scholarly journals Peculiar epidermal peg pattern in cane rat skin

2020 ◽  
Vol 18 (2) ◽  
pp. 100-103
Author(s):  
M.O. Akpan ◽  
O.M. Samuel ◽  
B.O. Emikpe
Keyword(s):  
Structural Stability ◽  
Research Work ◽  
Single Species ◽  
The Body ◽  
Histological Evaluation ◽  
Rat Skin ◽  
Microscopic Field ◽  
Greater Cane Rat ◽  
Three Samples ◽  
Dermal Papillae

Skin is the largest organ in the body of man and animal where interdigitation of the dermal papillae with epidermal pegs enhances structural stability of the skin especially where frequent pressure is applied. Cane rats are robust rodents with stocky bodies. They are only found in Africa and only a single species known as Thryonomys has been found to exist. This work was designed to establish the nature of the interdigitating structural disposition of the epidermal-dermal interface in T. swinderianus (Greater cane rat) which may account for the fragility and easy tear of their skin. A total of twenty adult male greater cane rats were used. Three samples sized 1cm to 2cm were taken from each of 14 different body sites for histological evaluation for rete pegs. These pegs were generally few in six regions with the following average per light microscopic field: head (5.5±3.7), neck (1.0±1.7), forelimb (5.6±3.7), trunk (4.3±4.2), tail (1.0±1.7) and the hindlimb (6.3±5.3). The neck and the tail parts of the body have the least concentration of this structure compared to other regions evaluated. This few in number of rete pegs may account for the fragility of the skin which makes it difficult to restrain or handle without damage during research work procedures and management during domestication. Keywords: Epidermal pegs, Fragility, Histology, Peculiar, Thryonomys

Determination of Some Heavy Metals in Milk of Cow Grazing At Selected Areas, of Kaduna Metropolis

2017 ◽  
Vol 7 (7) ◽  
pp. 341 ◽  
Author(s):  
Mahmud Mohammed Imam ◽  
Zahra Muhammad ◽  
Amina Zakari
Keyword(s):  
Heavy Metals ◽  
Cadmium Toxicity ◽  
Research Work ◽  
The Body ◽  
Cow Milk ◽  
Scientific Model ◽  
Potential Health ◽  
Milk Samples ◽  
Lead And Cadmium ◽  
Digestion Technique

In this research work the concentration of zinc, copper, lead, chromium, cadmium, and nickel in cow milk samples obtained from four different grazing areas   (kakuri, kudendan, malali, kawo) of Kaduna metropolis. The samples were digested by wet digestion technique .The trace element were determined using bulk scientific model VPG 210 model  Atomic Absorption Spectrophotometer (AAS).. The concentration of the determined heavy metal were The result revealed that Cr,  Ni and Cd were not detected in milk samples from Kawo, Malali  and Kudendan whereas lead (Pb) is detected in all samples and found to be above  the stipulated limits of recommended dietary allowance (NRC,1989) given as 0.02mg/day. Cu and Zn are essential elements needed by the body for proper metabolism and as such their deficiency or excess is very dangerous for human health. However, they were found in all samples and are within the recommended limits while Cd (2.13 – 3.15 mg/kg) in milk samples from Kakuri was found to be above such limit (0.5mg/day). Cow milk samples analyzed for heavy metals in this research work pose a threat of lead and cadmium toxicity due to their exposure to direct sources of air, water and plants in these grazing areas, thereby, resulting to a potential health risk to the consumers.

Updating long-held assumptions about fat stigma: For women, body shape plays a critical role

2020 ◽  
Author(s):  
Jaimie Krems ◽  
Steven L. Neuberg
Keyword(s):  
Body Shape ◽  
Critical Role ◽  
The Body ◽  
Theoretical Assumption ◽  
Obesity Stigma ◽  
Obese Female ◽  
Three Samples ◽  
Female Bodies ◽  
Different Parts ◽  
Fat Stigma

Heavier bodies—particularly female bodies—are stigmatized. Such fat stigma is pervasive, painful to experience, and may even facilitate weight gain, thereby perpetuating the obesity-stigma cycle. Leveraging research on functionally distinct forms of fat (deposited on different parts of the body), we propose that body shape plays an important but largely underappreciated role in fat stigma, above and beyond fat amount. Across three samples varying in participant ethnicity (White and Black Americans) and nation (U.S., India), patterns of fat stigma reveal that, as hypothesized, participants differently stigmatized equally-overweight or -obese female targets as a function of target shape, sometimes even more strongly stigmatizing targets with less rather than more body mass. Such findings suggest value in updating our understanding of fat stigma to include body shape and in querying a predominating, but often implicit, theoretical assumption that people simply view all fat as bad (and more fat as worse).

Global food safety: determinants are Codex standards and WTO's SPS food safety regulations

2014 ◽  
Vol 11 (2) ◽  
pp. 176-191 ◽  
Author(s):  
Rajneesh Mahajan ◽  
Suresh Garg ◽  
P.B. Sharma
Keyword(s):  
Food Safety ◽  
Research Work ◽  
The Body ◽  
Successful Implementation ◽  
Processed Food ◽  
Food Sector ◽  
Content Type ◽  
Safety Regulations ◽  
Food Safety Regulations ◽  
Global Food

Purpose – The purpose of this paper is to investigate perspective in explaining how global food safety can be created through stringent implementation of Codex and World Trade Organization (WTOs) Sanitary and Phytosanitary food safety regulations and suggests the appropriate food safety system for India. Design/methodology/approach – The study has been deployed a survey questionnaire using a sample of Indian Processed food sector. In order to collect data 1,000 supply chain professional were contacted for seeking their consent to be part of the survey. Whereas total responses collected were 252 from Delhi and NCR, with response rate 25.2 percent. The data collected was empirical tested using descriptive statistics, correlation analysis, regression and ANOVA. Findings – The results and discussions indicate that all the global food safety norms laid down by WTO such as goods manufacturing practices, good hygienic practice, hazard analysis critical control point, has been developed to embody principles of safe food processing sector globally. India has also developed their food safety norms as per laid down principles by WTO. Originality/value – The present research work makes an important contribution to the body of literature on global food safety. The paper has important implications for the processed food sector since it tries to bring out practices which would help in successful implementation of global food safety standards. It is useful for academic food research as well as for processed food corporate.

Concluding remarks

1956 ◽  
Vol 146 (922) ◽  
pp. 90-92 ◽  
Keyword(s):  
Guinea Pigs ◽  
Current Trend ◽  
Distinct Type ◽  
Single Species ◽  
Immunological Tolerance ◽  
The Body ◽  
Immunological Reaction ◽  
Picryl Chloride ◽  
Purified Antigen ◽  
Circulating Antibody

In many ways immunological tolerance is an ideal subject for discussion at the present time. Experimental work has gone far enough to allow us to claim that the principle of immunological tolerance is soundly established and that we can see more or less clearly some of its implications. But obviously very much remains to be learnt of the part played by tolerance in the various fields that have been discussed. It is by no means certain that we are dealing with a single topic when we compare tolerance to homografts with inhibition of antibody production against soluble protein in a rabbit. Such a situation provides much for discussion but does not make it easy to condense or interpret that discussion. One might begin by reiterating that immunology is concerned with much more than the production and properties of typical circulating antibody. There are at least four different types of immunological reaction and there are hints of many minor differences within the main types. Pappenheimer’s recent work on the variety of responses given by a single species, man, to a single purified antigen, diphtheria toxoid, offers a characteristic example of the current trend. Chase’s experiments on the response of guinea pigs to simple allergens like picryl chloride, have been only incidentally mentioned in today’s discussion, but their importance is obvious. A form of tolerance very similar to that produced by prenatal treatment of mice can be produced by administering the allergen to adult guinea-pigs by mouth. The animals are resistant to sensitization by skin treatment and the inhibition is general and unrelated to any persistence of allergen in the body. The question immediately arises whether all forms of tolerance are basically similar or whether for each of the qualitatively distinct types of positive immunological reaction, a correspondingly distinct type of inhibition or tolerance must be sought.

scholarly journals GENOTOXIC AND CARCINOGENIC STUDIES OF NORGESTREL IN DROSOPHILA MELANOGASTER

2018 ◽  
Vol 11 (10) ◽  
pp. 372
Author(s):  
Abou-eisha A ◽  
Adel E El-din
Keyword(s):  
Somatic Mutation ◽  
Cellular Proliferation ◽  
Research Work ◽  
The Body ◽  
The Other ◽  
Direct Stimulation ◽  
Carcinogenic Activity ◽  
Genetic Examination ◽  
First Time

Objective: The aim of this study was to investigate, for the first time, the possible in vivo genotoxic and carcinogenic activity associated with exposure to norgestrel (NGT) drug through employing the very recently established and adjusted genotoxic and tumorigenic methods in Drosophila melanogaster.Methods: Two in vivo genotoxic test systems were used; one detects the somatic mutation and recombination effects (somatic mutation and recombination test [SMART] wing-spot test) and the other detects the primary DNA damage (the comet test) in the body cells of D. melanogaster. On the other hand, the warts (wts)-based SMART assay is a vital genetic examination in Drosophila used to identify and characterize cancer potential of compounds.Results: Four experimental doses of NGT were used (ranging from 0.24 μM to 16 μM). NGT was found to be non-genotoxic at all tested concentrations even at the highest dose level 16 μM and failed to increase the frequency of tumors in the somatic cells of D. melanogaster.Conclusion: Our results strengthen the hypothesis that steroidal drugs might act through a non-genotoxic carcinogen mechanism where the carcinogenic properties occur by direct stimulation of cellular proliferation through a steroid receptor-mediated mechanism. In addition, the results obtained in this research work may contribute to highlighting the importance of NGT as a potent neuroprotective antioxidant drug.

A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

2016 ◽  
Vol 36 (9) ◽  
pp. 901-909 ◽  
Author(s):  
D Sheela ◽  
R Vijayaraghavan ◽  
S Senthilkumar
Keyword(s):  
Body Weight ◽  
Research Work ◽  
Safety Evaluation ◽  
Weight Ratio ◽  
The Body ◽  
Control Group ◽  
Body Weight Ratio ◽  
Significant Difference ◽  
Manual Group ◽  
Significant Change

Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work.

XIX. On the structure and development of myriothela

1875 ◽  
Vol 165 ◽  
pp. 549-575 ◽  
Keyword(s):  
Single Species ◽  
The Body ◽  
Entire Length ◽  
Species Being

Mykiothela, of which we have as yet no satisfactory evidence of more than a single species being known, consists of a solitary attached hydranth, carrying near its proximal or attached end the blastostyles or appendages which give origin and support to the gonophores (Plate 55). Full-sized specimens (fig. 1) measure, when extended, nearly 2 inches in length. They are then cylindrical in form, with the mouth occupying the summit of a short conical hypostome, behind which the tentacles commence, and thence extend over somewhat more than one half the entire length of the body; while the proximal end of the body is bent at right angles to the rest, is invested with a chitinous perisarc, and gives origin to short sucker-like processes of attachment.

Active thermography as a tool for internal composite structure observation and evaluation

2018 ◽  
Vol 9 (6) ◽  
pp. 779-792 ◽  
Author(s):  
Katarzyna Majewska ◽  
Magdalena Mieloszyk ◽  
Wieslaw Ostachowicz
Keyword(s):  
Research Work ◽  
Structural Condition ◽  
Original Research ◽  
Pulsed Thermography ◽  
Content Type ◽  
Three Samples ◽  
Structure Observation ◽  
Material Discontinuities ◽  
Excellent Tool ◽  
Composite Samples

Purpose The purpose of this paper is to study if it is possible applying infrared thermography (both vibro and pulsed) to detect and localise material discontinuities as well as to find the place where the inclusion was introduced. Design/methodology/approach The experimental investigation is performed on samples manufactured during infusion process. The measurements were performed on three four-layered rectangular composite samples with discontinuities. The discontinuities introduced in the samples were as follow: all three samples between first and second layer counting form the bottom two optical fibres (OFs) were embedded and additionally: sample no. 1 – one of the OF was broken, sample no. 2 – the drop of water was introduced, and sample no. 3 – the little amount of dust was introduced. Findings For some discontinuities, the vibrothermography is excellent tool (placement of broken OF, drop of water), for same is not sufficient (healthy OFs or dust). For dust, the pulsed thermography seems to be the required tool. Different approaches (vibrothermography and pulsed thermography) for the same sample will confirm that for same defects vibrothermograpy is better and for some pulsed thermography – complex combination of different thermography approaches is needed to have complex response about sample structural condition. Originality/value The presented paper is an original research work. There are very limited literature papers applying both vibro and pulsed thermography for one problem. The assessment of different discontinuities (inclusions) and detailed analysis is presented.

scholarly journals A microarray gene expressions with classification using extreme learning machine

Genetika ◽  
2015 ◽  
Vol 47 (2) ◽  
pp. 523-534
Author(s):  
M. Yasodha ◽  
P. Ponmuthuramalingam
Keyword(s):  
Extreme Learning Machine ◽  
High Speed ◽  
Dna Microarrays ◽  
Research Work ◽  
The Body ◽  
Cancer Classification ◽  
Medical Sciences ◽  
Gene Expressions ◽  
Learning Machine ◽  
Elm Classifier

In the present scenario, one of the dangerous disease is cancer. It spreads through blood or lymph to other location of the body, it is a set of cells display uncontrolled growth, attack and destroy nearby tissues, and occasionally metastasis. In cancer diagnosis and molecular biology, a utilized effective tool is DNA microarrays. The dominance of this technique is recognized, so several open doubt arise regarding proper examination of microarray data. In the field of medical sciences, multicategory cancer classification plays very important role. The need for cancer classification has become essential because the number of cancer sufferers is increasing. In this research work, to overcome problems of multicategory cancer classification an improved Extreme Learning Machine (ELM) classifier is used. It rectify problems faced by iterative learning methods such as local minima, improper learning rate and over fitting and the training completes with high speed.

scholarly journals IDENTIFIKASI SENYAWA GARLISIN DAN KUERSETIN SEBAGAI SENYAWA ANTIMIKROBA PADA SEDIAAN BASAH DAN KERING BAWANG PUTIH (Allium sativum L.)

2020 ◽  
Vol 8 (2) ◽  
pp. 176
Author(s):  
Fanny Thresia Yunus ◽  
Ari Suwondo ◽  
Martini Martini
Keyword(s):  
Traditional Medicine ◽  
Allium Sativum ◽  
Chemical Compounds ◽  
The Body ◽  
Garlic Extract ◽  
Antimicrobial Compounds ◽  
Vacuum Oven ◽  
Garlic Powder ◽  
Three Samples

Indonesian people have long used garlic as traditional medicine because it contains various chemical compounds that are beneficial to the body. In this study identification of garlicin and kuersetin compounds in garlic as an antibacterial. This study requires 500 grams of garlic each in wet preparations consist of fine garlic and garlic extract, and dry preparation consists of garlic powder. In addition, this research requires 2,1 liters of 96% ethanol. Garlic is dried at 400C with TMI Vacuum Oven and extracted at 250C. Garlic powder is made using Krisbow dry cabinet with a temperature of 1000F and a pressure of 10 Pa. Garlisin content was identified by GCMS Shimadzu TQ8030 and FTIR Perkin Elmer Spectrum Two UATR, while identification of quercetin using Shimadzu HPLC type UFLC. The result shows that the compound garlicin (C6H10S2) was found in the three samples with identical similarity levels. In addition, the three samples showed differences in kuersetin content. The highest kuersetin content was 458.729 ppm garlic extract while the lowest kuersetin content was 81.181 ppm fresh garlic. Both of these compounds have potential as antimicrobial compounds.

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