scholarly journals ISOLATION OF MIRICETINE-CONTAINING FRACTIONS FROM LINOSYRIS VILLOSA PLANT AND THEIR APPLICATION AS ANTIANEMIC AGENT

2020 ◽  
Vol 17 (35) ◽  
pp. 998-1012
Author(s):  
Natalya S. SALIKOVA ◽  
Ainash U. BEKTEMISSOVA ◽  
Valentina D. NAZAROVA ◽  
Bahyt E. BEGENOVA ◽  
Natalya V. OSTAFEICHUK
Keyword(s):  
Chemical Composition ◽  
Blood Cells ◽  
Human Life ◽  
White Blood Cells ◽  
Biologically Active ◽  
Practical Significance ◽  
Alcoholic Extract ◽  
Natural Substances ◽  
Northern Kazakhstan ◽  
Column Adsorption

With the development of chemistry, natural substances were actively supplanted from human life by chemical products. However, despite the enormous progress in this area, in recent decades, the problems of serious side effects of synthetic chemicals on the environment have become more and more pronounced. Methods of two-dimensional and one-dimensional paper chromatography, column adsorption chromatography, gas chromatography, and IR spectroscopy were used. The purpose of the article is to study the chemical composition of the Linosyris villosa plant by physicochemical methods of analysis. Creation of dosage forms based on it. The problem of the article is the search and creation of drugs based on the flora of Northern Kazakhstan. The scientific novelty lies in the fact that the chemical composition and biological activity of the Linosyris villosa plant, growing in the territory of Northern Kazakhstan, is being studied for the first time. According to the results of the analysis, in 13% of patients the treatment effect is insignificant, and in 87% of patients there was an improvement in blood values (increase in hemoglobin, an increase in the number of red blood cells, almost all patients returned color index of blood), the number of white blood cells increased to normal, and the WBC differential improved. Therefore, the drug “Vitin”, an aqueous-alcoholic extract of the Linosyris villosa, is an effective drug for the treatment of patients with anemia of varying severity. The practical significance of the work is defined as follows: biologically active compounds from the Linosyris villosa plant were obtained for the purpose of studying and applying them in medicine and agriculture.

scholarly journals Silage quality, growth performance and haematology of West African dwarf goats fed Moringa oleifera leaves ensiled with cassava peels

2021 ◽  
Vol 48 (2) ◽  
pp. 183-190
Author(s):  
S. M. Odeyinka ◽  
T. O. Abegunde ◽  
M. O. Ofoegbu ◽  
O. J. Apanisile
Keyword(s):  
Chemical Composition ◽  
Blood Cells ◽  
Moringa Oleifera ◽  
White Blood Cells ◽  
Dry Season ◽  
West African ◽  
Daily Weight Gain ◽  
West African Dwarf ◽  
Moringa Oleifera Leaves ◽  
Cassava Peels

Forage scarcity in the dry season is challenging for ruminant production in the tropics. The utilization of browse species, particularly as silage can bridge this gap. In this study, the potentials of Moringa oleifera leaves ensiled with varying levels of cassava peels as dry season feed for West African dwarf (WAD) goats were assessed. Different mixtures of Moringa oleifera leaves and cassava peels were ensiled and designated as follows: T1= 100% Moringa, T2= 60% Moringa + 40% Cassava peels, T3= 40% Moringa + 60% Cassava peels, T4= 50% Moringa + 50% Cassava peels, T5= 100% Cassava peels. Chemical composition and silage characteristics were investigated. Twenty five WAD goats with average body weights of 6.02±0.71 kg were used in the growth study that lasted 12 weeks. Blood samples were collected from the goats through the jugular vein for haematological status at the beginning and end of the experiment. Chemical composition of the silage diets showed that it contained 27.79 – 36.26 % dry matter (DM), 7.45 – 22.25 % crude protein (CP), 8.92 – 16.45 % crude fibre (CF), 2.55 – 7.01 % ether extract (EE), 6.10 – 10.08 % ash content, 42.40 - 68.14 % Nitrogen Free Extract (NFE). Appearance, odour and texture of the silage had acceptable physical attributes with pH values ranging from 3.53 – 5.80. Average daily feed intake (ADFI) and Feed conversion ratio (FCR) were not significantly (P<0.05) affected by diets while Average daily weight gain (ADWG) was significantly improved in T3 (40% M. oleifera + 60% cassava peels) than in others. White blood cells (WBC) ranged from 5.88 x109/L in T2 to 13.77 x109/L in T4. Red blood Cells (RBC) and Packed Cell Volume (PCV %) were not significantly (P<0.05) affected by diets. It was concluded that Moringa oleifera leaves and cassava peels silage with 40% Moringa oleifera as additive elicited the best performance indices in WAD goats fed diets consisting of mixtures of Moringa oleifera leaves and cassava peels ensiled together in graded levels or alone and did not affect animals negatively in terms of their haematological components.     Moringa, T2= 60% Moringa + 40% Pelures de manioc, T3= 40% Moringa + 60% Pelures de manioc, T4= 50% Moringa + 50% Pelures de manioc, T5= 100% Pelures de manioc. Des caractéristiques chimiques de composition et d'ensilage ont été étudiées. Vingt-cinq chèvres 'WAD' avec un poids corporel moyen de 6,02±0,71 kg ont été utilisées dans l'étude de croissance qui a duré 12 semaines. Des échantillons de sang ont été prélevés sur les chèvres par la veine jugulaire pour le statut hématologique au début et à la fin de l'expérience. La composition chimique des régimes d'ensilage a montré qu'elle contenait 27.79 – 36,26 % de matière sèche (DM), 7.45 à 22.25 % de protéines brutes (CP), 8.45 à 22.25 % de protéines brutes (le 'CP'), 8.45 92 – 16.45 % de fibres brutes (le 'CF'), 2.55 à 7.01 % d'extrait d'éther (le 'EE'), 6.10 à 10.08 % de cendres, 42.40 - 68.14 % Extrait sans azote (le 'NFE'). L'apparence, l'odeur et la texture de l'ensilage avaient des attributs physiques acceptables avec des valeurs de pH allant de 3.53 à 5.80. L'apport quotidien moyen en aliments (le 'ADFI') et le ratio de conversion des aliments pour animaux (le 'FCR') n'ont pas été significativement (P<0.05) affectés par les régimes alimentaires, tandis que le gain quotidien moyen de poids (le 'ADWG') a été sensiblement amélioré en T3 (40 % M. oleifera + 60 % de pelures de manioc) que dans d'autres. Les globules blancs (le 'WBC') allaient de 5,88 x109/L en T2 à 13.77 x109/L en T4. Les globules rouges (le 'RBC') et volume de cellules emballées (le 'PCV' %) n'ont pas été significativement (P<0.05) affectés par les régimes. On a conclu que les feuilles de Moringaoleifera et l'ensilage des pelures de manioc avec 40 % de Moringaoleifera comme additif ont obtenu les meilleurs indices de performance chez les chèvres WAD nourries à des régimes composés de mélanges de feuilles de Moringaoleifera et de pelures de manioc ensilées ensemble ou seuls et n'affectaient pas négativement les animaux en termes de composantes hématologiques.

scholarly journals SAT-734 HSD3B1 Expression in the Human Immune System

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jeffrey M McManus ◽  
Thi Hong Nga Le ◽  
Booki Min ◽  
Kewal Asosingh ◽  
Joe Zein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Blood Cells ◽  
White Blood Cells ◽  
Biologically Active ◽  
Rapid Progression ◽  
Human Immune System ◽  
Specific Expression ◽  
Asthma Patients ◽  
Cell Type Specific Expression ◽  
Key Enzyme

Abstract 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), catalyzing conversion of dehydroepiandrosterone (DHEA) to Δ 4-androstenedione, is an essential enzyme in the pathway toward production of biologically active androgens such as dihydrotestosterone from the adrenally produced precursor DHEA sulfate, the most predominant steroid hormone in circulation. We previously identified, in the gene (HSD3B1) that encodes 3βHSD1, a germline gain-of-function missense-encoding variant that has now been validated in several studies as predicting more rapid progression in prostate cancer patients treated with gonadal testosterone deprivation. Production of androgens from adrenal precursors is important not just in the context of prostate cancer but in other physiologic and pathophysiologic processes, which could include asthma. Androgens are associated with better lung function in both asthma and healthy cohorts, and increasing circulating androgen levels in males help explain the switchover in asthma being more common in boys than girls but then more common in women than men. A main treatment for asthma, as well as other inflammatory processes, is administration of glucocorticoids, yet unresponsiveness to glucocorticoids in a subset of patients remains a major problem. Systemic glucocorticoid administration suppresses adrenally produced DHEA and DHEA-S, suggesting a depleted pool for biologically active androgen production as a mechanism for glucocorticoid resistance. Our surprising preliminary data support a link between glucocorticoid responsiveness and the more active HSD3B1 allele: patients homozygous for the adrenal-permissive HSD3B1(1245C) allele exhibit better response to oral glucocorticoids than those homozygous for the adrenal-restrictive HSD3B1(1245A), with heterozygous patients falling in the middle. This suggests a model in which patients with the more active (adrenal-permissive) form of 3βHSD1 produce sufficient androgens despite the depleted pool of precursor hormones whereas patients with the less active (adrenal-restrictive) form cannot. To further elucidate the link between 3βHSD1 activity and immune response, we assayed HSD3B1 expression in different types of white blood cells. Leukocyte subsets from asthma patients and healthy controls were purified using fluorescence-activated cell sorting, and HSD3B1 expression was analyzed using qPCR. White blood cells of several types expressed HSD3B1 at levels comparable to or greater than both prostate cancer and placental choriocarcinoma cell lines with very robust 3βHSD1 activity. Further determining the cell type specific expression and activity of this key enzyme is an important step in unraveling the link between the HSD3B1 polymorphism and asthma along with potentially many other immune processes.

scholarly journals Detection and Classification of White Blood Cells through Deep Learning Techniques

2020 ◽  
Vol 16 (15) ◽  
pp. 94
Author(s):  
Samir Abou El-Seoud ◽  
Muaad Hammuda Siala ◽  
Gerard McKee
Keyword(s):  
Neural Network ◽  
Blood Cell ◽  
Convolutional Neural Network ◽  
White Blood Cell ◽  
Blood Cells ◽  
Human Life ◽  
White Blood Cells ◽  
Learning Techniques ◽  
Normal White Blood Cell ◽  
High Level

Leukemia is one of the deadliest diseases in human life, it is a type of cancer that hits blood cells. The task of diagnosing Leukemia is time consuming and tedious for doctors; it is also challenging to determine the level and type of Leukemia. The diagnoses of Leukemia are achieved through identifying the changes on the White blood Cells (WBC). WBCs are divided into five types: Neutrophils, Eosinophils, Basophils, Monocytes, and Lymphocytes. In this paper, the authors propose a Convolutional Neural Network to detect and classify normal white blood cells. The program will learn about the shape and type of normal WBC by performing the following two tasks. The first task is identifying high level features of a normal white blood cell. The second task is classifying the normal white blood cell according to its type. Using a Convolutional Neural Network CNN, the system will be able to detect normal WBCs by comparing them with the high-level features of normal WBC. This process of identifying and classifying WBC can be vital for doctors and medical staff to make a decision. The proposed network achieves an accuracy up to 96.78% with a dataset including 10,000 blood cell images.

A Comparison Between the Inflammatory Mediators Produced by the Blue-Tongue Lizard (Tiliqua-Scincoides) and Human White Blood-Cells

1988 ◽  
Vol 36 (2) ◽  
pp. 209 ◽  
Author(s):  
SR Mccoll ◽  
CB Daniels
Keyword(s):  
Arachidonic Acid ◽  
Free Radicals ◽  
Blood Cells ◽  
White Blood Cells ◽  
Leukotriene B4 ◽  
Biologically Active ◽  
Hydroxyeicosatetraenoic Acid ◽  
Oxygen Derived Free Radicals ◽  
Derivatives Of ◽  
Human White Blood Cells

Human white blood cells, particularly neutrophils and macrophages produce several biologically active molecules including oxygen-derived free radicals and some metabolites of arachidonic acid which are involved in mechanisms of host defence. White blood cells of the blue-tongue lizard Tiliqua scincoides produce certain derivatives of arachidonic acid which include prostaglandins, thromboxane and 12- and 15-hydroxyeicosatetraenoic acid. The ability to produce these compounds indicates that these animals possess the enzymes cyclooxygenase, 12- and 15-lipoxygenase, T. scincoides white blood cells did not produce leukotriene B4 or 5-hydroxyeicosatetraenoic acid indicating that, unlike human white blood cells, they do not possess a 5-lipoxygenase enxyme. T. scincoides cells are also capable of producing the oxygen-derived free radical superoxide enzyme.

Mirasol™ Pathogen Reduction of Packed Red Blood Cells (PRBCs) and Apheresis Platelet (Aplt) Concentrates Decreases Neutrophil Priming Activity Generated during Storage.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2893-2893
Author(s):  
Daniel R. Ambruso ◽  
Gail Thurman ◽  
Susanne Marschner ◽  
Ray Goodrich
Keyword(s):  
Blood Cells ◽  
Blood Donation ◽  
Uv Light ◽  
White Blood Cells ◽  
Biologically Active ◽  
Control Group ◽  
Superoxide Anion Production ◽  
Packed Red Blood Cells ◽  
Pathogen Reduction ◽  
Priming Activity

Abstract Introduction: During storage of cell containing components including PRBCs and Aplts, biologically active compounds such as lysophosphatidylcholine and other lipids are generated. Identified by their ability to enhance the fMLP stimulated respiratory burst in neutrophils, these biologic response modifiers (BRMs) have been implicated in the pathogenesis of transfusion related acute lung injury (TRALI). The Mirasol pathogen reduction system is a process that uses riboflavin and UV light to modify nucleic acids, reduce infectious pathogen load and inactivate white blood cells in blood components. An additional effect of the Mirasol in PRBCs and Aplts is a decrease in priming activity accumulated during storage. Methods: PRBCs were produced by standard technique from whole blood donation. PRBCs were treated with Mirasol (8) and stored; untreated, washed and stored in AS-3 additive solution (2); or produced untreated and stored in AS-3 (6). For platelets collected on Trima, one set of products was treated with Mirasol procedure on day 0. Another set was exposed to 25Gy of gamma irradiation. The control group was untreated and stored under standard conditions. Samples were removed on day 0 and 43 (PRBCs) and day 0, 5, 7 (Aplts); cells removed from residual supernatant/plasma by centrifugation and frozen at -70°C. Samples (10% by volume) were assayed to measure the ability to enhance the fMLP stimulated superoxide anion production (O2−) by peripheral blood neutrophils. O2− was measured as SOD inhibitable cytochrome c reduction and expressed as a ratio of the response to plasma followed by fMLP compared to fMLP alone. Priming by platelet activating factor (PAF) was a positive control. Priming is defined as >1.5 fold increase in O2− over the results for fMLP alone. Results: Samples from Mirasol treated PRBCs show no enhancement of fMLP stimulated O2− production either at day 0 or after 43 days of storage (Top figure). Washed controls exhibit a similar pattern. Unwashed controls demonstrate a small amount of priming on day 0 which further increased on day 43. For Aplts (Bottom figure), day 0 samples exhibited minimal priming. For Mirasol treated products, no changes were seen on days 5 and 7. In contrast, both gamma irradiated and untreated Aplts showed an increase comparable to that seen with PAF. Conclusion: Treatment of PRBCs and Aplts with Mirasol reduced the generation of priming activity normally developed during storage, possibly representing a decrease in production of BRMs including priming lipids. Mirasol treatment of cell containing components may reduce one class of etiologic agents associated with TRALI and may be a potential approach to reduce risk for this adverse event of transfusion. Figure Figure

scholarly journals Essential Oil Composition, Total Phenolic Content, and Antioxidant Activity - Determined from Leaves, Flowers and Stems of Origanum Vulgare L. Var. Aureum

2018 ◽  
Vol 1 (1) ◽  
pp. 555-561
Author(s):  
Cristian Moisa ◽  
Lucian Copolovici ◽  
Georgeta Pop ◽  
Andreea Lupitu ◽  
Virgiliu Ciutina ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Chemical Composition ◽  
Essential Oils ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Biologically Active ◽  
Total Phenolic ◽  
Alcoholic Extract ◽  
Origanum Vulgare ◽  
Specific Chemical

Abstract Origanum vulgare L. var. aureum is an aromatic medicinal plant belonging to the Lamiaceae family, rich in essential oils and antioxidants. Its specific chemical composition represents an important source of biologically active principles with diverse applications in food products and nutraceuticals. The aim of this study was to determine the differences between chemical composition of volatile oils, phenolic content and antioxidant activity of different plants parts: leaves, flowers, and stems. Essential oils from leaves and flowers had similar compositions with only few differences between γ-terpinene and trans-ß-ocimene. Total phenolic content and antioxidant activity were determined for the hydro-alcoholic extract obtained from post-distillation oregano waste material. The total phenolic content was determined using Folin-Ciocalteu reagent and varied from 3173 to 6522 mg GAE/L. The major compounds identified by HPLC were syringic acid, pyrocatechol, and catechin. Furthermore, all extracts showed high antioxidant activity, ranging from 31.3 to 44.5 mg GAE/L, with an inhibition percent varying from 63.1 to 88.6%.

scholarly journals Effect of a Succinate-Containing Drug on the Blood Leukocyte Composition in Rats at Rest and During a Weight-Loaded Forced Swimming Test

2021 ◽  
pp. 182-191
Author(s):  
Lidiya Yu. Rubtsova ◽  
◽  
Nikolay P. Mongalev ◽  
Nadezhda A. Vakhnina ◽  
Vera D. Shadrina ◽  
...  
Keyword(s):  
Blood Cells ◽  
Forced Swimming Test ◽  
White Blood Cells ◽  
Forced Swimming ◽  
Biologically Active ◽  
Male Rats ◽  
Control Groups ◽  
Protective Function ◽  
Swimming Test ◽  
Blood Leukocyte

This paper studied the dynamics of the blood leukocyte composition in Wistar male rats at rest and when swimming with a weight before and after being administered a succinate-containing drug (Suc, meso-2,3-dimercaptosuccinic acid). Two control groups of animals kept in standard vivarium conditions were selected: those that received Suc 12 hours before the examination (VivC+Suc) and those that did not receive it (VivC). Similarly, two groups of animals were formed that were swimming with a load (4 % of their body weight) to exhaustion: those that received the drug 12 hours before the test (Swim4%+Suc) and those that did not receive it (Swim4%). Unidirectional shifts characterizing the morphofunctional state of white blood cells under experimental conditions were detected. In VivC+Suc animals, compared to VivC, we found an increase in the number of leukocytes due to the growing number of eosinophils and monocytes, large lymphocytes and microlymphocytes with a relative decrease in the number of small lymphocytes and an unchanged level of granulocytes with a tendency towards a decrease in the number of stab neutrophils. In the Swim4%+Suc group, compared to the Swim4%, changes in the number of white blood cells and their subpopulation composition manifested themselves in a similar way to the redistribution of immunocytes identified in the control groups. The increase in the neutrophilto-lymphocyte ratio in the Swim4%+Suc group as an indicator of stress tolerance corresponded to the increase in the swimming time of rats by the factor of 2.8. The differences in the blood cell composition between the VivC+Suc and VivC groups are viewed as the influence of Suc on the body’s preparation to the fulfilment of the protective function under physical load, since the distribution pattern of the blood leukocyte composition in rats from the VivC+Suc group is very similar to that of the Swim4%+Suc group. The practical significance of this study is associated with the search for new biologically active substances that optimally influence the immune system of animals under increased load. New data on the mechanism of blood redistribution in animals under the action of Suc before the swimming test can be used to study the manifestation patterns of acute adaptation effect. For citation: Rubtsova L.Yu., Mongalev N.P., Vakhnina N.A., Shadrina V.D., Chupakhin O.N., Boyko E.R. Effect of a Succinate-Containing Drug on the Blood Leukocyte Composition in Rats at Rest and During a Weight-Loaded Forced Swimming Test. Journal of Medical and Biological Research, 2021, vol. 9, no. 2, pp. 182–191. DOI: 10.37482/2687-1491-Z056

scholarly journals Effect of alcoholic extract of Apium graveolens leaves on some physiological properties of a broilers

2014 ◽  
Vol 13 (1) ◽  
pp. 111
Author(s):  
S. A. Al – Gnami
Keyword(s):  
Treatment Group ◽  
Blood Cells ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Apium Graveolens ◽  
Control Group ◽  
Distilled Water ◽  
Alcoholic Extract ◽  
Physiological Properties ◽  
Before And After

This study was carried out on fourteen broilers arranged between (1100 – 1500) gm. in weight to estimate the effect of drenching of alcoholic extract of Apium graveolens leaves on some physiological properties. The birds were divided into two groups which are control and treatment group seven birds for each group. The birds in both groups are housed in the same condition, include temperature, light, food, and water during the experiment period. The control group savaged with 1 ml of distilled water while treatment group savaged with 10 mg\kg. B.W. of alcoholic extract of Apium graveolens leaves dissolved in 1 ml of distilled water for two weeks. The birds were weighed and a blood sample was taken two times before and after treatment. The results of this study were revealed a significant increase in red blood cells count, hemoglobin concentration, and packed cell volume, while there is no significant changes in white blood cells count, and body weight.

The release of radioactive arachidonate from lipids of red blood cells during prolonged incubations in vitro

1987 ◽  
Vol 65 (5) ◽  
pp. 444-451 ◽  
Author(s):  
R. Roy Baker ◽  
Zou Dao Loh
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Time Course ◽  
White Blood Cells ◽  
Red Cells ◽  
Biologically Active ◽  
Red Cell

Red blood cells were isolated from rat blood and incubated in the presence of [3H]arachidonate. A sizeable quantity (18%) of the radioactivity was incorporated into red cell lipids, of which phosphatidylcholine was the most highly labelled. Radioactive arachidonate was found at position 2 of this phospholipid. Free fatty acids were removed by washing the cells in solutions containing fatty-acid-free bovine serum albumin. The labelled red cells were then incubated for up to 16 h at 37 °C. After 16 h of incubation in saline–buffer–glucose or rat serum, 20 and 26%, respectively, of the total radioactivity was found in free fatty acids, and there were corresponding declines in the percentage radioactivities found in phosphatidylcholine. In the presence of serum, there was a more rapid release of radioactive fatty acid over the 2- to 16-h time course. There was not a significant drop in the phosphate levels of the total red cell phospholipids or phosphatidylcholine after 16 h of incubation and, as a result, there were large declines in the specific radioactivities of phosphatidylcholine. Diacylglycerols were not highly labelled and the action of phospholipase A2 on labelled phosphatidylcholine was indicated. When white blood cells were added to labelled red cells, there was little evidence of white cell involvement in the release of radioactive fatty acid, suggesting that the red cells themselves may be involved in arachidonate release. Red cells may serve as sources of arachidonate, released following hemorrhage in brain and metabolized to form various biologically active eicosanoids.

scholarly journals Changes in goslings’ blood pattern under the influence of different doses additives of selenium in forages

2020 ◽  
Vol 22 (92) ◽  
pp. 50-55
Author(s):  
S. V. Sobolieva ◽  
B. V. Gutyj ◽  
O. I. Sobolev
Keyword(s):  
Blood Cells ◽  
Biochemical Parameters ◽  
White Blood Cells ◽  
Immune Defense ◽  
The Body ◽  
Practical Significance ◽  
Poultry Feed ◽  
Control Group ◽  
Wide Range ◽  
Different Doses

According to many scientists, the list of trace elements that are currently used in compound feeds for various types of poultry is clearly insufficient. In recent years, applied research has been conducted to determine the physiological needs of poultry for certain mineral elements that perform important biochemical functions in the body. This also applies to such biotic ultramicroelement as selenium. Scientific research of domestic and foreign scientists in the field of physiology, biochemistry, medicine and veterinary medicine has proved that selenium is a trace element with a fairly wide range of physiological and biochemical effects. When developing and theoretically justifying optimal norms for introducing selenium into poultry feed, it is necessary to evaluate not only its productive qualities, but also the blood picture. The question of the influence of selenium on changes in blood parameters in the poultry body is a great theoretical and practical significance because it allows us to expand our knowledge of its biological role and explain the data obtained in experiments. In scientific and economic experience has been studied the influence of additives of different doses of selenium in compound feed on the morphological and biochemical parameters of the goslings' blood raised for meat. During the experiment, feeding of goslings of all groups were carried out with dry feed mixes in accordance with existing norms. The goslings of the first control group did not receive selenium supplementation. The poultry of the second experimental group were additionally fed selenium at the rate of 0.2 mg/kg, the third of 0.3 and the fourth of 0.4 mg/kg. It is established that the additive in the feed of different doses of selenium stimulate hemocytopoiesis are added to different compound feeds, this is achieved by a homogeneous tendency per day, within physiological values in the goslings' peripheral blood number of red blood cells (by 1.7–3.9 %), white blood cells (by 2.1–3.2 %) and hemoglobin (by 2.4–8.6 %). Immune defense mechanisms are activated, which is manifested in an increase in the level of total protein (by 1.4–3.8 %) and the concentration of immunoglobulins in the blood serum (by 3.2–9.7 %). It is found changes in the content of total glutathione and its reduced form in the blood indicate a positive effect of selenium on the non-enzymatic element of the antioxidant defense system of the poultry's body. The addition of selenium to compound feed at a dose of 0.3 mg/kg had a significant effect on the morphological and biochemical parameters of the goslings' blood raised for meat.

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