scholarly journals Infection of sheep with Strongyloides papillosus: The effect of intensity of parasitic infection as well as therapy with albendazole on certain biochemical parameters in the blood of sheep

2015 ◽  
Vol 69 (1-2) ◽  
pp. 41-61
Author(s):  
Blagoje Dimitrijevic ◽  
Slavoljub Jovic ◽  
Milanka Jezdimirovic ◽  
Dragan Bacic ◽  
Mila Savic ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Parasitic Infection ◽  
Infection Intensity ◽  
Total Activity ◽  
Control Group ◽  
Growth Trend ◽  
Calcium Phosphorus

The objective of this work was to investigate certain biochemical parameters in the blood of sheep in conditions of different intensity of parasitic infection with Strongyloides papillosus, and also after the therapy with albendazole. The research was carried out on the sheep of Wurtemberg breed (n = 30) in which there was determined low, medium and high intensity of parasitic infection with S. papillosus. The control group (n = 10) consisted of the sheep that were negative to the presence of the parasitic infection. The degree and type of changes were monitored by determining the concentration of glucose, total protein, albumin, Albumin/Globulin ratio, AST, urea, total bilirubin, calcium, phosphorus, lactate dehydrogenase (LDH) total activity and isoenzyme distribution LDH1-5. On the basis of the obtained results it was concluded, through isoenzyme distribution of lactate dehydrogenase, that parasitic infection with S. papillosus can cause damage to the liver, heart muscle and lungs, while after the therapy with albendazole, the most affected organ is the liver. The concentration of glucose, total protein and albumin linearly decreased with the increase of intensity of the parasitic infection (p < 0,05), and after the therapy with albendazole, a drop in concentration of these parameters was at a statistically significantly higher level (p< 0,01). AST activity as well as the concentration of urea and total bilirubin grew linearly along with the intensity of the parasitic infection (p < 0,05). After the therapy with ABZ, AST activity and concentration of total bilirubin were at a statistically significantly higher level (p < 0,001), while urea concentration kept the same level as in the case of the parasitic infection. The values of calcium concentration (p > 0,05) as well as phosphorus (p < 0,05) linearly decreased with the parasitic infection intensity growth. Trend towards the decline of the concentration of these macroelements continues even after the therapy with albendazole (p < 0,001). Considering our previous research in the field of oxidative stress, a phenomenon that is fundamentally related to the changes determined in this work, we strongly recommend that besides antihelmintics, preparations with antioxidative properties should be used in antiparasitic protocols as well. <br><font color="red"><b> This article has been retracted. Link to the retraction <u><a href="http://dx.doi.org/10.2298/VETGL190125001E">10.2298/VETGL190125001E</a><u></b></font>

Effect of glucomannan on haematological, coagulation and biochemical parameters in male rabbits fed aflatoxin-contaminated ration

2011 ◽  
Vol 4 (2) ◽  
pp. 183-188 ◽  
Author(s):  
A. Eisa ◽  
A. Metwally
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Serum Glucose ◽  
Control Group ◽  
Total Lipids ◽  
Total Proteins ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Calcium Phosphorus ◽  
Aflatoxin B

The main goal of the present work was to explore the effect of glucomannan (GM) as a biological detoxifying agent on haematological, coagulation and biochemical parameters in male rabbits fed aflatoxin B1 (AFB1)-contaminated ration. Thirty male White New Zealand rabbits were used in this study. They were divided into 3 equal groups. The first group was given a ration free from mycotoxins and kept as a control group. Rabbits in the second group were fed a ration naturally contaminated with AFB1 (0.1 mg/kg ration) for 28 days, while rabbits in the third group were fed AFB1-contaminated ration (0.1 mg/kg ration) in addition to GM (1 kg/ton) for 28 days. The results of the present work revealed that aflatoxicosis elicited a picture of microcytic hypochromic anaemia, leukopenia, lymphocytopenia and monocytopenia. Coagulopathy recorded in this work due to aflatoxicosis was characterised by thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time. Hepatotoxicity due to AFB1 recorded in this work was characterised by a significant increase in serum activity of alanine aminotransferase, gammaglutamyl transferase and total bilirubin in addition to a significant decrease in serum total proteins and albumin. Data recorded in this work showed a significant increase in serum urea, creatinine, total lipids and cholesterol in addition to a significant decrease in serum glucose, calcium, phosphorus and iron in rabbits fed aflatoxin-contaminated ration only. Supplementation of rabbit ration with GM resulted in the return of the above-mentioned parameters to normal control values. It could be concluded that GM provides new insights into counteracting the adverse effects of AFB1.

scholarly journals Changes in serum adenosine deaminase and isoenzyme levels in addition to routine liver biochemical parameters in sheep with chronic fascioliasis

2022 ◽  
Vol 52 (4) ◽  
Author(s):  
Nuri Altuğ ◽  
Yıldıray Başbuğan ◽  
Nazmi Yuksek
Keyword(s):  
Bile Duct ◽  
Adenosine Deaminase ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Clinical Signs ◽  
Infected Group ◽  
Direct Bilirubin ◽  
Control Group ◽  
And Control

ABSTRACT: This study assessed changes in the levels of adenosine deaminase (ADA) and its isoenzymes in addition to routine liver biochemical parameters in sheep with fascioliasis. The study was conducted on 35 Akkaraman sheep. Of these, 25 sheep were diagnosed with fascioliasis based on anamnesis and clinical signs, and had endoparasites based on parasitological examinations (Fasciola-infected group). The remaining 10 sheep that were sampled from a single healthy herd (same flock) different from the infected group did not have any clinical signs or endoparasites (control group). Total protein (TP), albumin (ALB), and globulin (GLB) levels gradually increased on days after treatment compared to the values measured before treatment; the increases were statistically significant on all days for TP levels but only on day 14 after treatment for GLB levels (P < 0.05). Although, the ALB levels did not increase significantly on days after treatment, the ALB level and ALB/GLB ratio on days 7 and 14 after treatment were still lower than the values of day 21 after treatment and control group (P < 0.05). Total bilirubin (T-Bil) and direct bilirubin (D-Bil) levels on days 14 and 21 were significantly lower than that of day 0 (before treatment) and day 7 after treatment (P < 0.05). These results indicated that the increase in adenosine deaminase (ADA) and ADA1 levels may be due to possible concomitant infection of Fasciola larvae (in the parenchyma) and adults (in the bile duct).

Effect of opioid peptides on liver function after patial hepatectomy

2018 ◽  
pp. 67-71
Author(s):  
А.В. Солин ◽  
А.Ю. Ляшев ◽  
Ю.Д. Ляшев
Keyword(s):  
Lactate Dehydrogenase ◽  
Liver Failure ◽  
Partial Hepatectomy ◽  
Opioid Receptors ◽  
Total Protein ◽  
Pronounced Effect ◽  
Male Rats ◽  
Control Group ◽  
Peptide Molecule ◽  
Selective Agonists

Цель исследования - сравнительный анализ влияния селективных агонистов отдельных классов опиоидных рецепторов на белковосинтетическую функцию печени, развитие цитолитического и холестатического синдромов у крыс, подвергшихся частичной гепатэктомии. Методика. Работа выполнена на 152 крысах-самцах Вистар массой 200-250 г. Частичную гепатэктомию выполняли по методу, описанному Higgins G.M. и Anderson R.M. с удалением 70% ткани печени. В плазме крови определяли концентрации общего белка, альбуминов, общего билирубина, активность аланинтрансаминазы (АЛТ), аспартаттрансаминазы (АСТ), лактатдегидрогеназы (ЛДГ) традиционными методами. Опиоиды: DAGO в дозе 6,3 мкг/кг, DSLET в дозе 10,0 мкг/кг, динорфин А (1-13) в дозе 20,1 мкг/кг, вводили внутрибрюшинно ежедневно 1 раз в сутки в течение 5 сут. эксперимента в объеме 0,2 мл. Контрольным животным аналогично вводили физраствор. Результаты. Удаление 70% ткани печени у крыс-самцов Вистар сопровождается развитием печеночной недостаточности, проявляющейся гипербилирубинемией, гипоальбуминемией, гипопротеинемией, повышением активности трансаминаз и лактатдегидрогеназы. Применение селективных агонистов опиоидных рецепторов у крыс, которым моделировали частичную гепатэктомию, оказывало гепатопротективное действие и снижало выраженность проявлений печеночной недостаточности, начиная с 3-х сут. после резекции. Активность трансаминаз, лактатдегидрогеназы и концентрация общего билирубина у животных, которым вводили опиоиды, были существенно ниже, чем в контрольной группе. Содержание общего белка и альбуминов было статистически значимо выше в группах, которые получали исследованные пептиды, по сравнению с контрольной группой на 7-е сут. после частичной гепатэктомии. Наиболее выраженное действие проявлял селективный агонист опиоидных мю-рецепторов DAGO. По нашему мнению, такое влияние пептидов объясняется присущими им антиоксидантным и антигипоксическим эффектами, что снижает повреждающее действие оперативного вмешательства на печень. Более выраженное влияние DAGO связано, по-видимому, с особенностями распределения опиоидных рецепторов или устойчивостью пептида к действию эндопептидаз благодаря модификациям в молекуле пептида. Заключение. Применение опиоидов стимулирует восстановление функциональной активности печени после частичной гепатэктомии. Наибольший эффект отмечается при введении мю-агониста DAGO. Aim. The aim of the study was to compare effects of selective agonists of opioid receptors from different classes on the protein-synthesizing function of liver and development of cytolytic and cholestatic syndromes in rats after partial hepatectomy. Methods. The study was conducted on 152 Wistar male rats weighing 200-250 g. The animals were subjected to partial hepatectomy according to the Higgins and Anderson method. Concentrations of total protein, albumin, total bilirubin, and activities of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were measured in plasma using standard methods. The opioids, DAGO (6.3 mg/kg), DSLET (10.0 mg/kg), and dynorphin A (1-13) (20.1 mg/kg), were injected in 0.2 ml of saline daily for 5 days. Control animals were injected with 0.2 ml of saline for 5 days. Results. Resection of 70% of liver tissue resulted in development of liver failure as evidenced by hyperbilirubinemia, hypoalbuminemia, hypoproteinemia, and increased transaminase and lactate dehydrogenase activities. Selective agonists of opioid receptors administered to the rats after partial hepatectomy exerted a hepatoprotective effect and alleviated the signs of liver failure beginning from the 3 day after resection. Transaminase and lactate dehydrogenase activities were significantly lower in opioid-treated rats than in the control group. Levels of total protein and albumins were significantly higher in the groups injected with the study peptides compared to the control group on the 7 day after partial hepatectomy. The selective agonist of opioid m-receptors, DAGO, exerted the most pronounced effect. Apparently, the similar effects of peptides were due to their antioxidant and anti-hypoxic action, which alleviated the detrimental effect of liver surgery. The more pronounced effect of DAGO apparently resulted from peculiarities of opioid receptors distribution or peptide resistance to endopeptidase action due to modifications of the peptide molecule. Conclusion. Administration of opioids stimulated restoration of liver functional activity after partial hepatectomy. Injections of the m-agonist, DAGO, produced the most pronounced effect.

scholarly journals Study on Oxidative Metabolic Changes to Differentiate Exudative from Transudative Pleural Effusions

1970 ◽  
Vol 1 (1) ◽  
pp. 38-43
Author(s):  
V Narsimha Reddy ◽  
V Anil Kumar ◽  
M Srinivas ◽  
V Narayana Reddy
Keyword(s):  
Oxidative Stress ◽  
Lactate Dehydrogenase ◽  
Pleural Fluid ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Oxygen Species ◽  
Pleural Effusions ◽  
Glucose Levels ◽  
Protein Serum ◽  
Serum Ratio

The purpose of this present study was to differentiate transudates and exudates in pleural effusions. Oxidative stress has been associated with various respiratory disorders. Ninety patients of pleural effusions of diverse etiologies were participated in this study. Subjects underwent diagnostic thoracentesis and standard biochemical parameters (total protein, lactate dehydrogenase, glucose, MDA levels) were measured in pleural fluid and serum. MDA, total protein, lactate dehydrogenase (LDH), glucose levels in plural fluid were higher in exudates compared to transudates (p < 0.001). Total protein pleural fluid/ total protein serum ratio, LDH pleural fluid/LDH serum ratio and MDA pleural fluid/MDA serum ratio were raised in exudates compared to transudates (p < 0.001). The present study showed that oxidative stress was more in exudates compared to transudates, probably due to the production of reactive oxygen species and it may serve as a marker for differentiation between transudates and exudates in clinical practice. Key Words: Exudates, Melondialdehyde, Oxidative Stress, Pleural Effusion, Transudates    doi:10.3329/sjps.v1i1.1806 S. J. Pharm. Sci. 1(1&2): 38-43

scholarly journals Plasma Calcium Levels in Pregnant Asian Women

1976 ◽  
Vol 13 (1-6) ◽  
pp. 339-344 ◽  
Author(s):  
Nina Polanska ◽  
R. A. Dale ◽  
M. R. Wills
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Dietary Intake ◽  
Total Protein ◽  
Plasma Calcium ◽  
Asian Women ◽  
Control Group ◽  
Calcium Phosphorus ◽  
And Control ◽  
Endogenous Synthesis

Plasma calcium, phosphorus, alkaline phosphatase, total protein, and albumin were measured during pregnancy in a group of Asian women living in the south of England and in a control group. The Asian women had slightly lower mean plasma calcium concentrations than the control group. Exposure of Asian women to sunshine appeared to be low, and it was inferred that they probably had little endogenous synthesis of cholecalciferol as a result. Both Asian and control subjects ingested similarly low amounts of vitamin D. The Asian women consumed greater amounts of phytate and vegetable fibres than the controls, and it is suggested that these substances may reduce absorption of insoluble lipids (including cholecalciferol) and calcium in a setting where the dietary intake and endogenous synthesis of vitamin D are already borderline for the subjects' requirements.

scholarly journals The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256661
Author(s):  
Fatima Dikhanbayeva ◽  
Elmira Zhaxybayeva ◽  
Zhuldyz Smailova ◽  
Arman Issimov ◽  
Zhechko Dimitrov ◽  
...  
Keyword(s):  
Blood Serum ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Camel Milk ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Group V ◽  
Group I ◽  
Serum Biochemical ◽  
Group Ii

This study aimed to assess potential feeding effect of camel milk curd mass and its mixes to experimental rat’s blood serum biochemical parameters, enzymatic activity and the peptide toxicity. Fifty healthy male Sprague-Dawley rats were divided into five groups (n = 10 each). Each group was fed with camel milk pure curd mass and its mixes for 16 days. At the end of the experiment, rats were sacrificed to collect the samples from the blood serum. Blood serum biochemical parameters total protein, cholesterol, glucose, albumin, triglycerides; the enzymatic activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase were determined on the A25 automatic analyser, and peptide toxicity analysed by the reference method. The statistical data have shown no significant differences in body weight gain in all groups. Total protein decreased in group II, IV, and V; however, it increased in group III compared to the control group. Cholesterol grew up in group II and it slightly increased in group V, dropped in groups III and IV compared to group I result. Glucose increased in groups II, III, IV compared to group I; still, group V results show a slight decrease. Albumin decreased in group IV, yet in group V it increased than the group I result. Simultaneously, groups II and III results were changed with less percentage. Triglyceride grew up in groups II, V, and it dropped significantly in groups III, IV compared to the control group. De Ritis ratio of enzymes in groups II, III, and IV fluctuated between 1.31 and 0.98 IU/L; however, group V demonstrated significant data versus group I. Diets peptide toxicity in all groups was lower than control group data. The experimental results indicated that curd mass from camel milk could be used as a pure or with additives and it did not discover the observed side effects.

scholarly journals Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats

2017 ◽  
Vol 6 (2) ◽  
pp. 149-155
Author(s):  
Parveen Kumar Goyal ◽  
◽  
Santosh Kumar Verma ◽  
Anil Kumar Sharma ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Creatinine Clearance ◽  
Ammonium Chloride ◽  
Biochemical Parameters ◽  
Calcium Phosphorus ◽  
Calcium Oxalate Calculi ◽  
Vernonia Cinerea

Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containing ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) was used to induce hyperoxaluria in Wistar rats. Thirty-six rats, divided into following six groups (each containing six animals), were treated with vehicle (normal control), ethylene glycol and ammonium chloride (urolithic), Neeri (standard), 100, 300 and 500 mg/kg, VCE (tests). The experimental protocol involved the estimation of different biochemical parameters in urine, serum, kidney homogenates, and histopathological examinations of the kidney. Results: The urolithic rats showed the presence of oxalate crystals in renal tubules and significant changes in biochemical parameters like decreased creatinine clearance, increased urinary levels of oxalates, urea, calcium, phosphorus, uric acid, proteins, decreased urinary magnesium levels; increased serum levels of urea nitrogen, uric acid, calcium, phosphorus, lactate dehydrogenase; increased calcium, phosphorus, and oxalate contents in kidney homogenates. It altered the renal architecture and impaired the functions. The extract significantly (p< 0.05) reversed the biochemical changes in urine, serum and kidney homogenates in a dose-dependent manner. It improved the renal functions as indicated by improved creatinine clearance, reduced lactate dehydrogenase activity and restoration of renal architecture towards normal. Conclusions: Vernonia cinerea showed significant antilithiatic potential against oxalate calculi in glycolated rats.

scholarly journals ANTIHEPATOTOXIC POTENTIALITY OF 2-3-6 TRIMETHYLOCT-6-ENAL AGAINST PARACETAMOL INDUCED LIVER DYSFUNCTION

2017 ◽  
Vol 9 (9) ◽  
pp. 59
Author(s):  
Suparna Datta ◽  
Manabendra Dutta Choudhury
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Liver Toxicity ◽  
Control Group ◽  
Protective Agent ◽  
Protective Activity ◽  
Standard Drug ◽  
Group Iii ◽  
Group I ◽  
Aspartate Amino Transferase

Objective: We investigated the liver protective activity of 2-3-6 trimethyloct-6-enal from the methanol extract of Pajanelia longifolia (Willd.) K. Schuman. The liver protective activity of 2,3,6 trimethyloct-6-enal was evaluated against paracetamol (2 mg/kg body weight per orally) induced liver toxicity in swiss albino mice.Methods: Considering the Spectral data (IR spectrum, 1HNMR spectrum and 13C NMR spectrum) the predictable structure of 2,3,6 trimethyloct-6-enal was elucidated. To study the liver protective activity of the compound, Swiss albino mice of either sex were divided into six groups and treated for 5 d. Group I and II served as normal and toxic control, Group III were treated with Silymarin as a standard drug (50 mg/kg), and Group IV to VI was treated with 2-3-6 trimethyloct-6-enal at the dose of 50 mg/kg, 150 mg/kg and 250 mg/kg b.w. p. o. respectively. The liver protective activity of the compound was measured on biochemical parameters such as aspertate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), triglycerides (TGL), total cholesterol (TC) and protein. Further antioxidant activity of the compound was also measured on antioxidant enzymatic and non-enzymatic levels such as reduced glutathione (GSH), lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)).Results: The study revealed that the compound has protective activity at the dose of 50, 150 and 250 mg/kg b.w. p. o. against paracetamol induced toxicity. In some biochemical parameters such as aspartate amino transferase and bilirubin, the compound has showed better result at a dose of 150 mg/kg compared to standard drug silymarin (value of aspartate amino transferase (compound) =71.10±0.12, (toxic) = 173.43±1.21, (silymarin) =79.86±0.02and total bilirubin (compound) = 1.04±0.11), (toxic) = 2.69±0.02, (silymarin) ==1.11±0.01. The findings were also confirmed by histopathological observations.Conclusion: 2,3,6 trimethyloct-6-enal from Pajanelia longifolia may be considered as a potent liver protective agent.

scholarly journals Diagnostic Value of Serum Lactate Dehydrogenase Isoenzyme and Amino Acid Patterns in Several Schistosomal and Non-Schistosomal Disorders as Compared to other Biochemical Parameters

1996 ◽  
Vol 13 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Samia A. Ahmed ◽  
Mohamed Z. Gad
Keyword(s):  
Bladder Cancer ◽  
Amino Acid ◽  
Lactate Dehydrogenase ◽  
Biochemical Parameters ◽  
Elevated Serum ◽  
Diagnostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Control Group ◽  
Ldh Isoenzyme

Serum lactate dehydrogenase (LDH) isoenzyme and amino acid (a. a) patterns were evaluated in comparison to several other biochemical parameters for liver and renal function with the objective of clarifying the differential diagnosis of hepatic disorders and predicting the outcome of schistosomal infection in Egyptian patients. Patients examined included those with complicated hepatic disorders and others with different stages of schistosomal infestation, hepatoma or bladder cancer, in addition to a normal control group. Several biochemical parameters appeared to be useful in establishing consistent differences or similarities between the studied groups. Examples are; elevated serum AST/ AL T ratio and methionine content in chronic schistosomiasis, elevated serum urea/creatinine ratio and leucine content in all schistosomal patients and extremely high levels of N-acetyl-β-D-glucosaminidase (NAG) in the urine of non-schistosomal bladder cancer patients. In addition, characteristic LDH isoenzyme profiles distinguish between the studied groups, in particular separating chronic schistosomiasis from schistosomal bladder cancer and hepatoma from other hepatic disorders.

Effect of occupational exposure to petrol and gasoline components on liver and renal biochemical parameters among gas station attendants, a review and meta-analysis

2020 ◽  
Vol 35 (4) ◽  
pp. 517-530
Author(s):  
Somayeh Rahimi Moghadam ◽  
Mahdi Afshari ◽  
Ali Ganjali ◽  
Mahmood Moosazadeh
Keyword(s):  
Uric Acid ◽  
Occupational Exposure ◽  
Total Protein ◽  
Total Bilirubin ◽  
Meta Analysis ◽  
Mean Difference ◽  
Control Group ◽  
Mesh Terms ◽  
Standard Mean Difference ◽  
Keywords Screening

AbstractObjectivesKidney and liver are of the most affected organs during permanent exposure to petrol and gasoline components in gas stations. This study aims to investigate the renal and liver involvements in these workers using meta-analysis.MethodsPubMed, Scopus, Science direct, ISI web of science, and Google scholar motor engine were searched using Mesh terms of the relevant keywords. Screening of titles, abstracts and full texts was continued until the eligible articles meeting the inclusion/exclusion criteria were selected. Quality assessment was conducted using NOS (Newcastle–Ottawa Quality score). The pooled standard mean difference of the renal and liver indices between exposed/unexposed groups was estimated using Stata ver. 11 software.ResultsIn this systematic review, 22 papers were entered. The pooled standard mean difference (95% confidence interval) between exposed and unexposed groups was estimated as of 0.74 (0.28, 1.21) for alkaline phosphatase (ALP), 2.44 (1.80, 3.08) for aspartate transaminase (AST), 2.06 (1.42, 2.69) for alanine transaminase (ALT), 0.10 (−0.09, 0.29) for total Bilirubin (TB), 0.74 (−0.42, −1.90) for total protein (TP), −0.49 (−0.82, −0.15) for albumin, 0.88 (−0.10, 1.87) for uric acid, 1.02 (0.45, 1.59) for creatinine and 1.44 (0.75, 2.13) for blood urea nitrogen (BUN).ConclusionOur meta-analysis showed that the serum AST, ALT, ALP, total protein, total bilirubin, BUN, uric acid and creatinine levels were higher among workers exposed to petrol and gasoline than control group, while albumin was lower in the serum of the exposed workers. Therefore, occupational exposure to gasoline stations can create adverse effects on kidney and liver function.

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