CAUSES OF THE INVESTIGATIVE LINKS OF THE GROWTH OF DIABETES MELLITUS

Vestnik ◽  
2021 ◽  
pp. 184-186
Author(s):  
А.Б. Кулдыбай ◽  
А.У. Шатырхан ◽  
А.С. Кенебаева ◽  
Г.Т. Ильясова
Keyword(s):  
Diabetes Mellitus ◽  
Multidisciplinary Approach ◽  
Vascular Complications ◽  
Diagnostic Process ◽  
Promising Direction ◽  
Essential Condition ◽  
Screening Programs ◽  
Optimal Organization ◽  
The World ◽  
Onset Of Diabetes

Сахарный диабет (СД) является одной из серьезнейших медико-социальных и экономических проблем здравоохранения всех стран мира. Наибольшая опасность этого заболевания связана с развитием сосудистых осложнений. Поддержание целевого контроля факторов риска: гликемии, гипертонии и дислипидемии непосредственно с дебюта СД на протяжении всей жизни пациента по-прежнему остается наиболее перспективным направлением профилактики развития и прогрессирования диабетических осложнений. Непреложным условием эффективного контроля СД является создание программ активного скрининга, направленных на максимально раннюю диагностику осложнений, и оптимальная организация клинико-диагностического процесса в рамках обеспечения мультидисциплинарного подхода в лечении. Diabetes mellitus (DM) is one of the most serious medical, social and economic health problems in all countries of the world. The greatest danger of this disease is associated with the development of vascular complications. Maintaining targeted control of risk factors: glycemia, hypertension and dyslipidemia directly from the onset of diabetes throughout the patient's life remains the most promising direction for preventing the development and progression of diabetic complications. An essential condition for effective DM control is the creation of active screening programs aimed at the earliest possible diagnosis of complications, and the optimal organization of the clinical and diagnostic process within the framework of ensuring a multidisciplinary approach to treatment.

scholarly journals Diabetes mellitus: development of technologies in diagnostics, treatment and prevention

2010 ◽  
Vol 13 (3) ◽  
pp. 6-13 ◽  
Author(s):  
Ivan Ivanovich Dedov
Keyword(s):  
Diabetes Mellitus ◽  
Hypoglycemic Agents ◽  
Diagnostic Tools ◽  
Diagnostic Process ◽  
Chronic Complications ◽  
Screening Programs ◽  
Therapeutic Modalities ◽  
Treatment And Prevention ◽  
Health Authorities ◽  
Onset Of Diabetes

Diabetes mellitus is a most serious socio-medical and economic problems facing health authorities throughout the world. A major threat is vascularcomplications of the disease. The currently available diagnostic tools, up-to-date means for monitoring glycemia, introduction of innovative insulinpreparations and hypoglycemic agents, development of high-technology therapeutic modalities may greatly improve disease prognosis, reduce the frequencyof chronic complications, related disablement and mortality rates. The targeted control of major risk factors, viz. hyperglycemia, hypertension,and dyslipidemia, during the patients lifetime starting from the onset of diabetes remains the most promising strategy for the prevention of diabeticcomplications. An indispensable condition for efficacious management of diabetes is the elaboration of active screening programs for the early diagnosisof complications and optimal organization of the clinico-diagnostic process in the framework of multidisciplinary approach.

scholarly journals International guidelines on the study of glycated hemoglobin HbA1c level as a diagnostic criterion for diabetes mellitus and otherdisorders of carbohydrate metabolism

2010 ◽  
Vol 13 (4) ◽  
pp. 57-61
Author(s):  
Gagik Radikovich Galstyan
Keyword(s):  
Diabetes Mellitus ◽  
High Frequency ◽  
High Performance ◽  
Metabolic Disorders ◽  
Glycated Hemoglobin ◽  
Vascular Complications ◽  
Cost Effective ◽  
The World ◽  
Diagnostic Criterion

Type 2 diabetes mellitus is rising at an epidemic scale throughout the world. Up to a certain moment, DM2 develops as a latent pathology which accounts for its late diagnosis and onset of therapy. Hence, the high frequency of vascular complications, early disablement and mortality. Therefore, the improvement of screening studies is of primary importance for the detection of metabolic disorders. At present, HbA1c determination is the most informative and cost-effective tool for the purpose. The choice of the method for measuring HbA1c is a paramount consideration. It must be standardized against a reference technique (high performance liquid chromatography) in conformity with the results of DCCT and UKPDS studies

scholarly journals Effect of Ayurvedic Churnam on the Elevated Blood Sugars by Stz Drug

2019 ◽  
Vol 9 (4) ◽  
pp. 71-74
Author(s):  
Ramesh M ◽  
Vincent Vidyasagar J ◽  
Tharun Kumar G ◽  
Akhila C R
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Vascular Complications ◽  
Antidiabetic Activity ◽  
World Population ◽  
Elevated Blood ◽  
Unhealthy Lifestyle ◽  
Secondary Complications ◽  
Standard Drug ◽  
The World

Diabetes Mellitus shortly called as DM is a metabolic disorder which is due to the improper secretion of the insulin by the pancreas. The insensitivity in the reuptake of insulin also causes diabetes. This increases the blood glucose level and affects physiological functions. The majority of the population that is suffering from DM are generally obese or following unhealthy lifestyle habits. There are about half of the world population is suffering from DM and related complications. DM secondary complications include nephropathy, neuropathy, retinopathy and vascular complications like PVD and PAD. Considering the activity of herbs and the safety of the same, an ayurvedic formulation was prepared using herbs, and the same is investigated for the antidiabetic activity. The ayurvedic formulation that is designed in the study is an ayurvedic churnam preparation out of the texts of the Ayurveda books. The polyherbal churnam that is prepared showed a significantly better activity compared to the standard drug and the marketed ayurvedic formulation too. The higher dose of the extract showed higher activity compared to the lower dose of the preparation.

Clinical Diagnostication Requirements for Diabetes

2020 ◽  
pp. 8-15
Author(s):  
Vladimir Klimov
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Mortality Rate ◽  
Vascular Complications ◽  
Modern Medicine ◽  
Late Complications ◽  
The World ◽  
Medicine Today ◽  
Diagnosis Of Diabetes Mellitus

Diabetes is one of the most pressing problems of modern medicine. Today, there are 150 million people with diabetes in the world; by 2025 this number is expected to reach 300 million. Diabetes mellitus is one of the significant causes of early disability and death due to late vascular complications owing to macroangiopathy, microangiopathy and neuropathy. Timely diagnosis of diabetes mellitus, prevention of the development of its early and late complications can significantly reduce the mortality rate for this pathology, improve the quality of life of patients and prevent formidable complications.

scholarly journals Novel Approaches in the Management of Type 2 Diabetes and Associated Vascular Complications

2021 ◽  
Author(s):  
K. V. S. Hari Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Presentation ◽  
Vascular Complications ◽  
Epidemiological Studies ◽  
Developing Nations ◽  
Β Cell ◽  
Cell Dysfunction ◽  
The World ◽  
Novel Approaches

AbstractDiabetes mellitus (DM) is growing in pandemic proportion and affects the affluent and developing nations equally. India has the dubious distinction of being known as the diabetes capital of the world. Epidemiological studies have shown that DM is under diagnosed and inadequately treated in our country. Insulin resistance and β-cell dysfunction are the two key pathophysiological determinants of the DM. The disease has metamorphosed during the last couple of decades with a significant change in the clinical presentation. Simultaneously, the therapeutic options for the management of DM have also increased in the last decade. This article highlights the research conducted by us over the last decade in the areas of pathogenesis, management, and complications of DM.

scholarly journals HEMORHEOLOGICAL FAILURE IN THE PATHOLOGY OF CARDIO-VASCULAR COMPLICATIONS IN PATIENTS WITH DIABETIC FOOT SYNDROME

2016 ◽  
Vol 6 ◽  
pp. 57-62
Author(s):  
Еlina Кorobko
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Blood Circulation ◽  
Vascular Complications ◽  
Cardiovascular Complications ◽  
Diabetic Foot Syndrome ◽  
Steady Growth ◽  
Myocardium Infarction ◽  
The World ◽  
Cardio Vascular

The literature that includes the study of cardiovascular complications in patients with diabetic foot syndrome was analyzed. The topicality of this problem is caused by the steady growth of diabetes mellitus morbidity among people. For today there are more than 170 mln people throughout the world with diabetes mellitus, among them 65–80 % have cardiovascular complications (myocardium infarction, acute disorder of brain blood circulation and so on). It is established for today, that pathogenesis of diabetic foot syndrome is multi-factor one and the development of purulent-necrotic stages of DFS is connected with the combination of different factors, especially microcirculation disorder. In this article we’ll consider the mechanisms of diabetic angiopathy development, the state of platelet-vascular hemostasis link in this category of patients.

scholarly journals A Synopsis of the Current Scenario of Diabetes Mellitus in Pakistan

2016 ◽  
Vol I (I) ◽  
pp. 21-35
Author(s):  
Rumla Khan
Keyword(s):  
Diabetes Mellitus ◽  
Public Awareness ◽  
World Health ◽  
Human History ◽  
Lifestyle Modifications ◽  
The World ◽  
Two Factors ◽  
Current Scenario ◽  
Onset Of Diabetes ◽  
Health Organization

Diabetes mellitus is one of the most frequently encountered diseases in human history, and it is triggered mostly by two factors: one is genetic and the other environmental. According to the World Health Organization, one in every four individuals is diabetic or pre-diabetic, which is a frightening statistic. During the Coronavirus pandemic, there is also a significant setback in the management of diabetes due to lockdown, many diabetes patients suffered greatly, and unfortunately, a large number of elderly diabetics kicked the bucket after contracting SARSCoV-2 last year as their already compromised immune system could not combat Covid-19. Now, more than ever, there is an urgent need to raise public awareness about the benefits of maintaining a healthy diet and to promote campaigns about how to avoid the onset of diabetes myelitis through lifestyle modifications

scholarly journals PERBANDINGAN NILAI AGREGASI TROMBOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN KOMPLIKASI VASKULAR DAN TANPA KOMPLIKASI VASKULAR DI RSUP PROF. DR. R. D KANDOU MANADO

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Gratia Tangkuman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Aggregation ◽  
Platelet Function ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Significant Difference ◽  
The World ◽  
Diabetes Melitus

Abstract: Diabetes melitus is a main medical problem around the world. WHO estimated that in 2000 there were 171 milion people with diabetes around the world and in 2030 there will be 366 million people. In diabetic patients, there are dysfunctions of platelet function caused microangiopati, macroangiopati, and platelet reactivity. Dysfunction of platelet function are associated with vascular complications of diabetes melitus. This study used an observational analytic method using comparative hypothesis test. This study was conducted to 30 diabetic patients, 15 patients have vascular complications while the other 15 have no vascular complications. Those patients are registered in Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. The samples were processed in Prokita Laboratorium in Malalayang, Manado. Data analysis showed that there are significant difference between platelet aggregation value examined using ADP 5 µm agonist in diabetic patient with vascular complications and diabetic patients without vascular compications (p = 0.004). The same result were obtained from comparing the platelet agggregation value examined using ADP 10 µm agonist (p = 0.000). There are significant difference between platelet aggregation value in type 2 diabetes melitus patients with vascular complications and without complications. Keywords: Platelet aggregation, type 2 diabetes melitus, vascular complications.  Abstrak: : Diabetes Melitus menjadi masalah kesehatan di dunia. WHO memperkirakan ada 171 juta orang di dunia dengan diabetes pada tahun 2000 dan diproyeksikan meningkat menjadi 366 juta pada tahun 2030. Pada diabetes melitus terjadi disfungsi dari trombosit sehingga menyebabkan mikroangiopati, makrongiopati dan hiperaktivitas trombosit. Gangguan fungsi trombosit ini dihubungkan dengan berbagai komplikasi vaskuler. Penelitian ini menggunakan observasional analitik dengan menggunakan metode uji hipotesis komparatif. Subjek dalam penelitian ini berjumlah 30 orang, 15 orang pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular yang terdaftar di Poliklinik Endokrin Metabolik RSUP Prof. Dr. R. D. Kandou Manado. Pembuatan sampel dilakukan di Laboratorium Prokita Malalayang Manado. Dari hasil analisis, didapatkan adanya perbedaan yang bermakna antara nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 5 µm pada pasien dengan komplikasi vaskuler dan pasien diabetes tanpa komplikasi vaskuler (p = 0,004). Hasil yang sama juga didapatkan pada nilai agregasi trombosit yang diperiksa menggunakan agonis ADP 10 µm (p = 0,000). Kesimpulan dari penelitian ini didapatkan terdapat perbedaan signifikan antara nilai agregasi trombosit pada pasien diabetes mellitus tipe 2 dengan komplikasi vaskular dan tanpa komplikasi vaskular. Kata Kunci: Agregasi trombosit, diabetes melitus tipe 2, komplikasi vaskular.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Mechanisms underlying heart failure in type 2 diabetes mellitus

2019 ◽  
pp. 37-39
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Experimental Studies ◽  
Vascular Complications ◽  
Molecular Alterations ◽  
Increased Risk ◽  
Cardioprotective Effects ◽  
Underlying Mechanisms ◽  
Cardio Vascular

The prevalence of heart failure is markedly increased in individuals with diabetes mellitus. Numerous observational studies suggest that this increased risk for heart failure can be attributed to exacerbated vascular complications and the presence of increased risk factors in diabetic subjects. In addition, experimental studies revealed the presence of a number of distinct molecular alterations in the myocardium that occur independently of vascular disease and hypertension. Many of these molecular alterations are similarly observed in failing hearts of nondiabetic patients and have thus been proposed to contribute to the increased risk for heart failure in diabetes. The interest in understanding the underlying mechanisms of impaired cardio- vascular outcomes in diabetic individuals has much increased since the demonstration of cardioprotective effects of SGLT-2 inhibitors and GLP-1 receptor agonists in recent clinical trials. The current review therefore summarizes the distinct mechanisms that have been proposed to increase the risk for heart failure in diabetes mellitus.

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