Effect of the Composition in β-TCP-MCPM Bone Cement Containing Dense ß-TCP Granules

2005 ◽  
Vol 284-286 ◽  
pp. 141-144 ◽  
Author(s):  
Kyung Sik Oh ◽  
Soo Ryong Kim
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Mixing Ratio ◽  
Small Departure ◽  
Drastic Decrease ◽  
Time Density ◽  
Effect Of The Composition ◽  
Ratio Range

Effect of the starting compostion was studied in bone cement containg coarse b-tricalcium phosphate (b-TCP) granules which was very dense and round. With respect to the mixing ratio between b-tricalcium phosphate and monocalcium monophophate (T:M), the properties such as setting time, density and compressive strength were measured. The properties of bone cement prepared from normal powdery b-TCP was strongly dependent on the initial mixing ratio (T:M). Though the compressive strength as well as density was maximum at T:M = 6:4, small departure of compostions from T:M=6:4 resulted in drastic decrease of compresive strength. On the contrary, in the specimens from granular b-TCP, compressive strength was much less deependent on the initial mixing ratio. Range of optimum compressive strength covered from T:M=6:4 to 8:2. Therefore, granular groups provided more degree of freedom to control other properties such as setting time while maintaing its compressive strength.

scholarly journals Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

2020 ◽  
Author(s):  
Changtian Gong ◽  
Shuo Fang ◽  
Kezhou Xia ◽  
Jingteng Chen ◽  
Liangyu Guo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Ph Value ◽  
Setting Time ◽  
Potassium Phosphate ◽  
Carboxymethyl Chitosan ◽  
Bioactive Substances ◽  
Magnesium Potassium Phosphate Cement

Abstract Incorporating bioactive substances into synthetic bioceramic scaffolds is challenging. In this work, oxygen-carboxymethyl chitosan (O-CMC), a natural biopolymer that is nontoxic, biodegradable and biocompatible, was introduced into magnesium potassium phosphate cement (K-struvite) to enhance its mechanical properties and cytocompatibility. This study aimed to develop O-CMC/magnesium potassium phosphate composite bone cement (OMPC), thereby combining the optimum bioactivity of O-CMC with the extraordinary self-setting properties and mechanical intensity of the K-struvite. Our results indicated that O-CMC incorporation increased the compressive strength and setting time of K-struvite and decreased its porosity and pH value. Furthermore, OMPC scaffolds remarkably improved the proliferation, adhesion and osteogenesis related differentiation of MC3T3-E1 cells. Therefore, O-CMC introduced suitable physicochemical properties to K-struvite and enhanced its cytocompatibility for use in bone regeneration.

scholarly journals A Novel Fast-Setting Strontium-Containing Hydroxyapatite Bone Cement With a Simple Binary Powder System

2021 ◽  
Vol 9 ◽  
Author(s):  
Lijuan Sun ◽  
Tongyang Li ◽  
Sen Yu ◽  
Mengmeng Mao ◽  
Dagang Guo
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Setting Time ◽  
Synthesis Temperature ◽  
Transformation Rate ◽  
Step Method ◽  
Cement Powder ◽  
Calcium Phosphate Bone Cement ◽  
One Step ◽  
Application Potential

In recent years, strontium-substituted calcium phosphate bone cement (Sr-CPC) has attracted more and more attentions in the field of bone tissue repair due to its comprehensive advantages of both traditional CPC and Sr ions. In this study, a crucial Sr-containing α-Ca3–xSrx(PO4)2 salt has been synthesized using a simplified one-step method at lower synthesis temperature. A novel Sr-CPC has been developed based on the simple binary Sr-containing α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder. The physicochemical properties and hydration mechanism of this Sr-CPC at various Sr contents were intensively investigated. The setting product of this Sr-CPC after a set for 72 h is a single-phase Sr-containing hydroxyapatite, and its compressive strength slightly decreased and its setting time extended with the increase of Sr content. The hydration process included the initial formation of the medium product CaHPO4⋅2H2O (30 min∼1 h), the following complete hydration of Ca4(PO4)2O and the initially formed CaHPO4⋅2H2O (2∼6 h), and the final self-setting of α-Ca3–xSrx(PO4)2 (6 h∼). The compressive strength of Sr-CPC, which was closely related to the transformation rate of Sr-containing hydroxyapatite, tended to increase with the extension of hydration time. In addition, Sr-CPC possessed favorable cytocompatibility and the effect of Sr ions on cytocompatibility of Sr-CPC was not obvious at low Sr contents. The present study suggests α-Ca3–xSrx(PO4)2 is a kind of vital Sr-containing salt source which is useful to develop some novel Sr-containing biomaterials. In addition, the new Sr-containing cement system based on this simple binary α-Ca3–xSrx(PO4)2/Ca4(PO4)2O cement powder displayed an attractive clinical application potential in orthopedics.

Study on Physicochemical Properties of the Carbonated Hydroxyapatite Bone Cement

2007 ◽  
Vol 280-283 ◽  
pp. 1545-1548
Author(s):  
Li Min Dong ◽  
Chen Wang ◽  
Jie Mo Tian ◽  
Jian Pan ◽  
Qing Feng Zan
Keyword(s):  
Compressive Strength ◽  
Phase Composition ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Pore Size ◽  
Setting Time ◽  
Mineral Phase ◽  
Carbonated Hydroxyapatite ◽  
Natural Bone ◽  
Ft Ir

Carbonated hydroxyapatite (CHA) bone cement is capable of self-setting and has the component similar to the mineral phase of natural bone. But it is compact in structure and short of cavity, which limits new bone growing into CHA bone cement. In this paper, the foaming method was adopted to prepare the porous CHA. The setting time, compressive strength, porosity and pore size of the CHA were examined. The phase composition of the CHA was tested with XRD and FT-IR. The microstructure of the CHA was observed with SEM. The results show that setting time of 7~19 minutes, compressive strength of 26~32MPa, pore size of 100~200µm, porosity of 50~60%.

Stearate Salts as Brushite Bone Cement Setting Retardants

2005 ◽  
Vol 284-286 ◽  
pp. 19-22 ◽  
Author(s):  
M.P. Hofmann ◽  
Uwe Gbureck ◽  
Liam M. Grover ◽  
J.E. Barralet
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
Sodium Stearate ◽  
Setting Times ◽  
Powder Component ◽  
Cement System ◽  
Cement Setting

This study sought to examine the efficiency of coating cement powder reactants in order to reduce the solubility rate of reactants and thereby increase setting times of cement systems. In this investigation magnesium and sodium stearate salts were used to coat the highly soluble monocalcium phosphate monohydrate (MCPM) powder component of a hydraulic brushite forming calcium phosphate cement system with b-tricalcium phosphate (b-TCP) as other component. The results showed that stearate coating of the MCPM reactant could lead to a 100% increase in setting and working times without affecting compressive strength of the set cement when applied with the appropriate P/L-ratio.

Evaluation of setting time and compressive strength of a new bone cement precursor powder containing Mg–Na–Ca

2018 ◽  
Vol 232 (10) ◽  
pp. 1017-1024 ◽  
Author(s):  
Mohammad Hossein Esnaashary ◽  
Hamid Reza Rezaie ◽  
Alireza Khavandi ◽  
Jafar Javadpour
Keyword(s):  
Compressive Strength ◽  
Bone Cement ◽  
Setting Time ◽  
Precursor Powder ◽  
Effective Parameters ◽  
X Ray Diffraction ◽  
Liquid Ratio ◽  
X Ray ◽  
The One ◽  
Kinetics Of

Taking the advantage of a novel magnesium phosphate precursor containing Na and Ca, the cementation rate of the cement, including only Mg/Mg–Na–Ca, was studied. Besides, two effective parameters, that is, calcination temperature, 650 °C and 800 °C, and powder-to-cement liquid ratio, 1 and 1.5 g/mL, were assessed. X-ray diffraction, scanning electron microscopy, ion chromatography, particle size analyser, Vicat needle and compression test were used to characterize the powders and obtained cements. The sample containing Mg–Na–Ca, calcined at 800 °C with powder-to-cement liquid ratio of 1.5, obtained the highest compressive strength, 20 MPa, but set fast. To control the kinetics of cementation, the powder containing Mg–Na–Ca calcined at 950 °C with powder-to-cement liquid ratio of 1.5 and 2 g/mL was assessed and the one with 2 g/mL set in 9 min possessing 22 MPa compressive strength was selected as optimal condition to be used as a candidate, injectable bone cement.

Radiopaque acrylic bone cement with bromine-containing acrylic monomer. II

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Marius Ciprian Rusu ◽  
Ionut Cameliu Ichim ◽  
Marcel Popa ◽  
Daniela Rusu ◽  
Mihai Rusu
Keyword(s):  
Thermal Stability ◽  
Compressive Strength ◽  
Glass Transition ◽  
Thermal Properties ◽  
Transition Temperature ◽  
Bone Cement ◽  
Setting Time ◽  
Maximum Temperature ◽  
Acrylic Bone Cement ◽  
Compression Tests

AbstractBromine-containing methacrylate, 2-(2-bromoisobutyryloxy) ethyl methacrylate (BIEM), had been used in the formulation of acrylic radiopaque cements. The effect of this monomer incorporated into the liquid phase of acrylic bone cement (ABC), on the curing parameters, thermal properties, water absorption, density, compression tests and radiopacity was studied. A decrease of maximum temperature and an increase of the setting time were observed with the addition of the brominecontaining monomer in the radiolucent cement composition. Adding BIEM in radiolucent ABCs composition results in the decrease of glass transition temperature and increase in its thermal stability. The ABCs modified with bromine-containing comonomer are characterized by polymerization shrinkage lower than the radiolucent cement. Addition of bromine-containing comonomer in radiolucent ABC composition determines the increase of compressive strength. The ABCs modified with brominecontaining comonomer proved to be radiopaque.

Analysis on the Setting of Brushite Bone Cement after Storage in the Humid Environment

2016 ◽  
Vol 696 ◽  
pp. 32-35
Author(s):  
Tai Joo Chung ◽  
Kyung Sik Oh
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Driving Force ◽  
Activation Barrier ◽  
Setting Time ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Major Phase ◽  
Phosphate Dihydrate ◽  
Humid Environment

The cause of the degradation was analyzed by applying the highly humid conditions during the storage of cement composed of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM). For the β-TCP and MCPM stored separately under the humid environment, the mild increase in the setting time was observed, and the product after the setting was entirely dicalcium phosphate dihydrate (CaHPO42H2O: DCPD). However, for the β-TCP and MCPM stored mixed under the same condition, the setting time significantly increased with the period of storage, and the product contained dicalcium phosphate (CaHPO4: DCP) as major phase, resulting in the loss of setting ability. The formation of DCP could be because of the weak driving force for setting, caused by a feeble supply of water from moisture. As the formation of DCPD requires stronger driving force to overcome the activation barrier, sufficient amount of water is essential. Humid environment during the storage decreased the driving force by the formation of DCP, and the driving force to produce DCPD was lost during the actual setting.

scholarly journals Calcium Phosphate Cement Modified with Silicon Nitride/Tricalcium Phosphate Microgranules

2020 ◽  
Vol 20 (1) ◽  
pp. 56-75
Author(s):  
Lubomir Medvecky ◽  
Radoslava Stulajterova ◽  
Maria Giretova ◽  
Tibor Sopcak ◽  
Maria Faberova ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Silicon Nitride ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Controlled Drug Release ◽  
Tetracalcium Phosphate ◽  
Composite Cement ◽  
Highly Porous

Abstract Tetracalcium phosphate/monetite biocement was modified with 10 and 30 wt. % addition of highly porous silicon nitride/α-tricalcium phosphate (αTCP) microgranules with various content of αTCP. A composite cement powder mixture was prepared using mechanical homogenization of basic components. The accelerated release of dexamethasone from composite cement was revealed, which indicates their possible utilization for controlled drug release. The wet compressive strength of cements (<17 MPa) was significantly reduced (more than 30%) in comparison with the unmodified cement and both compressive strength and setting time were influenced by the content of αTCP in microgranules. The addition of microgranules caused a 20% decrease in final cement density. Microgranules with a higher fraction of αTCP showed good in vitro SBF bioactivity with precipitation of hydroxyapatite particles. Microstructure analysis of fractured cements demonstrated excellent interconnection between microgranules and cement calcium phosphate matrix, but also showed lower mechanical strength of microgranule cores.

scholarly journals SEM Analysis of Composites with TCP/HA/Chitosan/Poly (Methylmethacrilate)

2017 ◽  
Vol 54 (1) ◽  
pp. 60-62
Author(s):  
Ileana Cojocaru ◽  
Doina Prodan ◽  
Violeta Popescu ◽  
Marioara Moldo
Keyword(s):  
Bone Cement ◽  
Cement Paste ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Sem Analysis ◽  
Peak Temperature ◽  
Cement Composites ◽  
Pmma Matrix ◽  
Pmma Cement

Modified cement composites were prepared by dispersing commercially available PMMA powders and chitosan/ tricalcium phosphate (TCP) or chitosan / hydroxyapatite (HA) fillers into a PMMA matrix. SEM and EDX were used to determine the compounds and the morphology of the composite. The characteristics of these materials indicate that the addition of chitosan/TCP and chitosan /HA as a constituent into the PMMA cement significantly decreases the curing peak temperature. Furthermore, the setting time increases from 4 min to 7 min, as compared to the PMMA cement. These changes could be beneficial for the handling of the bone cement paste and causing less damage to the surrounding tissues.

Physicochemical and Mechanical Properties of Composite of Chitosan Microspheres/Calcium Phosphate Cement

2007 ◽  
Vol 336-338 ◽  
pp. 1654-1657
Author(s):  
Rui Liu ◽  
Li Min Dong ◽  
Qing Feng Zan ◽  
Chen Wang ◽  
Jie Mo Tian
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Bone Cement ◽  
Setting Time ◽  
Chemical Properties ◽  
Phase Evolution ◽  
Chitosan Microspheres ◽  
Setting Times ◽  
Calcium Phosphate Bone Cement

The aim of this work is to improve the mechanical properties of calcium phosphate bone cement (CPC) by appending chitosan microspheres to CPC base. That chitosan degrades rapidly than bone cement has been proved by previous investigations. Porous CPC has low compressive strength because of the pores in it weakening the structure. Additive chitosan microspheres can improve the mechanical properties by bearing the compress with the CPC base and produce pores after degradation. This study investigates the effect of chitosan microspheres on the setting time, mechanical properties, phase evolution and morphology of CPC. The additive proportion of chitosan microspheres ranges from 0 wt% to 30 wt%. Compared with original CPC, the modified CPC has higher compressive strength, without significantly affecting the chemical properties. The phase composition of the CPC is tested by XRD. The microstructures of CPC are observed using SEM. The final setting times range from 5~15 minutes and can be modulated by using different liquid and powder (L/P) ratio.

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