scholarly journals Development, Evaluation and Safety Aspect of Enriched Weaning Food from Cereal, Legume and Vegetable

2021 ◽  
pp. 77-90
Author(s):  
Iwanegbe Izuwa

This study examined the development, evaluation and safety aspect of enriched weaning food from cereal, legume and vegetable. Maize was fermented, soybean was defatted and carrot was sliced, and all were processed to flour. The flours were formulated to blends. Laboratory analysis were done such as proximate, minerals, haematology and lipid studies of rat fed both formulated and commercial diets as well as the growth and feed intake of the rats. The data obtained were analyzed. The results showed that the moisture content observed was low ranging from 5.07% -12.91%. The lowest moisture (5.07%) was defatted soybean flour; this was followed by fermented maize flour (9.71%) while the highest moisture (12.91%) was seen in carrot powder. Carrot had the highest Ca (5850.0ppm), followed by defatted soybean (4700ppm), the least was maize (2900ppm). The highest count for white blood cell (WBC) was observed in rat fed rat pellet ie diet G (11.8x109). The high density lipoprotein (HDL) of rats fed different diets ranged from 31 to79mg/dl with group F (31.0 mg/dl) and C (79 mg/dl) which had the lowest and highest HDL respectively. At day 4, the highest (62.20g) feed intake was observed for rats that fed on diet C, next B (60.70 g), diet D (54.20 g), diet G (53.20 g), diet E (45.10 g), diet F (43.80 g). The least feed intake was diet A (39.6 g) in that decreasing order. This study has showed that diet C was outstanding among the diets and should be used to improve the body weight of infant, increased the HDL, reduced LDL, improves haematological parameters and improves nutritional qualities.

Author(s):  
Pablo A. Scacchi Bernasconi ◽  
Nancy P. Cardoso ◽  
Roxana Reynoso ◽  
Pablo Scacchi ◽  
Daniel P. Cardinali

AbstractCombinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats, the increase in blood pressure (BP) after diet manipulation is sex related and highly dependent on testosterone secretion. However, the extent of the impact of diet on rodent hypophysial-testicular axis remains undefined. In the present study, rats drinking a 10% fructose solution or fed a high-fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, without significant changes in circulating follicle-stimulating hormone or the weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an intraperitoneal glucose tolerance test (IPGTT), and plasma low-density lipoprotein cholesterol, cholesterol, triglycerides, and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high-fat-fed rats. Rather, melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT, and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequelae of rodent MS.


2014 ◽  
Vol 6 (4) ◽  
pp. 119 ◽  
Author(s):  
A. Annongu ◽  
O. R. Karim ◽  
A. A. Toye ◽  
F. E. Sola-Ojo ◽  
R. M. O. Kayode ◽  
...  

Chemical composition of Moringa oleifera seeds obtained from the middle belt of Nigeria, Benue State, was determined and the seed was blended to form a seed meal. The Moringa oleifera Seed Meal, MOSM was included in diets at graded levels of 2.50, 5.00 and 7.50% and the dietary performance of the broiler chicks on the test diets was compared with that of a corn-soy reference diet. Results on the chemical/nutritional composition of MOSM showed that the full-fat seeds contained (%) on proximate basis, reasonable concentration of 90.38 dry matter, 25.37 crude protein, 14.16 crude fat, 4.03 mineral matter, 30.64 crude fiber, 25.80 soluble carbohydrate and 5.79 kcal/g gross energy. Analyses also gave appreciable quantities of the water and fat soluble vitamins, macro - and micro-minerals. Feeding chicks with the seed meal at graded levels in diets resulted in decrease in feed intake and body weight gain as the inclusion level increased in diets relative to the conventional diet (p < 0.05). Reduction in feed consumption could be attributed to the full-fat nature of the seed meal used which might have imparted extra-caloric effect in the test diets and slowed digestion and absorption as the analyzed nutrients content of diets. A higher ether extract value on Moringa based diets relative to the control diet was obtained. Phytochemical composition of Moringa namely phenols including tannins, saponins, phytate, cyanogenic glucoside, glucosinolates and other numerous chemical constituents affected the body weight of the chicks negatively with increasing dietary MOSM. Decrease in weight gain following increase in dietary seed meal could also be due to decrease in feed intake as a result of the bitter taste of alkaloids, saponins, acting in concert with the other Moringa phytotoxins in test diets. Survival rate (100%) was not affected indicating that the level of highest inclusion in this study (7.50%) was not fatal to the experimental animal models. Further research is progressing to ascertain the highest inclusion level possible to elicit fatality and attempts to detoxify or treat the seed meal before feeding to animals.


2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Mahsa Maroofi ◽  
Javad Nasrollahzadeh

Abstract Background Intermittent calorie restriction (ICR) is a novel method of dietary restriction for body weight control with the potential to improve obesity-related cardiometabolic markers, but the impact of this diet on subjects with hypertriglyceridemia (HTG) remains unknown. Methods Eighty-eight subjects with overweight or obesity and mild-to-moderate HTG were randomized to the continuous calorie restriction (CCR) group, or ICR group (a very low-calorie diet during 3 days of the week) for 8 weeks (44 patients in each group). Body composition, plasma lipids, glucose, insulin, adiponectin, and liver enzymes were measured at baseline and after 8 weeks. An intention-to-treat analysis was performed. Results The body weight decreased in both groups (4.07 ± 1.83 kg in the CCR group and 4.57 ± 2.21 kg in the ICR group) with no significant difference between the groups. There was no significant difference between the two groups in the reduced amount of fat mass, fat-free mass, and waist circumference. Both groups achieved a significant reduction in plasma triglycerides after 8 weeks (by 15.6 and 6.3% in ICR and CCR groups, respectively) with no difference between treatment groups. HOMA-IR improved significantly in ICR compared to the CCR group (P = 0.03). Plasma glucose, insulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, liver enzyme, and adiponectin were not different between the two groups. Conclusions The results of this short-term study suggest that three-days a week of the ICR is comparable to a CCR diet for the reduction of triglycerides level in patients with HTG and in the short-term it appears to be more effective than continuous dieting in improving insulin resistance. However, longer-term studies are needed to confirm these findings. Trial registration Trial registration number:NCT04143971.


1985 ◽  
Vol 58 (2) ◽  
pp. 500-505 ◽  
Author(s):  
R. Bulbulian ◽  
K. K. Grunewald ◽  
R. R. Haack

The purpose of this study was to examine the effects of daily exercise of varying duration on the body composition, weight, and feed intake of mature Swiss albino mice. Fifty-four male mice were equally divided into a control group and five exercise groups (n = 9) performing 20, 40, 60, 120, and 240 min of daily exercise on a treadmill (7.2 m/min). Feed intake and body weight were measured weekly for 10 wk. At the completion of the study the mice were killed and the animal carcasses were chemically analyzed for fat, dry matter, and protein content. The results of this study demonstrate no differences in the body weight among groups (P less than 0.97) with all groups gaining 4.5–5.8 g during the 10-wk period. However, fat content decreased significantly from 15.7% in the control to 12.0% in the 120- and 240-min exercise groups (P less than 0.05). In contrast, protein content showed an insignificant rising trend from 13.0 to 14.6% with increasing duration of exercise. Feed intake showed a nonsignificant drop during the 20-min exercise treatment and remained unchanged among groups. These data show a slight but variable appetite-suppressing effect of light exercise in mice accompanied by favorable body composition changes even in the absence of differences in body weight. These findings suggest the mouse to be an acceptable experimental model for body composition and exercise studies.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Abdulfatai Ojewale ◽  
Sanusi Mada ◽  
Samson Oyebadejo ◽  
Adam Afodun ◽  
Okikioluwa Aladeyelu ◽  
...  

Diabetes mellitus has developed into one of the debilitating diseases disturbing the health of many people living with cardiovascular diseases in modern times. The root of Ageratum conyzoides was investigated for its effects on alloxan-induced diabetic Wistar rats’ cardiac tissues. Thirty-two (32) Wistar rats weighing between 180 and 190 g were randomly divided into four groups. The animals in groups B-D were induced with a single dose of 150 mg/kg body weight of alloxan (ALX) intraperitoneally. They were confirmed hyperglycemic after 72 hours of induction and then sustained in hyperglycemic condition for 2 weeks. Animals in groups C and D received AC intervention, as stated above, for four weeks. The body weight of the experimental animals and blood collection for glucose estimation were taken weekly for six weeks using appropriate instruments. Biochemical assays for lipid profile, antioxidant enzymatic, and nonenzymatic markers were carried out. Histopathological changes in the cardiac tissues were also studied. Administration of 150 mg/kg of ALX to experimental rats induced diabetes and significantly reduced the body weights, significantly ( p < 0.05 ) increased the glucose level, triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, and decreased the levels of high-density lipoprotein (HDL) and antioxidant enzymatic markers such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) while the antioxidant nonenzymatic marker such as malondialdehyde (MDA) level was significantly increased. By contrast, rats given the ethanolic extract root of A. conyzoides had significantly ( p < 0.05 ) increased the body weight gain, whereas the glucose levels significantly ( p < 0.05 ) improved in treated diabetic rats. This extract also improved the cardiovascular system of the diabetic rats by significantly decreasing TG and LDL levels, significantly ( p < 0.05 ) increasing the HDL level, significantly reducing the cardiac contents of CAT, SOD, and GPx, and significantly ( p < 0.05 ) decreasing MDA. Ethanolic extract root of A. conyzoides exhibited antihyperglycemic and antihyperlipidemic activities and mitigates damage to the heart from the ALX-induced myocardial toxicity associated with type-1 diabetes.


2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Xiao-Yan Wang ◽  
Xue-Lan Song ◽  
Yi Zhang ◽  
Gan Luo ◽  
Hai-Chuan Tai ◽  
...  

Schisandrae Fructus (SF), the fruit of Schisandra chinensis (Turcz.) Baillon, has been used for the treatment of liver injury and metabolism-related disorders in China. The objective of this study was to investigate the effects of supplementation with ethanol extract of SF seed (EtSF-S) on serum/hepatic lipid and glucose levels as well as fecal total cholesterol (TC) contents in mice fed a normal diet (ND) or high-fat/fructose diet (HFFD) containing 15% lard oil and 15% fructose. Female ICR mice (18–20 g in body weight) were fed with ND or HFFD for 3 months, and then EtSF-S was added to both chow diets at increasing concentrations of 1, 5, and 10% (w/w). Thirty days later, serum and hepatic lipids, including TC, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and glucose, were measured. Dietary supplementation with EtSF-S reduced hepatic TC (36 and 18%) and TG levels (38 and 28%) and increased serum HDL/LDL ratio (16 and 26%) in both ND- and HFFD-fed mice, respectively. Moreover, supplementation with EtSF-S elevated serum HDL (31%) in HFFD-fed mice and reduced serum LDL (27%) in ND-fed mice. EtSF-S treatment reduced fat mass (40%) in ND-fed mice and increased fecal TC contents (33%) in HFFD-fed mice. EtSF-S supplementation decreased hepatic glucose contents (29%) in both ND- and HFFD-fed mice. However, diet supplemented with EtSF-S elevated serum TG levels (up to 123%) and hepatic size (28%), but more importantly, suppressed the body weight gain (approximately 130%) in mice fed with HFFD. These findings suggested that dietary supplementation with EtSF-S as natural herbal function food may be a useful strategy for the treatment of patients with fatty liver disease or overweight without a high intake of sugar and fat.


Author(s):  
E. B. Umoren ◽  
J. F. Ekpenyong ◽  
O. E. Oyama ◽  
A. O. Obembe

Aim of the Study: This study was undertaken to ascertain if Hibiscus sabdariffa extract can affect the lipid profile (Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL)) levels in a paracetamol- induced hepatotoxicity using albino Wistar rat as a model. Materials and Methods: Thirty (30) rats used for this study were divided into three groups. Group A (n=10) served as control. Group B (n=10) was administered paracetamol only at a dose of 750 mg/kg body weight. Group C (n=10) was administered paracetamol (dose 750 mg/kg body weight) and aqueous extract of H. sabdariffa (dose 10 ml/kg body weight) of the animal for 3 weeks. All animals were allowed free access to clean drinking water and normal rat chow. Results: Results of the study revealed that TC was significantly lower (p<0.05) in the paracetamol + H. sabdariffa-treated group as compared to paracetamol-treated group and control respectively. Similar trend was observed with TG, VLDL-c, LDL-c and HDL-c. However, the decrease in HDL-c was not statistically significant when compared to control. Conclusion: The presence of bioactive constituents vis; anthocyanins, flavonoids, polyvenols and free radical scavenging properties in H. sabdariffa enabled a hypolipidemic effect on the animals by lowering the levels of serum TG, VLDL-c, LDL-c despite challenge on the liver. However, it was unable to produce significant effect on HDL concentration -very important cholesterol required in high level to maintain homeostasis inside the body. This may be due to the challenge on the liver as a result of the paracetamol abuse.


2021 ◽  
Vol 12 (3) ◽  
pp. 554-563
Author(s):  
M. A. Lieshchova ◽  
A. A. Bohomaz ◽  
V. V. Brygadyrenko

Phytotherapy for the correction of excess body weight is widely used. However, a comprehensive study of herbal preparations on the organism of model animals has been carried out only for a few plant species. Supplementing the diet of rats with closely related sage species (Salvia officinalis L. and S. sclarea L.) against the background of high-fat hypercaloric diet triggered multidirectional changes in their metabolism. The addition of crushed dry shoots of S. officinalis to the diet of animals led to a sharp increase in their body weight (up to 130.8% of the initial one in 30 days of the experiment). The body weight of the rats treated with S. sclarea for 30 days increased only up to 103.8% of their initial weight and was lower than in the control group. Addition of S. officinalis caused an increase in daily weight gain up to 253.1% of the control group, and S. sclarea – its decrease to 27.8% of the daily weight gain in the control group. In the S. officinalis group, the relative weight of the brain, spleen, and thymus decreased, while in the S. sclarea group, the relative weight of the thymus decreased and that of the colon increased. Under the influence of S. officinalis, the concentration of urea, total bilirubin, and triglycerides in the blood plasma of male rats decreased and the concentration of total protein and the activity of alkaline phosphatase increased. While consuming S. sclarea shoots, there was an increase of alkaline phosphatase activity in the rats’ blood, but atherogenic index (23.1% of the level of the control group) sharply dropped due to an increase in the concentration of high-density lipoprotein cholesterol (286.9% of the control) and a decrease in the concentration of low-density lipoprotein cholesterol (67.7% of control). In rats feeding on S. sclarea shoots, we observed a decrease in the concentration of triglycerides in the blood (39.9% of the control), a decrease in the activity of gamma-glutamyl transferase (62.8%), and an increase in the Ca/P ratio (132.5% of the control group). No significant changes were observed in CBC and WBC differential of male rats when eating S. officinalis and S. sclarea shoots. According to the results of the open field test, the physical and orientational activity of male rats under the influence of S. officinalis significantly decreased by the end of the experiment. Emotional status of rats, on the contrary, decreased when they ate dry crushed shoots of S. sclarea in the composition of the food. Thus, excess body weight of rats in the conditions of hypercaloric diet led to more pronounced deviations from the norm while consuming dry crushed shoots of S. officinalis. The addition of S. sclarea dry crushed shoots to the animals’ diet normalized the body weight in comparison with the control group, reduced the negative manifestations of obesity at the biochemical and organismal levels. In this regard, the substances that contains S. sclarea should be carefully studied for anti-atherosclerotic activity, and tea supplemented with S. sclarea shoots can be recommended as a corrective supplement in the diet of overweight people.


2021 ◽  
Vol 12 ◽  
Author(s):  
Azmat Rozjan ◽  
Weibi Shan ◽  
Qiaoling Yao

ObjectiveThis study aims to investigate whether hypoxia-inducible factor 1α (HIF1α) in the neurons of the mediobasal hypothalamus is involved in the regulation of body weight, glucose, and lipid metabolism in mice and to explore the underlying molecular mechanisms.MethodsHIF1αflox/flox mice were used. The adeno-associated virus that contained either cre, GFP and syn, or GFP and syn (controls) was injected into the mediobasal hypothalamus to selectively knock out HIF1α in the neurons of the mediobasal hypothalamus. The body weight and food intake were weighed daily. The levels of blood glucose, insulin, total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein (HDL), and low-density lipoprotein (LDL)were tested. Intraperitoneal glucose tolerance test (IPGTT) was performed. The insulin-stimulated Akt phosphorylation in the liver, epididymal fat, and skeletal muscle were examined. Also, the mRNA expression levels of HIF1α, proopiomelanocortin (POMC), neuropeptide Y (NPY), and glucose transporter protein 4 (Glut4) in the hypothalamus were checked.ResultsAfter selectively knocking out HIF1α in the neurons of the mediobasal hypothalamus (HIF1αKOMBH), the body weights and food intake of mice increased significantly compared with the control mice (p &lt; 0.001 at 4 weeks). Compared with that of the control group, the insulin level of HIF1αKOMBH mice was 3.5 times higher (p &lt; 0.01). The results of the IPGTT showed that the blood glucose level of the HIF1αKOMBH group at 20–120 min was significantly higher than that of the control group (p &lt; 0.05). The serum TC, FFA, HDL, and LDL content of the HIF1αKOMBH group was significantly higher than those of the control group (p &lt; 0.05). Western blot results showed that compared with those in the control group, insulin-induced AKT phosphorylation levels in liver, epididymal fat, and skeletal muscle in the HIF1αKOMBH group were not as significantly elevated as in the control group. Reverse transcription-polymerase chain reaction (RT-PCR) results in the whole hypothalamus showed a significant decrease in Glut4 mRNA expression. And the mRNA expression levels of HIF1α, POMC, and NPY of the HIF1αKOMBH group decreased significantly in ventral hypothalamus.ConclusionsThe hypothalamic neuronal HIF1α plays an important role in the regulation of body weight balance in mice under normoxic condition. In the absence of hypothalamic neuronal HIF1α, the mice gained weight with increased appetite, accompanied with abnormal glucose and lipid metabolism. POMC and Glut4 may be responsible for this effect of HIF1α.


2010 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
R Adiwinarti ◽  
I P Kusuma ◽  
C M Sri Lestari

This research has been done during August 2004 - January 2005 at Laboratorium Ilmu Ternak Potong dan Kerja, Fakultas Peternakan Universitas Diponegoro Semarang. The study was set up to investigate the performance of ongole crossbred and Friesian Holstein crossbred young bulls fed concentrate and Napier grass hay. This research used 4 yearling ongole crossbred (PO) bulls with the initial body weight: 228,17 + 14,77 kg (CV = 6,47%) and 4 yearling friesian holstein crossbred (PFH) bulls with the body weight: 196,34 + 7,64 kg (CV = 3,89%). The Independent Sample Comparisons was used in this study. Those bulls were fed 30% hay of Napier grass and 70% concentrate made of “bungkil kelapa sawit” (80%) and rice bran (20%). The ration was given based on dry matter need, 2.5% of the body weight. Parameters observed were the average daily gain (ADG), feed intake (dry matter intake, crude protein intake, Total Digestible Nutrients’ 2 Sains Peternakan Vol.8 (1), Maret 2010 intake) and feed conversion. Data were analyzed using t-test; except for feed conversion was analyzed deskriptifely.The result indicated that those cattle fed concentrate and Napier grass had ADG and feed intake relatively similar. The average of ADG PO bulls were 0.21 kg and PFH bulls were 0.22 kg. Dry matter intakes of PO and PFH bulls were 3.33 kg/day and 2.83 kg/day. Crude protein intake of PO bulls were 0,45 kg/day and that of PFH bulls were 0,38 kg/day, whereas TDN intake of PO bulls were 1,93 kg/day and PFH bulls were 1,20 kg/day. Feed conversion of PO bulls was 15.86 and that of PFH bulls was 12.86. It can be concluded that the performance of Ongole crossbred and Friesian Holstein crossbred young bulls fed concentrate and Napier grass hay was similar. Those indicated that PFH bulls had productivity that was the same as PO bulls. Key words : Bulls, performance, feed intake, feed conversion


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