco2 ◽  
Protein Carbonyls ◽  
Total Lipids ◽  
Cell Protection ◽  
Total Proteins

AbstractAt two natural volcanic seeps in Papua New Guinea, the partial pressure of carbon dioxide (pCO2) in the seawater is consistent with projections for 2100. Here, the cover of massive scleractinian corals Porites spp. is twice as high at elevated compared with ambient pCO2, while that of branching corals such as Acropora millepora is greater than twofold reduced. To assess the underlying mechanisms for such community shifts under long-term exposure to elevated pCO2, biochemical parameters related to tissue biomass, energy storage, pigmentation, cell protection, and cell damage were compared between Porites spp. and A. millepora from control (mean pHtotal = 8.1, pCO2 = 323 µatm) and CO2 seep sites (mean pHtotal = 7.8, pCO2 = 803 µatm) each at two reefs. In Porites spp., only one of the biochemical parameters investigated (the ratio of photoprotective to light-harvesting pigments) responded to pCO2, while tissue biomass, total lipids, total proteins, and some pigments differed between the two reefs, possibly reflecting differences in food availability. Furthermore, some fatty acids showed pCO2 –reef interactions. In A. millepora, most pigments investigated were reduced at elevated pCO2, while other parameters (e.g. tissue biomass, total proteins, total lipids, protein carbonyls, some fatty acids and pigments) differed between reefs or showed pCO2–reef interactions. Tissue biomass, total lipids, and cell-protective capacities were distinctly higher in Porites spp. than in A. millepora, indicating higher resistance to environmental stress in massive Porites. However, our data suggest that important biochemical measures remain relatively unaffected in these two coral species in response to elevated pCO2 up to 800 µatm, with most responses being smaller than differences between species and locations, and also when compared with responses to other environmental stressors such as ocean warming.

scholarly journals ANTIHEPATOTOXIC POTENTIALITY OF 2-3-6 TRIMETHYLOCT-6-ENAL AGAINST PARACETAMOL INDUCED LIVER DYSFUNCTION

2017 ◽  
Vol 9 (9) ◽  
pp. 59
Author(s):  
Suparna Datta ◽  
Manabendra Dutta Choudhury
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Liver Toxicity ◽  
Control Group ◽  
Protective Agent ◽  
Protective Activity ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Aspartate Amino Transferase

Objective: We investigated the liver protective activity of 2-3-6 trimethyloct-6-enal from the methanol extract of Pajanelia longifolia (Willd.) K. Schuman. The liver protective activity of 2,3,6 trimethyloct-6-enal was evaluated against paracetamol (2 mg/kg body weight per orally) induced liver toxicity in swiss albino mice.Methods: Considering the Spectral data (IR spectrum, 1HNMR spectrum and 13C NMR spectrum) the predictable structure of 2,3,6 trimethyloct-6-enal was elucidated. To study the liver protective activity of the compound, Swiss albino mice of either sex were divided into six groups and treated for 5 d. Group I and II served as normal and toxic control, Group III were treated with Silymarin as a standard drug (50 mg/kg), and Group IV to VI was treated with 2-3-6 trimethyloct-6-enal at the dose of 50 mg/kg, 150 mg/kg and 250 mg/kg b.w. p. o. respectively. The liver protective activity of the compound was measured on biochemical parameters such as aspertate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), triglycerides (TGL), total cholesterol (TC) and protein. Further antioxidant activity of the compound was also measured on antioxidant enzymatic and non-enzymatic levels such as reduced glutathione (GSH), lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)).Results: The study revealed that the compound has protective activity at the dose of 50, 150 and 250 mg/kg b.w. p. o. against paracetamol induced toxicity. In some biochemical parameters such as aspartate amino transferase and bilirubin, the compound has showed better result at a dose of 150 mg/kg compared to standard drug silymarin (value of aspartate amino transferase (compound) =71.10±0.12, (toxic) = 173.43±1.21, (silymarin) =79.86±0.02and total bilirubin (compound) = 1.04±0.11), (toxic) = 2.69±0.02, (silymarin) ==1.11±0.01. The findings were also confirmed by histopathological observations.Conclusion: 2,3,6 trimethyloct-6-enal from Pajanelia longifolia may be considered as a potent liver protective agent.

scholarly journals Serum Ferritin Status in Microcytic Hypochromic Anaemic Medical Students

2014 ◽  
Vol 28 (1-2) ◽  
pp. 23-28
Author(s):  
Hafiza Akhter ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Tabassum Ferdous ◽  
Hasina Akhter ◽  
...  
Keyword(s):  
Young Adults ◽  
Medical Students ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Control Group ◽  
Medical College ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Significant Difference

Background: Microcytic hypochromic anaemia is common in young adults , specially in females. It is important to know the serum ferritin status of the medical students who will be involved, in future, with the health care delivery system and to prevent anaemia among them. Objective: To observe the serum ferritin status in microcytic hypochromic anaemic medical students. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2009 to June 2010. A total number of 516 apparently healthy young adults of both sexes, age ranged from 18 to 22 years , were selected for the study from two medical college in Dhaka city. Of them, 276 were nonanaemic (control group A) and 240 were anaemic (study group B). Again , anaemic (B) subjects are divided into anaemic female (B1) and anaemic male (B2) . Among the anaemic (B) subjects, 170 had normocytic normochromic , 68 had microcytic hypochromic and 2 had macrocytic hypochromic anaemia. Serum ferritin was estimated by Micro-particle Enzyme Immunoassay in subjects (68 in number) who were suffering from microcytic hypochromic anaemia. The statistical analysis was done by using unpaired ‘t’ test , Pearson’s correlation coefficient test as applicable. Result: The mean serum ferritin level was almost similar and showed no statistically significant difference between group B1 and B2. Again, a significant positive correlation of serum ferritin level with haemoglobin was observed in both female and male in microcytic hypochromic anaemic group. Conclusion: This study reveals that serum ferritin level is one of the most sensitive and accurate indicator indicating iron status and thus microcytic hypochrmic anaemia. DOI: http://dx.doi.org/10.3329/bjpp.v28i1-2.20077 Bangladesh J Physiol Pharmacol 2012; 28(1&2):23-28

scholarly journals Vitamin D Metabolism Alteration in Acromegaly and Its Impact on Calcium-Phosphorus Metabolism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A651-A652
Author(s):  
Alexandra Povaliaeva ◽  
Liudmila Rozhinskaya ◽  
ScD, Artem Zhukov ◽  
Ekaterina A Pigarova ◽  
ScD, Larisa K Dzeranova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Phosphorus Metabolism ◽  
Total Calcium ◽  
Healthy Individuals ◽  
Hydroxylase Activity ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus

Abstract Objective: to evaluate metabolism of vitamin D and calcium-phosphorus metabolism in patients with an active phase of acromegaly in comparison with healthy individuals. Materials and Methods: The study included 44 patients with an active acromegaly (IGF-1 788 [521; 963] ng/mL), as well as 49 conditionally healthy individuals. There were more men in the Acromegaly group (41% vs. 20%, p &lt;0.05), patients were older (median age 42.7 [35.5; 26.5] vs. 26.3 [25; 33.5] years, p &lt;0.05) and had a higher BMI (28.4 [25.2; 30.2] vs. 22.2 [20.1; 26.1] kg/m2, p &lt;0.05) in a minor way compared with the control group. All participants were tested for vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3) by UPLC-MS/MS, free 25(OH)D and vitamin D-binding protein by ELISA, PTH by electrochemiluminescence immunoassay, as well as routine biochemical parameters of blood serum (calcium, phosphorus, creatinine, albumin, magnesium) and urine (calcium and phosphorus-creatinine ratio in spot urine). Results: In the Acromegaly group, we observed significantly higher levels of serum total calcium (2.46 [2.37; 2.56] vs. 2.38 [2.33; 2.45] mmol/L, p &lt;0.05), albumin-corrected calcium (2.33 [2.28; 2.42] vs. 2.26 [2.21; 2.31] mmol/L, p &lt;0.05) and phosphorus (1.39 [1.25; 1.55] vs. 1.15 [1.06; 1.23] mmol/L, p &lt;0.05) as well as lower levels of serum albumin (45 [44; 47] vs. 46 [45; 48] g/L, p &lt;0.05). The rest of the studied biochemical parameters and PTH levels did not differ significantly between the groups. The IGF-1 level in patients with acromegaly positively correlated with the level of total calcium (r = 0.49, p &lt;0.05), albumin-corrected calcium (r = 0.49, p &lt;0.05) and phosphorus (r = 0.55, p &lt;0.05). The Acromegaly group showed lower levels of 25(OH)D3 (14.8 [11.8; 20.5] vs. 20.5 [14.8; 24.6] ng/mL, p &lt;0.05), 3-epi-25(OH)D3 (1.0 [0.7; 1.4] vs. 1.4 [0.9; 1.8] ng/mL, p &lt;0.05), 24,25(OH)2D3 (0.8 [0.4; 1.2] vs. 1.7 [0.9; 2.6] ng/ml, p &lt;0.05) and free 25(OH)D (4.6 [3.7; 5.6] vs. 5.9 [4.0; 7.5] pg/mL, p &lt;0.05), higher levels of 1,25(OH)2D3 (50 [42; 63] vs. 39 [34; 45] pg/mL, p &lt;0.05), a lower 25(OH)D3/1,25(OH)2D3 ratio (289 [226; 443] vs. 517 [340; 641], p &lt;0.05) and a higher 25(OH)D3/24,25(OH)2D3 ratio (19.3 [15.4; 27.7] vs. 11.9 [9.6; 15.2], p &lt;0.05). Conclusion: Our data suggest that high levels of the active vitamin D metabolite (1,25(OH)2D3) resulting from an increase in 1α-hydroxylase activity may contribute to the elevation of calcium and phosphorus serum levels in patients with acromegaly. Our results also indicate a decrease in 24-hydroxylase activity in patients with acromegaly, which may be due to lower levels of 25(OH)D3 in these patients. The results obtained should be evaluated taking into account the observed differences in age, gender and BMI between groups.

scholarly journals The consequences of using mixture with buffers effects on some biochemical parameters in blood serum during the fattening of the lambs

2011 ◽  
Vol 27 (4) ◽  
pp. 1463-1468
Author(s):  
B. Jasovic ◽  
J. Stojkovic ◽  
B. Milosevic ◽  
M. Milenkovic ◽  
Z. Spasic ◽  
...  
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Control Group ◽  
Closed Area ◽  
Calcium Phosphorus ◽  
Experimental Group

This work has an aim to explore the effects of the product based on the natural zeolit during the fattening of the lambs and also the effects on contents of calcium, phosphorus and magnesium in blood serum. The experiment lasted 15 days in the closed area of the Agricultural school in Kraljevo, and the lambs were divided into three groups of 15 lambs (Control group -C, Experimental group E1 and E2). They were fed with sheep?s milk, concentrate for lambs? fattening and meadow hay. The lambs in the experimental groups, in contrast to Control group, were fed with the different concentration of the preparation based on the natural zeolit (O1=1%, O2=1.5%), so that the manifested differences would be treated as the resault of the different concentration of the zeolit that was added to the lambs? food.At the end of the experiment the differences in the parameters of the lambs? blood serum were distinguished and especially in the concentration of calcium, phosphorus and magnesium.

scholarly journals MON-390 Vitamin D Metabolism in Patients with Acromegaly: A Case-Control Pilot Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Alexandra Povaliaeva ◽  
Ekaterina Pigarova ◽  
Artem Zhukov ◽  
Larisa Dzeranova ◽  
Victor Bogdanov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Reference Interval ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Phosphorus Metabolism ◽  
Creatinine Ratio ◽  
Healthy Individuals ◽  
Blood Calcium ◽  
Calcium Phosphorus

Abstract Objective: to study the differences in the metabolism of vitamin D and calcium-phosphorus metabolism in patients with an active phase of acromegaly in comparison with healthy individuals. Materials and methods: The study included 8 patients with an active acromegaly, median age 36.5 ± 6.25 years, BMI 27.9 ± 1.95 kg/m2, IGF-1 907.3 ± 239 ng/ml, as well as 8 conditionally healthy individuals selected by age, sex and level of 25(OH)D determined by the immunochemiluminescent method (DEQAS certified). All participants were tested for calcium-phosphorus metabolism, PTH, and vitamin D metabolites by HPLC/MS-MS (25(OH)D3, 25(OH)D2, 3-epi-25(OH)D3 and 24,25(OH)2D3) before oral administration of 150 000 IU of an aqueous solution of cholecalciferol and 7 days after administration. Results: In the Acromegaly group, on the 7th day after taking the drug, there was a statistically significant increase in 25(OH)D3 (89.8 ± 10.5 vs. 54.1 ± 14.8 nmol/L), 3-epi-25(OH)D3 (9.0 ± 2.6 vs. 3.3± 1.1 nmol/L) and 24,25(OH)2D3 (8.3 ± 1.9 vs. 6.4 ± 2.1 nmol/L), and a decrease of 25(OH)D2 (0.8 ± 0.2 vs. 1.1 ± 0.3 nmol/L) and a ratio of 24,25(OH)2D3 to 25(OH)D3 (0.1 ± 0.02 vs. 0.13 ± 0.03). A statistically significant increase in albumin-adjusted calcium was also noted (2.39 ± 0.14 vs. 2.31 ± 0.13 mmol/L). The medians of the levels of PTH and phosphorus initially were 27.1 ± 13.5 pg/ml and 1.6 ± 0.3 mmol/l and did not change by day 7 after taking the drug; creatinine and magnesium levels also remained the same. The level of calcium-creatinine ratio in a single portion of urine (CCR) was initially within the reference interval for all patients, its median did not change by day 7, however, in two patients there was a clinically insignificant increase higher than the upper limit of the reference interval; the phosphorus-creatinine ratio in a single portion of urine increased significantly. In the control group, after taking cholecalciferol similar changes in the levels of the studied vitamin D metabolites were observed, the levels of PTH also remained the same, however, there were no changes in the median biochemical parameters of blood and urine by day 7 after drug intake. Among the studied vitamin D metabolites, there were initially no significant differences between the groups; on day 7 a difference was recorded for the level of 3-epi-25(OH)D3 (9.0 ± 2.6 in the Acromegaly group vs. 18.8 ± 8.9 nmol/L in the control group). Among the biochemical parameters in the Acromegaly group higher levels of ionized blood calcium (1.14 ± 0.05 vs 1.1 ± 0.03 mmol/L), blood phosphorus (1.61 ± 0.26 vs 1.15 ± 0.09 mmol/L) and CCR were observed. Conclusion: Loading dose of cholecalciferol in patients with acromegaly is associated with less production of 3-epi-25(OH)D3, and results in lower inactive fraction of vitamin D than in healthy controls. More studies are needed to evaluate the effect of 1.25(OH)2D3 level on calcium-phosphorus metabolism in acromegaly.

Serum fetuin-A levels and association with hematological parameters in chronic kidney disease and hemodialysis patients

2019 ◽  
Vol 44 (4) ◽  
pp. 517-523
Author(s):  
Aybala Erek Toprak ◽  
Fetullah Gerin ◽  
Hayriye Erman ◽  
İlyas Duran ◽  
Eray Atalay ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Acute Phase Reactant ◽  
Hemodialysis Patients ◽  
Serum Glucose ◽  
Control Group ◽  
Fetuin A ◽  
Calcium Phosphorus

Abstract Aim The objective of the current study is to examine the association between serum fetuin-A concentrations and some other inflammation markers neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV) and C reactive protein (CRP) in patients with chronic kidney disease (CKD) and hemodialysis. Methods The study subjects are composed of healthy volunteers (n = 47) and two patient groups; CKD patients (n = 26) and hemodialysis patients (n = 33). We measured serum glucose, urea, creatinine, total protein, albumin, sodium, potassium, calcium, phosphorus, iron, alkaline phosphatase, parathyroid hormone, ferritin and CRP levels by auto-analyzer and fetuin-A levels by ELISA method. Also, complete blood count parameters were analyzed and NLR was calculated. Results There were significant differences in serum fetuin-A concentrations, NLR and MPV values among three groups (p < 0.001, p < 0.001, p < 0.001). The correlation analyses revealed that fetuin-A negatively correlated with urea, creatinine, ferritin, and CRP concentrations (r: 0.349, 0.367, 0.399, 0.550, respectively, p < 0.05). Conclusion Fetuin-A is lower in CKD and hemodialysis patients than the control group; supporting as a negative acute phase reactant. Determination of serum fetuin-A, NLR and MPV might be useful to assess inflammation in CKD and hemodialysis patients.

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