GENES AND THE ROLE OF GENETIC FACTORS INVOLVED IN THE DEVELOPMENT OF ASTHMA (LITERATURE REVIEW)

Vestnik ◽  
2021 ◽  
pp. 32-40
Author(s):  
Ж.Б. Испаева ◽  
Р.Б. Бекмагамбетова
Keyword(s):  
Gene Network ◽  
Severe Form ◽  
Pathological Process ◽  
Individual Characteristics ◽  
Steady Increase ◽  
Specific Patient ◽  
Literary Sources ◽  
High Prevalence ◽  
The Individual

В статье представлен обзор современных литературных источников, обобщающий результаты исследований генов, которые участвуют в развитии бронхиальной астмы (БА), полиморфизма генов при астме и о выявленных вариантах генов, которые являются генами - модификаторами ускоряющими и усугубляющими патологический процесс. Составление генной сети для каждого многофакторного заболевания и разработка на этой основе комплекса профилактических мероприятий для конкретного пациента составляет основу нового, быстро развивающегося направления - предиктивной медицины. Актуальность темы обусловнено тем, что БА попрежнему входит в ранг важной медицинской и социальной проблемы, наблюдается высокая распространенность и неуклонный рост заболеваемости БА во всем мире. Тема также является актуальной, так как хроническое рецидивирующее течение БА накладывает значительные ограничения на повседневную жизнь пациентов, увеличивает доли больных с тяжелой формой заболевания. Все это свидетельствуют об актуальности изучения сложных механизмов развития этого заболевания с целью разработки эффективных методов диагностики и профилактики с учетом индивидуальных особенностей каждого больного. За последние годы протестировано более чем 500 генов, которые показывают связь с данным заболеванием, и для более чем 100 из них показана ассоциация с БА, на основании чего можно сказать, что данные гены являются генами предрасположенности к ней. The article presents a review of modern literary sources, summarizing the results of studies of genes that are involved in the development of asthma, gene polymorphism in asthma and the identified variants of genes that are modifier genes that accelerate and aggravate the pathological process. The compilation of a gene network for each multifactorial disease and the development on this basis of a set of preventive measures for a specific patient forms the basis of a new, rapidly developing direction - predictive medicine. The relevance of the topic is due to the fact that BA is still included in the rank of an important medical and social problem, there is a high prevalence and a steady increase in the incidence of asthma all over the world. The topic is also relevant, since the chronic relapsing course of asthma imposes significant restrictions on the daily life of patients, increases the proportion of patients with a severe form of the disease. All this testifies to the relevance of studying the complex mechanisms of the development of this disease in order to develop effective methods of diagnosis and prevention, taking into account the individual characteristics of each patient. In recent years, more than 500 genes that show a connection with this disease have been tested, and for more than 100 of them association with asthma is shown, on the basis of which it can be said that these genes are genes for predisposition to it.

scholarly journals The role of diet in the prevention of migraine attacks

2021 ◽  
Vol 23 (6) ◽  
pp. 865-871
Author(s):  
O. O. Kopchak ◽  
O. Ye. Hrytsenko
Keyword(s):  
Scientific Data ◽  
Individual Characteristics ◽  
Dietary Factors ◽  
Positive Effects ◽  
Migraine Headaches ◽  
High Prevalence ◽  
Bidirectional Relationship ◽  
The Central Nervous System ◽  
The Individual

The review provides information concerning the influence of dietary factors and different types of diet on the origin and frequency of migraine headaches according to the up-to-date scientific data. The relevance of the problem is associated with high prevalence of migraine, which is a common cause of disability amongst young people. Gut – brain axis takes a significant place in the pathophysiology of migraine. The concept of a gut-brain axis explains a bidirectional relationship between the gastrointestinal system and the central nervous system. It has been suggested that changes in the gut-brain axis functioning may play a role in the pathogenesis of migraine. The review describes possible mechanisms of gut microbiota involvement in the pathogenesis of migraine. Knowledge of the important role of food triggers in migraine has contributed to the development of a dietary therapeutic strategy for the prevention of migraine headache. The paper contains data concerning possible pathogenetically substantiated effects of various types of diet (elimination, epigenetic, ketogenic) in migraine prevention, given the lack of efficacy and side effects of current migraine drug therapy. The review discusses the possible positive effects of dietary approaches on migraine through their beneficial influence on the intestinal microbiota and functioning of the gut-brain axis. Conclusions. An update on the role of diet in the pathogenesis and prevention of migraine attacks is an extremely important and promising scientific field, which requires further research with the development of personalized approaches taking into account the individual characteristics of each patient.  

MEDIA SOCIALIZATION OF PERSONALITY IN THE CONTEXT OF INMUTATION IN THE MASS MEDIA

2021 ◽  
pp. 104-109
Author(s):  
Chernysh O.O.
Keyword(s):  
Mass Media ◽  
Negative Impact ◽  
Effective Interaction ◽  
Individual Characteristics ◽  
Media Culture ◽  
Active Growth ◽  
Media Space ◽  
The Media ◽  
The Individual

The urgency of the researched problem is connected with the growing role of mass media in modern conditions leads to change of values and transformation of identity of the person. The active growth of the role of the media, their influence on the formation and development of personality leads to the concept of “media socialization” and immutation in the media. The aim of the study is to outline the possibilities of the process of media socialization in the context of immutation in the media. The methods of our research are: analysis of pedagogical, psychological, literature, synthesis, comparison, generalization. The article analyzes the views of domestic and foreign scientists on the problem of immutation in the media and the transformation of the information space. In the context of the mass nature of the immutation of society, the concept of “media socialization” becomes relevant, which is the basis for reducing the negative impact of the media on the individual.The author identifies the lack of a thorough study of the concept of “media socialization” in modern scientific thought. Thus, media socialization is associated with the transformation of traditional means of socialization, and is to assimilate and reproduce the social experience of mankind with the help of new media.The article analyzes the essence of the concepts “media space”, “mass media” and “immutation”. The influence of mass media on the formation and development of the modern personality is described in detail.The study concluded that it is necessary to form a media culture of the individual, to establish safe and effective interaction of young people with the modern media system, the formation of media awareness, media literacy and media competence in accordance with age and individual characteristics for successful media socialization. The role of state bodies in solving the problem of media socialization of the individual was also determined. It is determined that the process of formation of media culture in youth should take place at the level of traditional institutions of socialization of the individual.The author sees the prospect of further research in a detailed analysis and study of the potential of educational institutions as an institution and a means of counteracting the mass nature of the immutation of society.Key words: immutation, media socialization, mass media, media space, information.

scholarly journals Understanding the role of convenience in consumer food choices: a review article

SURG Journal ◽  
1969 ◽  
Vol 2 (2) ◽  
pp. 40-48 ◽  
Author(s):  
Mary-Ellen Wales
Keyword(s):  
Consumer Demand ◽  
Food Choices ◽  
Home Delivery ◽  
Review Article ◽  
Individual Characteristics ◽  
Western World ◽  
Internet Shopping ◽  
Meal Preparation ◽  
The Individual

It is evident that convenience plays a prominent role in the food choices of today’s consumers. A trend having begun throughout the Western world, consumer demand for convenience foods is now on the rise around the globe. The growing presence of drive-thru windows, microwave dinners, take-out meals, home delivery for groceries and internet shopping, all demonstrate the importance of convenience in determining food choices. Costa et al. have argued that convenience itself determines where, when, why, what, how, and even with whom we eat. Several studies have examined the role that convenience plays in determining food choices, in particular, studies looking at the role of convenience in relation to full meal preparation and/ or consumption.The two areas of investigation will be 1) the dimensions of convenience as a part of the meal preparation and consumption processe, and 2) the individual characteristics of consumers and how they value these dimensions.

scholarly journals MIKHAIL VRUBEL IN SEARCH OF THE “STYLISHLY BEAUTIFUL”. THE BIOGRAPHICAL ASPECT

Articult ◽  
2021 ◽  
pp. 56-67
Author(s):  
Olga S. Davydova ◽  
Keyword(s):  
Art History ◽  
Individual Characteristics ◽  
The Self ◽  
Present Stage ◽  
Leading Role ◽  
Stage Of Development ◽  
Russian Symbolism ◽  
The Individual ◽  
Independent Existence

The article is a conceptual exploration of the life and creative path of Mikhail Aleksandrovich Vrubel (1856-1910) in the context of the individual characteristics of his personality. The relevance of this study is determined by the need to find new conceptual angles in the field of understanding the idealistic component of M.A. Vrubel's work, i.e. in the field of his iconographic poetics. The visual myth-making of the artist, who drew on authentic spiritual prototypes, defined the leading role of Vrubel not only in Russian Symbolism and Modernism, but also in Modernism as a whole. The linking of the biographical aspect with M.A. Vrubel's poetic thinking, examined through the prism of “pure art”, i.e. in the context of the idea of the legitimacy of the independent existence of the self-contained reality of the work, can give entirely new accents of understanding the deep origins and potential meanings of the artist's work at the present stage of development of art history.

scholarly journals The Factors’ Affecting Innovative Competency Development of Vietnamese Universities’ Lecturers

2021 ◽  
Vol 3 (3) ◽  
pp. p1
Author(s):  
Dr. Pham Xuan Hung ◽  
MA. Pham Hoang Khanh Linh
Keyword(s):  
Industrial Revolution ◽  
Individual Characteristics ◽  
Self Control ◽  
Competency Development ◽  
Factors Affecting ◽  
University Teachers ◽  
Know How ◽  
Fourth Industrial Revolution ◽  
The Individual

The world’s in the process of globalization with the Fourth Industrial Revolution that connects people, influential nations, interactions, interdependence in every way. To survive and develop all of us must constantly innovate, create new products excel. Optimal solutions and breakthrough decisions’re entirely dependent on the creativity of each member of the organization. In this context, higher education, the role of universities’ teachers’re seen as the vanguard of innovation with mission to train human resources of high quality to meet the needs’ economic development - social. The articles’ give three groups of factors that influence the development of innovative competency’s university teachers; in which influential group’s within themselves, motives, the individual characteristics, the energy of the behavior. Self-motivation’s the key to formation and creation. And the way to develop the creative ability of university lecturers’re awaken the potential in each person so that they know how to self-control, master, orient themselves to develop their career.

scholarly journals PHASE INTERACTION BETWEEN EEG RHYTHMS IN THE STUDY OF PROCESSES OF TIME PERCEPTION

2014 ◽  
Vol 13 (6) ◽  
pp. 121-125
Author(s):  
Yu. V. Bushov ◽  
M. V. Svetlik
Keyword(s):  
Time Perception ◽  
Individual Characteristics ◽  
Bispectral Analysis ◽  
Eeg Rhythms ◽  
Activity Type ◽  
Gamma Rhythm ◽  
Perception Of Time ◽  
The Individual ◽  
Occipital Lobes

The present study pursued to investigate the role of phase interactions between EEG rhythms in the process of the perception of time. The purpose of the study was to analyse the dependence of these interactions on the type and stage of the activity being performed, as well as on the individual characteristics of a human. For this purpose, 27 boys and 29 girls, all university students, were asked to reproduce and measure short intervals of time (200 and 800 ms), during which their EEG was recorded in frontal, central, parietal, temporal, and occipital lobes, according to the system 10–20%. While studying phase interactions between EEG rhythms, we used wavelet bispectral analysis and calculated the bicoherence function. As it follows from the conducted research, most often close phase interactions are observed between the gamma-rhythm and other rhythms of EEG or between different frequencies of the gamma-rhythm. It was established that the phase interactions under study were influenced by the factors of “sex”, “activity type”, and “activity stage”. The study showed correlations of phase interactions with the levels of intellect, extraversion, neuroticism, with the particularities of the lateral organisation of brain, and the accuracy of time perception.

Are top executives important for earning management and firm risk? Empirical evidence from selected Chinese firms

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Khurram Iftikhar Bhatti ◽  
Muhammad Iftikhar Ul Husnain ◽  
Abubakr Saeed ◽  
Iram Naz ◽  
Syed Danial Hashmi
Keyword(s):  
Financial Reporting ◽  
Quantitative Data ◽  
Active Role ◽  
Individual Characteristics ◽  
Earning Management ◽  
Top Management ◽  
Firm Risk ◽  
Content Type ◽  
The Individual

PurposeThis study examines the role of the observable and unobservable characteristics of top management on earning management and firm risk in China.Design/methodology/approachThe authors used manager-firm matched panel for 104 non-financial firms listed on the Shanghai Stock Exchange between 2010 and 2018. The authors also trace the persistence of managerial financial styles and their active role across two different firms between which managers switched during the sample period.FindingsThe results show that managers' financial styles indeed influence earning management and firm risk and that this influence differs across different managers. These findings are robust when tested for the persistence and active role of managers. Furthermore, individual characteristics such as age, gender, qualification and experience influence managers' financial styles.Practical implicationsGiven their findings, the authors propose that financial analysts and potential investors should not only depend on quantitative data but also consider the individual characteristics of managers when evaluating firms.Social implicationsThe findings of this study carry serious implications for managers, policymakers and potential investors. The findings assist the external auditors in measuring the risk of material misstatement, the various regulatory bodies to assess the quality of financial reporting and the users of financial statements to evaluate the earnings and make further investment decisions considering not only the quantitative data but also the individual characteristics of top managers.Originality/valueThe current study examines the observable and unobservable characteristics of top management on firm risk and earnings management in Chinese context.

Ergology of Western Polissian folk reed pipes

Ethnomusic ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 104-131
Author(s):  
Victoriya Yarmola ◽  
Keyword(s):  
Musical Instrument ◽  
Age Group ◽  
Specific Production ◽  
Step Process ◽  
Longitudinal Splitting ◽  
The Core ◽  
Literary Sources ◽  
The Individual ◽  
First Time

In the publication, a technological system of traditional whistling reed pipes produced by folk artists, widespread in Western Polissia, is revealed for the first time in a step-by-step process. The proposed exploration is based on its expeditionary records and material collected by various folklorists and employ- ees of Kyiv and Lviv research institutions, as well as some literary sources. 131 The existence of three types of nozzle instruments, the names of which correspond to the methods of their production: a pipe made from bark, a vykrutka and kolianka are established. Western Polissian folk reed pipes belong to the type of longitudinal whis- tle flutes with an internal cleft formed by the insertion of the whistling device at the upper end of the tube, and with holes placed on the front, sometimes on the back of the instrument. Whistle airphones have specific production features, according to the age group of masters: shepherd children, teens and adults. The easiest to manufacture among the discovered pipe instruments are ones made of bark, which had been previously removed from the branches of bush trees. In the process of removing the bark shepherds told special spells, which were recorded by the author on the researched area. The following two types of tools were made of wood: a kolianka in the form of a longitudinal splitting of the branch into two equal parts, a vykrutka - a screwing out the core of pine wood, which required a masters knowledge of certain empirical and professional skills. The folk pipe instruments played the role of a musical instrument, which corresponded to the individual artistic and aesthetic test of the flute maker and served as an integral part of the Polisian shepherd's everyday life

scholarly journals INNOVATIONS IN THE AGRICULTURAL BUSINESS: PROBLEMS AND PROSPECTS IN UKRAINE

2020 ◽  
pp. 9-18
Author(s):  
Tetiana Mulyk ◽  
Yaroslavna Mulyk
Keyword(s):  
Swot Analysis ◽  
Innovation Process ◽  
Innovative Activity ◽  
Innovation Activity ◽  
Literary Sources ◽  
Innovative Solutions ◽  
Agricultural Business ◽  
The Individual ◽  
Implementation Of Innovations

The main purpose of the research is to determine the role of innovation of agrarian enterprises for their effective management, as well as analysis of the internal and external environment of innovation activity of agrarian enterprises, their threats and opportunities with the help of SWOT-analysis. The systematization of literary sources and approaches to innovative activity of agrarian enterprises made it possible to generalize that the fundamental questions related to the interpretation of the essence of innovations, innovation activity and innovative processes of enterprises, with the specifics of their manifestation in agrarian enterprises, were investigated by domestic and foreign scientists as well as regulated by normative- legal acts. The urgency of solving this scientific problem lies in the fact that the determining factor of the efficiency of economic activity of the enterprise is their innovative development, which is based on the introduction and implementation of innovations, which determine the improvement of its activities, affect the strengthening of its market positions and produce suitable conditions for its development. One of the promising areas for innovations is the agrarian sector. Introduction of innovations in practice in all spheres of agrarian enterprises contributes to: the increase of labor productivity, decrease of expenses and cost of production, saving of various kinds of resources, increase of volumes and improvement of efficiency of agrarian production. The article analyzes the main directions of IT innovations in agrarian business, innovative solutions (products) and opportunities. It is determined, that any agrarian enterprise has its own peculiarities and specificity and requires individual innovative solutions. The management of the company often can easily identify, what is needed to increase the efficiency. And sometimes the services of analysts and IT consultants, who are professionals of their business, and can unmistakably determine the individual needs and decisions, can be useful. The peculiarities of formation and development of innovation process in agriculture were analyzed. A SWOT analysis of innovative activity of agrarian enterprises was conducted, which allowed to identify their strengths (weaknesses) sides, opportunities and threats. The results of the research can be useful for scientists, specialists and heads of agrarian enterprises, teachers of higher educational establishments, postgraduates, students and all those, who are interested in problems of development and efficiency of innovation activity.

scholarly journals Ultraviolet crosslinking of corneal collagen in patients with thin cornea. Literature review

2021 ◽  
Vol 6 (6-1) ◽  
pp. 229-236
Author(s):  
A. V. Tereshchenko ◽  
I. G. Trifanenkova ◽  
Yu. Y. Golubeva ◽  
S. K. Demianchenko ◽  
E. N. Vishnyakova
Keyword(s):  
Corneal Thickness ◽  
Biomechanical Properties ◽  
Pathological Process ◽  
Individual Characteristics ◽  
Lamellar Keratoplasty ◽  
Cross Linking ◽  
Corneal Tissue ◽  
Initial Stage ◽  
The Individual ◽  
Corneal Collagen

For the treatment of progressive keratoconus in the early stages, corneal collagen crosslinking is currently actively used. This technique is based on the stabilization of the pathological process by increasing the biomechanical properties of the own cornea. The thickness of the cornea less than 400 microns significantly limits the possibility of a standard cross-linking procedure performing.The article analyzes the literature data on the use of various methods of corneal crosslinking with a corneal thickness of less than 400 microns, which signifi cantly limits the possibilities of the standard procedure.It is known, that during crosslinking, at the initial stage, de-epithelialization of the cornea is performed, which, in the postoperative period, leads to a pronounced corneal syndrome. This determined the direction of the fi rst modifi cations of the technique associated with the use of partial de-epithelialization or its complete absence. Later, during cross-linking of “thin” corneas, techniques with the use of additional covering materials were actively used in order to replenish the missing corneal tissue of the patient during the UV irradiation procedure. Among them are the use of a soft contact lens without an ultraviolet fi lter, the use of a corneal lenticule obtained after SMILE surgery, the use of a protective fl ap of the donor cornea obtained using a femtosecond laser from the residual stroma of the corneal disc after descemet membrane transplantation or posterior lamellar keratoplasty. The variety of the proposed modifications and the ongoing search for better options indicate the demand for this technology and the need for further research, taking into account the individual characteristics of the patient’s ectasia.

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