Immunocorregating properties of propolis and their composite forms

Gastrointestinal and respiratory diseases of young farm animals account for the largest percentage of all diseases. Currently, vaccines have been developed and successfully used for the specific prevention of diseases of infectious etiology, but it is not always possible to develop immunity of sufficient intensity, since vaccination without immunostimulation does not contribute to sufficient antibody formation. One of the important tasks of practical veterinary medicine was to find environmentally safe immunocorregulating substances that do not have a suppressive effect on the body. It was established that the drug ferran activated hematopoietic reactions of the body. Ferran in combination with enterozyme restores immunopoiesis and erythropoiesis to the indicators of physiological norms. The combined use of enterozyme with propolis hasda high immunostimulating effect, enhanced the productive phase of the immune response, removed the suppressive effect of the vaccine and increased the factors of natural and colonization resistance of the intestine.

Agroforestry development in Lake Toba catchment area: Farmer’s perception and interest

The Lake Toba Catchment Area (LTCA) has degraded due to a lack of implementation of conservation principles. Agroforestry is one of the land-use techniques with a conservation approach. Agroforestry development in LTCA should be supported by stakeholders, especially farmers. Farmers’ support will be formed if they have a good perception and interest in developing the agroforestry systems. The study aims to determine farmers’ characteristics, perceptions, and interests in agroforestry development in LTCA. The study was conducted from July until August 2019 at Simalungun Regency, North Sumatra Province. Data were collected through semi-structured interviews using a questionnaire with 30 respondents. Measurement of farmers’ perception and interest use a Likert scale. The data were then analyzed descriptively. The results showed that the farmers’ age is dominated by the productive phase (30-50 years old); they are only completed elementary schools, with average landholding was <0.3 ha, and farming experience >10 years. Farmers’ perceptions and interests in agroforestry development in LTCA are in good categories, each with a score of 4.18. These perceptions and interests of farmers are supporting factors that would positively impact the development of sustainable agroforestry in LTCA.

Inventory of Weeds In Oil Palm Plants (Elaeis guineensis Jacq.) In Balai Pengawasan dan Sertifikasi Benih Perkebunan

Weeds have a direct influence on the growth and yield of oil palm production, resulting in various losses. Weed control aims to suppress growth or destroy weeds in plantations. In order to reduce the risk of failure in weed control, weed inventory activities need to be carried out first. Weed inventory is an activity to collect data on the types of weeds, and is expected to reveal potential and information about weeds. The purpose of this study was to identify and recognize the diversity of weed species that can be used as the basis for weed control in the productive phase of oil palm plantations at the Plantation Seed Monitoring and Certification Center. The method used in this study was a descriptive qualitative approach. The results of the study found 2 divisions, 4 classes, 13 orders, 18 families, 22 genera and 22 plant species on oil palm plantations with narrow, broad, and ferns. In general, based on the results of the inventory, broadleaf weeds were more common than narrow leaf weeds and fern weeds.

Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling

Recognition of Zika virus (ZIKV) sexual transmission (ST) among humans challenges our understanding of the maintenance of mosquito-borne viruses in nature. Here we dissected the relative contributions of the components of male reproductive system (MRS) during early male-to-female ZIKV transmission by utilizing mice with altered antiviral responses, in which ZIKV is provided an equal opportunity to be seeded in the MRS tissues. Using microRNA-targeted ZIKV clones engineered to abolish viral infectivity to different parts of the MRS or a library of ZIKV genomes with unique molecular identifiers, we pinpoint epithelial cells of the epididymis (rather than cells of the testis, vas deferens, prostate, or seminal vesicles) as a most likely source of the sexually transmitted ZIKV genomes during the early (most productive) phase of ZIKV shedding into the semen. Incorporation of this mechanistic knowledge into the development of a live-attenuated ZIKV vaccine restricts its ST potential.

PENGARUH KONSENTRASI PUPUK NPK CAIR DAN JUMLAH RUAS STEK PUCUK TERHADAP PERTUMBUHAN TANAMAN NILAM (Pogostemon cablin Benth)

The good quality patchouli plants, it takes patchouli cuttings that have good initial vegetative growth. The initial vegetative growth in plants is an important phase that supports the further growth of patchouli until the productive phase. To produce patchouli plants with good initial vegetative growth, fertilization is necessary to ensure the availability of nutrients needed in the metabolic process of patchouli plants. Patchouli plants require adequate amounts of nutrients, especially macro nutrients such as nitrogen and others which can be done by administering NPK with the right dose and frequency of administration. The results showed that (1) the treatment of patchouli cuttings (treatment B) had a very significant effect on the growth of patchouli at week 2,4,6,8,10 and 12 WAP. Meanwhile, the concentration of liquid NPK fertilizer (treatment A) had a very significant effect only at the age of 10 and 12 WAP for the number of leaves. (2) The treatment of the number of patchouli cuttings (treatment B) had a significant effect on the growth of patchouli at week 4 WAP, had a very significant effect at week 2,6,8 and 12 WAP. As for the treatment, the concentration of liquid NPK fertilizer (treatment A) had a significant effect on week 8 MST and had a very significant effect at week 10 and 12 MST for the number of shoots (3) There was an interaction between the two treatments, namely at the age of 10 and 12 MST while on the number of shoots only occurred at the age of 12 MST

Biomolecular Modeling and Simulation: A Prospering Multidisciplinary Field

We reassess progress in the field of biomolecular modeling and simulation, following up on our perspective published in 2011. By reviewing metrics for the field's productivity and providing examples of success, we underscore the productive phase of the field, whose short-term expectations were overestimated and long-term effects underestimated. Such successes include prediction of structures and mechanisms; generation of new insights into biomolecular activity; and thriving collaborations between modeling and experimentation, including experiments driven by modeling. We also discuss the impact of field exercises and web games on the field's progress. Overall, we note tremendous success by the biomolecular modeling community in utilization of computer power; improvement in force fields; and development and application of new algorithms, notably machine learning and artificial intelligence. The combined advances are enhancing the accuracy and scope of modeling and simulation, establishing an exemplary discipline where experiment and theory or simulations are full partners. Expected final online publication date for the Annual Review of Biophysics, Volume 50 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

ASSESSMENT OF THE EFFECT OF CARBON MONOXIDE DONOR (CORM-2) ON BLOOD CLOTTING RATE UNDER CONDITIONS OF IMMUNE RESPONSE

The balance between the liquid state support of the blood and the thrombus formation process depends on the activity of plasma factors and thrombocytes. In a vascular injury condition, thrombocytes form a thrombocyte plug, vasoconstriction and, further, take part in the restoration of the tissues. Reducing the clotting function of thrombocytes is a current problem. The search for agents - modulators of thrombocyte activity - is a promising area of research. Compounds - gas-transmitters can be used to model the activity of thrombocytes hemostasis. Carbon monoxide (CO) gas belongs to this group as well. CO in very low concentrations affects in a different way the process of apoptosis, stimulates calcium-dependent potassium channels, and changes the activity of mitochondria. To investigate the effect of CO on blood clotting rate, laboratory mice were injected with the compound CO donor (CORM-2). This substance was administered separately during the inductive and productive phases of the immune response. The dynamics of the immune response were measured by IgA, IgM and IgG immunoglobulin levels. It was found that blood clotting was intensified under the influence of CORM-2 (20 mg/kg). Especially, the increase was during the productive phase. At the end of the experiment, the percentage of megakaryoblasts in the total population of thrombocyte precursors decreased in the bone marrow of animals (to which CORM-2 was administered). Against this background, an increased content of megakaryocytes was found in the group that received CORM-2 during the productive phase. In the group that received CORM-2 during the inductive phase, in addition to an increase in megakaryocyte levels, there was an increase in thrombocyte levels. The group that received CORM-2 during the productive phase also had a predominance of metamegakaryocytes and reducing of thrombocyte amount. Key words: thrombocytes, carbon monoxide donor, CORM-2, immune response phases.

Morphological characteristic of coronavirus infection of the first and second waves of the pandemic

Introduction. A peculiarity of the first two waves of the epidemic of a novel coronavirus infection was that during their development only diagnostic methods, treatment regimens and anti-epidemic measures were only being developed, there were no vaccines and no mass vaccination was carried out. In this regard, the pandemic of the novel coronavirus infection of the first two waves is characterized by spontaneous progression of the disease. Aim of the research. Comparative study of morphological and clinical features of the novel coronavirus infection in the 1st and 2nd waves of the pandemic in 2020. Materials and methods. The autopsy protocols of deceased patients at the City Clinical Hospital No. 1 (Novosibirsk) during the 1st (May — June 2020) (1st group) and 2nd (October — December 2020) (2nd group) waves of the epidemic were analyzed. The 1st group included 30 cases, that is 14 women (46.7%) and 16 men (53.3%), in the 2nd — 110 cases, of which 43 were women (39.1%) and 67 – men (60.9%). In all cases, the presence of SARS-CoV-2 RNA in nasopharyngeal swabs from the patients was confirmed by polymerase chain reaction. Results. The novel coronavirus infection (coronavirus disease 2019 (COVID-19), ICD-10 code: U07.1) as the principal diagnosis in both the 1st and 2nd waves was recorded in more than 66% of observations. Among the comorbidities, the circulatory and endocrine disorders (primarily diabetes mellitus and obesity), kidneys and urinary tract diseases, mainly chronic pyelonephritis, prevailed. The COVID-19 pneumonia was predominantly bilateral polysegmental serоhemorrhagic in nature, however, in the 1st wave of the pandemic, the frequency of subtotal and seropurulent pneumonias was higher than in patients hospitalized during the 2nd wave. Diffuse alveolar damage in the 1st wave of the epidemic was characterized by the predominance of the early (exudative) phase of inflammation, in contrast to the 2nd wave, which was characterized by the predominance of the late (productive) phase in patients. Histologically, in patients of the 1st wave, the signs of exudative inflammation and hemorrhagic phenomena (with neutrophils and hyaline membranes in the alveoli, infarctions caused by thrombosis and pulmonary thromboembolism) prevailed. In the 2nd wave, signs of productive inflammation were more common in the lungs (predominance of macrophages in the alveoli, organizing pneumonia (pneumofibrosis), squamous cell metaplasia). Conclusion. The differences in the course of the novel coronavirus infection in the 1st and 2nd waves of the 2020 epidemic concerned primarily the frequency and structure of comorbidities and the level of polymorbidity, which were higher in patients during the 2nd wave. The severity of lung damage in patients of the 2nd wave was less pronounced: subtotal bilateral pneumonias were less common, lower lobe seropurulent pneumonias were more common. Diffuse alveolar damage in the 1st wave of the epidemic was characterized by the predominance of the early (exudative) phase, in contrast to the 2nd wave, which was characterized by the predominance of the late, productive phase of inflammation.

From Svetokret to Tank: Zenitism and the Slovenian interwar avant-garde (1921-1927)

In January 1921, Svetokret, the first radical avant-garde magazine in the newly founded Kingdom of Serbs, Croats, and Slovenes, was launched in Ljubljana by Virgil Poljanski (1898-1947). This unique edition was a herald of Zenit (1921-1926), a mouthpiece of the ambitious zenitist movement, embodied by Poljanski's elder brother Ljubomir Micić (1895-1971). This article examines the dynamics of relations between the protagonists of the Slovenian interwar avant-garde and the leading zenitists, as documented in correspondence, newspaper reports, and, above all, in the magazine and publishing production of the avant-garde movements themselves. In the first phase, these relations revolved around Anton Podbevšek and his group, which had gathered around the Trije labodje magazine (The Three Swans, 1922), but cooperation remained limited. In the second, more productive phase, zenitist ideas were partially embraced by the group of Slovenian constructivists led by Avgust Černigoj and Ferdo Delak. Zenitism and its magazine were certainly an important source of information and inspiration for Slovenian avant-garde artists (e.g., the poet Srečko Kosovel) but, despite several attempts, the cooperation did not produce lasting results before Zenit was banned in 1926. In 1927, the Ljubljana-based Tank magazine, edited by the ambitious Delak and supported by Micić, tried to continue the zenitist legacy. Unfortunately, its existence was short-lived.

The Effectiveness Of Providing Vulanic Ash (Tuff Vulcan) And Dolomite As Amelioran Materials On The Growth Of Immature Liberica Coffee Plants In Peat Land Of Mekar Jaya Village

Liberika coffee is one type of coffee that is widely cultivated by people in wetland areas (peat) precisely in Betara District, Tanjung Jabung Barat Regency. In recent years, this district has become a development center and provider of Liberika coffee seeds for coffee plantation farmers from various regions such as Palembang, Kalimantan and Riau. Liberika coffee is a type of coffee that is able to adapt and produce quite well in peatlands with areca nut as a cover crop. The productivity of coffee in this area is still low at an average of 715 / kg when compared to the potential yield of Liberika coffee which can reach 950 kg / ha. Increasing production and productivity can be done through intensification and extensification. One of the efforts to improve the physical and chemical properties of peat soils so as to increase the growth and production of coffee plants is the use of ameliorants (soil enhancers). This study aims to develop a technology for using ameliorant to improve the chemical properties of peat soil. Specifically, through this study, the dosage combination of vulcan tuff ash and dolomite can be identified. which can substitute the use of artificial fertilizers (inorganic) so that it can increase the growth and production of immature liberica coffee plants on peatlands. especially the coffee plantation of farmers in the village of mekar jaya, betara district, tanjung jabung west district. From the results of this study it can be concluded that the treatment of volcanic ash and dolomite did not show significant differences in plant height parameters and, stem diameter. but it gives a real difference to the growth of live area, the number of flowers per bunch and the number of flowers in each bunch. treatment of volcanic ash 500 / gr / tree and dolomite 500 / gr / tree and a combination of volcanic ash 250 / gr / tree + dolomite 250 / gr / tree after 7 weeks of application can significantly spur on the initiation of flowering an average of 7 bunches of branch flowers if compare with control (no treatment). Likewise, observations 8 weeks after application showed the same thing, there was an increase in the number of flowers formed an average of 11 flower clumps branching. From the results of this study, it can be concluded that the provision of ameliorant from vulcan tuff ash and dolomite can improve the chemical properties of peat soil so as to increase nutrient availability for growth and production of the Liberika coffee plant. From the results of this study, it can also be suggested that the use of volcanic ash and dolomite at a dose of 250-500 gr / tree to accelerate the productive phase of immature liberica coffee plants (young plants) in peatlands.