scholarly journals Holocene climatic changes in the Westerly-Indian Monsoon realm and its anthropogenic impact

2020 ◽  
Author(s):  
Nicole Burdanowitz ◽  
Tim Rixen ◽  
Birgit Gaye ◽  
Kay-Christian Emeis
Keyword(s):  
Transition Period ◽  
Indian Subcontinent ◽  
Fold Increase ◽  
Indus Civilization ◽  
Linear Interaction ◽  
Westerly Jet ◽  
Non Linear ◽  
Agricultural Societies ◽  
Earth’S Climate ◽  
The Impact

Abstract. The Indian Summer Monsoon (ISM) with its rainfall is the lifeline for people living on the Indian subcontinent today and possibly was the driver of the rise and fall of early agricultural societies in the past. Intensity and position of the ISM have shifted in response to orbitally forced thermal land-ocean contrasts. At the northwestern monsoon margins, interactions between the subtropical westerly jet (STWJ) and the ISM constitute a tipping element in the Earth's climate system, because their non-linear interaction may be a first-order influence on rainfall. We reconstructed marine sea surface temperature (SST), supply of terrestrial material and vegetation changes from a very well-dated sediment core from the northern Arabian Sea to reconstruct the STWJ-ISM interaction. The Holocene record (from 11,000 years) shows a distinct, but gradual, southward displacement of the ISM in the Early to Mid-Holocene, increasingly punctuated by phases of intensified STWJ events that are coeval with interruptions of North Atlantic overturning circulation (Bond events). Effects of the non-linear interactions culminate between 4.6–3 ka BP, marking a climatic transition period during which the ISM shifted southwards and the influence of SWTJ became prominent. The lithogenic input shows an up to 4-fold increase after this time period signaling the strengthened influence of agricultural activities of the Indus civilization with enhanced erosion of soils amplifying the impact of Bond events and adding to the marine sedimentation rates adjacent to the continent.

scholarly journals Signals of Holocene climate transition amplified by anthropogenic land-use changes in the westerly–Indian monsoon realm

2021 ◽  
Vol 17 (4) ◽  
pp. 1735-1749
Author(s):  
Nicole Burdanowitz ◽  
Tim Rixen ◽  
Birgit Gaye ◽  
Kay-Christian Emeis
Keyword(s):  
Land Use ◽  
Transition Period ◽  
Indian Subcontinent ◽  
Land Use Changes ◽  
Fold Increase ◽  
Indus Civilization ◽  
Linear Interaction ◽  
Non Linear ◽  
The Impact ◽  
Anthropogenic Land Use

Abstract. The Indian summer monsoon (ISM) rainfall is the lifeline for people living on the Indian subcontinent today and was possibly the driver of the rise and fall of early agricultural societies in the past. The intensity and position of the ISM have shifted in response to orbitally forced thermal land–ocean contrasts. At the northwestern monsoon margins, interactions between the subtropical westerly jet (STWJ) and the ISM constitute a tipping element in the Earth's climate system because their non-linear interaction may be a first-order influence on rainfall. We reconstructed marine sea surface temperature (SST), supply of terrestrial material and vegetation changes from a very well-dated sediment core from the northern Arabian Sea to reconstruct the STWJ–ISM interaction. The Holocene record (from 11 000 years) shows a distinct, but gradual, southward displacement of the ISM in the Early to Mid-Holocene, increasingly punctuated by phases of intensified STWJ events that are coeval with interruptions of North Atlantic overturning circulation (Bond events). The effects of the non-linear interactions culminate between 4.6 and 3 ka BP, marking a climatic transition period during which the ISM shifted southwards and the influence of STWJ became prominent. The lithogenic matter input shows an up to 4-fold increase after this time period, probably related to the strengthened influence of agricultural activities of the Indus civilization, with enhanced erosion of soils. This anthropogenic land-use change is amplifying the impact of Bond events and adding to the marine sedimentation rates adjacent to the continent.

scholarly journals Associations between TG/HDL ratio and insulin resistance in the US population: a cross-sectional study

2021 ◽  
Author(s):  
Rongpeng Gong ◽  
Gang Luo ◽  
Mingxiang Wang ◽  
Lingbo Ma ◽  
Shengnan Sun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Alcohol Use ◽  
The United States ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Linear Interaction ◽  
Non Linear ◽  
Adjusted Logistic Regression ◽  
The Impact ◽  
The Relationship

BACKGROUND: Clinical data on the relationship between TG/HDL ratio and IR suggests that TG/HDL ratio may be a risk factor for insulin resistance. However, there is evidence that different races have different risk of developing insulin resistance. The relationship on TG/HDL ratio and insulin resistance in various populations needs to be improved. Therefore, we investigated whether TG/HDL ratio was linked to insulin resistance in different groups in the United States after controlling for other covariates. METHODS: The current research was conducted in a cross-sectional manner. From 2009 to 2018, NHANES had a total of 49,696 participants, all of whom were Americans. The target-independent variable was TG/HDL ratio measured at baseline, and the dependent variable was insulin resistance. Additionally, the BMI, waist circumference, education, race, smoking, alcohol use, ALT, AST, and other covariates were also included in this analysis. RESULTS: The average age of the 10,132 participants was 48.6±18.4 years, and approximately 4936 (48.7%) were male. After correcting for confounders, fully-adjusted logistic regression revealed that TG/HDL ratio was correlated with insulin resistance (OR=1.51, 95%CI 1.42-1.59). A non-linear interaction between TG/HDL ratio and IR was discovered, with a point of 1.06. The impact sizes and confidence intervals on the left and right sides of the inflection point were 6.28 (4.66-8.45) and 1.69 (1.45-1.97), respectively. According to subgroup analysis, the correlation was strong in female, alcohol use, and diabetes patients. Meanwhile, the inverse pattern was observed in the aged, obese, high-income, and smoking populations. CONCLUSION: In the American population, the TG/HDL ratio is positively associated with IR in a non-linear interaction pattern.

Non-Linear Interaction of MHD Waves with Small-Scale Ionospheric Irregularities

2004 ◽  
Vol 61 (7-12) ◽  
pp. 1055-1071
Author(s):  
N. N. Gerasimova ◽  
V. G. Sinitsin ◽  
Yu. M. Yampolski
Keyword(s):  
Ionospheric Irregularities ◽  
Mhd Waves ◽  
Small Scale ◽  
Linear Interaction ◽  
Non Linear

Novel Applications of Nanotechnology in Controlling HIV and HSV Infections

2020 ◽  
Vol 12 ◽  
Author(s):  
Sai Akilesh M ◽  
Ashish Wadhwani
Keyword(s):  
Drug Delivery ◽  
Viral Infections ◽  
Polymeric Nanoparticles ◽  
Volume Ratio ◽  
Fold Increase ◽  
Multi Drug Resistance ◽  
Health Crisis ◽  
Pharmaceutical Properties ◽  
Simplex Virus ◽  
The Impact

: Infectious diseases have been prevalent since many decades and viral pathogens have caused global health crisis and economic meltdown on a devastating scale. High occurrence of newer viral infections in the recent years, in spite of the progress achieved in the field of pharmaceutical sciences defines the critical need for newer and more effective antiviral therapies and diagnostics. The incidence of multi-drug resistance and adverse effects due to the prolonged use of anti-viral therapy is also a major concern. Nanotechnology offers a cutting edge platform for the development of novel compounds and formulations for biomedical applications. The unique properties of nano-based materials can be attributed to the multi-fold increase in the surface to volume ratio at the nano-scale, tunable surface properties of charge and chemical moieties. Idealistic pharmaceutical properties such as increased bioavailability and retention times, lower toxicity profiles, sustained release formulations, lower dosage forms and most importantly, targeted drug delivery can be achieved through the approach of nanotechnology. The extensively researched nano-based materials are metal and polymeric nanoparticles, dendrimers and micelles, nano-drug delivery vesicles, liposomes and lipid based nanoparticles. In this review article, the impact of nanotechnology on the treatment of Human Immunodeficiency Virus (HIV) and Herpes Simplex Virus (HSV) viral infections during the last decade are outlined.

scholarly journals Impact of alternative regional trade arrangements on the Ethiopian economy

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Habtamu Shiferaw Amogne ◽  
Taiji Hagiwara
Keyword(s):  
Transition Period ◽  
Terms Of Trade ◽  
Endowment Effect ◽  
Welfare Loss ◽  
Customs Union ◽  
Regional Trade ◽  
Partnership Agreement ◽  
Saving Effect ◽  
The Impact ◽  
Trade And Investment

AbstractThe Common Market for Eastern and Southern Africa (COMESA) is a Free Trade Area (FTA) regional trade agreement in Africa. Currently, Ethiopia is negotiating to join COMESA FTA. This study assesses the impact of three regional trade arrangements, COMESA FTA, customs unions, and the European Partnership Agreement (EPA) on the economy of Ethiopia. The analysis is based on a static Global Trade Analysis Project (GTAP) model, version 9 database. Unlike previous studies, the customs union scenarios are designed at the detailed Harmonized System (HS) level. COMESA FTA (scenario 1) with standard GTAP model results in a welfare loss for Ethiopia due to negative terms of trade and investment-saving effect, but with unemployment closure (scenario 2); Ethiopia enjoys a welfare gain mainly due to endowment effect. In scenario 3 (COMESA customs union) and scenario 4 (European Partnership Agreement), Ethiopia loses due to negative terms of trade and investment-saving effect. There is a large increase in demand for unskilled labor force in Ethiopia by around US$23 million, US$112 million, and US$43 million for scenario 2, 3, and 4 respectively. Moreover, there is a positive output effect for oilseeds, leather, and basic metals across all scenarios. The world, as a whole, enjoys welfare gains with COMESA FTA (scenario 1 and 2). However, with scenario 3 and 4, there is an overall welfare loss. There is no strong reason for Ethiopia to move to the customs union, and the EPA in the short run. Therefore, a transition period is necessary, but it is recommended for Ethiopia to join COMESA FTA.

scholarly journals Administrative Coding Methods Impact Surgical Site Infection Rates

2020 ◽  
Vol 41 (S1) ◽  
pp. s111-s112
Author(s):  
Mohammed Alsuhaibani ◽  
Mohammed Alzunitan ◽  
Kyle Jenn ◽  
Daniel Diekema ◽  
Michael Edmond ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Surgical Procedures ◽  
Hip Prosthesis ◽  
Knee Prosthesis ◽  
Surgical Site Infections ◽  
Fold Increase ◽  
Abdominal Hysterectomy ◽  
Absolute Difference ◽  
Coding Method ◽  
The Impact

Background: Surveillance for surgical site infections (SSI) is recommended by the CDC. Currently, colon and abdominal hysterectomy SSI rates are publicly available and impact hospital reimbursement. However, the CDC NHSN allows surgical procedures to be abstracted based on International Classification of Diseases, Tenth Revision (ICD-10) or current procedural terminology (CPT) codes. We assessed the impact of using ICD and/or CPT codes on the number of cases abstracted and SSI rates. Methods: We retrieved administrative codes (ICD and/or CPT) for procedures performed at the University of Iowa Hospitals & Clinics over 1 year: October 2018–September 2019. We included 10 procedure types: colon, hysterectomy, cesarean section, breast, cardiac, craniotomy, spinal fusion, laminectomy, hip prosthesis, and knee prosthesis surgeries. We then calculated the number of procedures that would be abstracted if we used different permutations in administration codes: (1) ICD codes only, (2) CPT codes only, (3) both ICD and CPT codes, and (4) at least 1 code from either ICD or CPT. We then calculated the impact on SSI rates based on any of the 4 coding permutations. Results: In total, 9,583 surgical procedures and 180 SSIs were detected during the study period using the fourth method (ICD or CPT codes). Denominators varied according to procedure type and coding method used. The number of procedures abstracted for breast surgery had a >10-fold difference if reported based on ICD only versus ICD or CPT codes (104 vs 1,109). Hip prosthesis had the lowest variation (638 vs 767). For SSI rates, cesarean section showed almost a 3-fold increment (2.6% when using ICD only to 7.32% with both ICD & CPT), whereas abdominal hysterectomy showed nearly a 2-fold increase (1.14% when using CPT only to 2.22% with both ICD & CPT codes). However, SSI rates remained fairly similar for craniotomy (0.14% absolute difference), hip prosthesis (0.24% absolute difference), and colon (0.09% absolute difference) despite differences in the number of abstracted procedures and coding methods. Conclusions: Denominators and SSI rates vary depending on the coding method used. Variations in the number of procedures abstracted and their subsequent impact on SSI rates were not predictable. Variations in coding methods used by hospitals could impact interhospital comparisons and benchmarking, potentially leading to disparities in public reporting and hospital penalties.Funding: NoneDisclosures: None

scholarly journals Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as A Way to Enhance Dissolution Rate and Permeability

2021 ◽  
Vol 14 (5) ◽  
pp. 453
Author(s):  
Gabriela Wiergowska ◽  
Dominika Ludowicz ◽  
Kamil Wdowiak ◽  
Andrzej Miklaszewski ◽  
Kornelia Lewandowska ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Density Functional ◽  
Hydroxypropyl Methylcellulose ◽  
Fold Increase ◽  
Crystalline Form ◽  
Amorphous Form ◽  
Freeze Dried ◽  
Apparent Solubility ◽  
Gastrointestinal Epithelium ◽  
The Impact

To improve physicochemical properties of vardenafil hydrochloride (VAR), its amorphous form and combinations with excipients—hydroxypropyl methylcellulose (HPMC) and β-cyclodextrin (β-CD)—were prepared. The impact of the modification on physicochemical properties was estimated by comparing amorphous mixtures of VAR to their crystalline form. The amorphous form of VAR was obtained as a result of the freeze-drying process. Confirmation of the identity of the amorphous dispersion of VAR was obtained through the use of comprehensive analysis techniques—X-ray powder diffraction (PXRD) and differential scanning calorimetry (DSC), supported by FT-IR (Fourier-transform infrared spectroscopy) coupled with density functional theory (DFT) calculations. The amorphous mixtures of VAR increased its apparent solubility compared to the crystalline form. Moreover, a nearly 1.3-fold increase of amorphous VAR permeability through membranes simulating gastrointestinal epithelium as a consequence of the changes of apparent solubility (Papp crystalline VAR = 6.83 × 10−6 cm/s vs. Papp amorphous VAR = 8.75 × 10−6 cm/s) was observed, especially for its combinations with β-CD in the ratio of 1:5—more than 1.5-fold increase (Papp amorphous VAR = 8.75 × 10−6 cm/s vs. Papp amorphous VAR:β-CD 1:5 = 13.43 × 10−6 cm/s). The stability of the amorphous VAR was confirmed for 7 months. The HPMC and β-CD are effective modifiers of its apparent solubility and permeation through membranes simulating gastrointestinal epithelium, suggesting a possibility of a stronger pharmacological effect.

scholarly journals Determinants of participation and quality of life of young adults with cerebral palsy: longitudinal approach and comparison with the general population – SPARCLE 3 study protocol

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Catherine Arnaud ◽  
Carine Duffaut ◽  
Jérôme Fauconnier ◽  
Silke Schmidt ◽  
Kate Himmelmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Cerebral Palsy ◽  
Young People ◽  
General Population ◽  
Transition Period ◽  
Well Being ◽  
Personal Factors ◽  
The Impact

Abstract Background Effective inclusion in society for young people with disabilities is increasingly seen as generating opportunities for self-development, and improving well-being. However, significant barriers remain in the vast majority of activities meaningful for young adults. Research argues that various personal (disabilities, health) and environmental (access to the resources needed, accessible environment, discrimination, lack of personal economic independence) factors contribute to limited participation. However, previous studies conducted in young people with cerebral palsy (CP) mainly investigated the transition period to adulthood, and did not fully consider the whole range of impairment severity profiles or environmental barriers. In this study, we will use the follow-up of the SPARCLE cohort and a comparison group from the general population (1) to investigate the impact of the environment on participation and quality of life of young adults with CP, (2) to determine predictors of a successful young adulthood in educational, professional, health and social fields, (3) to compare quality of life and frequency of participation in social, work and recreational activities with the general population, (4) to document on participation and quality of life in those with severe disabilities. Methods The SPARCLE3 study has a combined longitudinal and cross-sectional design. Young adults with CP aged 22 to 27 years in 6 European regions previously enrolled in the SPARCLE cohort or newly recruited will be invited to self-complete a comprehensive set of questionnaires exploring participation (daily life and discretionary activities), health-related quality of life, body function, personal factors (health, personal resources), and contextual factors (availability of needed environmental items, family environment, services provision) during home visits supervised by trained researchers. Proxy-reports or adapted questionnaires will be used for those with the most severe impairments. The recruitment of a large group from the general population (online survey) will enable to identify life areas where the discrepancies between young people with CP and their able-bodied peers are the most significant. Discussion This study will help identify to what extent disabilities and barriers in environment negatively affect participation and quality of life, and how previous valued experiences during childhood or adolescence might modulate these effects.

scholarly journals Grill Workers Exposure to Polycyclic Aromatic Hydrocarbons: Levels and Excretion Profiles of the Urinary Biomarkers

2020 ◽  
Vol 18 (1) ◽  
pp. 230
Author(s):  
Marta Oliveira ◽  
Sílvia Capelas ◽  
Cristina Delerue-Matos ◽  
Simone Morais
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
High Performance ◽  
Principal Component ◽  
Fold Increase ◽  
Urinary Biomarkers ◽  
Analysis Model ◽  
Exposed Workers ◽  
Polycyclic Aromatic ◽  
The Impact

Grilling activities release large amounts of hazardous pollutants, but information on restaurant grill workers’ exposure to polycyclic aromatic hydrocarbons (PAHs) is almost inexistent. This study assessed the impact of grilling emissions on total workers’ exposure to PAHs by evaluating the concentrations of six urinary biomarkers of exposure (OHPAHs): naphthalene, acenaphthene, fluorene, phenanthrene, pyrene, and benzo(a)pyrene. Individual levels and excretion profiles of urinary OHPAHs were determined during working and nonworking periods. Urinary OHPAHs were quantified by high-performance liquid-chromatography with fluorescence detection. Levels of total OHPAHs (∑OHPAHs) were significantly increased (about nine times; p ≤ 0.001) during working comparatively with nonworking days. Urinary 1-hydroxynaphthalene + 1-hydroxyacenapthene and 2-hydroxyfluorene presented the highest increments (ca. 23- and 6-fold increase, respectively), followed by 1-hydroxyphenanthrene (ca. 2.3 times) and 1-hydroxypyrene (ca. 1.8 times). Additionally, 1-hydroxypyrene levels were higher than the benchmark, 0.5 µmol/mol creatinine, in 5% of exposed workers. Moreover, 3-hydroxybenzo(a)pyrene, biomarker of exposure to carcinogenic PAHs, was detected in 13% of exposed workers. Individual excretion profiles showed a cumulative increase in ∑OHPAHs during consecutive working days. A principal component analysis model partially discriminated workers’ exposure during working and nonworking periods showing the impact of grilling activities. Urinary OHPAHs were increased in grill workers during working days.

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