POLYEL - COMPOUND WITH ANTIOXIDANT PROPERTIES

A new complex compound, Polyel, which contains thiourea, macro- and microelements in the form of salts and coordination complexes, as well as vitamins, was obtained and tested. Biological tests were performed in laboratory experiments and in the vegetation complex of the Institute of Genetics, Physiology and Plant Protection. As subjects of investigations served the plants Glycine max (Merr) cultivars L. ‘Deia’, ‘Moldovița’, and ‘Enigma’ varieties, grown in the Mitcherlih vegetation pots with a volume of 40 kg soil and exposed to the drought stress at the phase "flowering - pods formation”. The beneficial effect of Polyel on antioxidant protection systems by reducing the accumulation of malondialdehyde (MDA) and intensifying the activity of antioxidant protection enzymes has been established. Polyel has been shown to be one of the new biologically active chemicals that can be used in agriculture to reduce the negative impact of oxidative stress caused by reactive oxygen species (ROS). The use of Polyel as a physiologically active substance (PAS) with antioxidant proprieties for pre-treatment of seeds and foliar apparatus is much more effective under moderate drought conditions.

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Редокс-реакція насіння кукурудзи Оржиця 237 МВ на дію гербіцидів

Вісник Полтавської державної аграрної академії ◽

10.31210/visnyk2015.03.06 ◽

2015 ◽

pp. 50-53

Author(s):

Ю. В. Лихолат ◽

Г. С. Россихіна-Галича

Keyword(s):

Superoxide Dismutase ◽

Lipid Oxidation ◽

High Activity ◽

Negative Impact ◽

Lipid Hydroperoxides ◽

Antioxidant Protection ◽

Hybrid Corn ◽

Ripening Process ◽

Protection Systems

Висвітлено вплив гербіцидних препаратів на нако-пичення ТБК-активних продуктів, гідропероксидівліпідів і активність супероксиддисмутази (СОД) тапероксидази (ПО) у насінні кукурудзи гібриду Оржиця237МВ. У достигаючому насінні кукурудзи, обробле-ної гербіцидами, виявлено інтенсифікацію перебігуреакцій окиснення ліпідів різної сили та функціону-вання компонентів антиоксидантного захисту (СОД,ПО). Уповільнення накопичення продуктів перокси-дації, відзначене у стиглому насінні, пов’язано з висо-кою активністю супероксиддисмутази, стабільнимфункціонуванням каталази та пероксидази. Наведеневище дає змогу дійти висновку, що за дії гербіцидів унасінні рослин кукурудзи гібриду Оржиця 237МВ упроцесі достигання підвищена здатність до належ-ної активації досліджених ферментних захисних сис-тем та їх функціонування на рівні, який забезпечив бивідновлення і підтримку гомеостазу. Встановлено,що найменша негативна дія спричинена гербіцидами«Харнес», «Майстер» і «Аденго». The paper deals with the effect of herbicidal agents on accumulation of TBA-active products, lipid hydroperoxides and activity of superoxide dismutase (SOD) and peroxidase (PO) in seeds of Orzhytsa 237MV hybrid corn. In the ripening corn seeds treated with herbicides, intensification of the course of reactions of lipid oxidation of the varying degree and functioning of antioxidant protection components (SOD, PО) has been revealed. Slowed accumulation of peroxidation products recorded in ripe seeds is connected with high activity of superoxide dismutase, and stable functioning of catalase and peroxidase. The above leads to the conclusion that the action of herbicides on seeds of plants of Orzhytsa 237MV hybrid corn in their ripening process promotes the ability to proper activation of studied enzymatic protection systems and functioning thereof at the level which would ensure the restoration and maintenance of homeostasis. It is found that Harness, Meister and Adengo herbicides have the least negative impact.

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RADIOPROTECTIVE PROPERTIES OF POLYPHENOLIC COMPOUNDS OF EDIBLE AND AROMATIC PLANTS

Food Science and Technology ◽

10.15673/fst.v14i3.1797 ◽

2020 ◽

Vol 14 (3) ◽

Author(s):

P. Oliіnyk ◽

D. Voronenko ◽

R. Lysiuk

Keyword(s):

Radiation Damage ◽

Negative Impact ◽

Effective Means ◽

Antioxidant Properties ◽

Polyphenolic Compounds ◽

Biologically Active ◽

Antimutagenic Activity ◽

Aromatic Plants ◽

Toxicological Studies ◽

Radiation Nephropathy

The proliferation of nuclear technologies threatens by the negative impact of ionizing radiation on the human body and requires the search of new effective means for prevention from radiation damage. Informational search in scientific editions and search databases on radioprotective effects of food and aromatic plants, radiation nephropathy and promising herbal drugs for its prevention has been carried out. Methods of analysis, systematization, comparison, generalization of information data have been applied. An overview of the results of experimental phytochemical and clinical studies of domestic and foreign scientists on radioprotective effects of biologically active substances of food and aromatic herbs has been carried out. It is revealed that plant polyphenolic compounds, due to their antioxidant properties, are able to neutralize free radicals and thus leading to a stop of radio-induced chain oxidation reactions in cells, to scavenge and neutralize of lipoperoxyl radicals, chelate ions of metals, as well as to exhibit antimutagenic activity. Radiotherapy might cause several radiation-induced kidney injuries, including radiation nephropathy. Search of promising herbal substances for prevention and alleviation of radiation nephropathy is under active investigation in recent years. Preventive inclusion of radioprotective agents, containing polyphenolic compounds, before irradiation seems to be an obvious renoprotective strategy. The prospect for further phytochemical, pharmacodynamic and toxicological studies of properties of polyphenolic compounds in food and aromatic plants with an objective to create new effective remedies for the prevention and treatment of radiation damage is shown.

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History and main directions of research on plant protection in the Nikitsky Botanical Gardens

Plant Biology and Horticulture: theory, innovation ◽

10.36305/2712-7788-2020-4-157-7-17 ◽

2021 ◽

Vol 1 (157) ◽

pp. 7-17

Author(s):

Yu. V. Plugatar ◽

E. B. Balykina

Keyword(s):

Plant Protection ◽

Integrated Control ◽

Cost Effective ◽

Biologically Active ◽

Main Task ◽

Natural Polymers ◽

Mechanical Destruction ◽

Botanical Gardens ◽

Protection Systems ◽

Methods Of Control

The article provides information on the history of the creation and development of the Department of plant protection in the Nikitsky Botanical Gardens and the results of modern theoretical and applied research on the protection of native and introduced plants for 2000-2020. The main concepts, directions and methods in the development of integrated plant protection systems for fruit and park plantations are considered. There are five stages in solving the main task of plant protection-the rational management of the phytosanitary state of agrobiocenoses: 1. use of agrotechnical methods of control, including mechanical destruction of phytophages; 2. chemical method of plant protection using polytoxic broad-spectrum pesticides; 3. integrated control in the form of the concept of a reduced treatment scheme, taking into account the economic thresholds of abundance and harmfulness and combining all existing methods of control; 4. managing the growth of populations of harmful organisms using biologically active substances of the information type according to integrated indicators; 5. development of a post-genomic approach to limiting the number of phytophages, based on the use of fragments of natural polymers of nucleic acids, development of contact DNA insecticides based on short antisense fragments of genes, as well as preparations based on double-stranded RNA fragments. Modern research has a high theoretical and applied significance for the development of integrated protection systems for fruit, ornamental, and forest crops in the Russian Federation and Crimea. It allows us to objectively assess the phytosanitary state of the garden and park agrobiocenosis, identify the dominant types of pathogens and pests, predict their development trends, and select environmentally safe, cost-effective methods for controlling their numbers.

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The Impact of Plant Protection Systems on the Productivity of Soybean Varieties under Irrigated Conditions

Scientific and Technical Bulletin of the Institute of Oilseed Crops NAAS ◽

10.36710/ioc-2019-28-11 ◽

2019 ◽

pp. 109-117

Keyword(s):

Plant Protection ◽

Crop Protection ◽

Production Costs ◽

Protection System ◽

Average Weight ◽

The South ◽

Biological Origin ◽

Chemical Protection ◽

Protection Systems ◽

The Impact

The application of preparations of biological origin in the protection system of soybean grown under conditions of intensive irrigated crop rotations conforms to the modern tendencies of science and production development. The use of them contributes to solving ecological, production and social-economic problems. The study presents the three-year research on the efficiency of systems protecting soybean from pests and diseases based on biological and chemical preparations. The research was conducted in typical soil and climate conditions of the South of Ukraine. Zonal agricultural methods and generally accepted research methodology were used. The purpose of the research was to create a soybean protection system based on preparations of biological origin, ensuring high productivity of high-quality products reducing a negative impact of the crop production on the environment. The study emphasizes that, under irrigated conditions of the South of Ukraine, the application of biological preparations has a positive impact on the indexes of growth, development and formation of the elements of soybean yield structure. There was an increase in the crop biological weight by 13.8 % and 22.1 % and the number of seeds per plant rose by 11.6 and 14.6 % as a consequence of eliminating harmful organisms with the plant protection systems. The larger ground mass was formed by medium-ripe varieties Danai and Svyatogor, on which the increase from protection measures was higher. Weight 1000 pcs. the seeds did not undergo significant changes. It is established that the larger seeds were formed by Danaya and Svyatogor varieties, in which the average weight is 1000 pcs. seeds were 142 and 136 g, respectively, while in the variety Diona this figure was 133 g. There was an increase in the height of the lowest pod when the total plant height rose. For medium-ripe varieties was characterized by a higher attachment of beans, where the highest values of this indicator acquired in the variety Svyatogor. The medium maturing soybean variety Danaia formed the maximum yield of 3.23 and 3.35 t/ha respectively, when biological and chemical protection systems were applied. The research establishes that the application of the bio-fungicide Psevdobakterin 2 (2.0 l/ha) in the crop protection system at the beginning of soybean flowering and the bio-fungicide Baktofit (2.5 l/ha) with the bio-insecticide Lepidotsid-BTU (10.0 l/ha) at the beginning of pod formation does not reduce the productivity of the soybean varieties under study considerably, when compared to the application of chemical preparations. The research determines that the soybean protection system under study ensures a decrease in the coefficient of soybean water uptake by 7.2-13.0 %, increasing the total water intake to an inconsiderable degree. Biologization of the soybean crop protection system leads to a reduction in production costs compared to the chemical protection system. Taking into account the needs for the collection of additional products, costs increase by an average of 1 thousand UAH/ha, while for chemical protection systems by 1.8 thousand UAH/ha. At the same time, the cost is reduced by 220-360 UAH/t and the profitability of growing crops is increased by 3.8-7.8 %. There has been a reduction in the burden of pesticides on the environment and the production of cleaner products. This indicates the prospect of using the biofungicides Pseudobacterin 2 and Bactophyte and the bioinsecticide Lepidocid-BTU on soybeans to protect plants from pests.

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Potency of Super Red Dragon Fruit Flesh Extract (Hylocereus costaricencis) in Herbal Lipstick as Colorant, Antioxidant and Antibacterial

SCISCITATIO ◽

10.21460/sciscitatio.3 ◽

2020 ◽

Vol 1 (1) ◽

Author(s):

Lusiana Dian Anjarsari ◽

Dwi Aditiyarini ◽

Guntoro

Keyword(s):

Staphylococcus Aureus ◽

Chemical Compound ◽

Negative Impact ◽

Antioxidant Properties ◽

Natural Source ◽

Fruit Extract ◽

Fruit Flesh ◽

Self Confidence ◽

Dragon Fruit ◽

Ic50 Value

Lipstick is one kind of cosmetics which is used as lips colorant to increase self-confidence. Nowadays, lipsticks from natural source is popular to reduce the negative impact of chemical compound or synthetics colorant in lipstick intensively for health. Super red dragon fruit is one kind of natural ingredients which can be used as colorant for lipstick. Moreover, this fruit is rich of antioxidant and antibacterial component that is good for skin health. In this research, extract of super red dragon fruit flesh was added in the lipstick during preparation with variation of concentration 0, 10, 20, 30 and 40%. Antioxidant analysis resulted the IC50 value in 81.55% indicating the strong antioxidant properties. Furthermore, the concentration of dragon fruit extract 40% was able to inhibit the growth of Staphylococcus aureus bacteria.

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Analogues of the cholecystokinin octapeptide modified in the central part of the molecule

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19911963 ◽

1991 ◽

Vol 56 (9) ◽

pp. 1963-1970 ◽

Cited By ~ 3

Author(s):

Jan Hlaváček ◽

Václav Čeřovský ◽

Jana Pírková ◽

Pavel Majer ◽

Lenka Maletínská ◽

...

Keyword(s):

Amino Acid ◽

Biological Activities ◽

Point Of View ◽

Biologically Active ◽

Side Chain ◽

Amino Acid Residues ◽

Cholecystokinin Octapeptide ◽

Biological Tests ◽

Biological Potency ◽

Biologically Active Conformation

In a series of analogues of the cholecystokinin octapeptide (CCK-8) the amino acid residues were gradually modified by substituting Gly by Pro in position 4, Trp by His in position 5, Met by Cle in position 6, or the Gly residue was inserted between Tyr and Met in positions 2 and 3 of the peptide chain, and in the case of the cholecystokinin heptapeptide (CCK-7) the Met residues were substituted by Nle or Aib. These peptides were investigated from the point of view of their biological potency in the peripheral and central region. From the results of the biological tests it follows that the modifications carried out in these analogues and in their Nα-Boc derivatives mean a suppression of the investigated biological activities by 2-3 orders of magnitude (at a maximum dose of the tested substance of 2 . 10-2 mg per animal).This means that a disturbance of the assumed biologically active conformation of CCK-8, connected with a considerable decrease of the biological potency of the molecule, takes place not only after introduction of the side chain into its centre (substitution of Gly4), but also after the modification of the side chains of the amino acids or by extension of the backbone in further positions around this central amino acid.

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Optimized Supercritical CO2 Extraction Enhances the Recovery of Valuable Lipophilic Antioxidants and Other Constituents from Dual-Purpose Hop (Humulus lupulus L.) Variety Ella

Antioxidants ◽

10.3390/antiox10060918 ◽

2021 ◽

Vol 10 (6) ◽

pp. 918

Author(s):

Nóra Emilia Nagybákay ◽

Michail Syrpas ◽

Vaiva Vilimaitė ◽

Laura Tamkutė ◽

Audrius Pukalskas ◽

...

Keyword(s):

Supercritical Co2 ◽

Antioxidant Properties ◽

Extraction Yield ◽

Biologically Active ◽

High Yield ◽

Acid Extraction ◽

Supercritical Co2 Extraction ◽

Bioactive Constituents ◽

Total Extract

The article presents the optimization of supercritical CO2 extraction (SFE-CO2) parameters using response surface methodology (RSM) with central composite design (CCD) in order to produce single variety hop (cv. Ella) extracts with high yield and strong in vitro antioxidant properties. Optimized SFE-CO2 (37 MPa, 43 °C, 80 min) yielded 26.3 g/100 g pellets of lipophilic fraction. This extract was rich in biologically active α- and β-bitter acids (522.8 and 345.0 mg/g extract, respectively), and exerted 1481 mg TE/g extract in vitro oxygen radical absorbance capacity (ORAC). Up to ~3-fold higher extraction yield, antioxidant recovery (389.8 mg TE/g pellets) and exhaustive bitter acid extraction (228.4 mg/g pellets) were achieved under the significantly shorter time compared to the commercially used one-stage SFE-CO2 at 10–15 MPa and 40 °C. Total carotenoid and chlorophyll content was negligible, amounting to <0.04% of the total extract mass. Fruity, herbal, spicy and woody odor of extracts could be attributed to the major identified volatiles, namely β-pinene, β-myrcene, β-humulene, α-humulene, α-selinene and methyl-4-decenoate. Rich in valuable bioactive constituents and flavor compounds, cv. Ella hop SFE-CO2 extracts could find multipurpose applications in food, pharmaceutical, nutraceutical and cosmetics industries.

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Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity

Molecules ◽

10.3390/molecules26123579 ◽

2021 ◽

Vol 26 (12) ◽

pp. 3579

Author(s):

Svetlana A. Popova ◽

Evgenia V. Pavlova ◽

Oksana G. Shevchenko ◽

Irina Yu. Chukicheva ◽

Aleksandr V. Kutchin

Keyword(s):

Antioxidant Activity ◽

Antioxidant Properties ◽

Biological Properties ◽

High Reactivity ◽

Biologically Active ◽

Brain Lipids ◽

Wide Range ◽

Privileged Structure ◽

Vitro Model

The pyrazoline ring is defined as a “privileged structure” in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.

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Cosmetic and Dermatological Properties of Selected Ayurvedic Plant Extracts

Molecules ◽

10.3390/molecules26030614 ◽

2021 ◽

Vol 26 (3) ◽

pp. 614

Author(s):

Martyna Zagórska-Dziok ◽

Aleksandra Ziemlewska ◽

Tomasz Bujak ◽

Zofia Nizioł-Łukaszewska ◽

Zofia Hordyjewicz-Baran

Keyword(s):

Skin Diseases ◽

Multiple Reaction Monitoring ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Biologically Active ◽

Cell Protection ◽

Skin Cells ◽

Skin Cell ◽

Aging Properties ◽

Enzyme Superoxide Dismutase

Due to the constantly growing interest in ingredients of natural origin, this study attempts to evaluate the possibility of using extracts from three Ayurvedic plants in preparations for the care and treatment of skin diseases. Therefore, studies of antioxidant properties were carried out using DPPH and ABTS radicals, obtaining 76% and 88% of these radical scavenging, respectively. A significant decrease in the intracellular level of free radicals and an increase in the activity of the antioxidant enzyme-superoxide dismutase by almost 60% were also observed. In addition, the extracts were assessed for anti-inflammatory and anti-aging properties, obtaining over 70% inhibition of lipoxygenase activity and almost 40% of collagenase. Additionally, the cytoprotective properties of the obtained extracts on skin cells, keratinocytes and fibroblasts, were demonstrated. To assess the content of biologically active compounds, HPLC-electrospray ionization (ESI)-MS/MS multiple reaction monitoring (MRM) analyses were performed. The obtained results show that all three analyzed plants are a valuable source of biologically active substances with desired properties in the context of skin cell protection. Particularly noteworthy is the extract of Epilobium angustifolium L., for which the most promising results were obtained.

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Solid Dispersions of Anthelmintics and Plant Protection Preparations

Solids ◽

10.3390/solids2010003 ◽

2021 ◽

Vol 2 (1) ◽

pp. 60-75

Author(s):

Salavat S. Khalikov

Keyword(s):

Plant Protection ◽

Rapid Development ◽

Solid Dispersions ◽

Animal Health ◽

Water Soluble ◽

Biologically Active ◽

Cultivated Plants ◽

Industrial Complex ◽

Scientific Papers ◽

Poorly Soluble

Because of the rapid development of nanotechnologies, materials, in particular, solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

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