scholarly journals Exploring the Potentials of Curcumin as a Single Agent in the Management of Metabolic Syndrome

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kasimu Ghandi Ibrahim ◽  
Amina Yusuf Jega
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Therapeutic Agent ◽  
Curcuma Longa ◽  
Single Agent ◽  
The Body ◽  
Concurrent Treatment ◽  
Holistic Treatment ◽  
Beneficial Effects

Despite the rising global prevalence of metabolic syndrome (MetS), a collection of cardio-metabolic risk factors that predispose individuals who have them to the development of cardiovascular disease and type 2 diabetes mellitus, its management is still based on the treatment of the different risk factors. There is currently no single therapeutic agent that is used for the concurrent treatment of all the risk factors. The current push for the use of natural products in the management of diseases has inspired research into the beneficial effects of many plant products. Curcumin is a bioactive curcuminoid from the rhizomes of turmeric (Curcuma longa) that has been shown to possess anti-obesity, anti-diabetic, hypolipidaemic and anti-hypertensive properties amongst others. These properties are closely linked to the ability of curcumin to act on several molecular targets in the body to bring about its effects. Considering these anti-MetS activities of curcumin, it holds promise as a potential therapeutic agent for the holistic treatment of the syndrome.

scholarly journals Global Innovation in Measles Vaccine Delivery: Focus on Sub-Saharan Africa

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kasimu Ghandi Ibrahim ◽  
Amina Yusuf Jega
Keyword(s):  
Risk Factors ◽  
Therapeutic Agent ◽  
Curcuma Longa ◽  
The Body ◽  
Sub Saharan Africa ◽  
Holistic Treatment ◽  
Beneficial Effects ◽  
Global Innovation ◽  
Sub Saharan

Despite the rising global prevalence of metabolic syndrome (MetS), a collection of cardio-metabolic risk factors that predispose individuals who have them to the development of cardiovascular disease and type 2 diabetes mellitus, its management is still based on the treatment of the different risk factors. There is currently no single therapeutic agent that is used for the concurrent treatment of all the risk factors. The current push for the use of natural products in the management of diseases has inspired research into the beneficial effects of many plant products. Curcumin is a bioactive curcuminoid from the rhizomes of turmeric (Curcuma longa) that has been shown to possess anti-obesity, anti-diabetic, hypolipidaemic and anti-hypertensive properties amongst others. These properties are closely linked to the ability of curcumin to act on several molecular targets in the body to bring about its effects. Considering these anti-MetS activities of curcumin, it holds promise as a potential therapeutic agent for the holistic treatment of the syndrome.

scholarly journals Evaluation of Metabolic Syndrome and Its Associated Risk Factors in Type 2 Diabetes: A Descriptive Cross-Sectional Study at the Komfo Anokye Teaching Hospital, Kumasi, Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Francis Agyemang-Yeboah ◽  
Benjamin Ackon Jnr. Eghan ◽  
Max Efui Annani-Akollor ◽  
Eliezer Togbe ◽  
Sampson Donkor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Teaching Hospital ◽  
The Body ◽  
Diabetic Patients ◽  
Study Population ◽  
Associated Risk Factors

Background. Metabolic syndrome (MS) is a collection of cardiovascular risk factors comprising insulin resistance, dyslipidemia, obesity, and hypertension, which may cause further complications in diabetes. Although metabolic syndrome (MS) is increasing in incidence in diabetics and leading to significant cardiovascular diseases and mortality, there is dearth of data in Ghana. This study investigated metabolic syndrome, its prevalence, and its associated risk factors in type 2 diabetes at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Methods. The study involved 405 diabetic patients attending the Diabetic Clinic of the Komfo Anokye Teaching Hospital (KATH) Kumasi, in the Ashanti Region of Ghana. A well-structured questionnaire was used to obtain demographic background such as their age and gender. Anthropometric measurements were obtained using the Body Composition Monitor (Omron ® 500, Germany) which generated digital results on a screen and also by manual methods. Fasting venous blood was collected for the measurement of biochemical parameters comprising fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-c), and triglyceride (TG). Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). Results. Out of the total of 405 participants, 81 were males and 324 were females, and the estimated mean age was 58.5 ± 9.9 years. The female patients exhibited higher mean waist circumference (WC) and mean hip circumference (HC) as well as an approximately higher body mass index than males (28.3 ± 5.1, 26.5 ± 4.2 for the female and male respectively). Overall, the prevalence of metabolic syndrome observed among the study population was 90.6%. Conclusions. The prevalence of metabolic syndrome observed among the study population was 90.6%, with a higher percentage in females than males. High triglyceride levels and high waist circumference were the main risk factors for MS in the diabetic population.

scholarly journals Potential of Beetroot and Blackcurrant Compounds to Improve Metabolic Syndrome Risk Factors

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 338
Author(s):  
Cameron Haswell ◽  
Ajmol Ali ◽  
Rachel Page ◽  
Roger Hurst ◽  
Kay Rutherfurd-Markwick
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Metabolic Abnormalities ◽  
Dietary Nitrate ◽  
Increased Risk ◽  
High Concentrations

Metabolic syndrome (MetS) is a group of metabolic abnormalities, which together lead to increased risk of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM), as well as reduced quality of life. Dietary nitrate, betalains and anthocyanins may improve risk factors for MetS and reduce the risk of development of CHD and T2DM. Beetroot is a rich source of dietary nitrate, and anthocyanins are present in high concentrations in blackcurrants. This narrative review considers the efficacy of beetroot and blackcurrant compounds as potential agents to improve MetS risk factors, which could lead to decreased risk of CHD and T2DM. Further research is needed to establish the mechanisms through which these outcomes may occur, and chronic supplementation studies in humans may corroborate promising findings from animal models and acute human trials.

Association between muscle strength and risk factors for metabolic syndrome in children and adolescents: a systematic review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Tiago R. de Lima ◽  
Priscila C. Martins ◽  
Giuseppe L. Torre ◽  
Alice Mannocci ◽  
Kelly S. Silva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Metabolic Syndrome ◽  
Muscle Strength ◽  
Children And Adolescents ◽  
Lower Risk ◽  
Preliminary Evidence ◽  
Risk Of Bias ◽  
The Body ◽  
Reference List

AbstractThe aim of this systematic review was to identify and summarize evidence for the association between muscle strength (MS) and metabolic syndrome (MetS), and MS and combinations of risk factors for MetS in children and adolescents. Five databases (Medline/PubMed, EBSCO, Scielo, Scopus, and Web of Knowledge) were searched up to November 2019 with complementary reference list searches. Inclusion criteria were studies that investigated the relationship between MS and MetS or MS and combinations of risk factors for MetS in children and adolescents (≤19 years of age). Risk of bias was assessed using standard procedures. From the total of 15,599 articles initially identified, 13 articles were included, representing 11,641 children and adolescents. Higher MS values were associated with lower risk for MetS or combinations of risk factors for MetS (n=11/13 studies). Of the total of included studies, about 23.1% (03/13) were longitudinal and all included studies were classified as having a moderate risk of bias. This review provides preliminary evidence for a beneficial relationship between MS and MetS among children and adolescents. Additionally, although the body of evidence points to the beneficial relationship between higher MS and lower risk for combination of factors for MetS in children and adolescents, this relationship is inconclusive.

scholarly journals Early vascular aging risk assessment in patients with metabolic syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Salasyuk ◽  
S Nedogoda ◽  
I Barykina ◽  
V Lutova ◽  
E Popova
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Metabolic Syndrome ◽  
Vascular Aging ◽  
Clinical Markers ◽  
Cvd Risk ◽  
Vascular Age

Abstract Background Metabolic syndrome (MetS) and abdominal obesity are one of the most common CVD risk factors among young and mature patients. However, the currently used CVD risk assessment scales may underestimate the CV risk in people with obesity and MS. Early vascular aging rather than chronological aging can conceptually offer better risk prediction. MetS, as accumulation of classical risk factors, leads to acceleration of early vascular aging. Since an important feature of MetS is its reversibility, an adequate risk assessment and early start of therapy is important in relation to the possibilities of preventing related complications. Purpose To derive a new score for calculation vascular age and predicting EVA in patients with MetS. Methods Prospective open cohort study using routinely collected data from general practice. The derivation cohort consisted of 1000 patients, aged 35–80 years with MetS (IDF,2005 criteria). The validation cohort consisted of 484 patients with MetS and carotid-femoral pulse wave velocity (cfPWV) values exceeding expected for average age values by 2 or more SD (EVA syndrome). Results In univariate analysis, EVA was significantly correlated with the presence of type 2 diabetes and clinical markers of insulin resistance (IR), body mass index (BMI), metabolic syndrome severity score (MetS z-score), uric acid (UA) level, hsCRP, HOMA-IR, total cholesterol (TC), triglycerides (TG), heart rate (HR), central aortic blood pressure (CBP), diastolic blood pressure (DBP). Multiple logistic regression shown, that presence of type 2 diabetes and IR were associated with greater risk of EVA; the odds ratios were 2.75 (95% CI: 2.34, 3.35) and 1.57 (95% CI: 1.16, 2.00), respectively. In addition, the risk of having EVA increased by 76% with an increase in HOMA-IR by 1 unit, by 17% with an increase in hsCRP by 1 mg/l, by 4% with an increase in DBP by 1 mm Hg, and by 1% with each 1 μmol / L increase in the level of UA. The area under the curve for predicting EVA in patients with MetS was 0,949 (95% CI 0,936 to 0,963), 0,630 (95% CI 0,589 to 0,671), 0,697 (95% CI 0,659 to 0,736) and 0,686 (95% CI 0,647 to 0,726), for vascular age, calculated from cfPWV, SCORE scale, QRISK-3 scale and Framingham scale, respectively. Diabetes mellitus and clinical markers of IR (yes/no), HOMA-IR and UA level were used to develop a new VAmets score for EVA prediction providing a total accuracy of 0.830 (95% CI 0,799 to 0,860). Conclusion cfPWV at present the most widely studied index of arterial stiffness, fulfills most of the stringent criteria for a clinically useful biomarker of EVA in patients with MetS. Although, parallel efforts for effective integration simple clinical score into clinical practice have been offered. Our score (VAmets) may accurately identify patients with MetS and EVA on the basis of widely available clinical variables and classic cardiovascular risk factors can prioritize using of vascular age in routine care. ROC-curves for predicting EVA in MetS Funding Acknowledgement Type of funding source: None

scholarly journals Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

2021 ◽  
Vol 22 (5) ◽  
pp. 2639
Author(s):  
Ana Rita de Oliveira dos Santos ◽  
Bárbara de Oliveira Zanuso ◽  
Vitor Fernando Bordin Miola ◽  
Sandra Maria Barbalho ◽  
Patrícia C. Santos Bueno ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Interleukin 1 ◽  
The Body ◽  
Healthy Weight ◽  
Beta Oxidation ◽  
Necrosis Factor Alpha ◽  
Beneficial Effects ◽  
Muscle Tissues ◽  
Endocrine Organs ◽  
Sharing Space

Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to an organism and still perform crosstalk, acting through the endocrine, paracrine, and autocrine pathways. This study aims to review the crosstalk between adipokines, myokines, and hepatokines. Far beyond understanding the actions of each biomarker alone, it is important to underline that these cytokines act together in the body, resulting in a complex network of actions in different tissues, which may have beneficial or non-beneficial effects on the genesis of various physiological disorders and their respective outcomes, such as type 2 diabetes mellitus (DM2), obesity, metabolic syndrome, and cardiovascular diseases (CVD). Overweight individuals secrete more pro-inflammatory adipokines than those of a healthy weight, leading to an impaired immune response and greater susceptibility to inflammatory and infectious diseases. Myostatin is elevated in pro-inflammatory environments, sharing space with pro-inflammatory organokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), resistin, and chemerin. Fibroblast growth factor FGF21 acts as a beta-oxidation regulator and decreases lipogenesis in the liver. The crosstalk mentioned above can interfere with homeostatic disorders and can play a role as a potential therapeutic target that can assist in the methods of diagnosing metabolic syndrome and CVD.

Beneficial effects of rosiglitazone on novel cardiovascular risk factors in patients with Type 2 diabetes mellitus

2008 ◽  
Vol 25 (3) ◽  
pp. 333-340 ◽  
Author(s):  
N. P. E. Kadoglou ◽  
F. Iliadis ◽  
N. Angelopoulou ◽  
D. Perrea ◽  
C. D. Liapis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Beneficial Effects

scholarly journals Regular swimming session improves metabolic syndrome risk factors in women and men from Palestine: Quasi-experimental study

2020 ◽  
Author(s):  
Jamal Omar ◽  
Nidal Jaradat ◽  
Mohammad Qadoumi ◽  
Abdel Naser Qadoumi
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Experimental Study ◽  
Reference Group ◽  
High Density Lipoproteins ◽  
Post Exercise ◽  
Quasi Experimental ◽  
Blood Pressures

Abstract Background: Swimming and other aquatic fitness are important aerobic exercises that have been proposed as an effective nonpharmacological approach in the management of type 2 diabetes (T2DM), hyperlipidemia, and hypertension (HTN). The current study aimed to assess the effect of long-term swimming sessions on glycemic and lipidemic parameters, body composition, and hemodynamic responses for patients with metabolic risk factors. Methods: Forty participants from both genders with T2DM and HTN (aged 52.4±5.5 yrs) agreed to take part in this quasi-experimental study and were divided into two groups. The first group included the participants who performed long-term swimming sessions and the second group served as the reference. The first group exercised for 2 h, 3 times/week in 29-33 ◦C swimming pool for 16 weeks. While the reference group did not participate in any kind of exercise and advised to keep on with their normal lifestyle. All the obtained metabolic syndrome risk factors data were analyzed using a paired t-test which was applied to separately determine the differences between pre- and post-tests for both genders and groups, and the percentage of change (Δ %) was computed. Independent t-test was applied to determine the differences in the post-tests (Exp. vs Ref) in men patients as well as for women separately. Results: The results showed that there were statistically significant differences at p ≤ 0.05 between pre- and post- exercise concerning Total Cholesterol (TC), High-Density Lipoproteins (HDL), Low-Density Lipoproteins (LDL), Triglycerides (TG), glycemic parameters, systolic and diastolic blood pressures, body mass index (BMI) and fat mass percent in favor of posttests in the experimental group for both genders. Whereas, no significant differences were found at p≤0.05 between pre- and post-tests for all studied variables in the reference group for both genders. Significant differences were found at p≤0.05 on the post-tests in favor of the experimental for both genders.Conclusion: Findings of the current study suggested that the regular 16 weeks of the conducted swimming sessions could be considered as nonpharmacological approaches in the management of T2DM and HTN.

scholarly journals Effects of Extreme Weight Loss on Cardiometabolic Health in Children With Metabolic Syndrome: A Metabolomic Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingxin Liu ◽  
Lin Zhu ◽  
Jing Liao ◽  
Xiaoguang Liu
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Body Composition ◽  
Organic Acids ◽  
Cardiometabolic Risk ◽  
The Body ◽  
Cardiometabolic Risk Factors ◽  
Plasma Metabolites ◽  
Cardiometabolic Health

Objectives: To evaluate the effect of extreme weight loss programs on circulating metabolites and their relationship with cardiometabolic health in children with metabolic syndrome.Methods: This study was a quasi-experimental design with a pretest and post-test. Thirty children with metabolic syndrome and aged 10–17years were recruited to an extreme weight loss program (i.e., exercise combined with diet control). The primary outcomes included plasma metabolites, body composition, and cardiometabolic risk factors. A total of 324 metabolites were quantitatively detected by an ultra-performance liquid chromatography coupled to tandem mass spectrometry system, and the variable importance in the projection (VIP) value of each metabolite was calculated by the orthogonal projection to latent structures discriminant analysis. The fold change (FC) and p value of each metabolite were used to screen differential metabolites with the following values: VIP>1, p value<0.05, and |log2FC|>0.25. Pathway enrichment and correlation analyses between metabolites and cardiometabolic risk factors were also performed.Result: A large effect size was observed, presenting a weight loss of −8.9kg (Cohen’s d=1.00, p<0.001), body mass index reduction of −3.3kg/m2 (Cohen’s d=1.47, p<0.001), and body fat percent reduction of −4.1 (%) (Cohen’s d=1.22, p<0.001) after the intervention. Similar improvements were found in total cholesterol (Cohen’s d=2.65, p<0.001), triglycerides (Cohen’s d=2.59, p<0.001), low-density lipoprotein cholesterol (Cohen’s d=2.81, p<0.001), glucose metabolism, and blood pressure. A total of 59 metabolites were changed after the intervention (e.g., aminoacyl-tRNA biosynthesis, glycine, serine, and threonine metabolism; nitrogen metabolism, tricarboxylic acid cycle, and phenylalanine, tyrosine, and tryptophan biosynthesis). The changes in metabolites (e.g., amino acids, fatty acids, organic acids, and carnitine) were related to lipid metabolism improvement (p<0.05). Organic acids and carnitines were associated with changes in the body composition (p<0.05).Conclusion: Exercise combined with dietary control improved the body composition and cardiometabolic health in children with metabolic syndrome, and these changes may be related to plasma metabolites.

scholarly journals Study on health risk factors as a basis to implement programs that promote a nutritional culture in students of the la Sabana University

2021 ◽  
pp. 89-94
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Chemistry ◽  
Monitoring And Control ◽  
The Metabolic Syndrome

Background. Nowadays the importance of lifestyles in the prevention of type 2 diabetes and the metabolic syndrome has been largely accertained. Objective. The purpose of our work is to implement programs that promote a nutritional culture in adolescents and young adults of the La Sabana University. Methods. The methodology entailed, after the corresponding informed consent, taking measures of the triceps and supraescapular skinfolds, waist circumference, body mass index (BMI), lean mass, and fat mass. Fasting blood samples were also taken to quantify cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL). Results. The results obtained show that of the 165 students, 10.3% were underweight, 13.93% were overweight and 0.6% were obese. With regards to gender, 4.8% of the men and 9% of the women were overweight, 3% of the men and 7.2% of the women were underweight, and 0.6% of the women were obese. The blood chemistry showed that 30% had hypercholesterolemia, 18% hypertriglyceridemia, 17% reported low HDL levels and 67% reported high LDL levels. Of all the cases studied, 40% are at risk of a metabolic syndrome. 60% claimed not to practice any physical activity - especially women who reported 44.70%. Conclusions. These findings have allowed us at the institution to implement a culture of healthy habits. The have also allowed us to identify students with risk factors for type 2 diabetes and metabolic syndrome. This is why the cardiometabolic monitoring and control based on healthy eating and physical activity are important.

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