With the phenomenon of information acquisitions and sharing, this section aims to drawn from experiences of collaboration for intellectual contributions. Especially in the recent global economic meltdown, there is increased complexity about how to optimize business resources on a worldwide scale. Hence, the role collaboration plays in business management is not only to facilitate information sharing but more importantly, to enhance business performance. This chapter reviews the current literature in the fields of collaboration, as well as the interaction between collaboration and business performance in the area of Wenzhou. Moreover, influences from political, legal, business forces, cultural, psycho-social and technology development would also affect the performance of collaboration. A detailed discussion of the importance of the trust underpinning inter-organizational collaboration is included from the psycho-social perspective. Currently, a research gap exists in the examination of the relationships between collaboration and business performance via diffusing e-business in this industry.