SARS-CoV-2 infection during pregnancy and risk of neurodevelopmental disorders in neonatals: a literature review

Introduction: With the emergence of SARS-CoV-2 and its rapid spread, a concern with the pregnant women have increased, since viruses have a wide range of obstetric and neonatal issues. Recent findings indicate that the gestational period and the postpartum period make mothers and their offspring more susceptible to COVID-19 and the rapid progression to the critical stage of the disease. Objectives: To carry out a bibliographic study on SARS-CoV- 2 during pregnancy and the potential risk of neurodevelopmental disorders in neonates. Methods: A review, developed from articles selected on the following bases: PubMed, Web of Science and Scopus. In the search, articles indexed until March 2021 and published in English, using the descriptors: “COVID-19”; “Pregnancy”; “Offspring”; “Neonatal”; “Neurodevelopment”; “Anomalies” and “Complications”. Exclusion criteria: duplicates and articles outside the scope of the study. Results: The initial search resulted in 533 articles, 498 from PubMed, 2 from Web of Science and 33 from Scopus. After reading the title and abstract, the application of the inclusion and exclusion criteria, the sample of 48 documents were included. In the studies, 89.0% of all patients had cesarean delivery (n = 201), 33.3% had gestational complications, 35.3% had premature delivery and about 2.5% were stillborn or had neonatal death. Among those tested, 6.45% of neonates diagnosed positive for COVID-19. In another study, the newborn showed neurological issues similar to the adult patients and transient neurological complications due to cerebral vasculitis. Conclusions: The results demonstrate that further investigations are needed to determine the potential for vertical intrauterine transmission in pregnant women with COVID-19 and possibles fetal and neonatal consequences.

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Violência doméstica contra a mulher gestante

Revista de Enfermagem UFPE on line ◽

10.5205/1981-8963-v11i12a22279p4999-5008-2017 ◽

2017 ◽

Vol 11 (12) ◽

pp. 4999

Author(s):

Naiany Monise Gomes Ramalho ◽

Josefa Danielma Lopes Ferreira ◽

Carla Lidiane Jácome de Lima ◽

Thalys Maynnard Costa Ferreira ◽

Sayonara Lays Umbelino Souto ◽

...

Keyword(s):

Risk Factors ◽

Domestic Violence ◽

Pregnant Women ◽

Violence Against Women ◽

Exclusion Criteria ◽

Scientific Publications ◽

Cross Sectional ◽

Wide Range ◽

Factores De Riesgo ◽

Violencia Domestica

RESUMOObjetivo: analisar as publicações científicas sobre a violência doméstica contra a mulher gestante. Método: revisão integrativa, com buscas nas bases de dados MEDLINE, SCOPUS, LILACS e BDENF, usando os descritores em português e inglês violência doméstica, mulher grávida e Enfermagem. Foram identificados 536 artigos. Após critérios de inclusão e exclusão, obtiveram-se 16 estudos que compuseram a amostra. A apresentação dos resultados e a discussão final foram feitas de forma descritiva, além de estatística simples por porcentagem e apresentados sob a forma de figuras. Resultados: dos estudos incluídos na revisão, 18,8% foram publicados em 2007. Quanto ao tipo de estudo, 56,3% foram estudos de corte transversal. Os tipos de violência mais retratados foram o sexual, o físico e o psicológico. Todos os estudos relatavam os fatores de risco para a violência contra a mulher gestante. Conclusão: analisando os estudos, foi possível identificar uma ampla gama de fatores de risco encontrados na literatura e a falta de registros sobre a assistência de saúde à mulher grávida em situação de violência. Descritores: Enfermagem; Violência Doméstica; Mulher Grávida; Violência Contra a Mulher; Cuidados De Enfermagem; Fatores de Risco.ABSTRACTObjective: to analyze the scientific publications on domestic violence against pregnant women. Method: integrative review, with searches in the MEDLINE, SCOPUS, LILACS and BDENF databases, using the descriptors in Portuguese and English, domestic violence, pregnant women and Nursing. A total of 536 articles were identified. After inclusion and exclusion criteria, we obtained 16 studies that composed the sample. The presentation of the results and final discussion was done in a descriptive way, in addition to simple statistics by percentage and presented in the form of figures. Results: of the studies included in the review, 18.8% were published in 2007. Regarding the type of study, 56.3% were cross-sectional studies. The types of violence most portrayed were sexual, physical and psychological. All studies reported the risk factors for violence against pregnant women. Conclusion: analyzing the studies, it was possible to identify a wide range of risk factors found in the literature and the lack of records on health care for pregnant women in situations of violence. Descriptors: Nursing; Domestic Violence; Pregnant Woman; Violence Against Women; Nursing Care; Risk Factors.RESUMENObjetivo: analizar las publicaciones científicas sobre la violencia doméstica contra la mujer gestante. Método: revisión integrativa, con búsquedas en las bases de datos MEDLINE, SCOPUS, LILACS y BDENF, usando los descriptores en portugués e inglés violencia doméstica, mujer embarazada y Enfermería. Se identificaron 536 artículos. Después de criterios de inclusión y exclusión, se obtuvieron 16 estudios que compusieron la muestra. La presentación de los resultados y la discusión final fueron hechas de forma descriptiva, además de estadística simple por porcentaje y presentados bajo la forma de figuras. Resultados: de los estudios incluidos en la revisión, el 18,8% fueron publicados en 2007. En cuanto al tipo de estudio, el 56,3%, fueron estudios de corte transversal. Los tipos de violencia más retratados fueron el sexual, el físico y el psicológico. Todos los estudios relataban los factores de riesgo para la violencia contra la mujer embarazada. Conclusión: analizando los estudios, fue posible identificar una amplia gama de factores de riesgo encontrados en la literatura y la falta de registros sobre la asistencia de salud a la mujer embarazada en situación de violencia. Descriptores: Enfermería; La Violencia Doméstica; Mujer Embarazada; Violencia Contra la Mujer; Atención de Enfermería; Factores de Riesgo.

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Possible risk of fetal development of autism in pregnant women infected by SARS-CoV-2

Revista Neurociências ◽

10.34024/rnc.2021.v29.11197 ◽

2021 ◽

Vol 29 ◽

pp. 1-24

Author(s):

Sayd Douglas Rolim Carneiro Oliveira ◽

José Eduardo Ribeiro Honório Júnior ◽

Gislei Aragao

Keyword(s):

Pregnant Women ◽

Immune Activation ◽

Neurodevelopmental Disorders ◽

Autism Spectrum ◽

Spectrum Disorder ◽

World Health ◽

Rapid Progression ◽

Maternal Immune Activation ◽

Gestational Period ◽

Health Organization

Introduction. In March 2020, the World Health Organization (WHO) announced the emergence of a global pandemic, COVID-19. A disease triggered by the new coronavirus infection (SARS-CoV-2). More recent findings indicate that the gestational period makes the mother and her offspring more susceptible to the new coronavirus and the rapid progression to the critical stage of the disease. The maternal organism presents a certain degree of immunological and cardiorespiratory deficiency due to physiological adaptations to the gestational period and, consequently, if affected by prenatal infections caused by viruses, they lead to an exacerbated Maternal Immune Activation (MIA), thus contributing to alterations in maternal-fetal neurogenesis, fetal myelinization, and is directly involved in the pathogenesis of neurodevelopmental disorders in the offspring, especially autism. Objective. This study hypothesizes that maternal COVID-19 infections during pregnancy are a potential risk for the offspring to develop Autism Spectrum Disorder. Conclusion. The exposure to viral infectious agents during the gestational period leads to exacerbated maternal immune activation. It contributes to alterations in maternal-fetal neurogenesis and is directly involved in the pathogenesis of neurodevelopmental disorders, being correlated to the predisposition to affective and psychiatric disorders in the offspring. Therefore, greater attention should be given to the offspring of pregnant women infected by COVID-19, since prenatal infectious processes have a strong correlation with the prevalence of Autistic Spectrum Disorder in the offspring.

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The COVID-19 Pandemic Can Impact Perinatal Mental Health and the Health of the Offspring

Behavioral Sciences ◽

10.3390/bs10110162 ◽

2020 ◽

Vol 10 (11) ◽

pp. 162

Author(s):

Rafael A. Caparros-Gonzalez ◽

Ana Ganho-Ávila ◽

Alejandro de la Torre-Luque

Keyword(s):

Pregnant Women ◽

Perinatal Period ◽

Premature Delivery ◽

Risk Of Mortality ◽

Rapid Spread ◽

Spanish Flu ◽

Short And Long Term ◽

Males And Females ◽

Health Deterioration

The COVID-19 ongoing pandemic constitutes a major challenge for countries throughout the world due to the rapid spread of SARS-CoV-2 and devastating consequences in health. No one is free from COVID-19 impact. In this regard, pregnant women are not the exception. The COVID-19 outbreak represents a massive source of stressful agents for women and their babies during the perinatal period. The COVID-19 pandemic has been suggested to potentially have short- and long-term detrimental effects on pregnant women and the baby. These adverse consequences range from mental to medical diseases. During the last centuries, several dreadful and fatal incidents have put pregnant women and their babies at higher risk of mortality and health deterioration. For example, it has been informed that women exposed to the 1918 flu pandemic (commonly known as the Spanish flu) while pregnant showed higher rates of premature delivery in the short term. Long-term consequences have also been reported and individuals (both males and females) who were exposed to the 1918 flu pandemic while in utero had a higher risk of developing schizophrenia, diabetes, coronary heart disease or cancer throughout their lifespan.

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Optimisation of tactics of conducting pregnancy and labours at women after auxiliary reproductive technologies

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.160 ◽

2016 ◽

pp. 160-164

Author(s):

D.N. Maslo ◽

Keyword(s):

Pregnant Women ◽

Resistance Index ◽

First Trimester ◽

Reproductive Technologies ◽

Premature Delivery ◽

Control Group ◽

Uterine Arteries ◽

Placental Dysfunction ◽

Placental Blood ◽

Two Stages

The objective: frequency decrease perinatal pathologies at women after ART on the basis of studying clinical-ehografical, endocrinological, biochemical, dopplerometrical, cardiotokografical and morphological researches, and also improvement of algorithm of diagnostic and treatment-and-prophylactic actions. Patients and methods. The work basis is made spent by us from 2012 on 2015 by complex inspection of 300 pregnant women from which 250 were after ART and 50 – firstlabours which pragnency without ART, and also their newborns. For the decision of an object in view of research spent to two stages. At 1 stage spent prosperctive research which included 150 pregnant women: з them 100 women pregnancy at which has come out ART (1 group) and 50 healthy women (control group). At 2 stage spent prospective randomization in which result of patients after ART have divided on two equal groups by therapy principle: 2 basic group - 75 pregnant women after ART at which used the algorithm improved by us; 3 group of comparison - 75 pregnant women after ART which have been spent on the standard treatment-and-prophylactic actions. Results. The results suggest that women after using ART is a high frequency of reproductive losses in the first trimester (10.0%), 3.0% of spontaneous abortion from 16 to 22 weeks, and 3.0% "early" premature delivery (22 to 28 weeks of pregnancy). The frequency of violations of the functional state of placenta in women after using IVF is 63.0%, which is the main cause of high levels of perinatal losses (40.0 ‰), and delivery by cesarean section (96.0%). Placental dysfunction in women after using ART characterized by retrohorialnyh hematoma (21.0%); size mismatch fruit (30.0%) and hypertonicity of the uterus (73.0%) against changes in fruit-placental blood flow - increased resistance index in umbilical artery and increased vascular resistance in the uterine arteries. Endocrinological and biochemical changes in placental dysfunction in women after using IVF starting from 28 weeks of pregnancy and are in significant reduction in progesterone, placental b1-microglobulin, B2-microglobulin of fertility and trophic в-glycoprotein. Conclusion. The received results: use of the algorithm of diagnostic and treatment-and-prophylactic actions improved by us allows to lower frequency of spontaneous interruption of pregnancy till 22 weeks – from 13.0% to 5.7%; «early» premature birth – from 3.0% to 1.0%; placentary dysfunction from 63.0% to 40.6%; cesarean sections – from 96.0% to 56.5%, and also perinatal losses – from 40.0‰ to 16.2‰. Key words: pregnancy, childbirth, auxiliary reproductive technologies.

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The Influence of Barrier and Applied Voltage Parameters on the Impulse Surface Discharge Characteristics

Elektrichestvo ◽

10.24160/0013-5380-2020-11-17-27 ◽

2020 ◽

Vol 11 (11) ◽

pp. 17-27

Author(s):

Vadim V. VOEVODIN ◽

◽

Marina V. SOKOLOVA ◽

Viktor R. SOLOV’YEV ◽

Nikolay Yu. LYSOV ◽

...

Keyword(s):

Applied Voltage ◽

Voltage Pulse ◽

Discharge Zone ◽

Surface Discharge ◽

Initial Surface ◽

Barrier Material ◽

Dielectric Barrier ◽

Discharge Ignition ◽

Study Results ◽

Wide Range

The results from an experimental study of impulse surface discharge occurring in an electrode system containing a dielectric plate are presented. On one of its sides, the plate had a corona-producing electrode made of 50 mm thick copper foil grounded through a current shunt for measuring the discharge current. On its other side, the plate had a high-voltage electrode, to which the voltage from a pulse generator was applied. The article presents the results from measurements of the initial voltage and the sizes of the surface discharge area in air when applying single voltage pulses with different pulse front steepness in the range 0,1–3,4 kV/ms and amplitude in the range 7–15 kV. The measurements were carried out for different dielectric barrier materials with the e values from 2 to 35. The dielectric barrier thickness was 0,9–1,8 mm. The study results have shown that the initial surface discharge ignition voltage depends essentially on the voltage pulse parameters, whereas the barrier characteristics have a weaker effect on this voltage. It has been determined that the discharge has different discharge zone length and different structure depending on the dielectric barrier properties and applied voltage parameters. The streamer zone sizes decrease with increasing the barrier material e value at the same voltage pulse steepness and increase with increasing the steepness for each barrier material. The data obtained for a wide range of external conditions can be used in numerical modeling of discharge.

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CRIMINOLOGICAL FEATURES OF CORRUPTION-RELATED CRIMES IN THE FUEL AND ENERGY COMPLEX

Vestnik Samarskogo iuridicheskogo instituta ◽

10.37523/sui.2020.40.4.003 ◽

2020 ◽

pp. 23-27

Author(s):

Сергей Иванович Вележев ◽

Антон Михайлович Седогин

Keyword(s):

Legal Protection ◽

Criminal Activity ◽

Criminal Cases ◽

Law Enforcement Agencies ◽

Energy Complex ◽

Significant Damage ◽

Study Results ◽

Wide Range ◽

Illegal Activities ◽

High Level

В представленной статье авторами рассматриваются вопросы уголовно-правовой охраны топливно-энергетического комплекса Российской Федерации от преступных проявлений, в том числе от коррупционной противоправной деятельности должностных лиц. Такие действия причиняют значительный ущерб нормальному функционированию предприятий топливно-энергетического комплекса. Авторами приводятся результаты исследования некоторых криминологических характеристик должностных лиц, совершивших преступления коррупционного характера. Дан анализ причин и условий, способствующих совершению вышеуказанных противоправных действий. Определена типовая модель преступника для данной категории преступлений и его характеристики: в первую очередь, это высокий уровень компетентности, специальное образование и т. д. Авторами отмечается высокий уровень латентной преступности в данной отрасли. Предложены некоторые пути профилактики данной категории правонарушений. Исследование проводилось на основе анализа конкретных уголовных дел, возбужденных следственными органами по результатам оперативно-розыскной деятельности правоохранительных органов. In the article the authors consider the issues of criminal and legal protection of the fuel and energy complex of the Russian Federation from criminal activity including corrupt illegal practices of officials. The authors cite the results of some criminological characteristics study of the fuel and energy complex staff committed corruption crimes. As a result of these illegal actions significant damage is caused to the normal functioning of the fuel and energy enterprises. Such officials` actions determine not only a wide range of other illegal activities, but also lead to public outcry and discredit the industry as a whole. The analysis of the reasons and conditions contributing to the above illegal actions commission is given. A typical model of a criminal for a given crime category and its characteristics are determined. First of all it is a high level competence, special education, etc. A high level of latent crime in this industry is shown. The study results are presented on the example of specific criminal cases initiated by the investigating authorities based on the results of the operation detection activities of law enforcement agencies. Some ways of preventing this category of offenses are proposed.

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Environmental Flow Assessment Considering Inter- and Intra-Annual Streamflow Variability under the Context of Non-Stationarity

Water ◽

10.3390/w10121737 ◽

2018 ◽

Vol 10 (12) ◽

pp. 1737 ◽

Cited By ~ 3

Author(s):

Kang Ren ◽

Shengzhi Huang ◽

Qiang Huang ◽

Hao Wang ◽

Guoyong Leng

Keyword(s):

Kendall Test ◽

Environmental Flow ◽

Mean Value ◽

Test Method ◽

Stationary Condition ◽

Annual Streamflow ◽

Riverine Ecosystems ◽

Study Results ◽

Wide Range ◽

Streamflow Variability

A key challenge to environmental flow assessment in many rivers is to evaluate how much of the discharge flow should be retained in the river in order to maintain the integrity and valued features of riverine ecosystems. With the increasing impact of climate change and human activities on riverine ecosystems, the natural flow regime paradigm in many rivers has become non-stationary conditions, which is a new challenge to the assessment of environmental flow. This study presents a useful framework to (1) detect change points in runoff time series using two statistical methods (Mann-Kendall test method and heuristic segmentation method), (2) adjust data of the changed period against the original flow series into a stationary condition using a procedure of reconstruction; and (3) incorporate inter- and intra-annual streamflow variability with adjusted streamflow to evaluate environmental flow. The Jialing to Han inter-basin water transfer project was selected as the case study. Results indicate that a change point of 1994 was identified, revealing that the stationarity of annual streamflow series is invalid. The variations of reconstructed streamflow series are roughly consistent with original streamflow series, especially in the maximum/minimum values and rise/fall rates, but the mean value of reconstructed streamflow series is increased. The reconstructed streamflow series would further serve to eliminate the non-stationary of original streamflow, and incorporating the inter- and intra-annual variability would upgrade the ecosystem fitness. Selecting different criteria for the conservation of riverine ecosystems can have significantly different consequences, and we should not focus on the protection of specific objectives that will inevitably affect other aspects. This study provides a useful framework for environmental flow assessment and can be applied to a wide range of instream flow management approaches to protect the riverine ecosystem.

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SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

International Journal of Molecular Sciences ◽

10.3390/ijms21155475 ◽

2020 ◽

Vol 21 (15) ◽

pp. 5475 ◽

Cited By ~ 11

Author(s):

Manuela Pennisi ◽

Giuseppe Lanza ◽

Luca Falzone ◽

Francesco Fisicaro ◽

Raffaele Ferri ◽

...

Keyword(s):

Nervous System ◽

Molecular Mechanisms ◽

Neuronal Damage ◽

Neurological Complications ◽

Neurological Manifestations ◽

Wide Range ◽

Inflammatory State ◽

Acute Polyneuropathy ◽

The Central Nervous System ◽

The Impact

Increasing evidence suggests that Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) can also invade the central nervous system (CNS). However, findings available on its neurological manifestations and their pathogenic mechanisms have not yet been systematically addressed. A literature search on neurological complications reported in patients with COVID-19 until June 2020 produced a total of 23 studies. Overall, these papers report that patients may exhibit a wide range of neurological manifestations, including encephalopathy, encephalitis, seizures, cerebrovascular events, acute polyneuropathy, headache, hypogeusia, and hyposmia, as well as some non-specific symptoms. Whether these features can be an indirect and unspecific consequence of the pulmonary disease or a generalized inflammatory state on the CNS remains to be determined; also, they may rather reflect direct SARS-CoV-2-related neuronal damage. Hematogenous versus transsynaptic propagation, the role of the angiotensin II converting enzyme receptor-2, the spread across the blood-brain barrier, the impact of the hyperimmune response (the so-called “cytokine storm”), and the possibility of virus persistence within some CNS resident cells are still debated. The different levels and severity of neurotropism and neurovirulence in patients with COVID-19 might be explained by a combination of viral and host factors and by their interaction.

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Two-Dimensional Numerical Modeling of Flow in Physical Models of Rock Vane and Bendway Weir Configurations

Water ◽

10.3390/w13040458 ◽

2021 ◽

Vol 13 (4) ◽

pp. 458

Author(s):

Drew C. Baird ◽

Benjamin Abban ◽

S. Michael Scurlock ◽

Steven B. Abt ◽

Christopher I. Thornton

Keyword(s):

Numerical Modeling ◽

Physical Model ◽

Numerical Models ◽

Hydraulic Performance ◽

Physical Models ◽

Protection Measures ◽

Design Engineers ◽

Model Study ◽

Study Results ◽

Wide Range

While there are a wide range of design recommendations for using rock vanes and bendway weirs as streambank protection measures, no comprehensive, standard approach is currently available for design engineers to evaluate their hydraulic performance before construction. This study investigates using 2D numerical modeling as an option for predicting the hydraulic performance of rock vane and bendway weir structure designs for streambank protection. We used the Sedimentation and River Hydraulics (SRH)-2D depth-averaged numerical model to simulate flows around rock vane and bendway weir installations that were previously examined as part of a physical model study and that had water surface elevation and velocity observations. Overall, SRH-2D predicted the same general flow patterns as the physical model, but over- and underpredicted the flow velocity in some areas. These over- and underpredictions could be primarily attributed to the assumption of negligible vertical velocities. Nonetheless, the point differences between the predicted and observed velocities generally ranged from 15 to 25%, with some exceptions. The results showed that 2D numerical models could provide adequate insight into the hydraulic performance of rock vanes and bendway weirs. Accordingly, design guidance and implications of the study results are presented for design engineers.

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Advances in Hepatitis E Virus Biology and Pathogenesis

Viruses ◽

10.3390/v13020267 ◽

2021 ◽

Vol 13 (2) ◽

pp. 267

Author(s):

Shaoli Lin ◽

Yan-Jin Zhang

Keyword(s):

Pregnant Women ◽

Hepatitis E Virus ◽

Case Fatality ◽

Hepatitis E ◽

Host Cells ◽

High Rate ◽

Rapid Progression ◽

Genotype 1 ◽

Genotype 3 ◽

Zoonotic Infections

Hepatitis E virus (HEV) is one of the causative agents for liver inflammation across the world. HEV is a positive-sense single-stranded RNA virus. Human HEV strains mainly belong to four major genotypes in the genus Orthohepevirus A, family Hepeviridae. Among the four genotypes, genotype 1 and 2 are obligate human pathogens, and genotype 3 and 4 cause zoonotic infections. HEV infection with genotype 1 and 2 mainly presents as acute and self-limiting hepatitis in young adults. However, HEV infection of pregnant women with genotype 1 strains can be exacerbated to fulminant hepatitis, resulting in a high rate of case fatality. As pregnant women maintain the balance of maternal-fetal tolerance and effective immunity against invading pathogens, HEV infection with genotype 1 might dysregulate the balance and cause the adverse outcome. Furthermore, HEV infection with genotype 3 can be chronic in immunocompromised patients, with rapid progression, which has been a challenge since it was reported years ago. The virus has a complex interaction with the host cells in downregulating antiviral factors and recruiting elements to generate a conducive environment of replication. The virus-cell interactions at an early stage might determine the consequence of the infection. In this review, advances in HEV virology, viral life cycle, viral interference with the immune response, and the pathogenesis in pregnant women are discussed, and perspectives on these aspects are presented.

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