scholarly journals Bioprospecting Novel Bioactive Molecules from the Seaweeds in Oman

Author(s):  
Louay Labban ◽  
Amal Al Yaaqoubi ◽  
Ibrar Al Saadi ◽  
Aisha Al Kazrooni ◽  
Amira Al Jafari ◽  
...  

Seaweeds or marine macro-algae form the base for the marine ecosystems and considered as direct or indirect source of food for people across the world. Today, algae have made their way to almost all the areas of human life like food, feed, fuel, medicines etc. Marine algae provide exceptional diverse storage of bioactive compounds such as antimicrobial elements. 5 different varieties of seaweeds were collected from Salalah and they were: Ulva fasciata, Asparagopsis taxiform, Rhizoids of Jolyna laminarioide, Jolyna laminarioides and Laminaria brasiliensis. The biochemical composition of these seaweeds were determined by using several analytical techniques such as gas chromatography coupled with mass spectrometry and spectrophotometric methods. The phenolic content, antioxidant of TPC, DPPH (2,2-Diphenyl-1-Picrylhydrazyl) and FRAP analysis were measured. The results have shown a higher antioxidant activity in Brown (Rhizoids of Jolyna laminarioides) comparing with the other varieties. The antimicrobial activity of Ulva fasciataon on E. coli (G-) and Rhizoids of Jolyna laminarioides) on S. aureus (G+) was higher comparing with the control sample and the difference was significant (p < 0.05). In conclusion, this study points out the possibility of seaweeds to be used in making different products that can be employed in biotechnological, nutraceutical and pharmaceutical applications even though more investigations are required for separating, purifying and characterizing the varieties of seaweeds in Oman.

1969 ◽  
Vol 114 (2) ◽  
pp. 429-435 ◽  
Author(s):  
David J. Pillinger ◽  
John Hay ◽  
Ernest Borek

1. The ability of chemically hypermethylated Escherichia coli B transfer RNA to accept 19 amino acids was studied and the results were compared with those obtained with a control sample of E. coli B transfer RNA incubated under similar conditions in the absence of methylating agent. 2. There is a marked decrease in the ability of the modified transfer RNA to accept amino acids in almost all instances. 3. The acceptance of cysteine appears to be unique in that it is enhanced in the hypermethylated transfer RNA. 4. More detailed studies on the kinetics of acceptance for six amino acids is presented, emphasizing the variation in response of the individual amino acids. 5. Increasing hypermethylation causes a progressive decrease in the amino acid acceptance. 6. The results are discussed in terms of methylation at functional sites within the transfer RNA and possible conformational alterations to the structure of the macromolecule.


2020 ◽  
Vol 15 (1) ◽  
pp. 33
Author(s):  
Rika Istianingrum, Yunita Suryani, N Yeffa Afnita A, Siti Umi Hanik

Abstrak Kepasrahan merupakan salah satu bentuk dari eksistensi hidup manusia. Seperti pada tokoh dalam cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway yang memilih pasrah dalam memandang kematian. Tujuan penelitian dalam artikel ini untuk memberikan deskripsi perbedaan dan persamaan mengenai makna kepasrahan yang dialami seorang tokoh dalam cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway. Metode yang digunakan adalah metode deskriptif dengan analisis komparatif dengan teori psikologi sastra. Teknik pengumpulan data adalah studi pustaka dengan sumber data berupa cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway. Teknik analisis dengan deskriptif interpretatif. Hasil yang ditemukan dalam penelitian ini adalah pada kedua cerpen tersebut terdapat persamaan tema cerita yaitu kematian. Perbedaanya terletak pada karakter tokoh dalam memaknai kepasrahan dengan sikap merelakan, menerima, mengatasi sesuatu, dan melakukan tindakan. Kata-kata kunci: eksistensi, kepasrahan, tokoh, cerita pendek  AbstractSurrender is one form of existence of human life. As in the characters in the short story “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway who chose resignation in looking at death. The purpose of the research in this article is to provide a description of the differences and similarities regarding the meaning of surrender experienced by a character in the short story “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway. The method used is descriptive method with comparative analysis with literary psychology theory. Data collection techniques are literature study with data sources in the form of short stories “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway. Analytical techniques with interpretive descriptive. The results found in this study are in the two short stories there are similarities in the theme of the story that is death. The difference lies in the character's character in interpreting surrender by giving up, accepting, organizing something, and taking action. Keywords: existence, surrender, character, short stories


Author(s):  
E.A. Kovrigin ◽  
◽  
V.A. Vasilyev ◽  

Given the trends in the modern world, as well as the rapid growth of digitalization, it is safe to say that it will inevitably affect almost all areas of human life and activities. Dmitriev’s English dictionary defines the word readiness: «It is a state where everything is done to start doing something.» Accordingly, an assessment of the company’s readiness to integrate modern digital technologies will identify opportunities, risks and threats, strengths and weaknesses of the enterprise, as well as to formulate a list of initial measures that need to be implemented. Thus, there is an urgent need to find an answer to the following questions: «How (by, what criteria and indicators) to measure readiness?», «What are the approaches to readiness assessment?» The purpose of this article is to develop a model and algorithm to assess the company’s readiness to integrate modern digital technologies. Modelling techniques were used to achieve this goal, as well as to analyze and generalize information. As a result of the research, a model for assessing the company’s readiness to integrate modern digital technologies has been developed and tested, based on the quality management model presented in the ISO 9000 series standards. A particular example shows how to use it and what it ultimately allows you to see and evaluate.


2019 ◽  
Vol 70 (5) ◽  
pp. 1778-1783
Author(s):  
Andreea-Loredana Golli ◽  
Floarea Mimi Nitu ◽  
Maria Balasoiu ◽  
Marina Alina Lungu ◽  
Cristiana Cerasella Dragomirescu ◽  
...  

To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates � 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p[0.001), cefuroxime (p[0.01) and to cefepime (p[0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.


Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 380
Author(s):  
Hamed Ahari ◽  
Leila Khoshboui Lahijani

Packaging containing nanoparticles (NPs) can increase the shelf life of products, but the presence of NPs may hazards human life. In this regard, there are reports regarding the side effect and cytotoxicity of nanoparticles. The main aim of this research was to study the migration of silver and copper nanoparticles from the packaging to the food matrix as well as the assessment techniques. The diffusion and migration of nanoparticles can be analyzed by analytical techniques including atomic absorption, inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission, and inductively coupled plasma optical emission spectroscopy, as well as X-ray diffraction, spectroscopy, migration, and titration. Inductively coupled plasma-based techniques demonstrated the best results. Reports indicated that studies on the migration of Ag/Cu nanoparticles do not agree with each other, but almost all studies agree that the migration of these nanoparticles is higher in acidic environments. There are widespread ambiguities about the mechanism of nanoparticle toxicity, so understanding these nanoparticles and their toxic effects are essential. Nanomaterials that enter the body in a variety of ways can be distributed throughout the body and damage human cells by altering mitochondrial function, producing reactive oxygen, and increasing membrane permeability, leading to toxic effects and chronic disease. Therefore, more research needs to be done on the development of food packaging coatings with consideration given to the main parameters affecting nanoparticles migration.


Author(s):  
Katsumasa Miyazaki ◽  
Kunio Hasegawa ◽  
Koichi Saito

The fitness-for-service codes require the characterization of non-aligned multiple flaws for flaw evaluation, which is performed using a flaw proximity rule. Worldwide, almost all such codes provide their own proximity rule, often with unclear technical bases of the application of proximity rule to ductile or fully plastic fracture. In particular, the effect of flaw dimensions of multiple surface flaws on fully plastic fracture of non-aligned multiple flaws had not been clear. To clarify the effect of the difference of part through-wall and through-wall flaws on the behavior of fully plastic fracture, the fracture tests of flat plate specimens with non-aligned multiple part through-wall flaws were conducted. When the flaw depth a was shallow with 0.4 in ratio of a to thickness t, the maximum load Pmax occurred at penetration of multiple flaws and the effect of vertical distance of non-aligned multiple flaws H on Pmax was not so significant. However, when flaw depth was deep with 0.8 in a/t, Pmax occurred after penetration of flaws and the effect of H on Pmax could be seen clearly. It was judged that the through-wall flaw tests were appropriate for discussion of the effect of H on Pmax and the alignment rule of multiple flaws. In addition, in order to clarify the appropriate length parameter to estimate Pmax of test specimens with dissimilar non-aligned through-wall multiple flaws, the fracture tests of plate specimens were also conducted. The effect of different flaw length on Pmax was discussed with maximum, minimum and averages of dissimilar non-aligned multiple flaw lengths. Experimental results showed that the maximum length lmax would be an appropriate length parameter to estimate Pmax, when the non-aligned multiple through-wall flaws were dissimilar.


2012 ◽  
Vol 78 (13) ◽  
pp. 4677-4682 ◽  
Author(s):  
Charlotte Valat ◽  
Frédéric Auvray ◽  
Karine Forest ◽  
Véronique Métayer ◽  
Emilie Gay ◽  
...  

ABSTRACTIn line with recent reports of extended-spectrum beta-lactamases (ESBLs) inEscherichia coliisolates of highly virulent serotypes, such as O104:H4, we investigated the distribution of phylogroups (A, B1, B2, D) and virulence factor (VF)-encoding genes in 204 ESBL-producingE. coliisolates from diarrheic cattle. ESBL genes, VFs, and phylogroups were identified by PCR and a commercial DNA array (Alere, France). ESBL genes belonged mostly to the CTX-M-1 (65.7%) and CTX-M-9 (27.0%) groups, whereas those of the CTX-M-2 and TEM groups were much less represented (3.9% and 3.4%, respectively). One ESBL isolate wasstx1andeaepositive and belonged to a major enterohemorrhagicE. coli(EHEC) serotype (O111:H8). Two other isolates wereeaepositive butstxnegative; one of these had serotype O26:H11. ESBL isolates belonged mainly to phylogroup A (55.4%) and, to lesser extents, to phylogroups D (25.5%) and B1 (15.6%), whereas B2 strains were quasi-absent (1/204). The number of VFs was significantly higher in phylogroup B1 than in phylogroups A (P= 0.04) and D (P= 0.02). Almost all of the VFs detected were found in CTX-M-1 isolates, whereas only 64.3% and 33.3% of them were found in CTX-M-9 and CTX-M-2 isolates, respectively. These results indicated that the widespread dissemination of theblaCTX-Mgenes within theE. colipopulation from cattle still spared the subpopulation of EHEC/Shiga-toxigenicE. coli(STEC) isolates. In contrast to other reports on non-ESBL-producing isolates from domestic animals, B1 was not the main phylogroup identified. However, B1 was found to be the most virulent phylogroup, suggesting host-specific distribution of virulence determinants among phylogenetic groups.


Maska ◽  
2020 ◽  
Vol 35 (200s3) ◽  
pp. 98-108
Author(s):  
Miško Šuvaković

Abstract This text was written on the occasion of the 200th issue of Maska magazine. My goal is to identify and interpret the time when the text is written and when the 200th issue of Maska will be published. I identified a situation of sociability at the time of the coronavirus pandemic and the dominance of digital/postdigital communications. I am interested in the difference between media representation, virus events and political-or-artistic interpretation of modern and transitional forms of human life. If we are talking about digital art/culture/society in relation to the technological turns from the mechanical to the analogue-electronic world, from the analogue to the digital world, from the digital world to the post-digital world, and from the post-digital world into a De Re media possible world, then we are facing a conflict between the dialectic of emancipation through the new and the differentiation of the production/and/consumption of the new in a time and space where the human being is becoming the product of its own product. It is important to index the contemporary antagonism between the ‘digital proletarian’ and ‘digital fascism’. Confronted with digital fascism, digital proletarians pursue a risky process of self-fulfilment and thereby liberation/emancipation in complex digital practices and their impacts on other forms of existence – in a critical and dialectic ontology. Therein lies the essential difference between the politics of functionalism and that of liberation.


PEDIATRICS ◽  
1984 ◽  
Vol 73 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Robert E. Black ◽  
Kenneth H. Brown ◽  
Stan Becker

Village-based surveillance data from longitudinal studies in rural Bangladesh have been used to evaluate the nutritional consequences of infectious diseases, including diarrhea due to specific pathogens. The prevalences of specific illnesses were related to the ponderal and linear growth of young children for 2-month and 1-year periods. Of the common illnesses, only diarrhea had a significant inverse relationship with increments of weight during 2-month periods and of length during 1 year. Diarrhea accounted for 20% of the difference in linear growth between the study children and the international reference population during the first 5 years of life. Diarrhea associated with enterotoxigenic Escherichia coli had a significant negative effect on the bimonthly weight gain of children in this community and shigellosis had the strongest negative effect on bimonthly and annual linear growth. Control of diarrhea due to enterotoxigenic E coli and Shigella would not only substantially diminish diarrheal morbidity but would also improve the growth of children and thereby reduce the prevalence of protein-energy malnutrition.


2021 ◽  
Vol 2021 (02) ◽  
pp. 214-225
Author(s):  
Sergey Kulik ◽  
Аnatoliy Kashevarov ◽  
Zamira Ishankhodjaeva

During World War II, representatives of almost all the Soviet Republics fought in partisan detachments in the occupied territory of the Leningrad Region. Among them were many representatives of the Central Asian republics: Kazakhstan, Kyrgyzstan and Uzbekistan. Many Leningrad citizens, including relatives of partisans, had been evacuated to Central Asia by that time. However, representatives of Asian workers’ collectives came to meet with the partisans. The huge distance, the difference in cultures and even completely different weather conditions did not become an obstacle to those patriots-Turkestanis who joined the resistance forces in the North-West of Russia.


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