Fluid-Solid Coupling Simulation of Wall Fluid Shear Stress on Cells under Gradient Fluid Flow

Fluid shear stress (FSS) plays a crucial role for cell migration within bone cavities filled with interstitial fluid. Whether the local wall FSS distribution on cell surface depends on the global gradient FSS of flow field should be clarified to explain our previous experimental observation. In this study, finite element models of discretely distributed or hexagonal closely packed cells adherent on the bottom plate in a modified plate flow chamber with different global FSS gradient were constructed. Fluid-solid coupling simulation of wall fluid shear stress on cells was performed, and two types of data analysis methods were used. The results showed that the profile of local FSS distribution on cell surface coincides with the angle of cell migration determined in the previous study, suggesting that RAW264.7 osteoclast precursors may sense the global FSS gradient and migrate toward the low-FSS region under a high gradient. For hexagonal closely packed cells, this profile on the surface of central cells decreased along with the increase of cell spacing, which may be caused by the higher local FSS difference along the direction of FSS gradient in the regions close to the bottom plate. This study may explain the phenomenon of the targeted migration of osteoclast precursors under gradient FSS field and further provide insights into the mechanism of mechanical stimulation-induced bone remodeling.

Quantitative modeling of regular retinal microglia distribution

Microglia are resident immune cells in the central nervous system, showing a regular distribution. Advancing microscopy and image processing techniques have contributed to elucidating microglia’s morphology, dynamics, and distribution. However, the mechanism underlying the regular distribution of microglia remains to be elucidated. First, we quantitatively confirmed the regularity of the distribution pattern of microglial soma in the retina. Second, we formulated a mathematical model that includes factors that may influence regular distribution. Next, we experimentally quantified the model parameters (cell movement, process formation, and ATP dynamics). The resulting model simulation from the measured parameters showed that direct cell–cell contact is most important in generating regular cell spacing. Finally, we tried to specify the molecular pathway responsible for the repulsion between neighboring microglia.

Hybrid Cell Structure for Wideband CMUT: Design Method and Characteristic Analysis

Capacitive micromachined ultrasonic transducer (CMUT) is an ultrasonic transducer based on the microelectromechanical system (MEMS). Wideband CMUT has good application prospects in ultrasonic imaging, ultrasonic identification, flow measurement, and nondestructive testing due to its excellent characteristics. This paper studies the method of increasing the bandwidth of the CMUT, proposes the structure of the wideband CMUT with a hybrid cell structure, and analyzes the design principles and characteristics of the wideband CMUT structure. By changing the cell spacing and the number of cells of different sizes composing the CMUT, we analyze the simulation of the effect of the spacing and number on the CMUT bandwidth, thereby optimizing the bandwidth characteristics of the CMUT. Next, the selection principle of the main structural parameters of the wideband CMUT is analyzed. According to the proposed principle, the CMUT in the air and water are designed and simulated. The results prove that both the air and water CMUT meet the design requirements. The design rules obtained in this paper can provide theoretical guidance for the selection of the main structural parameters of the wideband CMUT.

Quantitative modeling of regular retinal microglia distribution

Microglia are resident immune cells in the central nervous system (CNS), showing a regular distribution. Advancing microscopy and image processing techniques have contributed to elucidating microglia’s morphology, dynamics, and distribution. However, the mechanism underlying the regular distribution of microglia remains to be elucidated. First, we quantitatively confirmed the regularity of the distribution pattern of microglial soma. Second, we formulated a mathematical model that includes factors that may influence regular distribution. Next, we experimentally quantified the model parameters (cell movement, process formation, and ATP dynamics). The resulting model simulation from the measured parameters showed that direct cell-cell contact is most important in generating regular cell spacing. Finally, we tried to specify the molecular pathway responsible for the repulsion between neighboring microglia.

Comprehensive Passive Thermal Management Systems for Electric Vehicles

Lithium-ion (Li-ion) batteries have emerged as a promising energy source for electric vehicle (EV) applications owing to the solution offered by their high power, high specific energy, no memory effect, and their excellent durability. However, they generate a large amount of heat, particularly during the fast discharge process. Therefore, a suitable thermal management system (TMS) is necessary to guarantee their performance, efficiency, capacity, safety, and lifetime. This study investigates the thermal performance of different passive cooling systems for the LTO Li-ion battery cell/module with the application of natural convection, aluminum (Al) mesh, copper (Cu) mesh, phase change material (PCM), and PCM-graphite. Experimental results show the average temperature of the cell, due to natural convection, Al mesh, Cu mesh, PCM, and PCM-graphite compared with the lack of natural convection decrease by 6.4%, 7.4%, 8.8%, 30%, and 39.3%, respectively. In addition, some numerical simulations and investigations are solved by COMSOL Multiphysics®, for the battery module consisting of 30 cells, which is cooled by PCM and PCM-graphite. The maximum temperature of the battery module compared with the natural convection case study is reduced by 15.1% and 17.3%, respectively. Moreover, increasing the cell spacing in the battery module has a direct effect on temperature reduction.

Analysis of Power Generation for Solar Photovoltaic Module with Various Internal Cell Spacing

Photovoltaic (PV) systems directly convert solar energy into electricity and researchers are taking into consideration the design of photovoltaic cell interconnections to form a photovoltaic module that maximizes solar irradiance. The purpose of this study is to evaluate the cell spacing effect of light diffusion on output power. In this work, the light absorption of solar PV cells in a module with three different cell spacings was studied. An optical engineering software program was used to analyze the reflecting light on the backsheet of the solar PV module towards the solar cell with varied internal cell spacing of 2 mm, 5 mm, and 8 mm. Then, assessments were performed under standard test conditions to investigate the power output of the PV modules. The results of the study show that the module with an internal cell spacing of 8 mm generated more power than 5 mm and 2 mm. Conversely, internal cell spacing from 2 mm to 5 mm revealed a greater increase of power output on the solar PV module compared to 5 mm to 8 mm. Furthermore, based on the simulation and experiment, internal cell spacing variation showed that the power output of a solar PV module can increase its potential to produce more power from the diffuse reflectance of light.

The effects of composite primitive cells on band gap property of locally resonant phononic crystal

Locally resonant phononic crystal (LRPC) has the extraordinary property to prohibit the wave propagation in specific low-frequency ranges, however it exists limitation in engineering application due to narrow band gap width. Extensive achievements have been obtained on the locally resonant band gap (LRBG) tunability, whereas existing investigations mainly concern the independent primitive cells structure, which have the limitation in obtaining low-frequency and broadband simultaneously. In this paper, the composited locally resonant phononic crystals (CLRPC) are proposed and the effects of primitive cells contact state on the LRBG properties are investigated. The dispersion curves are applied to obtain the LRBG, and the corresponding modal features are analyzed to explain the band gap formation mechanism. The band structure indicates the design of composite primitive cells is able to increase the band gap number and obtain lower band gap, which is verified by the frequency response function (FRF). For the band gap formation mechanism, the asymmetric vibration due to primitive cells contact leads to diverse and strong coupling response, which generates more band gaps and reduces the band gap starting frequency, therefore the band gaps can be tuned by designing carefully the geometry structure of CLRPC. Further researches on band gap optimization demonstrate that the smaller cell spacing, smaller lattice constant and larger damping of coating layer should be satisfied to obtain broader LRBG and considerable attenuation synchronously. This investigation can provide references for the locally resonant isolation structure design in the low-frequency vibration control field.

Performance Analysis of Bifacial PV Modules with Transparent Mesh Backsheet

Due to their transparent rear side, bifacial modules can take advantage of rear side irradiance as opposed to monofacial modules. Glass or transparent backsheets are conventionally used as rear side encapsulation material. To increase coupling gains achieved through internal reflection at the module rear side, a white or reflecting mesh structure can be applied in the areas between the cells on the rear side material. In this study, an existing optical model based on a simplified ray tracing approach is extended to describe the effects achieved though this mesh structure. The model is further integrated into a complete cell-to-module loss and gain analysis. The performance of the mesh backsheet concept is assessed under varying parameters. The impact of mesh reflectance, bifaciality of the cell and width of the mesh compared to the cell spacing are investigated. Losses due to increased module temperature and gains due to internal reflection gains are compared. We confirm that the optimal power gain can be achieved when the width of the mesh is the same as the spacing between the cells. We find that the power gain due to the improved internal reflection outweighs the power loss due to increased module temperature.

Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation

The outer epithelial layer of zebrafish retinae contains a crystalline array of cone photoreceptors, called the cone mosaic. As this mosaic grows by mitotic addition of new photoreceptors at the rim of the hemispheric retina, topological defects, called “Y-Junctions”, form to maintain approximately constant cell spacing. The generation of topological defects due to growth on a curved surface is a distinct feature of the cone mosaic not seen in other well-studied biological patterns like the R8 photoreceptor array in the Drosophila compound eye. Since defects can provide insight into cell-cell interactions responsible for pattern formation, here we characterize the arrangement of cones in individual Y-Junction cores as well as the spatial distribution of Y-junctions across entire retinae. We find that for individual Y-junctions, the distribution of cones near the core corresponds closely to structures observed in physical crystals. In addition, Y-Junctions are organized into lines, called grain boundaries, from the retinal center to the periphery. In physical crystals, regardless of the initial distribution of defects, defects can coalesce into grain boundaries via the mobility of individual particles. By imaging in live fish, we demonstrate that grain boundaries in the cone mosaic instead appear during initial mosaic formation, without requiring defect motion. Motivated by this observation, we show that a computational model of repulsive cell-cell interactions generates a mosaic with grain boundaries. In contrast to paradigmatic models of fate specification in mostly motionless cell packings, this finding emphasizes the role of cell motion, guided by cell-cell interactions during differentiation, in forming biological crystals. Such a route to the formation of regular patterns may be especially valuable in situations, like growth on a curved surface, where the resulting long-ranged, elastic, effective interactions between defects can help to group them into grain boundaries.