scholarly journals Assessment of Blood Glucose and Electrolytes during Cardiopulmonary Bypass in Diabetic and Non-Diabetic Patients of Pakistan

2016 ◽  
Vol 8 (9) ◽  
pp. 159
Author(s):  
Muhammad Bilal ◽  
Abdul Haseeb ◽  
Mohammad Hassaan Khan ◽  
Akash Khetpal ◽  
Muhammad Saad ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cardiopulmonary Bypass ◽  
Repeated Measures ◽  
Artery Bypass ◽  
The Body ◽  
Diabetic Patients ◽  
Blood Electrolytes ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

<p><strong>INTRODUCTION: </strong>Perioperative hyperglycemia has been shown to be related to higher levels of morbidity and mortality in patients on cardiopulmonary bypass (CPB) undergoing coronary artery bypass grafting (CABG), both diabetic and non-diabetic. Blood electrolytes, like sodium, potassium, calcium, and chloride play a very important role in the normal functioning of the body and can lead to a variety of clinical disorders if they become deficient. A minimal number of studies have been conducted on the simultaneous perioperative changes in both blood glucose and electrolyte levels during CPB in Pakistan. Therefore, our aim is to record and compare the changes in blood glucose and electrolyte levels during CPB in diabetic and non-diabetic patients.</p><p><strong>MATERIALS &amp; METHODS: </strong>This was a prospective, observational study conducted on 200 patients who underwent CABG with CPB, from October 2014 to March 2015. The patients were recruited from the Cardiac Surgery Ward, Civil Hospital Karachi after they complied with the inclusion criteria. Repeated-measures analysis of variance (ANOVA) was used to compare the trend of the changes perioperatively for the two groups.</p><p><strong>RESULTS: </strong>There was no significant difference in changes in blood glucose between the two groups (<em>P</em> = 0.62). The only significant difference detected between the two groups was for PaCO<sub>2</sub> (<em>P</em> = 0.001). Besides, further analysis revealed insignificant group differences for the trend changes in other blood electrolytes (<em>P</em> &gt; 0.05).</p><p><strong>CONCLUSION: </strong>Our findings highlighted that there is no significant difference in blood electrolytes changes and the increase in blood glucose levels between diabetic and non-diabetic patients.</p>

Erythropoietin Treatment Is Associated with Decreased Blood Glucose Levels: A Preliminary Study in Hematologic Patients

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4793-4793
Author(s):  
Howard S Oster ◽  
Moran Gvili ◽  
Odelia Katz ◽  
Michael Hoffman ◽  
Drorit Neumann ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Repeated Measures ◽  
Mixed Model ◽  
Conflicts Of Interest ◽  
Cell Lineage ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Organ Systems ◽  
Average Glucose

Abstract Abstract 4793 Introduction: Erythropoietin (EPO) is the major hormone which enhances proliferation and maturation of the red cell lineage, and its recombinant form (rHuEPO) is used extensively to treat various types of anemia. rHuEPO has also been found to exert effects in other organ systems, and our previous work has demonstrated an immunomodulatory role for EPO. Recently, we have also found that mice exposed to high levels of EPO (either rHuEPO injections or transgenic mice overexpressing human EPO), have significantly lower levels of blood glucose than those of their respective controls (Katz et al., J Endocrinol 2010;205:87-95). The current retrospective study was designed to determine whether rHuEPO treatment in hematologic patients, is associated with decreased blood glucose levels. Methods: Patients receiving rHuEPO were examined, comparing glucose levels (morning blood tests, assumed to be fasting) while on rHuEPO treatment to those off treatment. All patients served as their own controls. To test the association between rHuEPO treatment and blood glucose levels, we employed a mixed-model repeated-measures analysis of variance (ANOVA). Results: The charts of 19 patients were reviewed to determine the starting date of rHuEPO and the levels of blood glucose in relation to rHuEPO treatment. Mean age: 77 (range: 54–93). Thirteen patients had myelodysplastic syndrome, and six had multiple myeloma. Two patients had diabetes mellitus. Average glucose levels (mean±95%CI) without rHuEPO treatment were 116.07±4.98. Glucose measurements were available for a median of 9.23 (interquartile range: 7.90–16.80) months after the initiation of rHuEPO treatment. The average glucose level over that period of time was 101.77±4.86 (p<0.0001). The two diabetic patients also demonstrated a trend towards reduced serum blood glucose and lower HbA1C while being treated with rHuEPO. Conclusions: Treatment of hematologic patients with rHuEPO is associated with significantly lower blood glucose levels, and might serve in the future to improve glucose control in anemic patients with hyperglycemia. Further studies with both diabetic and non-diabetic patients are currently underway to clarify this association. Disclosures: No relevant conflicts of interest to declare.

Conventional approach to glucose management for diabetic patients undergoing coronary artery bypass surgery

Perfusion ◽  
2002 ◽  
Vol 17 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Patricia A Gustafson ◽  
Debra L Zarro ◽  
David A Palanzo ◽  
Norman J Manley ◽  
Ralph M Montesano ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Insulin Infusion ◽  
Diabetic Patients ◽  
Type I ◽  
Cardioplegic Solution ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Continuous insulin infusion was not an effective mode of treatment in maintaining safe blood glucose levels (<200 mg/dl) during the intraoperative period of diabetic patients requiring open-heart surgery. The two modifications investigated to gain better control of the blood glucose were a change in the base solution of the cardioplegia and the use of a sliding insulin scale. Fifty patients including Type I and Type II diabetics were selected for the purpose of this study. The patients were then randomly divided into two groups categorized by the type of cardioplegic solution administered and the mode of insulin treatment. Group I patients received a dextrose 5%-based cardioplegic solution and blood glucose was treated via continuous intravenous insulin infusion. Group II patients received normal saline 0.9%-based cardioplegic solution and blood glucose was treated via sliding scale. Blood glucose levels were monitored pre- and postcardio- pulmonary bypass (CPB) and every 30 min while on CPB. Glucose values were analyzed by group t test. A p value of < 0.05 was considered statistically significant. When comparing Group I (mean=258 mg/dl) with Group II (mean= 158 mg/dl), there was a statistically significant difference between the glucose values at each of the time intervals when the glucose values were recorded. In conclusion, Group II maintained an acceptable blood glucose level (<200 mg/dl) throughout the entire intra- operative period, which suggests that the combination of the sliding insulin scale and modification of the base cardioplegic solution was an effective mode of treatment.

scholarly journals Perbedaan Kadar Glukosa Darah pada Plasma Edta dan Serum dengan Penundaan Pemeriksaan

2018 ◽  
Vol 4 (1) ◽  
pp. 19
Author(s):  
Apriani Apriani ◽  
Alfita Umami
Keyword(s):  
Blood Glucose ◽  
Clinical Laboratory ◽  
Ethylenediaminetetraacetic Acid ◽  
The Body ◽  
Actual State ◽  
Average Value ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Edta Ethylenediaminetetraacetic Acid

Abstract: Differences Of Blood Glucose Conditions In Plasma Edta And Serum With Delay Inspection. Blood glucose examination in the laboratory is used to determine blood glucose levels in the body. The delay in the examination can cause a decrease in blood glucose levels, so the results obtained do not match the actual state of the body. This study aims to determine the difference between blood glucose levels in EDTA (Ethylenediaminetetraacetic acid) and serum plasma samples that are directly examined and delayed for two hours. This research was conducted using experimental observation method that is an observation of clinical laboratory by measuring blood glucose level using photometer and GOD-PAP (glucose oxidase) method. The statistical test was performed using Z test for two free samples. The results of serum and plasma blood glucose examination in this study showed an average value of glucose levels with EDTA plasma directly examined 89.18 mg/ dl delayed 86.60 mg/ dl and serum directly examined 92.20 mg/ dl delayed 89, 54 mg/ dl. Decreased blood glucose levels delayed two hours in plasma 2.9%, serum 2.7%. The data concluded that there was no significant difference between blood glucose levels using EDTA and serum plasma samples.Abstrak: Perbedaan Kadar Glukosa Darah Pada Plasma Edta Dan Serum Dengan Penundaan Pemeriksaan. Pemeriksaan glukosa darah di Laboratorium digunakan untuk mengetahui kadar glukosa darah di dalam tubuh. Penundaan waktu pemeriksaan dapat menyebabkan penurunan kadar glukosa darah, sehingga hasil yang didapat tidak sesuai dengan keadaan tubuh yang sebenarnya. Penelitian ini bertujuan untuk mengetahui perbedaan antara kadar glukosa darah pada sampel plasma EDTA (Ethylenediaminetetraacetic acid) dan serum yang langsung diperiksa dan ditunda selama dua jam. Penelitian ini dilakukan menggunakan metode observasi eksperimental yaitu pengamatan laboratorium klinik dengan mengukur kadar glukosa darah menggunakan fotometer dan metode GOD-PAP (Glukosa Oksidase). Uji statistik dilakukan dengan menggunakan uji Z untuk dua sampel bebas. Hasil pemeriksaan kadar glukosa darah serum dan plasma dalam penelitian ini menunjukan nilai rata-rata kadar glukosa dengan plasma EDTA yang langsung diperiksa 89,18 mg/dl ditunda 86,60 mg/dl dan serum yang langsung diperiksa 92,20 mg/dl ditunda 89,54 mg/dl. Penurunan kadar glukosa darah yang ditunda dua jam pada plasma 2,9%, serum 2,7%. Data tersebut menyimpulkan bahwa tidak ada perbedaan yang signifikan  kadar glukosa darah pada serum dan plasma antara yang ditunda dengan yang langsung diperiksa.

scholarly journals effects of Orally Administered Monosodium Glutamate (MSG) on the Metabolic Syndrome of Adult Albino Rats

2020 ◽  
Vol 3 (3a) ◽  
pp. 27-37
Author(s):  
LN UTUME ◽  
PM Ansha ◽  
TA Gav
Keyword(s):  
Blood Glucose ◽  
Monosodium Glutamate ◽  
Experimental Period ◽  
The Body ◽  
Control Group ◽  
Albino Rats ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
Blood Glucose Levels ◽  
Significant Difference

Monosodium Glutamate (MSG) or glutamate is a commonly used flavour enhancer, naturally found in protein-rich foods; although produced commercially through the fermentation of molasses. MSG is essential in the metabolism of living bodies. The increase in MSG consumption has become a growing concern due to the lack of adequate data on its effects. This study investigates the effects of MSG on weight and blood glucose levels of adult albino rats for an experimental period of eight (8) weeks. Twenty-four (24) albino rats weighing between 48.7 g to 94.6 g were randomly divided into four (4) groups of six (6) rats each: 1 control group and 3 test groups. Test groups were fed and daily doses of MSG dissolved in water (8 g/L, 10 g/L and 15 g/L respectively) were administered orally. The control group were fed on plain water and rat chow (grower’s mash) only. Weekly weights, fasting blood glucose levels of rats were measured, and change in behaviour and exploratory tendencies observed, all through the experimental period. Glycosylated haemoglobin was tested at the end of the experimental period to confirm the weekly blood glucose levels. There was no significant difference in the average weights (P ˃ 0.05). Blood glucose levels maintained a normal range of 4.5 – 5.1 % (good glycemic control) over the experimental period. The study illustrates that Monosodium Glutamate has no adverse effects on weight and blood glucose levels when consumed daily, but not exceeding a 15 g dose. Further research to validate casual inference may be necessary. The consumption of MSG should be in moderation and individuals prone to hypoallergenic reactions should ensure to check product labels for MSG before the consumption of foods. Further research can be carried out using higher doses as well as other metabolic markers in the body to further consolidate empirical data.

scholarly journals Konseling Gizi, Kualitas Diit Berbasis Pangan Lokal Dengan Kadar Glukosa Darah Penderita Diabetes Mellitus Tipe Ii Di Wilayah Kerja Puskesmas Bahu

Jurnal GIZIDO ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 108-112
Author(s):  
Rivolta G,M, Walalangi ◽  
Muksin Pasambuna ◽  
Rudolf B. Purba ◽  
Agung Suryohadi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Local Food ◽  
T Test ◽  
The Body ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Before And After

Diabetes Mellitus is a group of chronic disease which is characterized by increased levels of glucose in the blood due to disorders of the body's metabolism system, in which the pancreas organ incapable of producing the hormone insulin according to needs of the body. Nutritional counselling with quality local food based diit can help control blood glucose levels. This research aims to identify the difference in blood glucose levels and the value of quality diit type II diabetes mellitus patients before and after given nutritional counseling with quality local food based diit. This type of research is Pre Experimental research using one group pretest-posttest design. The number of samples is determined by purposive sampling counted 31 people. Data analysis using Wilcoxon and T-test analysis. The Wilcoxon analysis with significance level of 95% can be seen to produce significant difference in pre-post glycemic index component with p=0,000 (p<0,05) and diversity of pre-post food with p=0,002 (p<0,05). In the result of T-test for pre-post blood glucose variable, there was no significant difference p=0,105 (p>0,05). However, there was a range of decreased glucose levels before and after in 22 respondents with an average decrease of 11.42 mg/dL. Conclusion there was no difference of blood glucose level before and after nutrition counseling with quality of diet based on local food.

Progressive Muscle Relaxatation Terhadap Kualitas Tidur Dan Kadar Gula Darah Pada Diabetes Di Desa Hulu Wilayah Kerja Puskesmas Pancur Batu Kecamatan Pancur Batu Kabupaten Deli Serdang Tahun 2019

2020 ◽  
Vol 5 (1) ◽  
pp. 19-35
Author(s):  
Magda Siringo-ringo ◽  
Pomarida Simbolon
Keyword(s):  
Blood Glucose ◽  
Sleep Quality ◽  
Statistical Tests ◽  
Muscle Relaxation ◽  
Intervention Group ◽  
The Body ◽  
Progressive Muscle Relaxation ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels

Introduction..Diabetes erupts relative to the production of insuline deficits which results in an uncontrolled control mechanism of the level of glucose in the body, giving rise to potential complications of hyperglycemia and hypoglycemia. These conditions make diabetic patients diabetes stress, great anxiety dangerous to increase blood glucose levels in the body, this is as a management recommended complementary therapy using progressive Muscle Relaxations .. The purpose of this study was to determine the effect of Progressive Muscle Relaxation on sleep quality and blood glucose levels in diabetMethod. The design of this study was quasi-experimental with pre and post with control groups, for each group consisting of 32 samples with consecutive sampling techniques. Data were analyzed by statistical tests used by the Wilcoxon Sign Range Test and Mann WhitneyU Result. The influence of Progressive Muscle Relaxation on improving sleep quality was very significant there was a difference in intervention 1 in diabets with p = 0.695 (<0.05) and diabetic intervention group p = 0.00 (p = <0.05). and the effect of progressive muscle relaxation on decreasing blood glucose with found differences before and after intervention I in diabetics p = 0.627 (p> 0.05), with differences in intervention group II diabetes p = 0.00 (p <0.05) showed a significant relationshipDuscussion. There is an autogenic relaxation effect on decreasing blood glucose levels in patients with diabetes mellitus type. Suggestions for Diabetes Progressive Muscle Relaxitation can control the prevention of complications of lowering / stabilizing blood glucose levels, because muscle relaxation is a simple, easy, economical implementation, not a special tutorial room, it just needs intention , the spirit of optimism to be healthy happy future. Hopefully, people with diabetes are always active in implementing progressive, regular muscle relaxation. And the efforts to remain obedient to control blood sugar while balanced a healthy balanced diet. For the Development of Health Sciences / Researchers The results of this study are expected to be used as a reference for data information in finding alternative therapies to control diabetes complications. It is suggested that further research the number of samples is greater in knowing the factors causing comorbidities. Other modifications to complement therapy such as combining music therapy, measuring stress levels, depression, examination (ABI), HBA1C examination

scholarly journals Cataracts Risk Factors and Comparison of Blood Glucose Levels in Diabetic and Non-Diabetic Patients towards the Occurrence of Cataracts

2019 ◽  
Vol 7 (20) ◽  
pp. 3359-3362
Author(s):  
Juliandi Harahap ◽  
Rashvini Rania
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Body Mass ◽  
High Body Mass Index ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Chronic Hyperglycemia ◽  
Blood Glucose Levels ◽  
Significant Difference

BACKGROUND: Cataracts are a multifactorial systemic disease that causes opacity of the optical lens. One aetiology of cataracts is chronic hyperglycemia, usually caused by uncontrolled diabetes mellitus. AIM: The objective of this study is to identify risk factors of cataracts and to analyse if there is a significant difference in blood glucose values between diabetic patients with cataracts and non-diabetic patients with cataracts. METHODS: This was an analytical case-control study with a sample size of 140 patients that were obtained via consecutive sampling of medical records. This study found that age, high body mass index and hypertension were the dominant risk factors of cataracts. RESULTS: The mean value of blood glucose levels in diabetic patients with cataracts is 195.58 ± 63.9 and 109.7 ± 26.4 in non-diabetic patients with cataracts. There was a significant difference between the blood glucose values of diabetic patients with cataracts and non-diabetic patients with cataracts (p < 0.001). The dominant risk factors of cataracts were old age, high body mass index and hypertension. The majority of hyperglycemic patients belong in the group of diabetic patients with cataracts. CONCLUSION: Chronic hyperglycemia can increase a patient’s risk of cataracts.  

Loudness Dependence of Auditory-evoked Potentials, a Marker of Central Serotonergic Activity, is Affected by Fasting and Selective Uptake of Food

2021 ◽  
pp. 155005942110009
Author(s):  
Christoph Bamberg ◽  
Vera Flasbeck ◽  
Georg Juckel ◽  
Martin Brüne
Keyword(s):  
Blood Glucose ◽  
Evoked Potentials ◽  
Repeated Measures ◽  
Auditory Evoked Potentials ◽  
Glucose Levels ◽  
Fasting Condition ◽  
Serotonergic Activity ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Loudness Dependence

Serotonin is an important neuromodulator involved in many physiological processes including mood and satiety. In the brain, serotonin is manufactured from tryptophan, as serotonin itself cannot cross the blood–brain barrier. Previous research has shown that blood-tryptophan levels increase upon ingestion of carbohydrates and decrease upon protein consumption. How this translates into serotonin availability is as yet under-researched. Therefore, we examined the effect of fasting versus consuming carbohydrates or protein on central serotonergic activity using a repeated-measures crossover design in a sample of 37 healthy men. The loudness dependence of auditory-evoked potentials (LDAEP) serves as a noninvasive method to study central serotonergic activity. Blood-glucose levels and mood changes were also monitored before and after the nutritional intervention. The intervention had a significant nutrition-specific effect on LDAEP and blood-glucose levels. A significant difference emerged between the fasting condition and satiety, with LDAEP being lower during satiety, irrespective of the type of food. Thus, this indicator of serotonergic activity increased after food consumption, which was further related to mood improvement. Moreover, the LDAEP differed between the 2 measurements only for the carbohydrate testing day, suggesting that LDAEP can be selectively modulated by the type of nutrition consumed. Our data further indicate a high intraindividual stability of LDAEP, as the electrophysiological signals were very similar in the fasting condition across the 2 testing days. Together, these findings demonstrate that the LDAEP can serve as a biological marker for central serotonergic activity, while at the same time being sensitive to nutritional changes.

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