scholarly journals Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Allison E Hamilos ◽  
Giulia Spedicato ◽  
Ye Hong ◽  
Fangmiao Sun ◽  
Yulong Li ◽  
...  

Clues from human movement disorders have long suggested that the neurotransmitter dopamine plays a role in motor control, but how the endogenous dopaminergic system influences movement is unknown. Here we examined the relationship between dopaminergic signaling and the timing of reward-related movements in mice. Animals were trained to initiate licking after a self-timed interval following a start-timing cue; reward was delivered in response to movements initiated after a criterion time. The movement time was variable from trial-to-trial, as expected from previous studies. Surprisingly, dopaminergic signals ramped-up over seconds between the start-timing cue and the self-timed movement, with variable dynamics that predicted the movement/reward time on single trials. Steeply rising signals preceded early lick-initiation, whereas slowly rising signals preceded later initiation. Higher baseline signals also predicted earlier self-timed movements. Optogenetic activation of dopamine neurons during self-timing did not trigger immediate movements, but rather caused systematic early-shifting of movement initiation, whereas inhibition caused late-shifting, as if modulating the probability of movement. Consistent with this view, the dynamics of the endogenous dopaminergic signals quantitatively predicted the moment-by-moment probability of movement initiation on single trials. We propose that ramping dopaminergic signals, likely encoding dynamic reward expectation, can modulate the decision of when to move.

Author(s):  
Allison E. Hamilos ◽  
Giulia Spedicato ◽  
Ye Hong ◽  
Fangmiao Sun ◽  
Yulong Li ◽  
...  

SUMMARYDeciding when to initiate action is essential to survival. Insights from movement disorders and pharmacological studies implicate the neurotransmitter dopamine as a regulator of movement timing, but the underlying neural mechanisms are not understood. Here we show dynamic dopaminergic signaling over seconds-long timescales controls movement timing in mice. Animals were trained to initiate licking after a self-timed interval following a start-timing cue. Surprisingly, dopaminergic signals ramped-up slowly between the start-timing cue and the self-timed movement, with the slope predicting the movement time on single trials. Steeply rising signals preceded early lick-initiation, whereas slowly rising signals preceded later initiation, reminiscent of a ramp-to-threshold process. Higher baseline activity also predicted earlier self-timed movements. Optogenetic activation of dopamine neurons during self-timing caused systematic early-shifting of movement initiation, whereas inhibition caused late-shifting. These results reveal a causal role for dynamic dopaminergic signaling unfolding over seconds in controlling the moment-by-moment decision of when to move.


Author(s):  
Ricky Wilson ◽  
Matt Dicks ◽  
Gemma Milligan ◽  
Jamie Poolton ◽  
David Alder

This study examined the anticipation responses of twenty skilled youth players who were assigned to either a change of direction (CODG) or small-sided games group (SSGG). Action capabilities were assessedviaa countermovement vertical jump (CMVJ), 20 m sprint, 5 m acceleration and arrowhead change of direction (COD) test. Anticipation was measuredviaa soccer-specific anticipation test (SSAT), which required participants to anticipate the actions of an opposing player and intercept a pass. Pre- and post-intervention testing procedures were identical for both groups. Following training there was an overall improvement in CMVJ performance (p < 0.05,r = 0.52) for both training groups and this improvement was correlated with movement initiation in the SSAT (r = 0.61,p < 0.05). The novel findings of this study highlight that different training modes can potentially have a positive impact on anticipation performance. Further investigation focussing on an examination of the relationship between training, anticipation, and action capabilities in sport is warranted for the development of research and applied perspectives in expertise.


Author(s):  
Gushchin

Luhmann's theory of double distinction is a cross-cutting theme that runs through the entire sociological heritage of the outstanding German sociologist. Since this theory is not a subject of sociology and goes far beyond its scope, it is natural that its essential consideration does not have to be sociological. In this regard, in the process of studying Luhmann's texts, one way or another, a contradiction arises between the collaboration representing the problem and the problem itself.  What is its essence in short? We distinguish between something as such in itself — singular and indivisible, without experiencing any existential difficulties.  But as soon as we intend to discern the very distinction, we immediately find ourselves in a turbulence of forms and identifications, measures and dimensions, along the way losing our own, once unshakable, observer position. A situation of uncertainty arises, pushing towards this or that choice, to this or that commitment as to something definite. Luhmann seeks to overcome the intention of commitment. The result is a dynamic panorama of continuously related distinctive acts.  This is perhaps the most difficult passage not only in Luhmann, but also in the theory of distinction in his double dynamic perspective.  The difficulty is to describe how it is possible to relate to what is itself as a result of the relationship. According to Luhmannany definite differentiated — is act in act, movement within movement, time within time, subject within subject, life in life, relationship within relationship, etc. No matter what we are talking about, we are always talking about a double perspective of differentiation. Luhmann seeks to clarify the essence of the relation in relation as the possibility of explication of what itself makes explicit. This opportunity Luhmann calls autopoiesis, in which the unity of distinctive acts finds its higher dynamic expression. The «stumbling block» that the theory of autopoiesis constantly «stumbles over» is not so much the fact that they want to find autopoiesis in applied empirical research, but rather the fact that at the moment of its discrimination, the very correlation of discrimination itself changes dramatically. Here there is no longer a return to the previous arguments, the development of a new context is constantly required, the grounds change many times. A few words about the method of presenting subject. In the process of writing the article, I had to make abstraction from specifically Luhmann's theoretical statements and «translate» the language of interpretation into the language of the version. We wanted not only to cover the scope of penetration into the problem of Luhmann's double distinctions, but also to approach it in my own way, as much as possible, at an extremely close distance. The task turned out to be twofold, in connection with which the so-called proposed by us was applied the formula for the relevance of the study, which would most likely be supported by a German sociologist: «author's interpretation» + «interpreter's version» = «lively response of understanding». Otherwise, we would have found ourselves in captivity exclusively to the author's system, unforgivably losing sight of the restless pulsation of the essence under study.  Throughout his entire scientific path, Luhmann not only struggles with all sorts of signs of a strictly determined system — it is more a consequence than a goal — he with enviable constancy tries to free the dynamic unity of distinctive acts from rigid conceptual and theoretical structures in order to reveal in him his relict permanent self-movement at the risk of being misunderstood by their professional community. Inspiring those who are sensitive to the grasp of thought, regardless of the rubrics that claim it.


2017 ◽  
Vol 16 (02) ◽  
pp. 653-665 ◽  
Author(s):  
NIMA BASSIRI

In a recent forum contribution to the American Historical Review on the relationship between history and biology, Lynn Hunt proposed that the future of academic scholarship devoted to exploring the origins and development of modern selfhood would depend on the disciplinary alliance between history and neuroscience. Tabling, for the moment, the cogency of her central assertion, we can nevertheless agree that Hunt espouses a sentiment shared by many historians: “the question of the self is a huge and difficult subject on its own,” she writes, and historical analysis of some sort can help us make better sense of it. The effort to do precisely that over the past several decades, through a variety of historiographic approaches, has engendered a remarkably sizable corpus of writings on the history and conceptual development of the modern, typically Western, self.


2021 ◽  
Vol 27 (3) ◽  
pp. 339-347
Author(s):  
Nathalie Barbosa de la CADENA

In this article I intend to highlight how the relationship between psychic subject and spiritual subject is fundamental for the understanding of intersubjectivity and the life world (Lebenswelt). In Ideas II, Husserl explains how, from the self, subject and object are constituted in the world: nature, soul and spirit. These three strata of the being are known from the theoretical attitude and the spiritual attitude and, in the process, the self is explicit. In a theoretical attitude we have nature's constitution, for which the body (Körper / Leib) is fundamental. Then the constitution of objects of animic nature, human or animal, including self-perception. Assuming the spiritual attitude, the other is perceived (Urpräsenz) initially as a body together with things, and beside this perception there is an apprehension (Appräsenz) of co-given horizons. There is an identity between the body of others and mine, it is the moment of empathy (Einfühlung). The world constituted from a naturalistic or theoretical attitude is a reduction of the surrounding world (Umwelt), but the everyday world of the personalistic or spiritual attitude precedes it, the life-world (Lebenswelt). It is therefore through the personalistic or spiritual attitude that a community of spiritual subjects is constituted. Palavras-chave : Husserl; Soul; Spirit; Intersubjectivity; Life-world.


2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.


2011 ◽  
Vol 5 (2) ◽  
pp. 297-332
Author(s):  
Kate Zebiri

This article aims to explore the Shaykh-mur?d (disciple) or teacher-pupil relationship as portrayed in Western Sufi life writing in recent decades, observing elements of continuity and discontinuity with classical Sufism. Additionally, it traces the influence on the texts of certain developments in religiosity in contemporary Western societies, especially New Age understandings of religious authority. Studying these works will provide an insight into the diversity of expressions of contemporary Sufism, while shedding light on a phenomenon which seems to fly in the face of contemporary social and religious trends which deemphasize external authority and promote the authority of the self or individual autonomy.


2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Ritu ◽  
Madhu Anand

Parental Modernity is an important aspect for the psycho-social development of the child. The present study aims to study the effect of parental modernity on rejection sensitivity and self-esteem of adolescents and the relationship between rejection sensitivity and self-esteem. The research is carried out on a sample of 240 parents (including 120 fathers and 120 mothers) and their 120 children. For observing the impact of modernity of parents on their children, Individual Modernity Scale was used and administered on father and mother. Rejection Sensitivity Questionnaire and Self-Esteem Inventory were used to measure the rejection sensitivity and self-esteem of children (age ranges from 14 to 19 years). The results suggest that parental modernity has an effect on the rejection sensitivity and personally perceived self of the self – esteem of adolescents. Furthermore, the rejection sensitivity has been found negatively associated with self-esteem.


2020 ◽  
Author(s):  
Adam Wiesner

With a conscious attempt to contribute to contemporary discussions in mad/trans/queer/monster studies, the monograph approaches complex postmodern theories and contextualizes them from an autoethnographic methodological perspective. As the self-explanatory subtitle reads, the book introduces several topics as revelatory fields for the author’s self-exploration at the moment of an intense epistemological and ontological crisis. Reflexively written, it does not solely focus on a personal experience, as it also aims at bridging the gap between the individual and the collective in times of global uncertainty. There are no solid outcomes defined; nevertheless, the narrative points to a certain—more fluid—way out. Through introducing alternative ways of hermeneutics and meaning-making, the book offers a synthesis of postmodern philosophy and therapy, evolutionary astrology as a symbolic language, embodied inquiry, and Buddhist thought that together represent a critical attempt to challenge the pathologizing discursive practices of modern disciplines during the neoliberal capitalist era.


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