Preparedness of Earthquake Disaster for Communities Koto Tangah Sub-District - Padang City (Case Study of Elementary School 31 Pasir Kandang)

In the last five years, the west coast of Sumatra island has experienced several earthquakes with strong intensity. The Pariaman earthquake on September 30, 2009, as reported by USGS, was located on the west coast of Pariaman with a magnitude of 7.9 SR and MMI VII-VIII standard, with a depth of 80 km. has caused victims to humans and property which is quite large. The socialization carried out is in the form of presentations in the classroom. The material presented includes the definition of a disaster, types of disasters (natural, non-natural, and social disasters), disaster management (before a disaster, when a disaster occurs, after a disaster).

Analysis of the Impact of the 2019–20 Australian Bushfire Season on the Atmospheric Environment

The 2019–20 Australian bushfire produced strong plumes that carried massive quantities of gases and aerosols through the tropopause into the stratosphere. The 2019 El Niño and a rare sudden stratospheric warming (SSW) in the Southern Hemisphere (SH) that occurred in austral spring 2019 caused reduced precipitation in eastern Australia, which caused the strongest bushfire in history in terms of area and disaster degree. High-intensity bushfires triggered chemical reactions, including the rapid secondary formation of formic acid (FA). The strong intensity of the bushfire and the isolated environment allowed their impacts to be well detected. We identified the most active bushfire period (December 30–January 1) and its impacts on atmospheric components. The trajectory and lifetime of bushfire plumes were analysed to reveal the bushfire process and most active period. Based on multiple satellite and reanalysis products, unique variations in atmospheric components were identified and attributed to three main factors: bushfire development period, stratospheric heating mechanism and rapid secondary formation of FA. The bushfire gradually increased in intensity from June, reached its most active period from December 30–January 1, and then weakened. The bushfire development period caused delays in the plumes and peak values of gases (CO, SO2, FA and ozone) and temperature. The diurnal cycle, particle concentration and time restricted the total radiative forcing of aerosols and gases, which prevented a high rate of temperature increase similar to that of gas input from plumes. The strong intensity of the bushfire caused rapid secondary formation of FA, which caused a sharp increase in FA production from December 30–January 1.

Histological Severity Risk Factors Identification in Juvenile-Onset Recurrent Respiratory Papillomatosis: How Immunohistochemistry and AI Algorithms Can Help?

Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a condition characterized by the repeated growth of benign exophytic papilloma in the respiratory tract. The course of the disease remains unpredictable: some children experience minor symptoms, while others require multiple interventions due to florid growth. Our study aimed to identify histologic severity risk factors in patients with JoRRP. Forty-eight children from two French pediatric centers were included retrospectively. Criteria for a severe disease were: annual rate of surgical endoscopy ≥ 5, spread to the lung, carcinomatous transformation or death. We conducted a multi-stage study with image analysis. First, with Hematoxylin and eosin (HE) digital slides of papilloma, we searched for morphological patterns associated with a severe JoRRP using a deep-learning algorithm. Then, immunohistochemistry with antibody against p53 and p63 was performed on sections of FFPE samples of laryngeal papilloma obtained between 2008 and 2018. Immunostainings were quantified according to the staining intensity through two automated workflows: one using machine learning, the other using deep learning. Twenty-four patients had severe disease. For the HE analysis, no significative results were obtained with cross-validation. For immunostaining with anti-p63 antibody, we found similar results between the two image analysis methods. Using machine learning, we found 23.98% of stained nuclei for medium intensity for mild JoRRP vs. 36.1% for severe JoRRP (p = 0.041); and for medium and strong intensity together, 24.14% for mild JoRRP vs. 36.9% for severe JoRRP (p = 0.048). Using deep learning, we found 58.32% for mild JoRRP vs. 67.45% for severe JoRRP (p = 0.045) for medium and strong intensity together. Regarding p53, we did not find any significant difference in the number of nuclei stained between the two groups of patients. In conclusion, we highlighted that immunochemistry with the anti-p63 antibody is a potential biomarker to predict the severity of the JoRRP.

Bioresponsive Microlasers with Tunable Lasing Wavelength

Lasing particles are emerging tools for amplifying light-matter interactions at the biointerface by exploiting its strong intensity and miniaturized size. Recent advances in implementing laser particles into living cells and...

A Low Budget Touch less Door Bell with Integrated Intruder Alerting Safety System

: A Door bell is a signaling device of your home which is used to indicate the Owner (host) that someone is at your door-step. The problem that is faced today is the touch contact of the Door-bell switch, wherein everyone will have to touch it, not having any other option than knocking or slamming the door. This is a critical issue condition nowadays, when by chance a Corona affected person unintentionally touches the switch, later followed by a healthy person, wherein which it now acts as a source of transmission. A touch less door bell (Buzzer) using sensors will solve this issue, wherein available solutions have Ultrasonic sensors for the same. Similarly this door bell can also produce a strong intensity of signal which can also be used as an alert system, if an intruder is trying to enter, while the host is not in the house. To implement both these together a PIR sensor would additionally be required to enable the Ultrasonic sensor and Sound sensor. The alert system can be controlled by the Host with the help of a Switch placed inside the house. The host is being alerted with a message in both scenarios with the help of a GSM module. All of these controlled by a single microcontroller, and the reuse of PIR and Buzzer, makes it cost effective.

P0185ROLE OF THE COMPLEMENT SYSTEM IN PROLIFERATIVE LUPUS NEPHRITIS

Background and Aims Lupus Nephritis (LN) is a serious complication in patients with Systemic Lupus Erythematosus (SLE) which confers a worse prognosis in patients that develop this condition. It is well known that histological lesions correlate poorly with the prognosis of the disease, but little is known about the role of complement proteins deposition in kidney tissue. The aim of this study was to evaluate the effect on renal manifestations of the deposition in renal tissue of C3, as a marker of alternative pathway, C4 as a marker of the classical pathway and C1q representing the lectin pathway. Method A retrospective observational study was performed, including native kidney biopsies with a diagnosis of lupus proliferative nephritis (class III/IV) (ISN/RPS 2003). Direct immunofluorescence microscopy was performed in -80ºC frozen sections to evaluate IgA, IgG, IgM, C4d, C1q and C3, and LES activity and chronicity scores were calculated according to NIH disease activity scoring system. The intensity of staining was graded as 0 (no staining), +1 (stainvisible at 40X magnification), +2 (at 20X), +3 (at X10), and +4 (at 2-4X). For statistical purpose we considered weak staining: 0, +1, +2 and strong staining: +3, +4. Patient´s files were retrospectively reviewed and clinical and analytical data were collected using a standardized form. Results 64 native kidney biopsies from 56 patients with a diagnosis of lupus proliferative nephritis were included, basal characteristics are described in attached Table. Activity index was significantly higher in biopsies showing strong intensity C3 staining compared to biopsies showing weak intensity C3 staining [(n=25) 10±1 vs (n=13) 5±1; p=0.002 respectively], alb/creat was significantly higher in patients in whom biopsy showed strong intensity C3 staining, compared to biopsies showing weak intensity C3 staining [(n=10) 1964.4±585.2 mg/gr vs (n=6) 823.6±58 mg/gr; p<0.001, respectively], prot/creat was significantly higher in biopsies that showed strong C3 staining intensity [(n=27) 2302.5±325 mg/gr vs (n=12) 1287.7±235 mg/gr, p<0.005, respectively], haematuria at NL diagnosis was more frequently in patients whose biopsy showed strong intensity C3 staining (n=21, 80.8%), compared to biopsies showing weak intensity C3 staining (n=5, 19.5%, p<0.001); most of the patients without haematuria at diagnosis showed a weak intensity C3 staining or not C3 staining (n=13, 62%). Endocapillary proliferation was significantly higher in biopsies showing strong intensity C3 staining (90.9% vs 9.1%, p<0.001).Time to proteinuria response is higher in patients showing strong intensity C4d stainingcompared with biopsies showing weak intensity C4d staining (15.2±2.4 vs 6.4±1.8 months; p=0.001), time to haematuria response is higher inbiopsies showing strong intensity C4d staining (19.5±5.5 vs 7.5±2.3 months, p=0.003). Time to proteinuria response is higher in patients showing strong intensity C1q stainingcompared to biopsies showing weak intensity C1q staining (14.0±9 vs 3.3±2.6 months, p <0.001). Conclusion Our results suggest that complement system is activated in kidney tissue of proliferative LN patients; C3 staining is associated with clinical, analytical and histological data related to acute lupus activity, whereas C4d and C1q staining are related with long-term outcomes like treatment response. Further studies are needed to elucidate the role of complement system in LN.

Highly Efficient Antibiofilm and Antifungal Activity of Green Propolis against Candida species in dentistry material

BackgroundThis study evaluated the influence of green propolis’ extract on the adhesion and biofilm formation of Candida species on dentistry material.MethodsPhytochemical analysis of green propolis’ extract was performed by High Performance Liquid Chromatography. Adhesion was quantified in a Neubauer chamber, counting the number of yeast cells adhered to the fragments; Biofilm formation was determined by counting the number of colony forming units (CFU). The intensity of biofilm formation adhesion was classified as negative, weak, moderate, strong and very strong. Fifteen compounds were identified in green propolis extract, mainly flavonoids.ResultsAll strains were able to adhere and form biofilm on the surface of the orthodontic materials studied. In steel and resin, the adhesion intensity of the yeast cells was weak at all incubation times, except for C. parapsilosis and C. tropicalis which at 12hs showed moderate intensity. Regarding biofilm formation (24 and 48 hours), it was observed in the steel that C. albicans had moderate intensity at 24 and 48 hours; C. parapsilosis at 24 and 48 hours had very strong intensity; C. tropicalis at 24 hours had strong intensity and at 48 hours very strong. While in the resin, all species at 24 and 48 hours had strong intensity, except for C. tropicalis which at 48 hours had very strong intensity. Green propolis extract showed antifungal activity and was able to inhibit both adhesion and biofilm formation at 2.5 μg/mL.ConclusionsThis study reinforces the idea that green propolis has antifungal activity and interferes with virulence factors of Candida species.

Forecasting Oil Price Using Web-based Sentiment Analysis

International oil price forecasting is a complex and important issue in the research area of energy economy. In this paper, a new model based on web-based sentiment analysis is proposed. For the oil market, sentiment analysis is used to extract key information from web texts from the four perspectives of: compound, negative, neutral, and positive sentiment. These are constructed as feature and input into oil price forecasting models with oil price itself. Finally, we analyze the effect in various views and get some interesting discoveries. The results show that the root mean squared error can be reduced by about 0.2 and the error variance by 0.2, which means that the accuracy and stability are thereby improved. Furthermore, we find that different types of sentiments can all improve performance but by similar amounts. Last but not least, text with strong intensity can better support oil price forecasting than weaker text, for which the root mean squared error can be reduced by up to 0.5, and the number of the bad cases is reduced by 20%, indicating that text with strong intensity can correct the original oil price forecast. We believe that our research will play a strong supporting role in future research on using web information for oil price forecasting.

The intensity order illusion: temporal order of different vibrotactile intensity causes systematic localization errors

Haptic illusions serve as important tools for studying neurocognitive processing of touch and can be utilized in practical contexts. We report a new spatiotemporal haptic illusion that involves mislocalization when the order of vibrotactile intensity is manipulated. We tested two types of motors mounted in a 4 × 4 array in the lower thoracic region. We created apparent movement with two successive vibrotactile stimulations of varying distance (40, 20, or 0 mm) and direction (up, down, or same) while changing the temporal order of stimulation intensity (strong-weak vs. weak-strong). Participants judged the perceived direction of movement in a 2-alternative forced-choice task. The results suggest that varying the temporal order of vibrotactile stimuli with different intensity leads to systematic localization errors: when a strong-intensity stimulus was followed by a weak-intensity stimulus, the probability that participants perceived a downward movement increased, and vice versa. The illusion is so strong that the order of the strength of stimulation determined perception even when the actual presentation movement was the opposite. We then verified this “intensity order illusion” using an open response format where observers judged the orientation of an imaginary line drawn between two sequential tactor activations. The intensity order illusion reveals a strong bias in vibrotactile perception that has strong implications for the design of haptic information systems. NEW & NOTEWORTHY We report a new illusion involving mislocalization of stimulation when the order of vibrotactile intensity is manipulated. When a strong-intensity stimulus follows a weak-intensity stimulus, the probability that participants perceive an upward movement increases, and vice versa. The illusion is so strong that the order of the strength of stimulation determined perception even when the actual presentation movement was the opposite. This illusion is important for the design of vibrotactile stimulation displays.