scholarly journals Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits

2018 ◽  
Vol 08 (04) ◽  
pp. 204-209
Author(s):  
Obaid Anwar ◽  
Mazhar Iqbal ◽  
Sadia Chiragh ◽  
Owais bin Qadeer Gill ◽  
Muhammad Iqbal
Keyword(s):  
Experimental Study ◽  
Alkaline Phosphatase ◽  
Body Weight ◽  
Raphanus Sativus ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Experimental Control ◽  
Histological Studies ◽  
Control Serum ◽  
Higher Doses

Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin induced hepatotoxicity in albino rabbits. Study design: Experimental study Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture, Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity produced by atorvastatin. Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation. Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by histological studies.

scholarly journals Antihyperglycemic and Antihyperlipidemic of Karala (Momordica charantia) Fruits in Streptozotocin Induced Diabetic Rats

2012 ◽  
Vol 5 (1) ◽  
pp. 29-37 ◽  
Author(s):  
MA Hossain ◽  
M Mostofa ◽  
D Debnath ◽  
AKMR Alam ◽  
Z Yasmin ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Total Cholesterol ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Higher Doses

To investigate the antihyperglycemic and antihyperlipidemic effect of Momordica charantia (Karala), the aqueous extract of the Karala fruit was tested on streptozotocin (STZ)-induced diabetic rats. Thirty six albino rats were used in the experiment, 30 diabetic and the remaining six as negative control (T1). Diabetes was induced by administering (injecting) STZ at dose of 55mg/kg body weight. Thirty diabetic animals were randomly divided into five groups such as diabetic control group (T2) without any application of treatment, and groups T3,T4,T5 and T6 were treated with aqueous extract of Karala fruits daily at the doses of 250,    500 and 750mg/kg and glibenclamide (at a dose of 5mg/kg body weight) respectively. The body weight was taken and blood samples were collected from individual animal to determine glucose levels at 15 day interval up to 90 days. In addition, Asparate  Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) were determined at day 15 and at the end of the experiment. All three doses of Karala extracts reduced diabetic induced blood sugar and the reduction is comparable with standard glibenclamide (GLM) dose particularly with higher doses Karala extracts (500 and 750mg). Karala also prevented body weight loss due to induced diabetes as did by GLM treatment.. The treatment also resulted in a significant reduction of Asparate Transaminenase(AST), Alanine Transaminenase(ALT), Alkaline Phosphatase(ALP), Total cholesterol (TCh) and Triglyceride (TGA) activities of treated rats when compared to the STZ induced  diabetic rats. Higher doses of Karala (500 and 750mg/kg) are as effective as standard GLM dose on measured variables. This study demonstrated that Karala has hyperglycemia and antihyperlipidemic effect against STZ induced diabetic rats. These findings open the possibility of using Karala extract to treat diabetic animal and human patients although further research is warranted. DOI: http://dx.doi.org/10.3329/jesnr.v5i1.11550 J. Environ. Sci. & Natural Resources, 5(1): 29 - 37, 2012  

scholarly journals Biosupplementation of Ethanolic Extract of Cashew Leaf (Anacardium occidentale L.) to Improve Weight Gain and Immunity of Jawa Super Chicken

2019 ◽  
Vol 7 (2) ◽  
pp. 57-65
Author(s):  
Manesta Edelweis Jingga ◽  
Haris Setiawan ◽  
Ardaning Nuriliani ◽  
Hendry Trisakti Saragih
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth And Development ◽  
Leaf Extract ◽  
Histological Analysis ◽  
Ethanolic Extract ◽  
Anacardium Occidentale ◽  
Bursa Of Fabricius ◽  
White Pulp ◽  
One Way Anova

Effect of ethanolic extract of cashew leaf (Anacardium occidentale L.) in the feed on the weight gain and immunity were investigated on Jawa Super Chicken. Ninety chicken were divided into 6 groups those were basal feed group and 5 different concentration of chasew leaf extract groups. Experiment was conducted for 16 days started by 2 days acclimatization after hatching. Body weight was measured every 3 days starting from 0th day. On 16th day, the chicken were sacrificed, spleen and bursa of Fabricius were collected to quantify some histological parameters such as white pulp and follicle area as well as follicle thickness of those organs. The data were analyzed by regression and one way ANOVA followed by Tuckey test. Histological analysis was performed using optilab and Image Raster software. The results showed that growth and development of immune system of chicken increased significantly as could be seen in body weight, organs weight and index, as well as histological parameters. The regression results showed that spleen and bursa of Fabricius weight influenced increasing of body weight by 64.2% and 38.4% respectively. It could be concluded that biosupplementation of cashew leaf extract in basal feed could increase growth and immunity of Jawa Super Chicken.

scholarly journals Evaluation of potentials of aqueous ethanolic extract of Psidium guajava on reproductive functions of male Albino rats

2021 ◽  
Vol 19 (3) ◽  
pp. 174-181
Author(s):  
S.A. Abwage ◽  
S.T. Agu ◽  
S.A. Saganuwan ◽  
A.H. Abu
Keyword(s):  
Body Weight ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
Reproductive Organs ◽  
Sperm Parameters ◽  
Albino Rats ◽  
Reproductive Parameters ◽  
Aqueous Ethanolic Extract ◽  
Ethanolic Leaf Extract

The therapeutic utilization of plants for managing several diseases by people of all continents, especially Africa, is as old as tradition. The objective of this study was to evaluate the potentials of aqueous ethanolic leaf extract of Psidium guajava on male reproductive parameters. Twenty-four male Albino rats were randomly assigned into four groups of six rats per group. Rats in the control group were administered Tween 20®. Rats in groups 2, 3, and 4 were administered Psidium guajava aqueous ethanolic leaf extract orally at the doses of 100, 200, and 400 mg/kg body weight, respectively, once daily for 60 days. The body weights of the rats were determined at the beginning and end of the experiment. Sperm parameters and some reproductive organs weight of each rat was also determined, some organs were collected for histopathology. Assay for follicle-stimulating hormone, luteinizing hormone, and testosterone was done using Enzyme-Linked Immunosorbent methods. Some reproductive organs were collected for histopathological analyses. The results showed a dose-dependent increase (p<0.05) in the weight of male reproductive organs, sperm parameters, and hormones. The extract significantly increased (P < 0.05) serum testosterone in the group treated 400 mg/kg body weight when treated groups were compared with control. Furthermore, the results of FSH and LH revealed a significant (p < 0.05) increase when the treated groups were compared with the control. The histopathological analysis did not reveal any form of damage to the architectural integrity of the testis. However, there was degenerating germinal epithelium in the group administered 400 mg/kg of the aqueous ethanolic leaf extract of P. guajava. Conclusion: aqueous ethanolic extract of P. guajava has positive effects on male reproductive parameters.

scholarly journals Post-Coital Antifertility Activity ofHibiscus rosa-sinensisLinn. Roots

2008 ◽  
Vol 5 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Neeru Vasudeva ◽  
S. K. Sharma
Keyword(s):  
Body Weight ◽  
Dose Level ◽  
Clinical Data ◽  
Estrogenic Activity ◽  
Ethanolic Extract ◽  
Fertility Regulation ◽  
Histological Studies ◽  
Contraceptive Agents ◽  
Hibiscus Rosa Sinensis ◽  
Ancient Literature

Ancient literature mentions the use of a number of plants/preparations for fertility regulation. Some local contraceptive agents have also been described in Ayurvedic and Unani texts. Documented experiments or clinical data are, however, lacking. Therefore, the present study was undertaken to explore the antifertility and estrogenic activity of ethanolic extract of the roots ofHibiscus rosa-sinensisLinn. A strong anti-implantation (inhibition 100%) and uterotropic activity was observed at the dose level of 400 mg/kg body weight. Histological studies were carried out to confirm this effect.

scholarly journals ANTIHYPERLIPIDEMIC PROPERTY OF BOERHAVIA DIFFUSA LEAF EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

2018 ◽  
Vol 11 (4) ◽  
pp. 173
Author(s):  
Vasundhara Ccs ◽  
Gayathri Devi S
Keyword(s):  
Body Weight ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Experimental Period ◽  
Diabetic Rats ◽  
Favorable Effect ◽  
Histopathological Analysis ◽  
Bioactive Components ◽  
Weight Method ◽  
Boerhavia Diffusa

 Objectives: The aim of the present research was to evaluate the antidiabetic, hyperlipidemic, and histopathological analysis in streptozotocin-induced diabetic rats (60 mg/kg body weight) using the ethanolic extract of leaves of Boerhavia diffusa (ELBD) (500 mg/kg body weight).Method: The rats were orally administered with the leaf extract for 45 days. Fasting blood was collected at the end of the experimental period by cardiac puncture to carry out the biochemical parameters, the organs such as liver, kidney, and pancreas were also excised to perform the histopathological analysis by fixing in 10% formalin solution.Results: Oral administration with the leaf extract resulted in decrease in the levels of blood glucose, with a concomitant increase in their body weight. The extracts also produced a significant decrease in the lipid levels when compared with the diabetic groups. Moreover, the extracts also exerted a favorable effect on the histopathological changes of liver, pancreas, and kidney.Conclusion: The results of the present study revealed that the ELBD possess antidiabetic and antihyperlipidemic properties. These effects may be due to the presence of bioactive components justifying its ethnomedical use.

Biochemical changes in the kidney and liver of rats following administration of ethanolic extract of Psidium guajava leaves

2010 ◽  
Vol 30 (9) ◽  
pp. 1266-1274 ◽  
Author(s):  
OS Adeyemi ◽  
MA Akanji
Keyword(s):  
Alkaline Phosphatase ◽  
Trypanosoma Brucei ◽  
Leaf Extract ◽  
Intraperitoneal Administration ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
The Other ◽  
Trypanosoma Brucei Brucei ◽  
Aqueous Leaf Extract ◽  
Kidney Liver

Furtherance to a previous report on the anti-trypanosomal properties of Psidium guajava aqueous leaf extract in rats experimentally infected with Trypanosoma brucei brucei, we have evaluated the effects of the daily intraperitoneal administration of P. guajava leaf extract to rats on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and acid phosphatase (ACP) in the kidney, liver and serum. The results obtained revealed that the administration of the extract produced significant increase in the serum activities of AST, ALT, ALP and ACP when compared with the control ( p < 0.05). Also AST, ALT and ALP and ACP activities in the tissues of animals administered the extract revealed inconsistent changes ( p < 0.05) relative to control. The increase in the serum activity of ALP may be an indicator that there was a likely compromise to the integrity of the plasma membrane as a result of the ethanolic extract administration. This could have caused leakages of the other enzymes investigated, which may explain the corresponding increases in the serum activities of AST, ALT and ACP observed.

scholarly journals POTENTIAL OF JAMBLANG (Syzygium cumini L.) LEAF EXTRACT ON BODY WEIGHT OF WISTAR RATS METABOLIC SYNDROME MODEL

2021 ◽  
Vol 10 (2) ◽  
pp. 139-147
Author(s):  
Ida Nurwati ◽  
Risya Cilmiaty AR ◽  
Danus Hermawan ◽  
Betty Saptiwi ◽  
Dyah Ratna Budiani ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
Syzygium Cumini ◽  
Anova Test ◽  
Antioxidant Agents ◽  
Reduce Weight Loss ◽  
Metabolic Syndrome Model

Jamblang (Syzygium cumini L.) leaves contain several phytochemical compounds. These phytochemicals are thought to have roles as antihyperglycemic, antihyperlipidemic, and antioxidant agents. This study aims to prove that there is an effect of giving ethanolic extract of jamblang leaves on body weight (BW) of metabolic syndrome (MS) Wistar rats induced by high-fat high-fructrose diet (HFFD) and injection of Streptozotocin (STZ)-Nicotinamide (Na), to determine different doses effect on the weight of Wistar rats. Laboratory experimental research with pre-post test control group. Samples were 8 weeks male Wistar (Rattus noverigicus) weighing 150-200 grams chosen by purposive random sampling method. Thirty rats were divided into 5 groups, each consisting of 6 rats. Normal group, metabolic syndrome group, 3 treatment groups MS were given jamblang leaf extract 100 mg/KgBW, 150mg/KgBW, 200mg/KgBW for 28 days. Data were analyzed by one way ANOVA test and repeated ANOVA test. The study showed an ethanolic extract of Jamblang leaves can reduce weight loss in Wistar rats with a metabolic syndrome model, and that the best dose used in this experiment is 150 mg/kgBW per day in Wistar rats with a metabolic syndrome model.

scholarly journals Haematopoietic Potential of Ethanolic Leaf Extract of Talinum triangulare in Wistar Rats

2019 ◽  
pp. 1-7
Author(s):  
A. I. Airaodion ◽  
E. O. Ogbuagu ◽  
J. A. Ekenjoku ◽  
U. Ogbuagu ◽  
E. O. Airaodion
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Ethanolic Extract ◽  
The Body ◽  
Local Market ◽  
Cell Parameters ◽  
Soxhlet Apparatus ◽  
Significant Difference ◽  
Talinum Triangulare

Aim: This study focuses on assessing the haematopoietic potential of ethanolic extract of Talinum triangulare leaves in Wistar rats. Methods: Fresh plants of T. triangulare were purchased from a local market in Orita-Challenge area of Ibadan, Nigeria. They were air dried at room temperature in an open laboratory space for 21 days and milled into powder. The extraction was done using soxhlet apparatus and ethanol as the solvent. The ethanol was evaporated in a rotary evaporator at 35°C with a yield of 2.76 g which represents a percentage yield of 11.04%. Ten adult male Wistar rats with body weight between 150 and 170 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group A were administered saline solution while those in group B were administered T. triangulare leaf extract. The administration was done 12 hourly for twenty-eight days at 100 mg/kg body weight via oral route since the plant is consumed orally. At the end of the treatment, animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture into heparinized bottles. Haematological parameters were determined using standard methods. Results: A  significant increase was observed in the PCV, Hb, RBC, MCV, WBC, lymphocyte and platelet counts of control animals when compared with those treated with leaf extract of T. triangulare at p<0.05. However, treatment had no significant difference on the neutrophil of animals. Conclusion: The significant increase observed in the erythrocyte parameters of animals used in this study indicates that T. triangulare leaves have haematopoietic properties and can be used to boost blood level especially in menstruating and pregnant women as well as anaemia patients. Its ability to significantly increase white blood cell parameters is an indication that T. triangulare leaves can boost the immune system and thus defend the body against xenobiotics.

Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

2020 ◽  
Vol 16 (1) ◽  
pp. 33-41
Author(s):  
Mohini C. Upadhye ◽  
Uday Deokate ◽  
Rohini Pujari ◽  
Vishnu Thakare
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Oral Glucose ◽  
Ficus Glomerata

Background: Ficus glomerata (F. glomerata) Linn. Family Moraceace is a large tree found all over India including outer Himalayan ranges, Punjab, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and also as a common plant in South India. It is planted around the home and temples. It is cultivated throughout the year, distributed in evergreen forests and moist localities. Objective: The Ethanolic Extract of roots of F. Glomerata (EEFG) belonging to the family Moraceace, was investigated for its antidiabetic activity using alloxan induced diabetic rats. Methods: Thirty rats were divided into 5 groups having 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. A dose of 100mg/kg and 200 mg/kg body weight of EEFG was administered to alloxan induced diabetic rats. The administration of the extract was lasted for 11 days. Effectiveness of the extract on glucose, cholesterol, triglycerides, and high density lipoprotein and protein concentrations was analyzed. Results: Significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride of the diabetic rats was observed after treatment with ethanolic extract. After subjecting to oral glucose tolerance test EEFG also showed significant improvement in glucose tolerance. Conclusion: F. glomerata root ethanolic extract showed that it possesses antidiabetic effect and can be found useful for the management of diabetes mellitus.

Sign in / Sign up

Export Citation Format

Share Document