A Comparative Clinical Evaluation on the Efficacy of Kuberaksha & Yava with Lifestyle Modification, in The Management of Prameha with Special Reference to Prediabetes

We are living in the age of complexity, contradiction, and challenge relating to various health issues such as lifestyle disorder, ageing, mental health euthanasia, drug resistance and so on. Diabetes Mellitus is a Giant disease and major health issue that has reached alarming level in spite of terrific advance in modern medical science. Prediabetes is the precursor stage before Diabetes Mellitus, in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high. Prediabetic persons are considered to be at increased risk for the subsequent development Diabetes Mellitus. Sushruta Samhita mentioned, all varieties of Prameha if not treated at appropriate time, become changed to Madhumeha which is incurable. So, early detection, treatment and prevention of this disease in Prediabetic stage is needed. The modification of lifestyle should be the first aim and objectives to restrict or combat such problems, beside this prime objective, some medication which is safe and efficacious to be introduced. So, a clinical study with 60 patients has been conducted on Prediabetes through the management with ‘Kuberaksha’ and ‘Yava’ in such 2 groups of treatment. The two drugs are carrying such properties which acts in Samprapti vighatana (prevent pathogenesis) of the disease. In both cases statistically significant results are found (P<0.001 & <0.01). On comparison between two groups Kuberaksha powder showed better result than Yava powder.

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The GSTM1 and GSTT1 Null Genotypes Increase the Risk for Type 2 Diabetes Mellitus and the Subsequent Development of Diabetic Complications: A Meta-analysis

Current Diabetes Reviews ◽

10.2174/1573399814666171215120228 ◽

2018 ◽

Vol 15 (1) ◽

pp. 31-43 ◽

Cited By ~ 6

Author(s):

Sayantan Nath ◽

Sambuddha Das ◽

Aditi Bhowmik ◽

Sankar Kumar Ghosh ◽

Yashmin Choudhury

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Meta Analysis ◽

Subsequent Development ◽

Asian Population ◽

Gstm1 Null Genotype ◽

Increased Risk

Background:Studies pertaining to association of GSTM1 and GSTT1 null genotypes with risk of T2DM and its complications were often inconclusive, thus spurring the present study.Methods:Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in determining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms in development of T2DM related complications were conducted.Results:Our study revealed an association between GSTM1 and GSTT1 null polymorphism with T2DM (GSTM1; OR=1.37;95% CI =1.10-1.70 and GSTT1; OR=1.29;95% CI =1.04-1.61) with an amplified risk of 2.02 fold for combined GSTM1-GSTT1 null genotypes. Furthermore, the GSTT1 null (OR=1.56;95%CI=1.38-1.77) and combined GSTM1-GSTT1 null genotypes (OR=1.91;95%CI=1.25- 2.94) increased the risk for development of T2DM related complications, but not the GSTM1 null genotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increase the risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DM complications than Caucasians for the same. </P><P> Discussion: GSTM1, GSTT1 and combined GSTM1-GSTT1 null polymorphism may be associated with increased risk for T2DM; while GSTT1 and combined GSTM1-GSTT1 null polymorphism may increase the risk of subsequent development of T2DM complications with Asian population carrying an amplified risk for the polymorphism.Conclusion:Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitus alone, in combination or with regards to ethnicity.

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White rice eaters in Asian countries and increased risk of development type-2 diabetes mellitus: Facts to ponder

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v15i4.30726 ◽

2016 ◽

Vol 15 (4) ◽

pp. 657-658

Author(s):

Srijit Das ◽

Zar Chi Thent

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Medical Science ◽

Asian Countries ◽

White Rice ◽

Increased Risk

Abstract not availableBangladesh Journal of Medical Science Vol.15(4) 2016 p.657-658

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Hypothyroidism and its influence in the development of Metabolic Syndrome (MetS)

10.1101/2021.03.13.21253240 ◽

2021 ◽

Author(s):

Daniel José Lins Leal Pinheiro ◽

Thaís Cardoso Santos ◽

Gabriel Reis Spacini ◽

Ana Paula Guerra ◽

M C. L. Bacci ◽

...

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Retrospective Study ◽

Risk Group ◽

Conditional Probabilities ◽

Health Issues ◽

Know How ◽

Complex Disorder ◽

Systemic Arterial Hypertension ◽

Increased Risk

Background: Metabolic syndrome (MetS) is a complex disorder that affects the cardiovascular system, and it is generally associated with mental and metabolic health issues. To diagnose MetS it is essential to identify certain comorbidities related to cardiovascular diseases. Hypothyroidism, for instance, is a common disorder that reduces the basal metabolism, leading to the development of other diseases. Therefore, it is important to know how hypothyroidism can increase the chances of MetS. Objectives: To assess whether there is an increased risk of patients with hypothyroidism developing MetS given the association of different comorbidities in a sample of an urban Brazilian population. Methods: This was an observational, exploratory and retrospective study of patients diagnosed with hypothyroidism (using levothyroxine for hormonal reposition therapy).The incidence and prevalence of four specific comorbidities were quantified by histograms, and all comparisons were performed by using joint and conditional probabilities with their respective confident intervals. Results: Consistent with the literature, our results also showed that there is a prevalence in women (79%) and in elderly patients (80%). Moreover, it also indicated that around 64% of the patients were women aged over 60 years and at least one comorbidity was associated with them. By analyzing the risk group for MetS, with two comorbidities, the combination with higher chances of acquiring a new comorbidity were Systemic arterial hypertension (SAH) and Diabetes Mellitus (DM), in this sample. Conclusion: Our results indicate that hypothyroidism can increase the chances to develop MetS or may worsen its effects due to the association of common comorbidities present in both cases. Keywords: metabolic syndrome, hypothyroidism, comorbidities, statistical analysis.

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EFFICACY OF YOGAABHYAS IN THE MANGEMENT OF MADHUMEHA W.S.R TO NIDDM (TYPE 2)

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj.3809012021 ◽

2021 ◽

Vol 09 (1) ◽

pp. 239-242

Author(s):

Bansode Sheetal

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lifestyle Modification ◽

Modern Medicine ◽

The Body ◽

Negative Effects ◽

Increased Risk ◽

Conscious Control

Ayurveda is the science of living being. It begins with right lifestyle including daily and seasonal health regime designed for each individual based upon their nature, constitution, environment and life circumstances. Madhumeha is the subtype of Prameha. Due to resemblance of the feature of Madhumeha with that of DM explained in modern medicine, it is correlated with DM. According to WHO approximately 220 million people worldwide have type 2 diabetes mellitus. It is widely recognized that stress may have negative effects on health and that patients with type 2 diabetes may be at an increased risk. Yoga is an ancient Indian psychological and physical exercise regime and a number of controlled studies exist on the effectiveness of yoga on diabetes mellitus. Yogic practices strengthen and increase the tone of weak muscles and help with conscious control over autonomic function of the body. So, the present study on the role of Yogaabhyas as a lifestyle modification in Madhumeha. Keywords: Madhumeha, type 2 diabetes, asana in diabetes

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COVID-19 in People with Diabetes: Perspectives from Saudi Arabia

Current Diabetes Reviews ◽

10.2174/1573399816999201110195222 ◽

2020 ◽

Vol 16 ◽

Author(s):

Asirvatham Alwin Robert ◽

Mohamed Abdulaziz Al Dawish

Keyword(s):

Saudi Arabia ◽

Evidence Based ◽

Health Issues ◽

Major Health ◽

Increased Risk ◽

The World ◽

Risk Of Disease ◽

The Government ◽

Evidence Based Programs ◽

The Impact

Abstract:: Coronavirus disease 2019 (COVID-19) and diabetes have major impacts on the health of the population across the world. Since the beginning of the COVID-19 pandemic, people with diabetes have been identified to be more vulnerable to infection and greater risk for hospitalization. As diabetes is one of the major health issues in Saudi Arabia, the current study describes the perspectives of COVID-19 in people with diabetes and the steps taken by the government to minimize the impact of it. Most patients with COVID-19 in Saudi Arabia, experience mild illness, while people with diabetes are at increased risk of disease severity and mortality. The government of Saudi Arabia has taken several measures to control and mitigate the effect of the pandemic, as Saudi population gradually returning back to normal life. However, currently there are limited studies from Saudi Arabia on COVID-19 among people with diabetes and the effectiveness of interventions. We emphasize the necessity for comprehensive research, which would provide a better understanding of the incidence of COVID-19 and its association with diabetes to develop evidence-based programs and policies in the country.

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Frequency of fear of fall among diabetic patients in Hayatabad Medical Complex Peshawar

Rehman Journal of Health Sciences ◽

10.52442/rjhs.v2i1.25 ◽

2020 ◽

Vol 2 (1) ◽

pp. 14-18

Author(s):

Adnan Khan ◽

Tajamul Ahmad ◽

Nadia Afridi ◽

Madiha Anees ◽

Bilal Khan

Keyword(s):

Diabetes Mellitus ◽

Sampling Technique ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Cross Sectional ◽

Female Population ◽

Major Health ◽

Patients With Diabetes ◽

History Of ◽

Major Health Issue

Introduction: A fall may be defined as a loss of balance, resulting in coming to rest on the ground or on another object below knee level. Fear of all or Basophobia is a condition of concern towards falls and natural fear of unable to stand or walk. Since the identification of the post-fall syndrome, fear of fall is considered the major health issue among elderly population. Therefore, this study was conducted to measure the level of fear of fall and factors which might contribute to it. Material & Methods: It was a cross sectional study conducted to measure the level of fear of fall among the diabetic patients of Hayatabad Medical Complex Peshawar. According to the inclusion criteria, participants who had age more than 40 years and diabetic history of more than 2 years were included in the study. We measured the fear of fall with age, gender and duration of diabetes mellitus. Convenient sampling technique was used for the recruitment of the participants. Data was collected by self-repored questionnaires and was analyzed by SPSS 20.0 version. Results: A total of 306 participants, 164 (53.59%) males and 142 (46.40%) female with a mean age 56.02 ± 9.68 years (mean ± sd) were recruited. The level of fear of all was high in diabetic patients in which 222 (72.5%) participants showed high, 48 (15.7%) moderate and 36 (11.8%) low concerns. Conclusion: Fear of fall is a common problem in both male and female population having diabetes mellitus. It is one of the major concerns among patients with diabetes. It has a positive relation with age, duration of DM, and insulin intake.

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Ayurvedic review on diabetic peripheral neuropathy

Journal of Ayurveda Campus ◽

10.51648/jac.36 ◽

2021 ◽

Vol 2 (1) ◽

pp. 65-69

Author(s):

Sarita Bajagain ◽

Shiv Mangal Prasad

Keyword(s):

Diabetes Mellitus ◽

Peripheral Neuropathy ◽

Hospital Stay ◽

Diabetic Peripheral Neuropathy ◽

Limb Amputation ◽

Foot Ulcers ◽

Effective Management ◽

Major Health ◽

Depth Study ◽

Major Health Issue

Diabetes mellitus is a major health issue in today's world. Main threat is not the disease itself but its complications like nephropathy, retinopathy and neuropathy etc. Diabetic peripheral neuropathy is one of the earliest complications which has the highest prevalence of about 40-50% and is becoming the leading cause of hospital stay among diabetic mallitus and also the leading cause of foot ulcers, their complications like limb amputation and cost associated with it. Madhumeha which has been described as 'Maharogas' i.e. difficult to treat disease has many similarities with Diabetes mellitus can be understood and studied as same disease. Ayurveda has mentioned the causes, pathophysiology and symptoms of DPN as 'karapada daha -suptata' in purvarupa lakshanas and upadrava lakshanas but in scattered form. Applying the ayurveda principals in diagnosis and management of diabetes mellitus and its complications like DPN can considerably reduce the chance of foot ulcers, and its consequences. But it needs depth study to understand the concept of DPN so as to form an effective management protocal.

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Comprehensive lifestyle modification as complementary therapy to prevent and manage post-transplant diabetes mellitus*

Postępy Higieny i Medycyny Doświadczalnej ◽

10.5604/01.3001.0014.8311 ◽

2021 ◽

Vol 75 ◽

pp. 238-245

Author(s):

Katarzyna Madziarska ◽

Katarzyna Hap ◽

Oktawia Mazanowska ◽

Edyta Sutkowska

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Kidney Transplantation ◽

Lifestyle Modification ◽

Immunosuppressive Treatment ◽

Early Period ◽

Post Transplantation ◽

Metabolic Complications ◽

Post Transplant ◽

Increased Risk

Post-transplant diabetes mellitus (PTDM) is one from the most common metabolic complications after kidney transplantation. PTDM develops in the early period after transplantation. The risk factors of PTDM are carbohydrate imbalances occurring in the patient prior to transplantation, surgery and the inclusion of immunosuppressive treatment. Kidney transplant patients tend to gain weight, which is associated with an increased risk of post-transplant diabetes, cardiovascular diseases and abnormal transplanted kidney function. Patients after kidney transplantation should be advised to adopt a lifestyle based on a proper diet, exercise, weight control and smoking cessation. The strategy to reduce the risk factors for PTDM development should start before transplantation and continue after kidney transplantation. A targeted, non-pharmacological approach to patients already during the dialysis period may have a significant impact on reducing post-transplantation diabetes. Lifestyle interventions can effectively reduce the risk of development and inhibit the progression of post-transplantation diabetes. The article describes elements of comprehensive non-pharmacological management based on available knowledge of rehabilitation, dietetics and psychology.

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ASSESSMENT OF THE PLATELET COUNT IN THE PREGNANT WOMEN IN IGIMS, PATNA, BIHAR

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i2.1185 ◽

2020 ◽

Vol 4 (2) ◽

Author(s):

Tanwi Singh ◽

Anshuman Sinha

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Screening Test ◽

Low Cost ◽

Medical Science ◽

Cost Effective ◽

Platelet Indices ◽

Increased Risk ◽

Low Platelet Count ◽

Severity Of The Disease

The major risk associated with low platelet count in pregnancy is the increased risk of bleeding during the childbirth or post that. There is an increased blood supply to the uterus during pregnancy and the surgical procedure requires cutting of major blood vessels. Women with thrombocytopenia are at increased risk of losing excessive blood. The risk is more in case of caesarean delivery as compared to vaginal delivery. Hence based on above findings the present study was planned for Assessment of the Platelet Count in the Pregnant Women in IGIMS, Patna, Bihar. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of January 2019 to June 2019. In the present study 200 pregnant females samples received for the platelet estimation were enrolled in the present study. Clinically platelet indices can be a useful screening test for early identification of preeclampsia and eclampsia. Also platelet indices can assess the prognosis of this disease in pregnant women and can be used as an effective prognostic marker because it correlates with severity of the disease. Platelet count is a simple, low cost, and rapid routine screening test. Hence the data generated from the present study concludes that platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period. Keywords: Platelet Count, Pregnant Women, IGIMS, Patna, Bihar, etc.

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