scholarly journals Lipometabolic Alteration in Mice Feeding Eatable Tissues of Chinese Mitten Crab

2016 ◽  
Vol 9 (1) ◽  
pp. 195
Author(s):  
Jun Jing ◽  
Wenhui Wu ◽  
Xinfeng Xiao ◽  
Yu Zhou ◽  
Xiaoyu Wang ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Chinese Mitten Crab ◽  
Male Crab ◽  
Mitten Crab ◽  
Crab Hepatopancreas ◽  
Edible Parts ◽  
Blood Lipid Levels

<p>Objective:<strong> </strong>Chinese mitten crab<em> </em>is a famous aquatic species in eastern Asian region, but their edible parts, particularly hepatopancreas and gonads, generally contain very high levels of lipids that may have negative effects on human health. This study investigated the effects of different edible parts of Chinese mitten crab on the body weight and lip metabolism for Kunming mice.</p><p>Method: The mice were fed with diets containing one part of an Chinese mitten crab or the mixture of parts of an Chinese mitten crab for 4 weeks. There were 9 treatments. The triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were enzymatically determined using commercial kits (purchased from Nanjing Jiancheng Bioengineering Institute, China). The arteriosclerosis index (AI) was calculated by the equation: AI = (TC – HDL-C)/HDL-C. The levels of fatty acid syntheses (FAS), the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) and lipoprotein lipase (LPL) were measured using commercially available kits according to the manufacturer’s instructions. The significant differences between the groups were further analyzed by Bonferronis’s t-test.</p><p>Results: Our results showed that the crab hepatopancreas, gonads and the mixed male crab-edible parts increased blood lipids in some experiment group of mice corresponding to a change in the nutrition-related liver enzymes. It shows that addition of the Chinese mitten crab has an adverse effect on the blood lipid levels in mice. The FFH, FFMI and FMMI groups had significantly higher weight than the FN group (P &lt; 0.05). The crab hepatopancreas, crab gonads and the mixed male crab-edible parts cause an increase in the blood lipid levels. The crab mixture significantly affected the AI value of male and female mice (P &lt; 0.01). The level of FMMI group was significantly higher than the FN group (P &lt; 0.05). Other groups showed no significant difference. The level of the FFMI group was significantly lower than the FN group (P &lt; 0.05), and levels in the MMM and MFMI groups were significantly lower than the MN group (P &lt; 0.05).<strong></strong></p><p>Conclusion: It clearly showed that long-term feeding with the Chinese mitten crab has an adverse effect on the blood lipid levels in mice. One the one hand, the weight, liver index and fat index of experimental mice were changed than normal mice. On the other hand, the crab diet affects the level of TC, TG, AI and FASN on increasing. It is suggested that the special diet has affected lip metabolic alteration associated with contents of serum lipids and metabolic enzymes. But according to a certain regular feeding, there would be no adverse effect on mice. On the contrary, it may adjust the blood lipid in mice<strong> </strong></p>

scholarly journals Blood Lipid Levels in Patients with Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Hang Zhao ◽  
An Song ◽  
Yong Li ◽  
Licui Qi ◽  
Chong Zheng ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Relevant Information ◽  
Lipid Lowering ◽  
Cochrane Library ◽  
Lipid Levels ◽  
Lipid Lowering Drugs ◽  
Blood Lipid Levels

Abstract Background: Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis.Methods: Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle-Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. Revman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference and 95% confidence interval. The heterogeneity test was conducted according to I2 and Q tests. Egger’s test was used to quantitatively evaluate publication bias.Results: This analysis involved 12 studies and included 12,395 subjects. The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C in postmenopausal women in osteopenia. TG was unchanged in the OP group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group but not in osteopenia group in all subjectsConclusions: HDL-C was elevated in patients with OP.

scholarly journals Urban-rural differences in the association between blood lipids and characteristics of the built environment: a systematic review and meta-analysis

2019 ◽  
Vol 4 (1) ◽  
pp. e001017 ◽  
Author(s):  
Rosa de Groot ◽  
Katja van den Hurk ◽  
Linda J Schoonmade ◽  
Wim L A M de Kort ◽  
Johannes Brug ◽  
...  
Keyword(s):  
Built Environment ◽  
Rural Areas ◽  
Urban Areas ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Urban Rural ◽  
Meta Analyses ◽  
Blood Lipid Levels

IntroductionThe built environment defines opportunities for healthy eating and physical activity and may thus be related to blood lipids. The aim of this study is to systematically analyse the scientific evidence on associations between built-environment characteristics and blood lipid levels in adults.MethodsPubMed, EMBASE and Web of Science were searched for peer-reviewed papers on population-based studies up to 9 October 2017. We included studies that reported on built-environment characteristics and blood lipid levels in adult populations (≥18 years). Two reviewers independently screened titles/abstracts and full-texts of papers and appraised the risk of bias of included studies using an adapted version of the Quality Assessment Tool for Quantitative Studies. We performed meta-analyses when five or more studies had sufficient homogeneity in determinant and outcome.ResultsAfter screening 6902 titles/abstracts and 141 potentially relevant full-text articles, we included 50 studies. Forty-seven studies explored associations between urban versus rural areas with blood lipid levels. Meta-analyses on urban versus rural areas included 133 966 subjects from 36 studies in total. Total cholesterol levels were significantly and consistently higher in urban areas as compared with rural areas (mean difference 0.37 mmol/L, 95% CI 0.27 to 0.48). Urban/rural differences in high density lipoprotein cholesterol were inconsistent across studies and the pooled estimate showed no difference (0.00 mmol/L 95% CI −0.03 to 0.04). Low density lipoprotein (LDL) cholesterol and triglyceride levels were higher in urban than in rural areas (mean difference 0.28, 95% CI 0.17 to 0.39 and 0.09, 95% CI 0.03 to 0.14, respectively).ConclusionsTotal and LDL cholesterol levels and triglycerides were consistently higher in residents of urban areas than those of rural areas. These results indicate that residents of urban areas generally have less favourable lipid profiles as compared with residents of rural areas.Prospero registration numberCRD42016043226.

scholarly journals Cord lipid profile comparison of newborns of hypertensive mothers

2020 ◽  
Vol 7 (5) ◽  
pp. 1038
Author(s):  
Kanwalpreet Kaur ◽  
Karuna Thapar ◽  
Preeti Malhotra
Keyword(s):  
Cord Blood ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Preterm Neonates ◽  
Low Density ◽  
Lipid Levels ◽  
Blood Lipid Profile ◽  
Blood Lipid Levels

Background: To compare the cord blood lipid profile of 100 newborn babies born to hypertensive (Group A) and normotensive mothers (Group B).Methods: Total 100 newborns were taken, 50 born to hypertensive mothers and 50 to normotensive mothers. 5ml umbilical venous blood was collected, after clamping the cord, from placental side of the cord and sent to laboratory for centrifugation. Serum was analysed for lipid profile by spectrophotometry by siemens dimensional Rxl- Total Cholesterol, Triglycerides, High density lipoprotein and Low density lipoprotein and Very low density lipoprotein. Comparison of the cord blood lipid levels in both the groups was done.Results: Cord blood lipid profile was deranged in newborns of hypertensive mothers with Cord TC, TG and LDL being statistically significantly higher than the mean reference value and 95th centile. Cord blood of term newborns of hypertensive mothers had Cord TC TG and LDL being statistically higher whereas only Cord TC being statistically higher in preterm neonates of hypertensive mothers.Conclusions: Cord blood lipid levels were significantly deranged in newborns of hypertensive mothers. This helps us in providing the target population at risk and cord blood lipid profile of newborn serving as an indirect guide for lifestyle modifications and helping in early intervention and prevention of future coronary heart disease.

scholarly journals Serum and Urine ANGPTL8 Expression Levels are Associated with Hyperlipidemia and Proteinuria in Primary Nephrotic Syndrome

2020 ◽  
Author(s):  
Xia Gao ◽  
Qingju Liu ◽  
Chengdong Kang ◽  
Weijing Cui ◽  
Zichuan Xu ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Healthy Controls ◽  
Mesangial Proliferative Glomerulonephritis ◽  
Lipid Levels ◽  
Primary Nephrotic Syndrome ◽  
Serum And Urine ◽  
Blood Lipid Levels

Abstract Background: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlationwith hyperlipidemia and proteinuria.Methods: ANGPTL8 levels were determined using Enzyme‑linked immunosorbentassay in 133 subjects with PNS, and 60 subjects with healthy controls.Results: Subjects with primary nephrotic syndrome had higher levels of serum andurine ANGPTL8 than healthy controls subjects (P < 0.001). In primary nephroticsyndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r =0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while no correlation with24hUTP. Urine ANGPTL8 was positively correlated with high density lipoprotein-cholesterol (r = 0.181, P < 0.05), while urine ANGPTL8 was significantly negativelycorrelated with creatinine (r = -0.323, P<0.001) and 24hUTP (r = -0.268, P = 0.002).Interestingly, urine ANGPTL8 concentrations were different between membranousnephropathy and mesangial proliferative glomerulonephritis pathological types.Conclusions: Serum and urine ANGPTL8 levels in primary nephrotic syndromepatients were correlated with blood lipid levels and proteinuria, respectively, suggestingthat ANGPTL8 may play a role in the development of primary nephrotic syndromehyperlipidemia and proteinuria.

scholarly journals Prevalence of dyslipidemia and associated risk factors among adult residents of Shenmu City, China

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250573
Author(s):  
Huiping Gao ◽  
Haiying Wang ◽  
Guangliang Shan ◽  
Rui Liu ◽  
Haiyuan Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Cerebrovascular Diseases ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Lipid Levels ◽  
Blood Lipid Levels

Objective Dyslipidemia is a leading risk factor for cardiovascular and cerebrovascular diseases. By collecting the blood lipid profiles among adult residents of Shenmu City in Shaanxi Province, China, we aim to assess and elucidate the prevalence and risk factors of dyslipidemia in this city. Method Stratified multistage sampling was used to survey 4,598 permanent adult residents in five areas of Shenmu (2 communities in the county seat, 2 in the southern area and 2 in the northern area) from September 2019 to December 2019. Questionnaire surveys and physical examinations were conducted. Data were analyzed using SPSS software version 26.0. Results The average level of total cholesterol (TC) is 4.47mmol/L, that of triglyceride (TG) 1.32mmol/L, high-density lipoprotein cholesterol (HDL-C) 1.27mmol/L, apolipoprotein A1 (ApoA1) 1.44g/L, low-density lipoprotein cholesterol (LDL-C) 2.7mmol/L and apolipoprotein B (ApoB) 0.97g/L. The prevalence of hypercholesterolemia (HTC), hypertriglyceridemia (HTG), low high-density lipoprotein (HDL-C) and high low-density lipoprotein (LDL-C) is 22.4%, 33.3%, 14.5%, and 5.81%, respectively, and the overall prevalence of dyslipidemia is 48.27%. Furthermore, blood lipid levels and prevalence of dyslipidemia vary by region, age, gender, occupation and educational level. Nine risk factors of dyslipidemia were identified, which are living in county seat or northern industrial area, increasing age, male, overweight or obesity, abdominal obesity, smoking, hypertension, abnormal glucose metabolism (pre-diabetes or diabetes) and hyperuricemia. Conclusion The blood lipid levels and dyslipidemia prevalence of adults in Shenmu City are higher comparing to national averages of China. Combining risk factors of dyslipidemia, early detection and public health interventions are necessary in high-risk population for associated cardiovascular and cerebrovascular diseases prevention.

Comparison of Volatile Compounds in Raw and Cooked Chinese Mitten Crab Hepatopancreas and Gonads

2014 ◽  
Vol 941-944 ◽  
pp. 1040-1044 ◽  
Author(s):  
Xian Chu Gao ◽  
Sai Qi Gu ◽  
Xi Chang Wang ◽  
Ning Ping Tao ◽  
Jing Zhuang ◽  
...  
Keyword(s):  
Volatile Compounds ◽  
Gas Chromatography Mass Spectrometry ◽  
Chinese Mitten Crab ◽  
Active Compounds ◽  
Male And Female ◽  
Mitten Crab ◽  
Significant Difference ◽  
Crab Hepatopancreas ◽  
New Type ◽  
Edible Parts

The volatile compounds in different edible parts (gonads, hepatopancreas) of raw and cooked Chinese mitten crab were extracted by a new type material (MonoTrap) and analyzed by gas chromatography-mass spectrometry (GC-MS). Totally 97 volatile compounds were identified by GC-MS and their odor characteristics were analyzed by ROAV values screen. There is a significant difference of odor-active compounds between male and female Chinese mitten crab. What’s more, the results indicated that the varieties and contents of volatile compounds in hepatopancreas were greater than in gonad. The results of ROAV values screen were summarized, 15 odor-active compounds whose ROAV values greater than 0.1and 9 key odor-active compounds whose ROAV values greater than 1 were further selected. The results indicated that decanal, trimethylamine, nonanal were the key odor-active compounds in hepatopancreas and gonads.

scholarly journals Effect of Baduanjin exercises on elevated blood lipid levels of middle-aged and elderly individuals: protocol for a systematic review and meta-analysis of randomised controlled trials

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017213 ◽  
Author(s):  
Junmao Wen ◽  
Tong Lin ◽  
Chenguang Jiang ◽  
Rui Peng ◽  
Wei Wu
Keyword(s):  
Randomised Controlled Trials ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Elevated Blood ◽  
Lipid Levels ◽  
Middle Aged ◽  
Elderly Individuals ◽  
Funnel Plot ◽  
Randomised Controlled ◽  
Blood Lipid Levels

ObjectiveTo assess the safety and effect on elevated blood lipid levels of Baduanjin exercises in middle-aged and elderly individuals.MethodsA systematic literature search for articles up to March 2017 will be conducted using seven databases: PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Science and Technology Periodicals Database, Chinese BioMedical Database and Wanfang Data. Inclusion criteria are randomised controlled trials of Baduanjin exercises that examine blood lipid levels in middle-aged and elderly individuals. The primary outcome measures will be total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol. Stata V.13.0 software will be used for data synthesis, sensitivity analysis, metaregression, subgroup analysis and risk of bias assessment. A funnel plot will be developed to evaluate reporting bias and Begg and Egger tests will be used to assess funnel plot symmetries. We will use the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of evidence.Ethics and disseminationThis systematic review will be submitted to a peer-reviewed journal. Our findings will provide information about the safety of Baduanjin exercises for middle-aged and elderly individuals and their effect on elevated blood lipid levels.Trial registration numberPROSPERO CRD 42017060613.

scholarly journals Study in the Effect of Yavavati in the Management of Dyslipidemia

2020 ◽  
Vol 11 (2) ◽  
pp. 265-270
Author(s):  
Tejas Laxman Kakade ◽  
Sadhana Misar Wajpeyi
Keyword(s):  
Total Cholesterol ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Female Gender ◽  
Lipid Levels ◽  
Causative Factors ◽  
Lukewarm Water ◽  
Blood Lipid Levels

Dyslipidemia is considered as metabolic disorders related to lipoprotein metabolism, manifested as rise in plasma levels of total Cholesterol, Triglyceride (TGs), or both, or a decrease in high density lipoprotein level or all three together that contributes to the formation of atherosclerosis. It can be included under santarpanjanyavyadhi. Various conditions like Shonitabhishyandana, Rasagata SnehaVriddhi (raised plasma lipid levels), Rasaraktagata Snehavriddhi (raised plasma and blood lipid levels), Medovriddhi (elevation of generalized fat), Medoroga (obesity), Aam Medodhatu (abnormal form of adipose tissue) can be correlated with Dyslipidemia due to resemblance of their etiopathogenesis and clinical features. Total 30 patients of dyslipidemia fulfilling the diagnostic criteria were selected and treated with Yavavati 1.5 gm twice a day before meal with lukewarm water for 30 days. In this study it was observed that incidence of  Dyslipidemia was more in advanced ages,female gender, middle socioeconomic group individuals having vatapittajaprakruti, madhyamagni and madhyamaakruti. In present study, sedentary lifestyle, day sleep, association of other diseases like hypertension, DM, hypothyroidism and hemiplegia are the main causative factors for Dyslipidemia. Yavavati showed significant improvement in BMI, total cholesterol, S.Triglicerides, S.VLDL and HDL level. This improvement may be due to its ruksha, lekhana, kaphamedahar, agnivadhaka and apatarpana properties of Yavavati. Hence from this study it can be concluded that, Yavavati is effective and can be safely used in the management of Dyslipidemia.

scholarly journals Polygenic Risk Score Modifies Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol

2020 ◽  
Author(s):  
Alessandro Bolli ◽  
Paolo Di Domenico ◽  
Roberta Pastorino ◽  
George Busby ◽  
Giordano Bottà
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Polygenic Risk Score ◽  
Lipid Levels ◽  
Polygenic Risk ◽  
Artery Disease ◽  
Cad Risk ◽  
Blood Lipid Levels

AbstractBackgroundAn individual’s lifetime risk of Coronary Artery Disease (CAD) is determined by a combination of genetic and lifestyle factors. Whilst adherence to a healthy lifestyle can help individuals with high genetic risk reduce their lifetime risk of CAD, the extent to which blood lipid levels affect CAD risk in individuals with varying genetic risk remains unknown. To explore how genetics, blood lipids and CAD risk interact, we derived a novel genome-wide polygenic risk score (PRS) for CAD. We then applied the PRS to individuals from the UK Biobank and divided them into Low PRS (bottom 10 percentiles of PRS distribution), Intermediate PRS (PRS in the 10th-90th percentiles), and High PRS (top 10 percentiles), and further stratified individuals by blood lipid levels.ResultsWe found that the elevated CAD risk conferred by high low-density lipoprotein cholesterol (LDL-C) was modified by the interaction with PRS (P-value interaction: <0.005). Individuals with High PRS and whose LDL-C was Borderline (between 130 and 160 mg/dL) had higher CAD relative risk (HR 3.10; 95% CI, 2.55-3.76) than those at Intermediate PRS whose LDL-C were Very High (>190 mg/dL; HR 2.77; 95% CI, 2.33-3.28). Furthermore, individuals with High PRS but whose lipid levels were below the following thresholds did not have a significantly increased risk for incident CAD: LDL-C <130 mg/dL, total Cholesterol (TC) <200 mg/dL, LDL-C:HDL <2.0 and TC:HDL <3.0. In addition, individuals with Low PRS and Very High LDL-C (>190 mg/dl) did not have increased CAD risk, which was comparable to individuals with Intermediate PRS and Optimal LDL-C (<130 mg/dL).ConclusionsOur results have important implications for the primary prevention of coronary artery disease. Currently, healthy individuals with Borderline LDL-C (130-159 mg/dL) are not considered to be at high risk of CAD. Here we demonstrate that the combination of Borderline LDL-C and High PRS results in CAD relative risk which is greater than individuals without high polygenic risk, but whose LDL-C levels are high enough for statins to be recommended (>190 mg/dL). This analysis therefore demonstrates that PRS can identify a proportion of the population who are at high-risk of CAD but who are invisible to current approaches for assessing CAD risk. Moreover, of perhaps greater significance is the evidence that individuals who have a combination of High PRS and Optimal blood lipid levels do not have greater risk of CAD than individuals without high polygenic risk and the same Optimal blood lipid levels. Our results suggest that high polygenic risk for CAD could be overcome by controlling blood lipid levels. We propose that incorporating PRS into CAD risk assessment early in life could allow individuals at high polygenic risk to benefit from tailored blood lipid guidelines and avoid lifetime exposure to potentially damaging PRS-dependent LDL-C levels.

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